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P57330 (UPPS_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
EC=2.5.1.31
Alternative name(s):
Ditrans,polycis-undecaprenylcistransferase
Undecaprenyl diphosphate synthase
Short name=UDS
Undecaprenyl pyrophosphate synthase
Short name=UPP synthase
Gene names
Name:uppS
Ordered Locus Names:BU236
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera ›

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide By similarity. HAMAP-Rule MF_01139

Catalytic activity

(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate. HAMAP-Rule MF_01139

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the UPP synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) HAMAP-Rule MF_01139
PRO_0000123584

Regions

Region27 – 304Substrate binding By similarity
Region71 – 733Substrate binding By similarity
Region200 – 2023Substrate binding By similarity

Sites

Active site261 By similarity
Active site741Proton acceptor By similarity
Metal binding261Magnesium By similarity
Metal binding2131Magnesium By similarity
Binding site311Substrate By similarity
Binding site391Substrate By similarity
Binding site431Substrate By similarity
Binding site751Substrate By similarity
Binding site771Substrate By similarity
Binding site1941Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P57330 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 5DEF9628012A88F5

FASTA25129,381
        10         20         30         40         50         60 
MQYKYLLEYN KKNHECNPCH VAIIMDGNGR WATRQGKIRI MGHKEGFRAV KEAIKFSIAN 

        70         80         90        100        110        120 
NLKILTLYAF SSENWNRPLF EIKALMELFL FALDTEIKNL KKHNIRFKVI GDITCFDKKL 

       130        140        150        160        170        180 
QNSIHYAEQI TFDNTGLILN IAANYGGRWD IIESVKKIIN RVQRGILDVN KIHENTISQY 

       190        200        210        220        230        240 
LSTSELLPVD LVIRTGGEKR ISNFLLWQIA YSELYFTDVL WPDFNCHIFQ HAIDSFVSRE 

       250 
RRFGGFKKNK K

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000003 Genomic DNA. Translation: BAB12951.1.
RefSeqNP_240065.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57330.
SMRP57330. Positions 15-240.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB12951; BAB12951; BAB12951.
GeneID1109679.
KEGGbuc:BU236.
PATRIC21243994. VBIBucAph127364_0249.

Phylogenomic databases

eggNOGCOG0020.
HOGENOMHOG000006054.
KOK00806.
OMAIAYSELF.
ProtClustDBCLSK2516824.

Family and domain databases

Gene3D3.40.1180.10. 1 hit.
HAMAPMF_01139. ISPT.
InterProIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERPTHR10291. PTHR10291. 1 hit.
PfamPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMSSF64005. UPP_synth. 1 hit.
TIGRFAMsTIGR00055. uppS. 1 hit.
PROSITEPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPS_BUCAI
AccessionPrimary (citable) accession number: P57330
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

SIMILARITY comments

Index of protein domains and families

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