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Protein

Threonine synthase

Gene

thrC

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-191-MONOMER.
UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:BU192
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Threonine synthasePRO_0000185627Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei108 – 1081N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiP57289.

Structurei

3D structure databases

ProteinModelPortaliP57289.
SMRiP57289. Positions 1-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiCOG0498.
HOGENOMiHOG000230743.
KOiK01733.
OMAiRRKNWQL.
OrthoDBiEOG65BDJX.

Family and domain databases

Gene3Di3.90.1380.10. 1 hit.
InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57289-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLYNLKNHN EQVNFEAAVK LGLGQQQGLF FPVELPTITP IELSKILKMD
60 70 80 90 100
FITRSTEILS KFICHEISKE ELYKHVKQAF SFKHPLKIKI TKDIHCFELF
110 120 130 140 150
HGPTLAFKDF GARFMAQMIL LLNKKNESVT ILTATSGDTG AAVANAFYGM
160 170 180 190 200
KNVRVIILYP KGKISELQEK LFCTLGRNIK TISINGSFDD CQKLVKEAFN
210 220 230 240 250
DKKLKESIGL NSANSINISR LLAQICYYFE AFSLISEEQR KNLVIAVPCG
260 270 280 290 300
NFGNLTAGLL SKSLGLPIKS FIACTNANDT VPRFLNNGTW NPKKTVSTIS
310 320 330 340 350
NAMDISQPNN WTRIEELFYR KKWDLKKLRF GSVSDHTTEE TLKELFKLGY
360 370 380 390 400
VSEPHAAIAY RLLRDQLKEN EFGLFLGTAH PAKFKNTVEK ILKNKISLPS
410 420
ELQNRIDLPL LSHNINPVFS KLKTFLLEK
Length:429
Mass (Da):48,660
Last modified:December 1, 2000 - v1
Checksum:iF66C73E6F5FAFFC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12909.1.
RefSeqiNP_240023.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12909; BAB12909; BAB12909.
GeneIDi1109635.
KEGGibuc:BU192.
PATRICi21243902. VBIBucAph127364_0203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12909.1.
RefSeqiNP_240023.1. NC_002528.1.

3D structure databases

ProteinModelPortaliP57289.
SMRiP57289. Positions 1-427.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP57289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB12909; BAB12909; BAB12909.
GeneIDi1109635.
KEGGibuc:BU192.
PATRICi21243902. VBIBucAph127364_0203.

Phylogenomic databases

eggNOGiCOG0498.
HOGENOMiHOG000230743.
KOiK01733.
OMAiRRKNWQL.
OrthoDBiEOG65BDJX.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.
BioCyciBAPH107806:GBZJ-191-MONOMER.

Family and domain databases

Gene3Di3.90.1380.10. 1 hit.
InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiTHRC_BUCAI
AccessioniPrimary (citable) accession number: P57289
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.