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Protein

Chaperone SurA

Gene

surA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  1. peptide binding Source: InterPro
  2. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. chaperone mediated protein folding requiring cofactor Source: InterPro
  2. Gram-negative-bacterium-type cell outer membrane assembly Source: InterPro
  3. maintenance of stationary phase Source: InterPro
  4. protein stabilization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-140-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone SurA
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase SurA (EC:5.2.1.8)
Short name:
PPIase SurA
Rotamase SurA
Gene namesi
Name:surA
Ordered Locus Names:BU140
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806 Componenti: Chromosome

Subcellular locationi

Periplasm By similarity
Note: Is capable of associating with the outer membrane.By similarity

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 430410Chaperone SurAPRO_0000025540Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP57240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 275102PpiC 1Add
BLAST
Domaini284 – 384101PpiC 2Add
BLAST

Domaini

The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition (By similarity).By similarity

Sequence similaritiesi

Contains 2 PpiC domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG0760.
HOGENOMiHOG000085868.
KOiK03771.
OMAiFGVHLIQ.
OrthoDBiEOG6M9DS4.

Family and domain databases

HAMAPiMF_01183. Chaperone_SurA.
InterProiIPR000297. PPIase_PpiC.
IPR023034. PPIase_SurA.
IPR015391. SurA_N.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
PF09312. SurA_N. 1 hit.
[Graphical view]
SUPFAMiSSF109998. SSF109998. 1 hit.
PROSITEiPS50198. PPIC_PPIASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKICIFIFFY IFSSIFYVLA KNNQVDNITA IVNDEIILNS DVNEILVFLK
60 70 80 90 100
KSKKKFIIPL KSDFLKEKVL EKLIVDSLIL QEANSKNINI TKEQIDTVIK
110 120 130 140 150
NIALKKHISV DHFKKQILLR NIKNPSYYDN FIKKIEILLK MKTIQDYELH
160 170 180 190 200
KRINISEQEV NTIFKKLIKD NEKFKKINLS YILLPSLKQD SDNAVRNRTK
210 220 230 240 250
IAENIVYKLK KGYDFEKLLI ECEKNKSTFI VKKMFWKPLL DIQNSFFKTL
260 270 280 290 300
NIFKKGQILG PIVGDKGLYI LKVNDIHHKK ENIVTEFYMQ HCLIKPSVIL
310 320 330 340 350
TNTEAKKKIF NIYENIKKGI YTFDDAVKNL SDDYYSSNKK GDLGWISKES
360 370 380 390 400
LGFDLNKKFL ILDKNEISEP VKSNWGWHIF KILDRRQVDA FYKLKKNQAF
410 420 430
NIVLNQKIIS EKNHWIEDLK NTAYIEIIRS
Length:430
Mass (Da):50,738
Last modified:November 30, 2000 - v1
Checksum:iCA4C425B3FBA5788
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12858.1.
RefSeqiNP_239972.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12858; BAB12858; BAB12858.
GeneIDi1109584.
KEGGibuc:BU140.
PATRICi21243794. VBIBucAph127364_0149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12858.1.
RefSeqiNP_239972.1. NC_002528.1.

3D structure databases

ProteinModelPortaliP57240.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB12858; BAB12858; BAB12858.
GeneIDi1109584.
KEGGibuc:BU140.
PATRICi21243794. VBIBucAph127364_0149.

Phylogenomic databases

eggNOGiCOG0760.
HOGENOMiHOG000085868.
KOiK03771.
OMAiFGVHLIQ.
OrthoDBiEOG6M9DS4.

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-140-MONOMER.

Family and domain databases

HAMAPiMF_01183. Chaperone_SurA.
InterProiIPR000297. PPIase_PpiC.
IPR023034. PPIase_SurA.
IPR015391. SurA_N.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
PF09312. SurA_N. 1 hit.
[Graphical view]
SUPFAMiSSF109998. SSF109998. 1 hit.
PROSITEiPS50198. PPIC_PPIASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiSURA_BUCAI
AccessioniPrimary (citable) accession number: P57240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2000
Last sequence update: November 30, 2000
Last modified: March 3, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.