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P57330

- UPPS_BUCAI

UniProt

P57330 - UPPS_BUCAI

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Protein

Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Gene

uppS

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.UniRule annotation

Catalytic activityi

(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei26 – 261UniRule annotation
Metal bindingi26 – 261MagnesiumUniRule annotation
Binding sitei31 – 311SubstrateUniRule annotation
Binding sitei39 – 391SubstrateUniRule annotation
Binding sitei43 – 431SubstrateUniRule annotation
Active sitei74 – 741Proton acceptorUniRule annotation
Binding sitei75 – 751SubstrateUniRule annotation
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei194 – 1941SubstrateUniRule annotation
Metal bindingi213 – 2131MagnesiumUniRule annotation

GO - Molecular functioni

  1. di-trans,poly-cis-decaprenylcistransferase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-236-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)UniRule annotation (EC:2.5.1.31UniRule annotation)
Alternative name(s):
Ditrans,polycis-undecaprenylcistransferaseUniRule annotation
Undecaprenyl diphosphate synthaseUniRule annotation
Short name:
UDSUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Short name:
UPP synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:BU236
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)PRO_0000123584Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP57330.
SMRiP57330. Positions 15-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 304Substrate bindingUniRule annotation
Regioni71 – 733Substrate bindingUniRule annotation
Regioni200 – 2023Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0020.
HOGENOMiHOG000006054.
KOiK00806.
OMAiNRPEQEV.
OrthoDBiEOG68H89T.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57330-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQYKYLLEYN KKNHECNPCH VAIIMDGNGR WATRQGKIRI MGHKEGFRAV
60 70 80 90 100
KEAIKFSIAN NLKILTLYAF SSENWNRPLF EIKALMELFL FALDTEIKNL
110 120 130 140 150
KKHNIRFKVI GDITCFDKKL QNSIHYAEQI TFDNTGLILN IAANYGGRWD
160 170 180 190 200
IIESVKKIIN RVQRGILDVN KIHENTISQY LSTSELLPVD LVIRTGGEKR
210 220 230 240 250
ISNFLLWQIA YSELYFTDVL WPDFNCHIFQ HAIDSFVSRE RRFGGFKKNK

K
Length:251
Mass (Da):29,381
Last modified:December 1, 2000 - v1
Checksum:i5DEF9628012A88F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12951.1.
RefSeqiNP_240065.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12951; BAB12951; BAB12951.
GeneIDi1109679.
KEGGibuc:BU236.
PATRICi21243994. VBIBucAph127364_0249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12951.1 .
RefSeqi NP_240065.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57330.
SMRi P57330. Positions 15-240.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB12951 ; BAB12951 ; BAB12951 .
GeneIDi 1109679.
KEGGi buc:BU236.
PATRICi 21243994. VBIBucAph127364_0249.

Phylogenomic databases

eggNOGi COG0020.
HOGENOMi HOG000006054.
KOi K00806.
OMAi NRPEQEV.
OrthoDBi EOG68H89T.

Enzyme and pathway databases

BioCyci BAPH107806:GBZJ-236-MONOMER.

Family and domain databases

Gene3Di 3.40.1180.10. 1 hit.
HAMAPi MF_01139. ISPT.
InterProi IPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view ]
PANTHERi PTHR10291. PTHR10291. 1 hit.
Pfami PF01255. Prenyltransf. 1 hit.
[Graphical view ]
SUPFAMi SSF64005. SSF64005. 1 hit.
TIGRFAMsi TIGR00055. uppS. 1 hit.
PROSITEi PS01066. UPP_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiUPPS_BUCAI
AccessioniPrimary (citable) accession number: P57330
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3