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P57281

- GRPE2_BUCAI

UniProt

P57281 - GRPE2_BUCAI

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Protein
Protein GrpE 2
Gene
grpE2, BU184
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding By similarity.UniRule annotation

GO - Molecular functioni

  1. adenyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. protein folding Source: InterPro
  2. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-183-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpE 2
Alternative name(s):
HSP-70 cofactor 2
Gene namesi
Name:grpE2
Ordered Locus Names:BU184
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Protein GrpE 2UniRule annotation
PRO_0000113760Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP57281.

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.

Phylogenomic databases

eggNOGiCOG0576.
HOGENOMiHOG000252084.
KOiK03687.
OMAiRTYAVAN.
OrthoDBiEOG61ZTJ2.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57281-1 [UniParc]FASTAAdd to Basket

« Hide

MDNKENKLDE KKIFKNNKIE EKKENLIDAI TVQNQKIENL KLKLLQNQKK    50
INDIELRKLA NIENIKKNTE EKIEKIKKTE IERFLKSIIP VIDSLEDILN 100
LSTTVDIKDQ PIIKGIELTL ESLLNILNKL GVKIEGQKNK VFNPDIHELV 150
SRELSKETLP NHVISVNKKG FTFNKIVLRK ASVIVAEN 188
Length:188
Mass (Da):21,726
Last modified:December 1, 2000 - v1
Checksum:i1FEC6225B582BC81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12901.1.
RefSeqiNP_240015.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12901; BAB12901; BAB12901.
GeneIDi1109627.
KEGGibuc:BU184.
PATRICi21243886. VBIBucAph127364_0195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12901.1 .
RefSeqi NP_240015.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57281.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB12901 ; BAB12901 ; BAB12901 .
GeneIDi 1109627.
KEGGi buc:BU184.
PATRICi 21243886. VBIBucAph127364_0195.

Phylogenomic databases

eggNOGi COG0576.
HOGENOMi HOG000252084.
KOi K03687.
OMAi RTYAVAN.
OrthoDBi EOG61ZTJ2.

Enzyme and pathway databases

BioCyci BAPH107806:GBZJ-183-MONOMER.

Family and domain databases

Gene3Di 2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPi MF_01151. GrpE.
InterProi IPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view ]
PANTHERi PTHR21237. PTHR21237. 1 hit.
Pfami PF01025. GrpE. 1 hit.
[Graphical view ]
PRINTSi PR00773. GRPEPROTEIN.
SUPFAMi SSF51064. SSF51064. 1 hit.
PROSITEi PS01071. GRPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiGRPE2_BUCAI
AccessioniPrimary (citable) accession number: P57281
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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