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P57330

- UPPS_BUCAI

UniProt

P57330 - UPPS_BUCAI

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Protein
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
Gene
uppS, BU236
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide By similarity.UniRule annotation

Catalytic activityi

(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Binds 2 magnesium ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei26 – 261 By similarity
Metal bindingi26 – 261Magnesium By similarity
Binding sitei31 – 311Substrate By similarity
Binding sitei39 – 391Substrate By similarity
Binding sitei43 – 431Substrate By similarity
Active sitei74 – 741Proton acceptor By similarity
Binding sitei75 – 751Substrate By similarity
Binding sitei77 – 771Substrate By similarity
Binding sitei194 – 1941Substrate By similarity
Metal bindingi213 – 2131Magnesium By similarity

GO - Molecular functioni

  1. di-trans,poly-cis-decaprenylcistransferase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-236-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) (EC:2.5.1.31)
Alternative name(s):
Ditrans,polycis-undecaprenylcistransferase
Undecaprenyl diphosphate synthase
Short name:
UDS
Undecaprenyl pyrophosphate synthase
Short name:
UPP synthase
Gene namesi
Name:uppS
Ordered Locus Names:BU236
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)UniRule annotation
PRO_0000123584Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP57330.
SMRiP57330. Positions 15-240.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 304Substrate binding By similarity
Regioni71 – 733Substrate binding By similarity
Regioni200 – 2023Substrate binding By similarity

Sequence similaritiesi

Belongs to the UPP synthase family.

Phylogenomic databases

eggNOGiCOG0020.
HOGENOMiHOG000006054.
KOiK00806.
OMAiNRPEQEV.
OrthoDBiEOG68H89T.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57330-1 [UniParc]FASTAAdd to Basket

« Hide

MQYKYLLEYN KKNHECNPCH VAIIMDGNGR WATRQGKIRI MGHKEGFRAV    50
KEAIKFSIAN NLKILTLYAF SSENWNRPLF EIKALMELFL FALDTEIKNL 100
KKHNIRFKVI GDITCFDKKL QNSIHYAEQI TFDNTGLILN IAANYGGRWD 150
IIESVKKIIN RVQRGILDVN KIHENTISQY LSTSELLPVD LVIRTGGEKR 200
ISNFLLWQIA YSELYFTDVL WPDFNCHIFQ HAIDSFVSRE RRFGGFKKNK 250
K 251
Length:251
Mass (Da):29,381
Last modified:December 1, 2000 - v1
Checksum:i5DEF9628012A88F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12951.1.
RefSeqiNP_240065.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12951; BAB12951; BAB12951.
GeneIDi1109679.
KEGGibuc:BU236.
PATRICi21243994. VBIBucAph127364_0249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12951.1 .
RefSeqi NP_240065.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57330.
SMRi P57330. Positions 15-240.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB12951 ; BAB12951 ; BAB12951 .
GeneIDi 1109679.
KEGGi buc:BU236.
PATRICi 21243994. VBIBucAph127364_0249.

Phylogenomic databases

eggNOGi COG0020.
HOGENOMi HOG000006054.
KOi K00806.
OMAi NRPEQEV.
OrthoDBi EOG68H89T.

Enzyme and pathway databases

BioCyci BAPH107806:GBZJ-236-MONOMER.

Family and domain databases

Gene3Di 3.40.1180.10. 1 hit.
HAMAPi MF_01139. ISPT.
InterProi IPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view ]
PANTHERi PTHR10291. PTHR10291. 1 hit.
Pfami PF01255. Prenyltransf. 1 hit.
[Graphical view ]
SUPFAMi SSF64005. SSF64005. 1 hit.
TIGRFAMsi TIGR00055. uppS. 1 hit.
PROSITEi PS01066. UPP_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiUPPS_BUCAI
AccessioniPrimary (citable) accession number: P57330
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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