Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P57265

- FOLC_BUCAI

UniProt

P57265 - FOLC_BUCAI

Protein

Bifunctional protein FolC

Gene

folC

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Conversion of folates to polyglutamate derivatives.

    Catalytic activityi

    ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).
    ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi50 – 567ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. dihydrofolate synthase activity Source: UniProtKB-EC
    3. tetrahydrofolylpolyglutamate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. folic acid biosynthetic process Source: UniProtKB-KW
    2. one-carbon metabolic process Source: UniProtKB-KW
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Folate biosynthesis, One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-167-MONOMER.
    UniPathwayiUPA00077; UER00157.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein FolC
    Including the following 2 domains:
    Folylpolyglutamate synthase (EC:6.3.2.17)
    Alternative name(s):
    Folylpoly-gamma-glutamate synthetase
    Short name:
    FPGS
    Tetrahydrofolylpolyglutamate synthase
    Short name:
    Tetrahydrofolate synthase
    Dihydrofolate synthase (EC:6.3.2.12)
    Gene namesi
    Name:folC
    Ordered Locus Names:BU167
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411Bifunctional protein FolCPRO_0000168300Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP57265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the folylpolyglutamate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0285.
    HOGENOMiHOG000019982.
    KOiK11754.
    OMAiDAMGYFP.
    OrthoDBiEOG6ZPSW2.

    Family and domain databases

    Gene3Di3.40.1190.10. 1 hit.
    3.90.190.20. 1 hit.
    InterProiIPR001645. Folylpolyglutamate_synth.
    IPR018109. Folylpolyglutamate_synth_CS.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    [Graphical view]
    PANTHERiPTHR11136. PTHR11136. 1 hit.
    PfamiPF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001563. Folylpolyglu_synth. 1 hit.
    SUPFAMiSSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsiTIGR01499. folC. 1 hit.
    PROSITEiPS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
    PS01012. FOLYLPOLYGLU_SYNT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57265-1 [UniParc]FASTAAdd to Basket

    « Hide

    MINKNYSLSL WLKYLEQLDK KRIYNLTELK FLAKKLGLLK SESFIFTVAG    50
    TNGKGTTCAV LERLLLDSGY QVGLYTSPHL INFVERVRIN GFVLHEEEHI 100
    DSFQNVELVR NGVLLTYFEF ITLAALILFK RYSLDCIILK VGLGGRLDAT 150
    NIIDSDISII TNIGIDHTSI LGRDRISIAR EKCGVFRKNK ISVIGETDIP 200
    CSMYQIAKEK KTILKKIDID WSWEKKRNYW NFFHSTIQLY NLPETQVPLS 250
    SAATALSTLY YSRFKIKEKI IRKSISNVQL PGRFQVISTF PYIIVDVAHN 300
    PNAAFYLSQK IDEINITGKI YAVVGILKDK DILGIIDPLA NKIHHWFTAP 350
    LKTIRTATKH ELKKFFPIHN TSILKSIEIA YKKALILVKK EDAIIIFGSF 400
    LTVSEFLSLK I 411
    Length:411
    Mass (Da):46,970
    Last modified:December 1, 2000 - v1
    Checksum:i5DDC2DC66539935A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12885.1.
    RefSeqiNP_239999.1. NC_002528.1.
    WP_010895983.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB12885; BAB12885; BAB12885.
    GeneIDi1109611.
    KEGGibuc:BU167.
    PATRICi21243850. VBIBucAph127364_0177.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12885.1 .
    RefSeqi NP_239999.1. NC_002528.1.
    WP_010895983.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57265.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB12885 ; BAB12885 ; BAB12885 .
    GeneIDi 1109611.
    KEGGi buc:BU167.
    PATRICi 21243850. VBIBucAph127364_0177.

    Phylogenomic databases

    eggNOGi COG0285.
    HOGENOMi HOG000019982.
    KOi K11754.
    OMAi DAMGYFP.
    OrthoDBi EOG6ZPSW2.

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00157 .
    BioCyci BAPH107806:GBZJ-167-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.10. 1 hit.
    3.90.190.20. 1 hit.
    InterProi IPR001645. Folylpolyglutamate_synth.
    IPR018109. Folylpolyglutamate_synth_CS.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    [Graphical view ]
    PANTHERi PTHR11136. PTHR11136. 1 hit.
    Pfami PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001563. Folylpolyglu_synth. 1 hit.
    SUPFAMi SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsi TIGR01499. folC. 1 hit.
    PROSITEi PS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
    PS01012. FOLYLPOLYGLU_SYNT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiFOLC_BUCAI
    AccessioniPrimary (citable) accession number: P57265
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3