Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P57281

- GRPE2_BUCAI

UniProt

P57281 - GRPE2_BUCAI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein GrpE 2

Gene

grpE2

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

GO - Molecular functioni

  1. adenyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. protein folding Source: InterPro
  2. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-183-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpE 2UniRule annotation
Alternative name(s):
HSP-70 cofactor 2UniRule annotation
Gene namesi
Name:grpE2UniRule annotation
Ordered Locus Names:BU184
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Protein GrpE 2PRO_0000113760Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP57281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0576.
HOGENOMiHOG000252084.
KOiK03687.
OMAiRTYAVAN.
OrthoDBiEOG61ZTJ2.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57281-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNKENKLDE KKIFKNNKIE EKKENLIDAI TVQNQKIENL KLKLLQNQKK
60 70 80 90 100
INDIELRKLA NIENIKKNTE EKIEKIKKTE IERFLKSIIP VIDSLEDILN
110 120 130 140 150
LSTTVDIKDQ PIIKGIELTL ESLLNILNKL GVKIEGQKNK VFNPDIHELV
160 170 180
SRELSKETLP NHVISVNKKG FTFNKIVLRK ASVIVAEN
Length:188
Mass (Da):21,726
Last modified:December 1, 2000 - v1
Checksum:i1FEC6225B582BC81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12901.1.
RefSeqiNP_240015.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12901; BAB12901; BAB12901.
GeneIDi1109627.
KEGGibuc:BU184.
PATRICi21243886. VBIBucAph127364_0195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12901.1 .
RefSeqi NP_240015.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57281.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB12901 ; BAB12901 ; BAB12901 .
GeneIDi 1109627.
KEGGi buc:BU184.
PATRICi 21243886. VBIBucAph127364_0195.

Phylogenomic databases

eggNOGi COG0576.
HOGENOMi HOG000252084.
KOi K03687.
OMAi RTYAVAN.
OrthoDBi EOG61ZTJ2.

Enzyme and pathway databases

BioCyci BAPH107806:GBZJ-183-MONOMER.

Family and domain databases

Gene3Di 2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPi MF_01151. GrpE.
InterProi IPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view ]
PANTHERi PTHR21237. PTHR21237. 1 hit.
Pfami PF01025. GrpE. 1 hit.
[Graphical view ]
PRINTSi PR00773. GRPEPROTEIN.
SUPFAMi SSF51064. SSF51064. 1 hit.
PROSITEi PS01071. GRPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiGRPE2_BUCAI
AccessioniPrimary (citable) accession number: P57281
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3