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P57193 (FABB_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 1
EC=2.3.1.41
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase I
Beta-ketoacyl-ACP synthase I
Short name=KAS I
Gene names
Name:fabB
Ordered Locus Names:BU092
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids By similarity.

Catalytic activity

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the beta-ketoacyl-ACP synthases family.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Lipid synthesis
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-oxoacyl-[acyl-carrier-protein] synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4064063-oxoacyl-[acyl-carrier-protein] synthase 1
PRO_0000180308

Sites

Active site1641 By similarity

Sequences

Sequence LengthMass (Da)Tools
P57193 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 8AF83C2E87D4649E

FASTA40644,119
        10         20         30         40         50         60 
MRRVVITGIG IVSSIGNNKK EVLASLYKGV SGIVSSEEMK KLGMRSAVWG NIKLESINII 

        70         80         90        100        110        120 
TQKLSRFMNN ASRYSFVAMM EAIKDAKIDR EYYQKNPRVG LISGSGCSFS KNTLTSDIHL 

       130        140        150        160        170        180 
MKNKHISKGI SPYLAVKTMP SGISACLSTL FKIYGVTYSI SSACATSAHC IGNAFELIQF 

       190        200        210        220        230        240 
GRQDLIFAGG GEEISLELAM QFDAMRALST CFNNDPKKAS RVYDVYRDGF VISGGAGMLV 

       250        260        270        280        290        300 
IEELNSALSR SAYIYAEIIG YAATSDGSNI VVPSGDGAIR CMNLARKGKN IPIDYLNVHG 

       310        320        330        340        350        360 
TGTKIGDLIE LEAIRKVFLN EKKPMISATK SMTGHGLGAS GVHEMIYTLL MLKYNFIAPT 

       370        380        390        400 
INIENLEPCA ENMNIIQKTT NIEINTAMSN SFGFGGTNVS LIVKKY

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed: 10993077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000003 Genomic DNA. Translation: BAB12811.1.
RefSeqNP_239925.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57193.
SMRP57193. Positions 1-405.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000003215; EBBUCP00000002991; EBBUCG00000003215.
GeneID1109495.
GenomeReviewsGene locus BU092 in contig BA000003_GR.
KEGGbuc:BU092.
PATRIC21243692. VBIBucAph127364_0099.

Phylogenomic databases

GeneTreeEBGT00050000007996.
HOGENOMHBG757733.
OMAMQMALAD.
PhylomeDBP57193.
ProtClustDBCLSK315248.

Enzyme and pathway databases

BioCycBSP107806:BU092-MONOMER.

Family and domain databases

InterProIPR000794. Beta-ketoacyl_synthase.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00647.
PANTHERPTHR11712. Ketoacyl_synth. 1 hit.
PfamPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 2 hits.
PROSITEPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABB_BUCAI
AccessionPrimary (citable) accession number: P57193
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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