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P57289 (THRC_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Threonine synthase

Short name=TS
EC=4.2.3.1
Gene names
Name:thrC
Ordered Locus Names:BU192
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.

Catalytic activity

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.

Sequence similarities

Belongs to the threonine synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionpyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

threonine synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Threonine synthase
PRO_0000185627

Amino acid modifications

Modified residue1081N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P57289 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: F66C73E6F5FAFFC6

FASTA42948,660
        10         20         30         40         50         60 
MKLYNLKNHN EQVNFEAAVK LGLGQQQGLF FPVELPTITP IELSKILKMD FITRSTEILS 

        70         80         90        100        110        120 
KFICHEISKE ELYKHVKQAF SFKHPLKIKI TKDIHCFELF HGPTLAFKDF GARFMAQMIL 

       130        140        150        160        170        180 
LLNKKNESVT ILTATSGDTG AAVANAFYGM KNVRVIILYP KGKISELQEK LFCTLGRNIK 

       190        200        210        220        230        240 
TISINGSFDD CQKLVKEAFN DKKLKESIGL NSANSINISR LLAQICYYFE AFSLISEEQR 

       250        260        270        280        290        300 
KNLVIAVPCG NFGNLTAGLL SKSLGLPIKS FIACTNANDT VPRFLNNGTW NPKKTVSTIS 

       310        320        330        340        350        360 
NAMDISQPNN WTRIEELFYR KKWDLKKLRF GSVSDHTTEE TLKELFKLGY VSEPHAAIAY 

       370        380        390        400        410        420 
RLLRDQLKEN EFGLFLGTAH PAKFKNTVEK ILKNKISLPS ELQNRIDLPL LSHNINPVFS 


KLKTFLLEK 

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000003 Genomic DNA. Translation: BAB12909.1.
RefSeqNP_240023.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57289.
SMRP57289. Positions 1-427.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP57289.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB12909; BAB12909; BAB12909.
GeneID1109635.
KEGGbuc:BU192.
PATRIC21243902. VBIBucAph127364_0203.

Phylogenomic databases

eggNOGCOG0498.
HOGENOMHOG000230743.
KOK01733.
OMAMMFISTR.
OrthoDBEOG65BDJX.

Enzyme and pathway databases

BioCycBAPH107806:GBZJ-191-MONOMER.
UniPathwayUPA00050; UER00065.

Family and domain databases

Gene3D3.90.1380.10. 1 hit.
InterProIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamPF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view]
SUPFAMSSF53686. SSF53686. 1 hit.
TIGRFAMsTIGR00260. thrC. 1 hit.
PROSITEPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHRC_BUCAI
AccessionPrimary (citable) accession number: P57289
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names