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P57240

- SURA_BUCAI

UniProt

P57240 - SURA_BUCAI

Protein

Chaperone SurA

Gene

surA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation By similarity.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    GO - Molecular functioni

    1. peptide binding Source: InterPro
    2. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. biofilm formation Source: InterPro
    2. chaperone mediated protein folding requiring cofactor Source: InterPro
    3. Gram-negative-bacterium-type cell outer membrane assembly Source: InterPro
    4. maintenance of stationary phase Source: InterPro
    5. protein stabilization Source: InterPro

    Keywords - Molecular functioni

    Chaperone, Isomerase, Rotamase

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-140-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chaperone SurA
    Alternative name(s):
    Peptidyl-prolyl cis-trans isomerase SurA (EC:5.2.1.8)
    Short name:
    PPIase SurA
    Rotamase SurA
    Gene namesi
    Name:surA
    Ordered Locus Names:BU140
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    Subcellular locationi

    Periplasm By similarity
    Note: Is capable of associating with the outer membrane.By similarity

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 430410Chaperone SurAPRO_0000025540Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP57240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini174 – 275102PpiC 1Add
    BLAST
    Domaini284 – 384101PpiC 2Add
    BLAST

    Domaini

    The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition By similarity.By similarity

    Sequence similaritiesi

    Contains 2 PpiC domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0760.
    HOGENOMiHOG000085868.
    KOiK03771.
    OMAiLGKMQLS.
    OrthoDBiEOG6M9DS4.

    Family and domain databases

    HAMAPiMF_01183. Chaperone_SurA.
    InterProiIPR000297. PPIase_PpiC.
    IPR023034. PPIase_SurA.
    IPR015391. SurA_N.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view]
    PfamiPF00639. Rotamase. 1 hit.
    PF09312. SurA_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF109998. SSF109998. 1 hit.
    PROSITEiPS50198. PPIC_PPIASE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P57240-1 [UniParc]FASTAAdd to Basket

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    MKICIFIFFY IFSSIFYVLA KNNQVDNITA IVNDEIILNS DVNEILVFLK    50
    KSKKKFIIPL KSDFLKEKVL EKLIVDSLIL QEANSKNINI TKEQIDTVIK 100
    NIALKKHISV DHFKKQILLR NIKNPSYYDN FIKKIEILLK MKTIQDYELH 150
    KRINISEQEV NTIFKKLIKD NEKFKKINLS YILLPSLKQD SDNAVRNRTK 200
    IAENIVYKLK KGYDFEKLLI ECEKNKSTFI VKKMFWKPLL DIQNSFFKTL 250
    NIFKKGQILG PIVGDKGLYI LKVNDIHHKK ENIVTEFYMQ HCLIKPSVIL 300
    TNTEAKKKIF NIYENIKKGI YTFDDAVKNL SDDYYSSNKK GDLGWISKES 350
    LGFDLNKKFL ILDKNEISEP VKSNWGWHIF KILDRRQVDA FYKLKKNQAF 400
    NIVLNQKIIS EKNHWIEDLK NTAYIEIIRS 430
    Length:430
    Mass (Da):50,738
    Last modified:December 1, 2000 - v1
    Checksum:iCA4C425B3FBA5788
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12858.1.
    RefSeqiNP_239972.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB12858; BAB12858; BAB12858.
    GeneIDi1109584.
    KEGGibuc:BU140.
    PATRICi21243794. VBIBucAph127364_0149.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12858.1 .
    RefSeqi NP_239972.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57240.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB12858 ; BAB12858 ; BAB12858 .
    GeneIDi 1109584.
    KEGGi buc:BU140.
    PATRICi 21243794. VBIBucAph127364_0149.

    Phylogenomic databases

    eggNOGi COG0760.
    HOGENOMi HOG000085868.
    KOi K03771.
    OMAi LGKMQLS.
    OrthoDBi EOG6M9DS4.

    Enzyme and pathway databases

    BioCyci BAPH107806:GBZJ-140-MONOMER.

    Family and domain databases

    HAMAPi MF_01183. Chaperone_SurA.
    InterProi IPR000297. PPIase_PpiC.
    IPR023034. PPIase_SurA.
    IPR015391. SurA_N.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view ]
    Pfami PF00639. Rotamase. 1 hit.
    PF09312. SurA_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF109998. SSF109998. 1 hit.
    PROSITEi PS50198. PPIC_PPIASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiSURA_BUCAI
    AccessioniPrimary (citable) accession number: P57240
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3