P57240 (SURA_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chaperone SurA

Alternative name(s):
Peptidyl-prolyl cis-trans isomerase SurA
Short name=PPIase SurA
EC=5.2.1.8
Rotamase SurA

Gene names

Name:	surA
Ordered Locus Names:	BU140

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Acyrthosiphon pisum)

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation By similarity. HAMAP-Rule MF_01183
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0). HAMAP-Rule MF_01183
Subcellular location	Periplasm By similarity. Note: Is capable of associating with the outer membrane By similarity.
Domain	The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition By similarity. HAMAP-Rule MF_01183
Sequence similarities	Contains 2 PpiC domains.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Repeat Signal
Molecular function	Chaperone Isomerase Rotamase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Gram-negative-bacterium-type cell outer membrane assembly Inferred from electronic annotation. Source: InterPro biofilm formation Inferred from electronic annotation. Source: InterPro chaperone mediated protein folding requiring cofactor Inferred from electronic annotation. Source: InterPro maintenance of stationary phase Inferred from electronic annotation. Source: InterPro protein peptidyl-prolyl isomerization Inferred from electronic annotation. Source: GOC protein stabilization Inferred from electronic annotation. Source: InterPro
Cellular_component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular_function	peptide binding Inferred from electronic annotation. Source: InterPro peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 430	410	Chaperone SurA HAMAP-Rule MF_01183		PRO_0000025540
Regions
	Domain	174 – 275	102	PpiC 1
	Domain	284 – 384	101	PpiC 2

Sequences

	Sequence		Length	Mass (Da)
	P57240 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: CA4C425B3FBA5788	FASTA	430	50,738
	10 20 30 40 50 60 MKICIFIFFY IFSSIFYVLA KNNQVDNITA IVNDEIILNS DVNEILVFLK KSKKKFIIPL 70 80 90 100 110 120 KSDFLKEKVL EKLIVDSLIL QEANSKNINI TKEQIDTVIK NIALKKHISV DHFKKQILLR 130 140 150 160 170 180 NIKNPSYYDN FIKKIEILLK MKTIQDYELH KRINISEQEV NTIFKKLIKD NEKFKKINLS 190 200 210 220 230 240 YILLPSLKQD SDNAVRNRTK IAENIVYKLK KGYDFEKLLI ECEKNKSTFI VKKMFWKPLL 250 260 270 280 290 300 DIQNSFFKTL NIFKKGQILG PIVGDKGLYI LKVNDIHHKK ENIVTEFYMQ HCLIKPSVIL 310 320 330 340 350 360 TNTEAKKKIF NIYENIKKGI YTFDDAVKNL SDDYYSSNKK GDLGWISKES LGFDLNKKFL 370 380 390 400 410 420 ILDKNEISEP VKSNWGWHIF KILDRRQVDA FYKLKKNQAF NIVLNQKIIS EKNHWIEDLK 430 NTAYIEIIRS

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB12858.1.
RefSeq	NP_239972.1. NC_002528.1.
3D structure databases
ProteinModelPortal	P57240.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB12858; BAB12858; BAB12858.
GeneID	1109584.
KEGG	buc:BU140.
PATRIC	21243794. VBIBucAph127364_0149.
Phylogenomic databases
eggNOG	COG0760.
HOGENOM	HOG000085868.
KO	K03771.
OMA	FGVHLIQ.
ProtClustDB	CLSK315493.
Family and domain databases
HAMAP	MF_01183. Chaperone_SurA.
InterPro	IPR000297. PPIase_PpiC. IPR023034. PPIase_SurA. IPR015391. SurA_N. IPR027304. Trigger_fact/SurA_dom. [Graphical view]
Pfam	PF00639. Rotamase. 1 hit. PF09312. SurA_N. 1 hit. [Graphical view]
SUPFAM	SSF109998. Trigger_fac_C_bac. 1 hit.
PROSITE	PS01096. PPIC_PPIASE_1. False negative. PS50198. PPIC_PPIASE_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SURA_BUCAI

Accession

Primary (citable) accession number: P57240

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program