P57209 (DCD_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	BU108

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.
Sequence caution	The sequence BAB12827.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	dCTP deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Deoxycytidine triphosphate deaminase HAMAP MF_00146		PRO_0000155969

Sequences

	Sequence		Length	Mass (Da)
	P57209 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: DE7DD7FD961FC9FA	FASTA	193	21,952
	10 20 30 40 50 60 MRLCDKDIEE WLERKELIIE PYPNKTLING ITVDIHLGNK FRFFYEHTGS CIDLSNSKII 70 80 90 100 110 120 GGLSLTEIMS NEIIFSKEQP CFLQPGSLVL CSTFESIKMP NNLVGWLDGR SSLARLGLMI 130 140 150 160 170 180 HATAHRIDPG WNGNIVLEMF NAGKLTLVLR PKMRIAALSF EVLSQPVLRP YNLRKEAKYK 190 IQNGVVPSRI HKE

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB12827.1. Different initiation.
RefSeq	NP_239941.2. NC_002528.1.
3D structure databases
ProteinModelPortal	P57209.
SMR	P57209. Positions 1-193.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000003127; EBBUCP00000002903; EBBUCG00000003127.
GeneID	1109553.
GenomeReviews	Gene locus BU108 in contig BA000003_GR.
KEGG	buc:BU108.
PATRIC	21243726. VBIBucAph127364_0116.
Phylogenomic databases
GeneTree	EBGT00050000008146.
HOGENOM	HBG553199.
OMA	HTAAYID.
PhylomeDB	P57209.
ProtClustDB	PRK00416.
Enzyme and pathway databases
BioCyc	BSP107806:BU108-MONOMER.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase. [Tree]
InterPro	IPR011962. dCTP_deam. IPR008180. dUTP_pyroPase. [Graphical view]
KO	K01494.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. DCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_BUCAI

Accession

Primary (citable) accession number: P57209

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program