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P57201

- HISX_BUCAI

UniProt

P57201 - HISX_BUCAI

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei131 – 1311NADBy similarity
    Binding sitei189 – 1891NADBy similarity
    Binding sitei212 – 2121NADBy similarity
    Binding sitei238 – 2381SubstrateBy similarity
    Metal bindingi260 – 2601ZincBy similarity
    Binding sitei260 – 2601SubstrateBy similarity
    Metal bindingi263 – 2631ZincBy similarity
    Binding sitei263 – 2631SubstrateBy similarity
    Active sitei327 – 3271Proton acceptorBy similarity
    Active sitei328 – 3281Proton acceptorBy similarity
    Binding sitei328 – 3281SubstrateBy similarity
    Metal bindingi361 – 3611ZincBy similarity
    Binding sitei361 – 3611SubstrateBy similarity
    Binding sitei415 – 4151SubstrateBy similarity
    Metal bindingi420 – 4201ZincBy similarity
    Binding sitei420 – 4201SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-100-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:hisD
    Ordered Locus Names:BU100
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435Histidinol dehydrogenasePRO_0000135742Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP57201.
    SMRiP57201. Positions 6-433.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiQKSLHAV.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57201-1 [UniParc]FASTAAdd to Basket

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    MKYFKNIIFW NKLHPDEQKK ILSRPILKEN NFIKKTVKEI IENVRLFGNS    50
    ALKKYTFLFD KQDINTFQVS KEKISSSSFY LSKVLKDSIS VAQKNITCFH 100
    KAQIPSKIDV ETEVGVRCEQ IYLPLNSIGI YIPGGTAPLF STVLMLAIPA 150
    KISGCKKIIL CSPPPISNEV LYAAHICGIH DIYQVGGAQA IAALALGTET 200
    VPKVDKIFGP GNAYVTEAKL QVSSIFNGTE IDMLAGPSEL LIIADNTANP 250
    DFIAADLLSQ AEHGVSSQVI LLTPCFELAE KVVLSINKQL NNLSRLSEIL 300
    KTLKNSSVII VKNLSECIEI SNMYAPEHLI IQTQSPREVL NYISNASSIF 350
    LGLWSPESAG DYASGTNHVL PTYGKSITNS SLGLCDFQKR VLVQELTAKG 400
    LMKLSNTIEI LSSAEKLQAH KNAVKIRVDF LKGKI 435
    Length:435
    Mass (Da):47,844
    Last modified:December 1, 2000 - v1
    Checksum:i83DD3DDC4E43430E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12819.1.
    RefSeqiNP_239933.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB12819; BAB12819; BAB12819.
    GeneIDi1109503.
    KEGGibuc:BU100.
    PATRICi21243710. VBIBucAph127364_0108.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12819.1 .
    RefSeqi NP_239933.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57201.
    SMRi P57201. Positions 6-433.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB12819 ; BAB12819 ; BAB12819 .
    GeneIDi 1109503.
    KEGGi buc:BU100.
    PATRICi 21243710. VBIBucAph127364_0108.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi QKSLHAV.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci BAPH107806:GBZJ-100-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiHISX_BUCAI
    AccessioniPrimary (citable) accession number: P57201
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3