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P57275

- RIR2_BUCAI

UniProt

P57275 - RIR2_BUCAI

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi85 – 851Iron 1PROSITE-ProRule annotation
    Metal bindingi116 – 1161Iron 1PROSITE-ProRule annotation
    Metal bindingi116 – 1161Iron 2By similarity
    Metal bindingi119 – 1191Iron 1PROSITE-ProRule annotation
    Active sitei123 – 1231PROSITE-ProRule annotation
    Metal bindingi205 – 2051Iron 2By similarity
    Metal bindingi239 – 2391Iron 2By similarity
    Metal bindingi242 – 2421Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-177-MONOMER.
    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:nrdB
    Ordered Locus Names:BU178
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Ribonucleoside-diphosphate reductase subunit betaPRO_0000190470Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP57275.
    SMRiP57275. Positions 2-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    HOGENOMiHOG000278087.
    KOiK00526.
    OMAiWIETWAF.
    OrthoDBiEOG6J48J7.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57275-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYTIFSKKK NNQLKEPMFF GQPVNIARYD QQKYKIFEQL IEKQLSFFWR    50
    PEEIDLSRDR IDFQNLPDNE KHIFISNLKY QTLLDSIQGR SPNIAFLPII 100
    SIPELETWIE TWSFSETIHS RSYTHIIRNI VNCPSLVFDD IISNKNIYDR 150
    AQNISIYYDE LINLTSYWHL LGEGIHLING KKIHINLRFL KKRLYLCLIS 200
    VNVLEAIRFY VSFACSFAFA ERELMEGNAK IIRLIARDEA LHLTGTQHIL 250
    NLLSNIKNNE NMEDVVLECK EEAINIFISA AQQEKKWASY LFKSGSMLGL 300
    NKDILCQYIE YITNIRMHAI GFKMPFKKQS NPIPWINDWL TSDNIQIAPQ 350
    ETEISSYLVG QIDSEVSDNE FKKFEL 376
    Length:376
    Mass (Da):44,146
    Last modified:December 1, 2000 - v1
    Checksum:iBECC1B02F77CBB32
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12895.1.
    RefSeqiNP_240009.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB12895; BAB12895; BAB12895.
    GeneIDi1109621.
    KEGGibuc:BU178.
    PATRICi21243874. VBIBucAph127364_0189.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12895.1 .
    RefSeqi NP_240009.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57275.
    SMRi P57275. Positions 2-342.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB12895 ; BAB12895 ; BAB12895 .
    GeneIDi 1109621.
    KEGGi buc:BU178.
    PATRICi 21243874. VBIBucAph127364_0189.

    Phylogenomic databases

    eggNOGi COG0208.
    HOGENOMi HOG000278087.
    KOi K00526.
    OMAi WIETWAF.
    OrthoDBi EOG6J48J7.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .
    BioCyci BAPH107806:GBZJ-177-MONOMER.

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiRIR2_BUCAI
    AccessioniPrimary (citable) accession number: P57275
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3