P57312 (FTSW_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid II flippase FtsW

Alternative name(s):
Cell division protein FtsW

Gene names

Name:	ftsW
Ordered Locus Names:	BU217

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Acyrthosiphon pisum)

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential cell division protein. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane By similarity. HAMAP-Rule MF_00913
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity. Note: Localizes to the division septum By similarity. HAMAP-Rule MF_00913
Sequence similarities	Belongs to the SEDS family. FtsW subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis by binary fission Inferred from electronic annotation. Source: HAMAP lipid-linked peptidoglycan transport Inferred from electronic annotation. Source: GOC peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell division site Inferred from electronic annotation. Source: HAMAP integral to plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular_function	lipid-linked peptidoglycan transporter activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Lipid II flippase FtsW HAMAP-Rule MF_00913		PRO_0000062697
Regions
	Transmembrane	33 – 53	21	Helical; Potential
	Transmembrane	71 – 91	21	Helical; Potential
	Transmembrane	98 – 118	21	Helical; Potential
	Transmembrane	160 – 180	21	Helical; Potential
	Transmembrane	182 – 202	21	Helical; Potential
	Transmembrane	204 – 224	21	Helical; Potential
	Transmembrane	287 – 307	21	Helical; Potential
	Transmembrane	324 – 344	21	Helical; Potential
	Transmembrane	359 – 379	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P57312 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: E92E3A94A88C1A8C	FASTA	399	45,458
	10 20 30 40 50 60 MKHLQKKNSK NPKKIEEKYN TRNSYFILYD RALVWLTLGL FSVGLIMVIS TSIPISQKIY 70 80 90 100 110 120 HNPLFFIKRE IFYFFLIFLL SFIFLRTPII FWEKNSNIIL IISIVLLVLV LLIGHSIHGS 130 140 150 160 170 180 FRWINIGFLH IQPSEICKIS SFCYLASYLS RKSNEVRNNF WGFFKPMSVI ITQSMLLLAE 190 200 210 220 230 240 PDLGTVVVLF FTTISVLFLS GAKIGQFFII ITVSILTIIL LILLEPYRIK RVLSFWNPWE 250 260 270 280 290 300 DPFGNGYQLT QSLIALGRGN FLGQGLGNSI QKLDYLPDAH SDFIFSIIGE ELGYIGSFLI 310 320 330 340 350 360 LLIIFTISFR AMYIGQKALE KKQIFSGFLA CSIGIWLSFQ TSINVGSVTG ILPTKGLTLP 370 380 390 FISYGGSSLI INSIAIFFLL RIDFETRLKT SQAFPRGPK

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB12933.1.
RefSeq	NP_240047.1. NC_002528.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB12933; BAB12933; BAB12933.
GeneID	1109660.
KEGG	buc:BU217.
PATRIC	21243956. VBIBucAph127364_0230.
Phylogenomic databases
eggNOG	COG0772.
HOGENOM	HOG000282689.
KO	K03588.
OMA	RIPMEVW.
ProtClustDB	CLSK315799.
Enzyme and pathway databases
BioCyc	BAPH107806:GBZJ-216-MONOMER.
Family and domain databases
HAMAP	MF_00913. FtsW_proteobact.
InterPro	IPR018365. Cell_cycle_FtsW-rel_CS. IPR001182. Cell_cycle_FtsW/RodA. IPR013437. Cell_div_FtsW. [Graphical view]
Pfam	PF01098. FTSW_RODA_SPOVE. 1 hit. [Graphical view]
TIGRFAMs	TIGR02614. ftsW. 1 hit.
PROSITE	PS00428. FTSW_RODA_SPOVE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTSW_BUCAI

Accession

Primary (citable) accession number: P57312

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	May 29, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program