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P57208

- 6PGD_BUCAI

UniProt

P57208 - 6PGD_BUCAI

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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene
gnd, BU107
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021NADP By similarity
Binding sitei102 – 1021Substrate By similarity
Active sitei182 – 1821Proton acceptor By similarity
Active sitei189 – 1891Proton donor By similarity
Binding sitei190 – 1901Substrate By similarity
Binding sitei259 – 2591Substrate; via amide nitrogen By similarity
Binding sitei286 – 2861Substrate By similarity
Binding sitei445 – 4451Substrate; shared with dimeric partner By similarity
Binding sitei451 – 4511Substrate; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADP By similarity
Nucleotide bindingi33 – 353NADP By similarity
Nucleotide bindingi74 – 763NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-107-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:BU107
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4684686-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090028Add
BLAST

Proteomic databases

PRIDEiP57208.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP57208.
SMRiP57208. Positions 1-466.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 1303Substrate binding By similarity
Regioni185 – 1862Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
HOGENOMiHOG000255147.
KOiK00033.
OMAiDKDGVFH.
OrthoDBiEOG6MSS4W.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57208-1 [UniParc]FASTAAdd to Basket

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MSRQQIGVVG MAVMGRNLAL NIESKNYSVS IFNRTRSVTE EVFNQNKKKN    50
IVPYFSIKDF IDSLLKPRCI LLMVQSGKAT DETIKMILPY LEKEDILIDA 100
GNTFYKDTIR RNEKLSKYEI NFIGMGVSGG ELGALNGPSI MPGGQKEAYK 150
LVLPMLEKIS AKFKGEPCVS YIGPNGAGHY VKMVHNGIEY GDMQLISESY 200
FLLKYLLNMS NEELSSTFSK WNKGELNSYL IEITKNIFIE KDEKGKYLID 250
RILDVAEDKG TGKWISKSAL DLREPLSLIT ESVFARYLSS LKRQRIIASK 300
ILQGPKIKTF IKDKNSFIEE VRRALYLGKI ISYAQGFSQL KRASEKYHWN 350
LKYGEIAKIF RAGCIIRANF LQKITDEYTQ NKNVVNLLLT PYFSKIANEY 400
ENSLRNIVMY AIKYGISTPT FSAAISYYDS YRALYLPANL IQAQRDYFGS 450
HTYQRTDQTG YFHTNWSQ 468
Length:468
Mass (Da):53,574
Last modified:December 1, 2000 - v1
Checksum:i3317FDDF8F3EF20A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12826.1.
RefSeqiNP_239940.1. NC_002528.1.
WP_010895948.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12826; BAB12826; BAB12826.
GeneIDi1109552.
KEGGibuc:BU107.
PATRICi21243724. VBIBucAph127364_0115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12826.1 .
RefSeqi NP_239940.1. NC_002528.1.
WP_010895948.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57208.
SMRi P57208. Positions 1-466.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P57208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB12826 ; BAB12826 ; BAB12826 .
GeneIDi 1109552.
KEGGi buc:BU107.
PATRICi 21243724. VBIBucAph127364_0115.

Phylogenomic databases

eggNOGi COG0362.
HOGENOMi HOG000255147.
KOi K00033.
OMAi DKDGVFH.
OrthoDBi EOG6MSS4W.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci BAPH107806:GBZJ-107-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry namei6PGD_BUCAI
AccessioniPrimary (citable) accession number: P57208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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