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P57262

- NUOL_BUCAI

UniProt

P57262 - NUOL_BUCAI

Protein

NADH-quinone oxidoreductase subunit L

Gene

nuoL

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.By similarity

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-164-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit L (EC:1.6.99.5)
    Alternative name(s):
    NADH dehydrogenase I subunit L
    NDH-1 subunit L
    Gene namesi
    Name:nuoL
    Ordered Locus Names:BU164
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 614614NADH-quinone oxidoreductase subunit LPRO_0000118214Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.By similarity

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei207 – 22721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei327 – 34721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei410 – 43021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei455 – 47521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei492 – 51221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei533 – 55321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei593 – 61321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 5 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1009.
    HOGENOMiHOG000100570.
    KOiK00341.
    OMAiRFFSYMN.
    OrthoDBiEOG6FZ48R.

    Family and domain databases

    InterProiIPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR001516. NADH_UbQ_OxRdtase_chain5/L_N.
    IPR003945. NADHpl_OxRdtase_5.
    IPR018393. NADHpl_OxRdtase_5_subgr.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    PF00662. Oxidored_q1_N. 1 hit.
    [Graphical view]
    PRINTSiPR01435. NPOXDRDTASE5.
    TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P57262-1 [UniParc]FASTAAdd to Basket

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    MSIIFFIILF PLIGFLFLST IQDFIFKRYT LNIGIFSIFI SFFITCFYGV    50
    SILKNNNQVF TQILWKWLSI NEFKIDFGFF LDGLSLSMLF VITGVGLLIH 100
    IFSSWYMRYK EGQSRFFAYT NLFIASMSVL VLADNFLFMY LGWEGVSVCS 150
    YLLIGFYYTE LKNNLCAFKA FILTRVSDVF LMIGMFLIYR EFNSFNFQEI 200
    KFLSSFLNVE NFYYLDYITL FLLLGVIGKS AQLPLQTWLS DAMVGPTPVS 250
    ALIHAATMVT AGVYLIARTH FLFLLTPGIL YLVGLIGTLT ILVSSISALV 300
    QKDIKRILAY STMSQIGYMF LALGVKAWSA AITHLIMHAI FKALLFLSAG 350
    SLIKSCKNEK NIFKMGGLRK QLPFLYISFI VGGASLVSFP LITAGFYSKG 400
    NILFSVLKSG CIDFFIIGLF CSFLTAIYTF RMIFVIFHGK NIHTADSSTN 450
    LQHNIPLFVL LLLSTVFGSY ISPPLSDVFP LSYTPIDHKF AFEIICSILS 500
    LSGIYLSYYI WIKNLYVLDK IFQFKFMRYL YYFFLKGWGF NWFYKISFVY 550
    FYLYISKRLS ADPLNKIINY FLKVTQIFNF YLLKTSNGYV RWYVASMILG 600
    INFIFLLMLF FYFN 614
    Length:614
    Mass (Da):70,882
    Last modified:December 1, 2000 - v1
    Checksum:i18CCC2DFC4FE27E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12882.1.
    RefSeqiNP_239996.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB12882; BAB12882; BAB12882.
    GeneIDi1109608.
    KEGGibuc:BU164.
    PATRICi21243844. VBIBucAph127364_0174.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12882.1 .
    RefSeqi NP_239996.1. NC_002528.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB12882 ; BAB12882 ; BAB12882 .
    GeneIDi 1109608.
    KEGGi buc:BU164.
    PATRICi 21243844. VBIBucAph127364_0174.

    Phylogenomic databases

    eggNOGi COG1009.
    HOGENOMi HOG000100570.
    KOi K00341.
    OMAi RFFSYMN.
    OrthoDBi EOG6FZ48R.

    Enzyme and pathway databases

    BioCyci BAPH107806:GBZJ-164-MONOMER.

    Family and domain databases

    InterProi IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR001516. NADH_UbQ_OxRdtase_chain5/L_N.
    IPR003945. NADHpl_OxRdtase_5.
    IPR018393. NADHpl_OxRdtase_5_subgr.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    PF00662. Oxidored_q1_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01435. NPOXDRDTASE5.
    TIGRFAMsi TIGR01974. NDH_I_L. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiNUOL_BUCAI
    AccessioniPrimary (citable) accession number: P57262
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3