P57273 (PTA_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphate acetyltransferase
EC=2.3.1.8

Alternative name(s):
Phosphotransacetylase

Gene names

Name:	pta
Ordered Locus Names:	BU176

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	708 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in acetate metabolism By similarity.
Catalytic activity	Acetyl-CoA + phosphate = CoA + acetyl phosphate.
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.
Subunit structure	Homohexamer By similarity.
Subcellular location	Cytoplasm Potential.
Domain	The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site By similarity.
Sequence similarities	In the N-terminal section; belongs to the CobB/CobQ family. In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphate acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 708	708	Phosphate acetyltransferase		PRO_0000179122
Regions
	Region	388 – 708	321	Phosphate acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	P57273 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 1EDC4394824ED89A	FASTA	708	80,770
	10 20 30 40 50 60 MSRIIMLIPL DKDIGLTSIG LSIIYFFYQK KIKKKSVQSI LYFSCTQNSS NSTSHVINKY 70 80 90 100 110 120 FSKIVHTVDY IDFSKVLFNS PEYSFLLNKV IDEHYNNKFL RELILIEGIK NNYCINSEEM 130 140 150 160 170 180 NYDISQNLNA EVIFIANLEN SSPEYIKNKE KKINFFLKQK KYKNILGVIF NQINSPFLEN 190 200 210 220 230 240 KYDFIKKLIV LKKIKNETKT IVPKKILKNN FFSIIACIPW NRNIVTTRVI DLFNFLNIQH 250 260 270 280 290 300 TNLVQKKNHI IEEIIIFDTH HLNLLNKHSL NTLVIVSFSR VDVFLNVLNC NVNRSKVKCI 310 320 330 340 350 360 ILTGILKLKK NIASLYKFLI KRSISIFFTE KNTIEILSQL QNFNFDISVK DITYIKKLQR 370 380 390 400 410 420 YISNFFCHSS FMFFKKKYNI NVIYPPKEFC YNLKLLSQKK NKRIKLPESY EIRILKSVAI 430 440 450 460 470 480 CSDSNIAQCV LLGDPKKIYS IANDNGINLK KNIEIIDPIS VRQEYLARFL EIRKGKNINE 490 500 510 520 530 540 FSAKKQLEDN TVLATLILES NHVDGLVSGS INTTSDTIRP ALQIIKTNPQ SLLVSSIFFM 550 560 570 580 590 600 LLPNQVLIYG DCAININPTA EELAVIAIQS ADSAKMFGIE PRIAMLSYST GCSGFGCQVE 610 620 630 640 650 660 KVKEATSIIK NRRSDLIIDG PIQYDAAVSN KVAKLKAPSS PISGSANVFI FPDLNSGNIA 670 680 690 700 YKAVQRSSRI VSIGPMLQGL RKPVNDLSRG ASVEDIIYTI ALTSIQSE

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB12893.1.
RefSeq	NP_240007.1. NC_002528.1.
3D structure databases
ProteinModelPortal	P57273.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000003271; EBBUCP00000003047; EBBUCG00000003271.
GeneID	1109619.
GenomeReviews	Gene locus BU176 in contig BA000003_GR.
KEGG	buc:BU176.
PATRIC	21243870. VBIBucAph127364_0187.
Phylogenomic databases
GeneTree	EBGT00050000007729.
HOGENOM	HBG576804.
OMA	ININPTA.
PhylomeDB	P57273.
ProtClustDB	CLSK315687.
Enzyme and pathway databases
BioCyc	BSP107806:BU176-MONOMER.
Family and domain databases
InterPro	IPR010766. DRTGG. IPR016475. P-Actrans_bac. IPR004614. P_AcTrfase. IPR002505. PTA_PTB. [Graphical view]
KO	K13788.
Pfam	PF07085. DRTGG. 1 hit. PF01515. PTA_PTB. 1 hit. [Graphical view]
PIRSF	PIRSF006107. PhpActrans_proteobac. 1 hit.
TIGRFAMs	TIGR00651. Pta. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PTA_BUCAI

Accession

Primary (citable) accession number: P57273

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program