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P57301

- ODP1_BUCAI

UniProt

P57301 - ODP1_BUCAI

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Protein
Pyruvate dehydrogenase E1 component
Gene
aceE, BU205
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-204-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
Gene namesi
Name:aceE
Ordered Locus Names:BU205
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 887887Pyruvate dehydrogenase E1 component
PRO_0000162240Add
BLAST

Proteomic databases

PRIDEiP57301.

Interactioni

Subunit structurei

Homodimer By similarity. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Structurei

3D structure databases

ProteinModelPortaliP57301.
SMRiP57301. Positions 58-887.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2609.
HOGENOMiHOG000115215.
KOiK00163.
OMAiKGIYKLD.
OrthoDBiEOG6BW4TW.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.

Sequencei

Sequence statusi: Complete.

P57301-1 [UniParc]FASTAAdd to Basket

« Hide

MSENLYNDVD PIETRDWVQA IESVIRREGH KRAHFLIEQV LKTAKINRKE    50
FFRSSFTSDY INTISREDEY EYPGNLILEK RIRSAIRWNA IMMVLRASKK 100
NLELGGHLSS FQSSATIYEV CFNHFFQAKN HKDGGDLVYF QGHISPGIYA 150
RSFLEGRLSE EQIDNFRQEV DGIGLSSYPH PKLMPNFWQF PTVSMGLGPL 200
CAIYQAKFLK YLHNRELKNT SKQIVYAFLG DGEMDEPESK GAISIAVREK 250
LDNLIFIINC NLQRLDGPVV GNGKIVNELE SFFYGAGWKV IKVIWGSRWD 300
CLLKKDTSGK LIQLMNETVD GDYQTFKSKD GAYVRKYFFG KYKETYDLVK 350
DMTDEEIWKL NRGGHDPKKM FNALKKAKET KYKPTVILAH TVKGYGMGVI 400
AEGKNIAHQI KKININGIIH IRDRFNIPVS NDEINKLPYV TFKKNSEEYC 450
YIHSQRKKLG GYIPFRLSSF TGKLILPKLI DFQSLLEEQK KDISTTVAFI 500
RVLNIILKNN SIKHLIVPII ADEARTFGME GLFRKIGIYS SSGQKYTPQD 550
REQLAYYKEE KKGQILQEGI NELGAASSWL AAATSYSTND FPMILFYIYY 600
SIFGFQRIGD LFWAAGDQQA RGFLIGGTSG RTTLNGEGLQ HEDGHSHIQS 650
LTIPNCISYD PAFAYEVAVI IQDGLRRMYG PSQENIYYYI TTINENYYMP 700
AMPIGVEEGI CKGIYKLKTL HGTTSKVQLI GSGAILRSVC EAAEILLKDY 750
SITTDIYSVT SFTELARNGE DCERWNMLHP NEKNKIAYVK QIMNKNPTVA 800
ATDYMKLFAE QIRHYIPSQE YHVLGTDGFG RSDSRDKLRD HFEVNAYYIV 850
IAALNLLANI NDIKKKVVED AIMKFNIDAN KINPRLS 887
Length:887
Mass (Da):101,396
Last modified:December 1, 2000 - v1
Checksum:iB6AB82C012826105
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12922.1.
RefSeqiNP_240036.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12922; BAB12922; BAB12922.
GeneIDi1109648.
KEGGibuc:BU205.
PATRICi21243928. VBIBucAph127364_0216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12922.1 .
RefSeqi NP_240036.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57301.
SMRi P57301. Positions 58-887.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P57301.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB12922 ; BAB12922 ; BAB12922 .
GeneIDi 1109648.
KEGGi buc:BU205.
PATRICi 21243928. VBIBucAph127364_0216.

Phylogenomic databases

eggNOGi COG2609.
HOGENOMi HOG000115215.
KOi K00163.
OMAi KGIYKLD.
OrthoDBi EOG6BW4TW.

Enzyme and pathway databases

BioCyci BAPH107806:GBZJ-204-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProi IPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF00456. Transketolase_N. 2 hits.
[Graphical view ]
PIRSFi PIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00759. aceE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiODP1_BUCAI
AccessioniPrimary (citable) accession number: P57301
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

External Data

Dasty 3

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