Reviewed, UniProtKB/Swiss-Prot P57224 (AROH_BUCAI)

Names and origin

Protein names

Recommended name:
    Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive
    EC=2.5.1.54
Alternative name(s):
    Phospho-2-keto-3-deoxyheptonate aldolase
    3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
    DAHP synthetase

Gene names

Name:	aroH
Ordered Locus Names:	BU124

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (Acyrthosiphon pisum symbiotic bacterium) [Complete proteome] [HAMAP]

Taxonomic identifier

118099 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.
Sequence similarities	Belongs to the class-I DAHP synthetase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive		PRO_0000140837

Sequences

	Sequence		Length	Mass (Da)
	P57224-1 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 8CCB7E8733D6DAF7	FASTA	348	38,889
	10 20 30 40 50 60 MKKTDELRTI RIDPLITPAE LARQYAITSD IMDTVIATRQ NIARIMTGQD ARLLVVIGPC 70 80 90 100 110 120 SVHDPIAAVE YAHRLYELRV KYKDRLEIIM RTYFEKPRTV VGWKGLISDP DLNGSFRVNH 130 140 150 160 170 180 GLAVARKLLL DINALGMPAA TEFLDIVIGQ FIADLISWGA IGARTTESQI HREMASALSC 190 200 210 220 230 240 PVGFKNGTDG NIRIAIDAIR AAKVRHLFFA PNKDGQMTIN HTSGNPYGHI IMRGGRAPNY 250 260 270 280 290 300 HPDDINSAVK HLREFDLLEH LMIDFSHGNC LKEHLRQKNV SKSVSYQISH GSKAIFGVMI 310 320 330 340 ESFLEEGFQT VTNNQPLIYG KSITDACLNW KDSVLIIEQL ADAVDARF

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tokyo 1998.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000003 Genomic DNA. Translation: BAB12842.1.
RefSeq	NP_239956.1.
3D structure databases
HSSP	HSSP built from PDB template 1GG1 based on UniProtKB P00886.
ModBase	Search...
Genome annotation databases
GeneID	1109568.
GenomeReviews	Gene locus BU124 in contig BA000003_GR.
KEGG	buc:BU124.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P57224.
OMA	NIARIMT.
Enzyme and pathway databases
BioCyc	BSP107806:BU124-MON.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21225. AroFGH. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
PIRSF	PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMs	TIGR00034. aroFGH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROH_BUCAI

Accession

Primary (citable) accession number: P57224

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	November 3, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)