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Protein

Putative lipid II flippase FtsW

Gene

ftsW

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.UniRule annotation

GO - Molecular functioni

  1. lipid-linked peptidoglycan transporter activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. FtsZ-dependent cytokinesis Source: UniProtKB-HAMAP
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis, Transport

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-216-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative lipid II flippase FtsWUniRule annotation
Alternative name(s):
Cell division protein FtsWUniRule annotation
Gene namesi
Name:ftsWUniRule annotation
Ordered Locus Names:BU217
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806 Componenti: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Note: Localizes to the division septum.UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalUniRule annotationAdd
BLAST
Transmembranei71 – 9121HelicalUniRule annotationAdd
BLAST
Transmembranei98 – 11821HelicalUniRule annotationAdd
BLAST
Transmembranei160 – 18021HelicalUniRule annotationAdd
BLAST
Transmembranei182 – 20221HelicalUniRule annotationAdd
BLAST
Transmembranei204 – 22421HelicalUniRule annotationAdd
BLAST
Transmembranei287 – 30721HelicalUniRule annotationAdd
BLAST
Transmembranei324 – 34421HelicalUniRule annotationAdd
BLAST
Transmembranei359 – 37921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. cell division site Source: UniProtKB-HAMAP
  2. integral component of plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Putative lipid II flippase FtsWPRO_0000062697Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the SEDS family. FtsW subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0772.
HOGENOMiHOG000282689.
KOiK03588.
OMAiWNPWDDP.
OrthoDBiEOG68M4JQ.

Family and domain databases

HAMAPiMF_00913. FtsW_proteobact.
InterProiIPR018365. Cell_cycle_FtsW-rel_CS.
IPR001182. Cell_cycle_FtsW/RodA.
IPR013437. Cell_div_FtsW.
[Graphical view]
PANTHERiPTHR30474. PTHR30474. 1 hit.
PfamiPF01098. FTSW_RODA_SPOVE. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02614. ftsW. 1 hit.
PROSITEiPS00428. FTSW_RODA_SPOVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLQKKNSK NPKKIEEKYN TRNSYFILYD RALVWLTLGL FSVGLIMVIS
60 70 80 90 100
TSIPISQKIY HNPLFFIKRE IFYFFLIFLL SFIFLRTPII FWEKNSNIIL
110 120 130 140 150
IISIVLLVLV LLIGHSIHGS FRWINIGFLH IQPSEICKIS SFCYLASYLS
160 170 180 190 200
RKSNEVRNNF WGFFKPMSVI ITQSMLLLAE PDLGTVVVLF FTTISVLFLS
210 220 230 240 250
GAKIGQFFII ITVSILTIIL LILLEPYRIK RVLSFWNPWE DPFGNGYQLT
260 270 280 290 300
QSLIALGRGN FLGQGLGNSI QKLDYLPDAH SDFIFSIIGE ELGYIGSFLI
310 320 330 340 350
LLIIFTISFR AMYIGQKALE KKQIFSGFLA CSIGIWLSFQ TSINVGSVTG
360 370 380 390
ILPTKGLTLP FISYGGSSLI INSIAIFFLL RIDFETRLKT SQAFPRGPK
Length:399
Mass (Da):45,458
Last modified:December 1, 2000 - v1
Checksum:iE92E3A94A88C1A8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12933.1.
RefSeqiNP_240047.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12933; BAB12933; BAB12933.
GeneIDi1109660.
KEGGibuc:BU217.
PATRICi21243956. VBIBucAph127364_0230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12933.1.
RefSeqiNP_240047.1. NC_002528.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB12933; BAB12933; BAB12933.
GeneIDi1109660.
KEGGibuc:BU217.
PATRICi21243956. VBIBucAph127364_0230.

Phylogenomic databases

eggNOGiCOG0772.
HOGENOMiHOG000282689.
KOiK03588.
OMAiWNPWDDP.
OrthoDBiEOG68M4JQ.

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-216-MONOMER.

Family and domain databases

HAMAPiMF_00913. FtsW_proteobact.
InterProiIPR018365. Cell_cycle_FtsW-rel_CS.
IPR001182. Cell_cycle_FtsW/RodA.
IPR013437. Cell_div_FtsW.
[Graphical view]
PANTHERiPTHR30474. PTHR30474. 1 hit.
PfamiPF01098. FTSW_RODA_SPOVE. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02614. ftsW. 1 hit.
PROSITEiPS00428. FTSW_RODA_SPOVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiFTSW_BUCAI
AccessioniPrimary (citable) accession number: P57312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: February 4, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.