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P57262

- NUOL_BUCAI

UniProt

P57262 - NUOL_BUCAI

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Protein

NADH-quinone oxidoreductase subunit L

Gene

nuoL

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity

Catalytic activityi

NADH + quinone = NAD+ + quinol.

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-164-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit L (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit L
NDH-1 subunit L
Gene namesi
Name:nuoL
Ordered Locus Names:BU164
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 614614NADH-quinone oxidoreductase subunit LPRO_0000118214Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex (By similarity).By similarity

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence AnalysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Transmembranei207 – 22721HelicalSequence AnalysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST
Transmembranei271 – 29121HelicalSequence AnalysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence AnalysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence AnalysisAdd
BLAST
Transmembranei410 – 43021HelicalSequence AnalysisAdd
BLAST
Transmembranei455 – 47521HelicalSequence AnalysisAdd
BLAST
Transmembranei492 – 51221HelicalSequence AnalysisAdd
BLAST
Transmembranei533 – 55321HelicalSequence AnalysisAdd
BLAST
Transmembranei593 – 61321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1009.
HOGENOMiHOG000100570.
KOiK00341.
OMAiRFFSYMN.
OrthoDBiEOG6FZ48R.

Family and domain databases

InterProiIPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR001516. NADH_UbQ_OxRdtase_chain5/L_N.
IPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_subgr.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF00662. Oxidored_q1_N. 1 hit.
[Graphical view]
PRINTSiPR01435. NPOXDRDTASE5.
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

P57262-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIIFFIILF PLIGFLFLST IQDFIFKRYT LNIGIFSIFI SFFITCFYGV
60 70 80 90 100
SILKNNNQVF TQILWKWLSI NEFKIDFGFF LDGLSLSMLF VITGVGLLIH
110 120 130 140 150
IFSSWYMRYK EGQSRFFAYT NLFIASMSVL VLADNFLFMY LGWEGVSVCS
160 170 180 190 200
YLLIGFYYTE LKNNLCAFKA FILTRVSDVF LMIGMFLIYR EFNSFNFQEI
210 220 230 240 250
KFLSSFLNVE NFYYLDYITL FLLLGVIGKS AQLPLQTWLS DAMVGPTPVS
260 270 280 290 300
ALIHAATMVT AGVYLIARTH FLFLLTPGIL YLVGLIGTLT ILVSSISALV
310 320 330 340 350
QKDIKRILAY STMSQIGYMF LALGVKAWSA AITHLIMHAI FKALLFLSAG
360 370 380 390 400
SLIKSCKNEK NIFKMGGLRK QLPFLYISFI VGGASLVSFP LITAGFYSKG
410 420 430 440 450
NILFSVLKSG CIDFFIIGLF CSFLTAIYTF RMIFVIFHGK NIHTADSSTN
460 470 480 490 500
LQHNIPLFVL LLLSTVFGSY ISPPLSDVFP LSYTPIDHKF AFEIICSILS
510 520 530 540 550
LSGIYLSYYI WIKNLYVLDK IFQFKFMRYL YYFFLKGWGF NWFYKISFVY
560 570 580 590 600
FYLYISKRLS ADPLNKIINY FLKVTQIFNF YLLKTSNGYV RWYVASMILG
610
INFIFLLMLF FYFN
Length:614
Mass (Da):70,882
Last modified:December 1, 2000 - v1
Checksum:i18CCC2DFC4FE27E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12882.1.
RefSeqiNP_239996.1. NC_002528.1.
WP_010895980.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12882; BAB12882; BAB12882.
GeneIDi1109608.
KEGGibuc:BU164.
PATRICi21243844. VBIBucAph127364_0174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12882.1 .
RefSeqi NP_239996.1. NC_002528.1.
WP_010895980.1. NC_002528.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB12882 ; BAB12882 ; BAB12882 .
GeneIDi 1109608.
KEGGi buc:BU164.
PATRICi 21243844. VBIBucAph127364_0174.

Phylogenomic databases

eggNOGi COG1009.
HOGENOMi HOG000100570.
KOi K00341.
OMAi RFFSYMN.
OrthoDBi EOG6FZ48R.

Enzyme and pathway databases

BioCyci BAPH107806:GBZJ-164-MONOMER.

Family and domain databases

InterProi IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR001516. NADH_UbQ_OxRdtase_chain5/L_N.
IPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_subgr.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
PF00662. Oxidored_q1_N. 1 hit.
[Graphical view ]
PRINTSi PR01435. NPOXDRDTASE5.
TIGRFAMsi TIGR01974. NDH_I_L. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiNUOL_BUCAI
AccessioniPrimary (citable) accession number: P57262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3