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P57254 (NUOCD_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit C/D

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit C/D
NDH-1 subunit C/D
Gene names
Name:nuoC
Synonyms:nuoCD, nuoD
Ordered Locus Names:BU156
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01359

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP MF_01359

Subunit structure

NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP MF_01359.

Sequence similarities

In the N-terminal section; belongs to the complex I 30 kDa subunit family.

In the C-terminal section; belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Multifunctional enzyme
Reference proteome
Gene Ontology (GO)
   Biological processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 600600NADH-quinone oxidoreductase subunit C/D HAMAP MF_01359
PRO_0000118681

Regions

Region1 – 190190NADH dehydrogenase I subunit C By similarity
Region214 – 600387NADH dehydrogenase I subunit D By similarity

Sequences

Sequence LengthMass (Da)Tools
P57254 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 033AA3AFAC5C567D

FASTA60069,576
        10         20         30         40         50         60 
MIDLMPKKNT FLLKKKYKED SNNSVINNLF DFFGKEFCFH QITLTGFPII WIDKTLLIEV 

        70         80         90        100        110        120 
GKFLYHLSQP YIMLYDLHGV DERIRLHRED LPKADFSVFY HLISIERNSD IMIKVPLLEN 

       130        140        150        160        170        180 
DLILPTFTGL FPNANWYERE TWDMFGIIFN NHPNLTRIIM PSTWKGHPLR KNYSARATEY 

       190        200        210        220        230        240 
EPFFLNEQKE DLEMEGLKFK PELWGMKRKN DNVEFMFLNL GPNHPSAHGA FRIVLQLDGE 

       250        260        270        280        290        300 
NIVDCVPDIG YHHRGAEKMA ERQSWHSYIP YTDRIEYLGG CVNELPYVLA VEKLANISVP 

       310        320        330        340        350        360 
EKAEVIRVMM SELFRINSHL LYISTFIQDV GCMTPVFFAF TDRQKIYDLI EAITGARMHP 

       370        380        390        400        410        420 
AWFRIGGVAN DLPQGWNILL KEFLDWMPKR LKYYINTALK NSILIHRSKG IAEYNKKEAL 

       430        440        450        460        470        480 
QWGVTGAGLR ATGLNFDVRK WRPYSGYQNY TFEVPVGSGI SDCYSRVMIK VEEIYQSLFI 

       490        500        510        520        530        540 
LKQCLCNMPS GPFKSEDSLT TPPSKECVLQ NIETMITHFL QVSWGPVIPE NESFQMIEAT 

       550        560        570        580        590        600 
KGINSYYLIS DGGTMSYRTR IRTPSFPHLQ QIPSVIRGSL ISDLIVYLGS IDFVMSDVDR 

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed: 10993077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000003 Genomic DNA. Translation: BAB12874.1.
RefSeqNP_239988.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57254.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000003236; EBBUCP00000003012; EBBUCG00000003236.
GeneID1109600.
GenomeReviewsGene locus BU156 in contig BA000003_GR.
KEGGbuc:BU156.
PATRIC21243828. VBIBucAph127364_0166.

Phylogenomic databases

GeneTreeEBGT00050000007742.
HOGENOMHBG459705.
OMAPHLQQIP.
PhylomeDBP57254.
ProtClustDBPRK11742.

Enzyme and pathway databases

BioCycBSP107806:BU156-MONOMER.

Family and domain databases

HAMAPMF_01359. NDH1_NuoCD_1.
[Tree]
InterProIPR010219. NADH_DH_1_suD.
IPR010218. NADH_DH_suC.
IPR023062. NADH_DH_suC/D.
IPR001135. NADH_Q_OxRdtase_suD.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
[Graphical view]
KOK13378.
PfamPF00329. Complex1_30kDa. 1 hit.
PF00346. Complex1_49kDa. 1 hit.
[Graphical view]
ProDomPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01961. NuoC_fam. 1 hit.
TIGR01962. NuoD. 1 hit.
PROSITEPS00542. COMPLEX1_30K. False negative.
PS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOCD_BUCAI
AccessionPrimary (citable) accession number: P57254
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

SIMILARITY comments

Index of protein domains and families