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Protein

Chaperone SurA

Gene

surA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone SurA
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase SurA (EC:5.2.1.8)
Short name:
PPIase SurA
Rotamase SurA
Gene namesi
Name:surA
Ordered Locus Names:BU140
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

Subcellular locationi

  • Periplasm By similarity
  • Note: Is capable of associating with the outer membrane.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002554021 – 430Chaperone SurAAdd BLAST410

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi107806.BU140

Structurei

3D structure databases

ProteinModelPortaliP57240
SMRiP57240
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 275PpiC 1Add BLAST102
Domaini284 – 384PpiC 2Add BLAST101

Domaini

The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition (By similarity).By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4105DBD Bacteria
COG0760 LUCA
HOGENOMiHOG000085868
KOiK03771
OMAiEMIISRV

Family and domain databases

HAMAPiMF_01183 Chaperone_SurA, 1 hit
InterProiView protein in InterPro
IPR000297 PPIase_PpiC
IPR023034 PPIase_SurA
IPR015391 SurA_N
IPR027304 Trigger_fact/SurA_dom_sf
PfamiView protein in Pfam
PF00639 Rotamase, 1 hit
PF09312 SurA_N, 1 hit
SUPFAMiSSF109998 SSF109998, 1 hit
PROSITEiView protein in PROSITE
PS50198 PPIC_PPIASE_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKICIFIFFY IFSSIFYVLA KNNQVDNITA IVNDEIILNS DVNEILVFLK
60 70 80 90 100
KSKKKFIIPL KSDFLKEKVL EKLIVDSLIL QEANSKNINI TKEQIDTVIK
110 120 130 140 150
NIALKKHISV DHFKKQILLR NIKNPSYYDN FIKKIEILLK MKTIQDYELH
160 170 180 190 200
KRINISEQEV NTIFKKLIKD NEKFKKINLS YILLPSLKQD SDNAVRNRTK
210 220 230 240 250
IAENIVYKLK KGYDFEKLLI ECEKNKSTFI VKKMFWKPLL DIQNSFFKTL
260 270 280 290 300
NIFKKGQILG PIVGDKGLYI LKVNDIHHKK ENIVTEFYMQ HCLIKPSVIL
310 320 330 340 350
TNTEAKKKIF NIYENIKKGI YTFDDAVKNL SDDYYSSNKK GDLGWISKES
360 370 380 390 400
LGFDLNKKFL ILDKNEISEP VKSNWGWHIF KILDRRQVDA FYKLKKNQAF
410 420 430
NIVLNQKIIS EKNHWIEDLK NTAYIEIIRS
Length:430
Mass (Da):50,738
Last modified:December 1, 2000 - v1
Checksum:iCA4C425B3FBA5788
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA Translation: BAB12858.1
RefSeqiNP_239972.1, NC_002528.1
WP_010895967.1, NC_002528.1

Genome annotation databases

EnsemblBacteriaiBAB12858; BAB12858; BAB12858
GeneIDi1109584
KEGGibuc:BU140
PATRICifig|107806.10.peg.149

Similar proteinsi

Entry informationi

Entry nameiSURA_BUCAI
AccessioniPrimary (citable) accession number: P57240
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

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