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P57290 (AKH_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional aspartokinase/homoserine dehydrogenase

Short name=AK-HD

Including the following 2 domains:

  1. Aspartokinase
    EC=2.7.2.4
  2. Homoserine dehydrogenase
    EC=1.1.1.3
Gene names
Name:thrA
Ordered Locus Names:BU194
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length816 AA.
Sequence statusComplete.
Protein existenceInferred from homology

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 816816Bifunctional aspartokinase/homoserine dehydrogenase
PRO_0000066684

Regions

Domain402 – 47978ACT
Nucleotide binding472 – 4798NADP Potential
Region1 – 250250Aspartokinase By similarity
Region251 – 471221Interface By similarity
Region472 – 816345Homoserine dehydrogenase By similarity

Sequences

Sequence LengthMass (Da)Tools
P57290 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: CEACE5C565465884

FASTA81691,809
        10         20         30         40         50         60 
MKLLKFGGTS LANAEKFLSV SSIIEENTQT DQIAVVLSAP AKITNYLVKI IENTIKNNQI 

        70         80         90        100        110        120 
LETVHLAENI FMQLINNFLN IQSNFPHKEI EKIIKKEFNE LKNIIQGILL LKQCPDNIRA 

       130        140        150        160        170        180 
IIISRGEILS VFIMKSILQS KNYNVTIINP VKNLVAIGDN YLDSTVDISE SKKNIQNMNI 

       190        200        210        220        230        240 
NQSNIILMAG FIAGNKDKKL VVLGRNGSDY SAAVLAACLD ANCCEIWTDV DGVFTSDPRK 

       250        260        270        280        290        300 
VPNARLLKSI SYQEAMELSY FGAKVLHPRT IEPIAQFKIP CLIKNTNNVK SIGTLICEQN 

       310        320        330        340        350        360 
CSEKDFLKGV THLDEIAMFN ISGPHIKDVG SVISRIFTMM SRGNIKILLI TQSSSENKIN 

       370        380        390        400        410        420 
FCVYEHDIYK ILYLFNKEFQ LELKDGLLNP FKIKKNLSIL SIVGSNIYKK HNIASKIFSV 

       430        440        450        460        470        480 
LGALKINVIA ISQGSSKHSI SLVIKKENIL KAVQHVHNTL FFNKKTIHMF LIGIGGIGST 

       490        500        510        520        530        540 
LLNQILKQKQ FLDKKNIEIK ICAIANSKKI LLLDNTNDLS NWKNDFKKST QKFNLELLNN 

       550        560        570        580        590        600 
LIKNNHFSNS VIVDCTSSQL LSEQYVNFID NNFHVVTSNK KANTSEWNYY KKIRKSVAQT 

       610        620        630        640        650        660 
GKKFLYETNV GAGLPVIETL QNLFKSGDNL ICFKGILSGS LSFIFGRLEE GILLSQATRE 

       670        680        690        700        710        720 
AKELGFTEPN PCDDLSGIDV ARKLLILARE SGYNIELKDI KIEPLLPNNF KIYEDTDKFL 

       730        740        750        760        770        780 
LKLKELDVYF SNKIKQALNV GNVLRFVATI EQKRQFFIKL EEVNINNPLY KVKNGENALA 

       790        800        810 
FYTNYYQPIP LVLRGYGAGN NVTASGVFSD LLRTLS 

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000003 Genomic DNA. Translation: BAB12911.1.
RefSeqNP_240025.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57290.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP57290.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB12911; BAB12911; BAB12911.
GeneID1109637.
KEGGbuc:BU194.
PATRIC21243906. VBIBucAph127364_0205.

Phylogenomic databases

eggNOGCOG0527.
HOGENOMHOG000271593.
KOK12524.
OMAIFISQAS.
OrthoDBEOG6M0T34.
ProtClustDBPRK09436.

Enzyme and pathway databases

BioCycBAPH107806:GBZJ-193-MONOMER.
UniPathwayUPA00034; UER00015.
UPA00050; UER00063.
UPA00050; UER00461.
UPA00051; UER00462.
UPA00051; UER00465.

Family and domain databases

Gene3D3.40.1160.10. 2 hits.
3.40.50.720. 1 hit.
InterProIPR002912. ACT_dom.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR001341. Asp_kinase_dom.
IPR018042. Aspartate_kinase_CS.
IPR011147. Bifunc_aspartokin/hSer_DH.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00696. AA_kinase. 1 hit.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF000727. ThrA. 1 hit.
SUPFAMSSF53633. SSF53633. 1 hit.
TIGRFAMsTIGR00657. asp_kinases. 1 hit.
PROSITEPS51671. ACT. 1 hit.
PS00324. ASPARTOKINASE. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAKH_BUCAI
AccessionPrimary (citable) accession number: P57290
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: February 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names