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P57240 (SURA_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chaperone SurA
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase SurA
Short name=PPIase SurA
EC=5.2.1.8
Rotamase SurA
Gene names
Name:surA
Ordered Locus Names:BU140
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation By similarity. HAMAP-Rule MF_01183

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0). HAMAP-Rule MF_01183

Subcellular location

Periplasm By similarity. Note: Is capable of associating with the outer membrane By similarity. HAMAP-Rule MF_01183

Domain

The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition By similarity. HAMAP-Rule MF_01183

Sequence similarities

Contains 2 PpiC domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 430410Chaperone SurA HAMAP-Rule MF_01183
PRO_0000025540

Regions

Domain174 – 275102PpiC 1
Domain284 – 384101PpiC 2

Sequences

Sequence LengthMass (Da)Tools
P57240 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: CA4C425B3FBA5788

FASTA43050,738
        10         20         30         40         50         60 
MKICIFIFFY IFSSIFYVLA KNNQVDNITA IVNDEIILNS DVNEILVFLK KSKKKFIIPL 

        70         80         90        100        110        120 
KSDFLKEKVL EKLIVDSLIL QEANSKNINI TKEQIDTVIK NIALKKHISV DHFKKQILLR 

       130        140        150        160        170        180 
NIKNPSYYDN FIKKIEILLK MKTIQDYELH KRINISEQEV NTIFKKLIKD NEKFKKINLS 

       190        200        210        220        230        240 
YILLPSLKQD SDNAVRNRTK IAENIVYKLK KGYDFEKLLI ECEKNKSTFI VKKMFWKPLL 

       250        260        270        280        290        300 
DIQNSFFKTL NIFKKGQILG PIVGDKGLYI LKVNDIHHKK ENIVTEFYMQ HCLIKPSVIL 

       310        320        330        340        350        360 
TNTEAKKKIF NIYENIKKGI YTFDDAVKNL SDDYYSSNKK GDLGWISKES LGFDLNKKFL 

       370        380        390        400        410        420 
ILDKNEISEP VKSNWGWHIF KILDRRQVDA FYKLKKNQAF NIVLNQKIIS EKNHWIEDLK 

       430 
NTAYIEIIRS 

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000003 Genomic DNA. Translation: BAB12858.1.
RefSeqNP_239972.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57240.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB12858; BAB12858; BAB12858.
GeneID1109584.
KEGGbuc:BU140.
PATRIC21243794. VBIBucAph127364_0149.

Phylogenomic databases

eggNOGCOG0760.
HOGENOMHOG000085868.
KOK03771.
OMAFGVHLIQ.
OrthoDBEOG6M9DS4.
ProtClustDBCLSK315493.

Enzyme and pathway databases

BioCycBAPH107806:GBZJ-140-MONOMER.

Family and domain databases

HAMAPMF_01183. Chaperone_SurA.
InterProIPR000297. PPIase_PpiC.
IPR023034. PPIase_SurA.
IPR015391. SurA_N.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamPF00639. Rotamase. 1 hit.
PF09312. SurA_N. 1 hit.
[Graphical view]
SUPFAMSSF109998. SSF109998. 1 hit.
PROSITEPS50198. PPIC_PPIASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSURA_BUCAI
AccessionPrimary (citable) accession number: P57240
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names