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P57311 (MURG_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:BU216
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_0000109153

Sequences

Sequence LengthMass (Da)Tools
P57311 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 70F23A1294E6B3A6

FASTA35439,500
        10         20         30         40         50         60 
MIPKKIIIMA GGSGGHVFPG LTIARYLIEK GWLVNWIGTK NSIESRIIPK YGIKIHYISI 

        70         80         90        100        110        120 
KGLRNTSLKN LIISPIYILR AYYAVKKIIK TWSPDIVLGM GGYVSGPGGV ASWNCNIPLL 

       130        140        150        160        170        180 
LHEQNKIAGI TNKWLSRIST KNMQASPGVL RNAEVVGNPV CQSIIKVPNP INRFKNRTGL 

       190        200        210        220        230        240 
LRVLVIGGSQ GSSILNRILP EVSFLLKEKI IFWHQTGNYE LEKTKKKYNK LRLNQNLITS 

       250        260        270        280        290        300 
FIKNIASAYE WADLIICRSG ALTVSEISIV GLGAIFIPYP HKDKQQHRNA EDLELIGAAK 

       310        320        330        340        350 
IIDQSNLNTK LIVNILNSLD RDKLFIMAKK AHSLGVRDAI FNIFNVINKI SKKT

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed: 10993077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000003 Genomic DNA. Translation: BAB12932.1.
RefSeqNP_240046.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57311.
ModBaseSearch...

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000002945; EBBUCP00000002721; EBBUCG00000002945.
GeneID1109659.
GenomeReviewsGene locus BU216 in contig BA000003_GR.
KEGGbuc:BU216.
PATRIC21243954. VBIBucAph127364_0229.

Phylogenomic databases

GeneTreeEBGT00050000008039.
HOGENOMHBG617076.
OMAEDHQTKN.
PhylomeDBP57311.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycBSP107806:BU216-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_BUCAI
AccessionPrimary (citable) accession number: P57311
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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