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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processQueuosine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00392

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:BU132
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001653881 – 357S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST357

Proteomic databases

PRIDEiP57232

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi107806.BU132

Structurei

3D structure databases

ProteinModelPortaliP57232
SMRiP57232
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2N Bacteria
COG0809 LUCA
HOGENOMiHOG000004402
KOiK07568
OMAiYSYGDGM

Family and domain databases

HAMAPiMF_00113 QueA, 1 hit
InterProiView protein in InterPro
IPR003699 QueA
IPR036100 QueA_sf
PANTHERiPTHR30307 PTHR30307, 1 hit
PfamiView protein in Pfam
PF02547 Queuosine_synth, 1 hit
SUPFAMiSSF111337 SSF111337, 1 hit
TIGRFAMsiTIGR00113 queA, 1 hit

Sequencei

Sequence statusi: Complete.

P57232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLSDFSFDL PKSLISFHPY FIRSTCRLMV MYGHTGMIFH KRFFNIIDEI
60 70 80 90 100
NSGDLIILNN TQVIPARFFG KKESGGKVEV LVEKILGINN ILASIKNSKN
110 120 130 140 150
INIGSKIFFG YKDKIKGSVV DCKNSFFEIF FHDNIDSAID IINNIGEIPL
160 170 180 190 200
PPYIKRFRNK LDVDLYQTVY KKKTGSIAAP TAGLHFDLPL LEALHNKGVD
210 220 230 240 250
IDYITLHIGS GTFQPIRRVQ IEEHIMHSES VEVSSSVIQK IKSCKKKGGR
260 270 280 290 300
IIAVGTSTLR ALESAYHSSE WSDSQDFISD TNIFIYPGYK HNIVDALITN
310 320 330 340 350
FHFPESTLIM LVCSFLGYKN TMNAYNTAIV NKYSFFSYGD AMYITHNKLA

PYENFII
Length:357
Mass (Da):40,506
Last modified:December 1, 2000 - v1
Checksum:i195CA261B2295ABA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA Translation: BAB12850.1
RefSeqiNP_239964.1, NC_002528.1
WP_010895965.1, NC_002528.1

Genome annotation databases

EnsemblBacteriaiBAB12850; BAB12850; BAB12850
GeneIDi1109576
KEGGibuc:BU132
PATRICifig|107806.10.peg.141

Similar proteinsi

Entry informationi

Entry nameiQUEA_BUCAI
AccessioniPrimary (citable) accession number: P57232
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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