Reviewed,
UniProtKB/Swiss-Prot P57212 (RISA_BUCAI)
Last modified
November 3, 2009.
Version 48.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Riboflavin synthase alpha chain EC=2.5.1.9 | ||||
| Gene names |
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| Organism | Buchnera aphidicola subsp. Acyrthosiphon pisum (Acyrthosiphon pisum symbiotic bacterium) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 118099 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera |
Protein attributes
| Sequence length | 208 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 6,7-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione By similarity. |
| Catalytic activity | 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. |
| Pathway | |
| Subunit structure | Oligomer that consist of 3 alpha subunits and 60 beta subunits By similarity. |
| Sequence similarities | Contains 2 lumazine-binding repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Riboflavin biosynthesis |
| Domain | Repeat |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | riboflavin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | riboflavin synthase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tokyo 1998. |
Cross-references
Sequence databases | |
|---|---|
| BA000003 Genomic DNA. Translation: BAB12830.1. | |
| RefSeq | NP_239944.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1I8D based on UniProtKB P29015. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1109556. |
| GenomeReviews | Gene locus BU112 in contig BA000003_GR. |
| KEGG | buc:BU112. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P57212. |
| OMA | CLTVTKI. |
Enzyme and pathway databases | |
| BioCyc | BSP107806:BU112-MON. |
Family and domain databases | |
| InterPro | IPR001783. Lumazine_bd. [Graphical view] |
| PANTHER | PTHR21098. Lumazine_bd. 1 hit. |
| Pfam | PF00677. Lum_binding. 2 hits. [Graphical view] |
| PIRSF | PIRSF000498. Riboflavin_syn_A. 1 hit. |
| ProDom | PD004110. Lum_binding. 2 hits. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00187. ribE. 1 hit. |
| PROSITE | PS51177. LUMAZINE_BIND. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RISA_BUCAI | ||||||||
| Accession | Primary (citable) accession number: P57212 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Buchnera aphidicola (subsp. Acyrthosiphon pisum) Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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