P57224 (AROH_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive
EC=2.5.1.54

Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
DAHP synthase
Phospho-2-keto-3-deoxyheptonate aldolase

Gene names

Name:	aroH
Ordered Locus Names:	BU124

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Acyrthosiphon pisum)

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.
Sequence similarities	Belongs to the class-I DAHP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW chorismate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive		PRO_0000140837

Sequences

	Sequence		Length	Mass (Da)
	P57224 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 8CCB7E8733D6DAF7	FASTA	348	38,889
	10 20 30 40 50 60 MKKTDELRTI RIDPLITPAE LARQYAITSD IMDTVIATRQ NIARIMTGQD ARLLVVIGPC 70 80 90 100 110 120 SVHDPIAAVE YAHRLYELRV KYKDRLEIIM RTYFEKPRTV VGWKGLISDP DLNGSFRVNH 130 140 150 160 170 180 GLAVARKLLL DINALGMPAA TEFLDIVIGQ FIADLISWGA IGARTTESQI HREMASALSC 190 200 210 220 230 240 PVGFKNGTDG NIRIAIDAIR AAKVRHLFFA PNKDGQMTIN HTSGNPYGHI IMRGGRAPNY 250 260 270 280 290 300 HPDDINSAVK HLREFDLLEH LMIDFSHGNC LKEHLRQKNV SKSVSYQISH GSKAIFGVMI 310 320 330 340 ESFLEEGFQT VTNNQPLIYG KSITDACLNW KDSVLIIEQL ADAVDARF

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB12842.1.
RefSeq	NP_239956.1. NC_002528.1.
3D structure databases
ProteinModelPortal	P57224.
SMR	P57224. Positions 6-347.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB12842; BAB12842; BAB12842.
GeneID	1109568.
KEGG	buc:BU124.
PATRIC	21243762. VBIBucAph127364_0133.
Phylogenomic databases
eggNOG	COG0722.
HOGENOM	HOG000220501.
KO	K01626.
OMA	RATRESH.
ProtClustDB	PRK09261.
Enzyme and pathway databases
UniPathway	UPA00053; UER00084.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
PANTHER	PTHR21225. PTHR21225. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
PIRSF	PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMs	TIGR00034. aroFGH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROH_BUCAI

Accession

Primary (citable) accession number: P57224

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program