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P57275 (RIR2_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase subunit beta

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:nrdB
Ordered Locus Names:BU178
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Tetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190470

Sites

Active site1231 By similarity
Metal binding851Iron 1 By similarity
Metal binding1161Iron 1 By similarity
Metal binding1161Iron 2 By similarity
Metal binding1191Iron 1 By similarity
Metal binding2051Iron 2 By similarity
Metal binding2391Iron 2 By similarity
Metal binding2421Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P57275 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: BECC1B02F77CBB32

FASTA37644,146
        10         20         30         40         50         60 
MSYTIFSKKK NNQLKEPMFF GQPVNIARYD QQKYKIFEQL IEKQLSFFWR PEEIDLSRDR 

        70         80         90        100        110        120 
IDFQNLPDNE KHIFISNLKY QTLLDSIQGR SPNIAFLPII SIPELETWIE TWSFSETIHS 

       130        140        150        160        170        180 
RSYTHIIRNI VNCPSLVFDD IISNKNIYDR AQNISIYYDE LINLTSYWHL LGEGIHLING 

       190        200        210        220        230        240 
KKIHINLRFL KKRLYLCLIS VNVLEAIRFY VSFACSFAFA ERELMEGNAK IIRLIARDEA 

       250        260        270        280        290        300 
LHLTGTQHIL NLLSNIKNNE NMEDVVLECK EEAINIFISA AQQEKKWASY LFKSGSMLGL 

       310        320        330        340        350        360 
NKDILCQYIE YITNIRMHAI GFKMPFKKQS NPIPWINDWL TSDNIQIAPQ ETEISSYLVG 

       370 
QIDSEVSDNE FKKFEL 

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000003 Genomic DNA. Translation: BAB12895.1.
RefSeqNP_240009.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57275.
SMRP57275. Positions 2-342.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB12895; BAB12895; BAB12895.
GeneID1109621.
KEGGbuc:BU178.
PATRIC21243874. VBIBucAph127364_0189.

Phylogenomic databases

eggNOGCOG0208.
HOGENOMHOG000278087.
KOK00526.
OMAWIETWAF.
OrthoDBEOG6J48J7.

Enzyme and pathway databases

BioCycBAPH107806:GBZJ-177-MONOMER.
UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_BUCAI
AccessionPrimary (citable) accession number: P57275
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names