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P57330

- UPPS_BUCAI

UniProt

P57330 - UPPS_BUCAI

Protein

Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Gene

uppS

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.UniRule annotation

    Catalytic activityi

    (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.UniRule annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei26 – 261UniRule annotation
    Metal bindingi26 – 261MagnesiumUniRule annotation
    Binding sitei31 – 311SubstrateUniRule annotation
    Binding sitei39 – 391SubstrateUniRule annotation
    Binding sitei43 – 431SubstrateUniRule annotation
    Active sitei74 – 741Proton acceptorUniRule annotation
    Binding sitei75 – 751SubstrateUniRule annotation
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei194 – 1941SubstrateUniRule annotation
    Metal bindingi213 – 2131MagnesiumUniRule annotation

    GO - Molecular functioni

    1. di-trans,poly-cis-decaprenylcistransferase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-236-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)UniRule annotation (EC:2.5.1.31UniRule annotation)
    Alternative name(s):
    Ditrans,polycis-undecaprenylcistransferaseUniRule annotation
    Undecaprenyl diphosphate synthaseUniRule annotation
    Short name:
    UDSUniRule annotation
    Undecaprenyl pyrophosphate synthaseUniRule annotation
    Short name:
    UPP synthaseUniRule annotation
    Gene namesi
    Name:uppSUniRule annotation
    Ordered Locus Names:BU236
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 251251Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)PRO_0000123584Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliP57330.
    SMRiP57330. Positions 15-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni27 – 304Substrate bindingUniRule annotation
    Regioni71 – 733Substrate bindingUniRule annotation
    Regioni200 – 2023Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the UPP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0020.
    HOGENOMiHOG000006054.
    KOiK00806.
    OMAiNRPEQEV.
    OrthoDBiEOG68H89T.

    Family and domain databases

    Gene3Di3.40.1180.10. 1 hit.
    HAMAPiMF_01139. ISPT.
    InterProiIPR001441. UPP_synth-like.
    IPR018520. UPP_synth-like_CS.
    [Graphical view]
    PANTHERiPTHR10291. PTHR10291. 1 hit.
    PfamiPF01255. Prenyltransf. 1 hit.
    [Graphical view]
    SUPFAMiSSF64005. SSF64005. 1 hit.
    TIGRFAMsiTIGR00055. uppS. 1 hit.
    PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57330-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQYKYLLEYN KKNHECNPCH VAIIMDGNGR WATRQGKIRI MGHKEGFRAV    50
    KEAIKFSIAN NLKILTLYAF SSENWNRPLF EIKALMELFL FALDTEIKNL 100
    KKHNIRFKVI GDITCFDKKL QNSIHYAEQI TFDNTGLILN IAANYGGRWD 150
    IIESVKKIIN RVQRGILDVN KIHENTISQY LSTSELLPVD LVIRTGGEKR 200
    ISNFLLWQIA YSELYFTDVL WPDFNCHIFQ HAIDSFVSRE RRFGGFKKNK 250
    K 251
    Length:251
    Mass (Da):29,381
    Last modified:December 1, 2000 - v1
    Checksum:i5DEF9628012A88F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12951.1.
    RefSeqiNP_240065.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB12951; BAB12951; BAB12951.
    GeneIDi1109679.
    KEGGibuc:BU236.
    PATRICi21243994. VBIBucAph127364_0249.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12951.1 .
    RefSeqi NP_240065.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57330.
    SMRi P57330. Positions 15-240.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB12951 ; BAB12951 ; BAB12951 .
    GeneIDi 1109679.
    KEGGi buc:BU236.
    PATRICi 21243994. VBIBucAph127364_0249.

    Phylogenomic databases

    eggNOGi COG0020.
    HOGENOMi HOG000006054.
    KOi K00806.
    OMAi NRPEQEV.
    OrthoDBi EOG68H89T.

    Enzyme and pathway databases

    BioCyci BAPH107806:GBZJ-236-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1180.10. 1 hit.
    HAMAPi MF_01139. ISPT.
    InterProi IPR001441. UPP_synth-like.
    IPR018520. UPP_synth-like_CS.
    [Graphical view ]
    PANTHERi PTHR10291. PTHR10291. 1 hit.
    Pfami PF01255. Prenyltransf. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64005. SSF64005. 1 hit.
    TIGRFAMsi TIGR00055. uppS. 1 hit.
    PROSITEi PS01066. UPP_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiUPPS_BUCAI
    AccessioniPrimary (citable) accession number: P57330
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3