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P57255

- NUOE_BUCAI

UniProt

P57255 - NUOE_BUCAI

Protein

NADH-quinone oxidoreductase subunit E

Gene

nuoE

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.By similarity

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi88 – 881Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi93 – 931Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi129 – 1291Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi133 – 1331Iron-sulfur (2Fe-2S)Sequence Analysis

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. NADH dehydrogenase (quinone) activity Source: UniProtKB-EC
    4. quinone binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-157-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit E (EC:1.6.99.5)
    Alternative name(s):
    NADH dehydrogenase I subunit E
    NDH-1 subunit E
    Gene namesi
    Name:nuoE
    Ordered Locus Names:BU157
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 162162NADH-quinone oxidoreductase subunit EPRO_0000118688Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP57255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 24 kDa subunit family.Curated

    Phylogenomic databases

    eggNOGiCOG1905.
    HOGENOMiHOG000257749.
    KOiK00334.
    OMAiTIHIAEG.
    OrthoDBiEOG6T4S12.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR002023. NuoE-like.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR10371. PTHR10371. 1 hit.
    PIRSFiPIRSF000216. NADH_DH_24kDa. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR01958. nuoE_fam. 1 hit.
    PROSITEiPS01099. COMPLEX1_24K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57255-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEISIKFKL TNEEINAIEN QKKYYEDFRA ISIEALKIVQ KKRGWVSDQA    50
    IYAIAEILHI NPSDVEGVAT FYSQIFRKPV GRNIIRYCDS VVCFLTGYKR 100
    IQIALENYLK IKIGETTKDD RFTLLPVCCL GNCDKGPTIM INEDTYSVLT 150
    PESIPSLLES YK 162
    Length:162
    Mass (Da):18,598
    Last modified:December 1, 2000 - v1
    Checksum:i428DC8DBA0B463F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12875.1.
    RefSeqiNP_239989.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB12875; BAB12875; BAB12875.
    GeneIDi1109601.
    KEGGibuc:BU157.
    PATRICi21243830. VBIBucAph127364_0167.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12875.1 .
    RefSeqi NP_239989.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57255.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB12875 ; BAB12875 ; BAB12875 .
    GeneIDi 1109601.
    KEGGi buc:BU157.
    PATRICi 21243830. VBIBucAph127364_0167.

    Phylogenomic databases

    eggNOGi COG1905.
    HOGENOMi HOG000257749.
    KOi K00334.
    OMAi TIHIAEG.
    OrthoDBi EOG6T4S12.

    Enzyme and pathway databases

    BioCyci BAPH107806:GBZJ-157-MONOMER.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR002023. NuoE-like.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR10371. PTHR10371. 1 hit.
    PIRSFi PIRSF000216. NADH_DH_24kDa. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR01958. nuoE_fam. 1 hit.
    PROSITEi PS01099. COMPLEX1_24K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiNUOE_BUCAI
    AccessioniPrimary (citable) accession number: P57255
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3