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P57255

- NUOE_BUCAI

UniProt

P57255 - NUOE_BUCAI

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Protein

NADH-quinone oxidoreductase subunit E

Gene

nuoE

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity

Catalytic activityi

NADH + quinone = NAD+ + quinol.

Cofactori

Binds 1 2Fe-2S cluster.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi88 – 881Iron-sulfur (2Fe-2S)Sequence Analysis
Metal bindingi93 – 931Iron-sulfur (2Fe-2S)Sequence Analysis
Metal bindingi129 – 1291Iron-sulfur (2Fe-2S)Sequence Analysis
Metal bindingi133 – 1331Iron-sulfur (2Fe-2S)Sequence Analysis

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. NADH dehydrogenase (quinone) activity Source: UniProtKB-EC
  4. quinone binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-157-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit E (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit E
NDH-1 subunit E
Gene namesi
Name:nuoE
Ordered Locus Names:BU157
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162NADH-quinone oxidoreductase subunit EPRO_0000118688Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP57255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 24 kDa subunit family.Curated

Phylogenomic databases

eggNOGiCOG1905.
HOGENOMiHOG000257749.
KOiK00334.
OMAiTIHIAEG.
OrthoDBiEOG6T4S12.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR10371. PTHR10371. 1 hit.
PIRSFiPIRSF000216. NADH_DH_24kDa. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01958. nuoE_fam. 1 hit.
PROSITEiPS01099. COMPLEX1_24K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57255-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEISIKFKL TNEEINAIEN QKKYYEDFRA ISIEALKIVQ KKRGWVSDQA
60 70 80 90 100
IYAIAEILHI NPSDVEGVAT FYSQIFRKPV GRNIIRYCDS VVCFLTGYKR
110 120 130 140 150
IQIALENYLK IKIGETTKDD RFTLLPVCCL GNCDKGPTIM INEDTYSVLT
160
PESIPSLLES YK
Length:162
Mass (Da):18,598
Last modified:December 1, 2000 - v1
Checksum:i428DC8DBA0B463F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12875.1.
RefSeqiNP_239989.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12875; BAB12875; BAB12875.
GeneIDi1109601.
KEGGibuc:BU157.
PATRICi21243830. VBIBucAph127364_0167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12875.1 .
RefSeqi NP_239989.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57255.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB12875 ; BAB12875 ; BAB12875 .
GeneIDi 1109601.
KEGGi buc:BU157.
PATRICi 21243830. VBIBucAph127364_0167.

Phylogenomic databases

eggNOGi COG1905.
HOGENOMi HOG000257749.
KOi K00334.
OMAi TIHIAEG.
OrthoDBi EOG6T4S12.

Enzyme and pathway databases

BioCyci BAPH107806:GBZJ-157-MONOMER.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR10371. PTHR10371. 1 hit.
PIRSFi PIRSF000216. NADH_DH_24kDa. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01958. nuoE_fam. 1 hit.
PROSITEi PS01099. COMPLEX1_24K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiNUOE_BUCAI
AccessioniPrimary (citable) accession number: P57255
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 1, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3