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Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-204-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
Gene namesi
Name:aceE
Ordered Locus Names:BU205
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 887887Pyruvate dehydrogenase E1 componentPRO_0000162240Add
BLAST

Proteomic databases

PRIDEiP57301.

Interactioni

Subunit structurei

Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).By similarity

Protein-protein interaction databases

STRINGi107806.BU205.

Structurei

3D structure databases

ProteinModelPortaliP57301.
SMRiP57301. Positions 58-887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2609.
HOGENOMiHOG000115215.
KOiK00163.
OMAiEVIKVIW.
OrthoDBiEOG6BW4TW.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.

Sequencei

Sequence statusi: Complete.

P57301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENLYNDVD PIETRDWVQA IESVIRREGH KRAHFLIEQV LKTAKINRKE
60 70 80 90 100
FFRSSFTSDY INTISREDEY EYPGNLILEK RIRSAIRWNA IMMVLRASKK
110 120 130 140 150
NLELGGHLSS FQSSATIYEV CFNHFFQAKN HKDGGDLVYF QGHISPGIYA
160 170 180 190 200
RSFLEGRLSE EQIDNFRQEV DGIGLSSYPH PKLMPNFWQF PTVSMGLGPL
210 220 230 240 250
CAIYQAKFLK YLHNRELKNT SKQIVYAFLG DGEMDEPESK GAISIAVREK
260 270 280 290 300
LDNLIFIINC NLQRLDGPVV GNGKIVNELE SFFYGAGWKV IKVIWGSRWD
310 320 330 340 350
CLLKKDTSGK LIQLMNETVD GDYQTFKSKD GAYVRKYFFG KYKETYDLVK
360 370 380 390 400
DMTDEEIWKL NRGGHDPKKM FNALKKAKET KYKPTVILAH TVKGYGMGVI
410 420 430 440 450
AEGKNIAHQI KKININGIIH IRDRFNIPVS NDEINKLPYV TFKKNSEEYC
460 470 480 490 500
YIHSQRKKLG GYIPFRLSSF TGKLILPKLI DFQSLLEEQK KDISTTVAFI
510 520 530 540 550
RVLNIILKNN SIKHLIVPII ADEARTFGME GLFRKIGIYS SSGQKYTPQD
560 570 580 590 600
REQLAYYKEE KKGQILQEGI NELGAASSWL AAATSYSTND FPMILFYIYY
610 620 630 640 650
SIFGFQRIGD LFWAAGDQQA RGFLIGGTSG RTTLNGEGLQ HEDGHSHIQS
660 670 680 690 700
LTIPNCISYD PAFAYEVAVI IQDGLRRMYG PSQENIYYYI TTINENYYMP
710 720 730 740 750
AMPIGVEEGI CKGIYKLKTL HGTTSKVQLI GSGAILRSVC EAAEILLKDY
760 770 780 790 800
SITTDIYSVT SFTELARNGE DCERWNMLHP NEKNKIAYVK QIMNKNPTVA
810 820 830 840 850
ATDYMKLFAE QIRHYIPSQE YHVLGTDGFG RSDSRDKLRD HFEVNAYYIV
860 870 880
IAALNLLANI NDIKKKVVED AIMKFNIDAN KINPRLS
Length:887
Mass (Da):101,396
Last modified:December 1, 2000 - v1
Checksum:iB6AB82C012826105
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12922.1.
RefSeqiNP_240036.1. NC_002528.1.
WP_010896002.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12922; BAB12922; BAB12922.
GeneIDi1109648.
KEGGibuc:BU205.
PATRICi21243928. VBIBucAph127364_0216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12922.1.
RefSeqiNP_240036.1. NC_002528.1.
WP_010896002.1. NC_002528.1.

3D structure databases

ProteinModelPortaliP57301.
SMRiP57301. Positions 58-887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi107806.BU205.

Proteomic databases

PRIDEiP57301.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB12922; BAB12922; BAB12922.
GeneIDi1109648.
KEGGibuc:BU205.
PATRICi21243928. VBIBucAph127364_0216.

Phylogenomic databases

eggNOGiCOG2609.
HOGENOMiHOG000115215.
KOiK00163.
OMAiEVIKVIW.
OrthoDBiEOG6BW4TW.

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-204-MONOMER.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiODP1_BUCAI
AccessioniPrimary (citable) accession number: P57301
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: June 24, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.