P57202 (HIS8_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	BU101

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_0000153329
Amino acid modifications
	Modified residue	215	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P57202 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 86221F9606D4B156	FASTA	368	42,123
	10 20 30 40 50 60 MTDNVLKLSR KNIKKLIPYQ SARRIGGEHG NILLNANESP VSIFFKLKKK PFNRYPECQP 70 80 90 100 110 120 SKLISSYAHY VNLSCNQILA TRGADEGIEL LIKAFCEPGK DAIIYCPPTY DMYRINATIA 130 140 150 160 170 180 GVEIKEIPTI KNTWQLDLLN IKLNLSRVKL IYICNPNNPT GNIFFKKDLI FLLNITLGQA 190 200 210 220 230 240 LVVIDEAYIE FSPEESMTNY LKDYPNLVVL RTLSKAFALA GIRCGFTLAK KEIIQTLSKV 250 260 270 280 290 300 ISPYPISIPV SDIAIRSLEK DYVQLMKNRV LDSNNNRIWL INQLKNITCV ETVFESNANY 310 320 330 340 350 360 VLVKFSMFEK VFETLWNKGI ILRNQNEKTN LKKCIRISMG TRSESLRLIK ELKIFSKKNM CQGEMSEK

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB12820.1.
RefSeq	NP_239934.1. NC_002528.1.
3D structure databases
ProteinModelPortal	P57202.
SMR	P57202. Positions 2-354.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000003151; EBBUCP00000002927; EBBUCG00000003151.
GeneID	1109504.
GenomeReviews	Gene locus BU101 in contig BA000003_GR.
KEGG	buc:BU101.
PATRIC	21243712. VBIBucAph127364_0109.
Phylogenomic databases
GeneTree	EBGT00050000007997.
HOGENOM	HBG646350.
OMA	NRYPEFQ.
PhylomeDB	P57202.
ProtClustDB	PRK01688.
Enzyme and pathway databases
BioCyc	BSP107806:BU101-MONOMER.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_BUCAI

Accession

Primary (citable) accession number: P57202

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program