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Reviewed, UniProtKB/Swiss-Prot P57201 (HISX_BUCAI)

Last modified November 25, 2008. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Histidinol dehydrogenase
      Short name=HDH
    EC=1.1.1.23
Gene names
Name: hisD
Ordered Locus Names: BU100
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (Acyrthosiphon pisum symbiotic bacterium) [Complete proteome] [HAMAP]
Taxonomic identifier118099 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

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Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.

Catalytic activity

L-histidinol + 2 NAD(+) = L-histidine + 2 NADH.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the histidinol dehydrogenase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Histidinol dehydrogenase
PRO_0000135742

Sites

Active site3271Proton acceptor By similarity
Active site3281Proton acceptor By similarity
Metal binding2601Zinc By similarity
Metal binding2631Zinc By similarity
Metal binding3611Zinc By similarity
Metal binding4201Zinc By similarity
Binding site1311NAD By similarity
Binding site1891NAD By similarity
Binding site2121NAD By similarity
Binding site2381Substrate By similarity
Binding site2601Substrate By similarity
Binding site2631Substrate By similarity
Binding site3281Substrate By similarity
Binding site3611Substrate By similarity
Binding site4151Substrate By similarity
Binding site4201Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
P57201-1 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 83DD3DDC4E43430E

FASTA43547,844
        10         20         30         40         50         60 
MKYFKNIIFW NKLHPDEQKK ILSRPILKEN NFIKKTVKEI IENVRLFGNS ALKKYTFLFD 

        70         80         90        100        110        120 
KQDINTFQVS KEKISSSSFY LSKVLKDSIS VAQKNITCFH KAQIPSKIDV ETEVGVRCEQ 

       130        140        150        160        170        180 
IYLPLNSIGI YIPGGTAPLF STVLMLAIPA KISGCKKIIL CSPPPISNEV LYAAHICGIH 

       190        200        210        220        230        240 
DIYQVGGAQA IAALALGTET VPKVDKIFGP GNAYVTEAKL QVSSIFNGTE IDMLAGPSEL 

       250        260        270        280        290        300 
LIIADNTANP DFIAADLLSQ AEHGVSSQVI LLTPCFELAE KVVLSINKQL NNLSRLSEIL 

       310        320        330        340        350        360 
KTLKNSSVII VKNLSECIEI SNMYAPEHLI IQTQSPREVL NYISNASSIF LGLWSPESAG 

       370        380        390        400        410        420 
DYASGTNHVL PTYGKSITNS SLGLCDFQKR VLVQELTAKG LMKLSNTIEI LSSAEKLQAH 

       430 
KNAVKIRVDF LKGKI

« Hide

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References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed: 10993077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tokyo 1998.

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Cross-references

Sequence databases

BA000003 Genomic DNA. Translation: BAB12819.1.
RefSeqNP_239933.1.

3D structure databases

HSSPHSSP built from PDB template 1KAE based on UniProtKB P06988.
ModBaseSearch...

Genome annotation databases

GeneID1109503.
GenomeReviewsGene locus BU100 in contig BA000003_GR.
KEGGbuc:BU100.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP57201.

Enzyme and pathway databases

BioCycBSP107806:BU100-MON.

Family and domain databases

HAMAPMF_01024.
[Tree]
InterProIPR001692. Histidinol_DHase.
IPR012131. Hstdl_DHase_prok.
[Graphical view]
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSPR00083. HOLDHDRGNASE.
ProDomPD002680. Histidinol_dh. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHISX_BUCAI
AccessionPrimary (citable) accession number: P57201
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 25, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents