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Reviewed, UniProtKB/Swiss-Prot P57224 (AROH_BUCAI)

Last modified November 3, 2009. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive
    EC=2.5.1.54
Alternative name(s):
    Phospho-2-keto-3-deoxyheptonate aldolase
    3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
    DAHP synthetase
Gene names
Name: aroH
Ordered Locus Names: BU124
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (Acyrthosiphon pisum symbiotic bacterium) [Complete proteome] [HAMAP]
Taxonomic identifier118099 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

Catalytic activity

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.

Sequence similarities

Belongs to the class-I DAHP synthetase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive
PRO_0000140837

Sequences

Sequence LengthMass (Da)Tools
P57224-1 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 8CCB7E8733D6DAF7

FASTA34838,889
        10         20         30         40         50         60 
MKKTDELRTI RIDPLITPAE LARQYAITSD IMDTVIATRQ NIARIMTGQD ARLLVVIGPC 

        70         80         90        100        110        120 
SVHDPIAAVE YAHRLYELRV KYKDRLEIIM RTYFEKPRTV VGWKGLISDP DLNGSFRVNH 

       130        140        150        160        170        180 
GLAVARKLLL DINALGMPAA TEFLDIVIGQ FIADLISWGA IGARTTESQI HREMASALSC 

       190        200        210        220        230        240 
PVGFKNGTDG NIRIAIDAIR AAKVRHLFFA PNKDGQMTIN HTSGNPYGHI IMRGGRAPNY 

       250        260        270        280        290        300 
HPDDINSAVK HLREFDLLEH LMIDFSHGNC LKEHLRQKNV SKSVSYQISH GSKAIFGVMI 

       310        320        330        340 
ESFLEEGFQT VTNNQPLIYG KSITDACLNW KDSVLIIEQL ADAVDARF 

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed: 10993077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tokyo 1998.

Cross-references

Sequence databases

BA000003 Genomic DNA. Translation: BAB12842.1.
RefSeqNP_239956.1.

3D structure databases

HSSPHSSP built from PDB template 1GG1 based on UniProtKB P00886.
ModBaseSearch...

Genome annotation databases

GeneID1109568.
GenomeReviewsGene locus BU124 in contig BA000003_GR.
KEGGbuc:BU124.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP57224.
OMANIARIMT.

Enzyme and pathway databases

BioCycBSP107806:BU124-MON.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHERPTHR21225. AroFGH. 1 hit.
PfamPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
PIRSFPIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsTIGR00034. aroFGH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROH_BUCAI
AccessionPrimary (citable) accession number: P57224
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 3, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents