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P57289

- THRC_BUCAI

UniProt

P57289 - THRC_BUCAI

Protein

Threonine synthase

Gene

thrC

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

    Catalytic activityi

    O-phospho-L-homoserine + H2O = L-threonine + phosphate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. threonine synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-191-MONOMER.
    UniPathwayiUPA00050; UER00065.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine synthase (EC:4.2.3.1)
    Short name:
    TS
    Gene namesi
    Name:thrC
    Ordered Locus Names:BU192
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429Threonine synthasePRO_0000185627Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei108 – 1081N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiP57289.

    Structurei

    3D structure databases

    ProteinModelPortaliP57289.
    SMRiP57289. Positions 1-427.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the threonine synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0498.
    HOGENOMiHOG000230743.
    KOiK01733.
    OMAiMMFISTR.
    OrthoDBiEOG65BDJX.

    Family and domain databases

    Gene3Di3.90.1380.10. 1 hit.
    InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00260. thrC. 1 hit.
    PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57289-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLYNLKNHN EQVNFEAAVK LGLGQQQGLF FPVELPTITP IELSKILKMD    50
    FITRSTEILS KFICHEISKE ELYKHVKQAF SFKHPLKIKI TKDIHCFELF 100
    HGPTLAFKDF GARFMAQMIL LLNKKNESVT ILTATSGDTG AAVANAFYGM 150
    KNVRVIILYP KGKISELQEK LFCTLGRNIK TISINGSFDD CQKLVKEAFN 200
    DKKLKESIGL NSANSINISR LLAQICYYFE AFSLISEEQR KNLVIAVPCG 250
    NFGNLTAGLL SKSLGLPIKS FIACTNANDT VPRFLNNGTW NPKKTVSTIS 300
    NAMDISQPNN WTRIEELFYR KKWDLKKLRF GSVSDHTTEE TLKELFKLGY 350
    VSEPHAAIAY RLLRDQLKEN EFGLFLGTAH PAKFKNTVEK ILKNKISLPS 400
    ELQNRIDLPL LSHNINPVFS KLKTFLLEK 429
    Length:429
    Mass (Da):48,660
    Last modified:December 1, 2000 - v1
    Checksum:iF66C73E6F5FAFFC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12909.1.
    RefSeqiNP_240023.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB12909; BAB12909; BAB12909.
    GeneIDi1109635.
    KEGGibuc:BU192.
    PATRICi21243902. VBIBucAph127364_0203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12909.1 .
    RefSeqi NP_240023.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57289.
    SMRi P57289. Positions 1-427.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P57289.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB12909 ; BAB12909 ; BAB12909 .
    GeneIDi 1109635.
    KEGGi buc:BU192.
    PATRICi 21243902. VBIBucAph127364_0203.

    Phylogenomic databases

    eggNOGi COG0498.
    HOGENOMi HOG000230743.
    KOi K01733.
    OMAi MMFISTR.
    OrthoDBi EOG65BDJX.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00065 .
    BioCyci BAPH107806:GBZJ-191-MONOMER.

    Family and domain databases

    Gene3Di 3.90.1380.10. 1 hit.
    InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00260. thrC. 1 hit.
    PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiTHRC_BUCAI
    AccessioniPrimary (citable) accession number: P57289
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3