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P57190

- IPYR_BUCAI

UniProt

P57190 - IPYR_BUCAI

Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Diphosphate + H2O = 2 phosphate.

    Cofactori

    Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi66 – 661Magnesium 1By similarity
    Metal bindingi71 – 711Magnesium 1By similarity
    Metal bindingi71 – 711Magnesium 2By similarity
    Metal bindingi103 – 1031Magnesium 1By similarity

    GO - Molecular functioni

    1. inorganic diphosphatase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. phosphate-containing compound metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-88-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inorganic pyrophosphatase (EC:3.6.1.1)
    Alternative name(s):
    Pyrophosphate phospho-hydrolase
    Short name:
    PPase
    Gene namesi
    Name:ppa
    Ordered Locus Names:BU088
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 182182Inorganic pyrophosphatasePRO_0000137484Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP57190.
    SMRiP57190. Positions 2-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPase family.Curated

    Phylogenomic databases

    eggNOGiCOG0221.
    HOGENOMiHOG000236473.
    KOiK01507.
    OMAiHETGRVY.
    OrthoDBiEOG6NKR4X.

    Family and domain databases

    Gene3Di3.90.80.10. 1 hit.
    HAMAPiMF_00209. Inorganic_PPase.
    InterProiIPR008162. Pyrophosphatase.
    [Graphical view]
    PANTHERiPTHR10286. PTHR10286. 1 hit.
    PfamiPF00719. Pyrophosphatase. 1 hit.
    [Graphical view]
    SUPFAMiSSF50324. SSF50324. 1 hit.
    PROSITEiPS00387. PPASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57190-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLNKIVAGD DIPNDIYVII EISSNSSPIK YEVDKKSGML FVDRFIPTPM    50
    FYPCNYGYIN HTLSLDGDPL DVLVPSHYPI KSSCVIHCKP IGILNMQDES 100
    GDDAKIIAVP KSKICQEYKN INDISDISEL LKKQITHFFQ NYKTLEKEKW 150
    VEIIGWGNCQ DAKLEINDAY NRAKKNSIFL NK 182
    Length:182
    Mass (Da):20,763
    Last modified:December 1, 2000 - v1
    Checksum:i2503EC5605F9C9B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12808.1.
    RefSeqiNP_239922.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB12808; BAB12808; BAB12808.
    GeneIDi1109492.
    KEGGibuc:BU088.
    PATRICi21243686. VBIBucAph127364_0096.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12808.1 .
    RefSeqi NP_239922.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57190.
    SMRi P57190. Positions 2-174.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB12808 ; BAB12808 ; BAB12808 .
    GeneIDi 1109492.
    KEGGi buc:BU088.
    PATRICi 21243686. VBIBucAph127364_0096.

    Phylogenomic databases

    eggNOGi COG0221.
    HOGENOMi HOG000236473.
    KOi K01507.
    OMAi HETGRVY.
    OrthoDBi EOG6NKR4X.

    Enzyme and pathway databases

    BioCyci BAPH107806:GBZJ-88-MONOMER.

    Family and domain databases

    Gene3Di 3.90.80.10. 1 hit.
    HAMAPi MF_00209. Inorganic_PPase.
    InterProi IPR008162. Pyrophosphatase.
    [Graphical view ]
    PANTHERi PTHR10286. PTHR10286. 1 hit.
    Pfami PF00719. Pyrophosphatase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50324. SSF50324. 1 hit.
    PROSITEi PS00387. PPASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiIPYR_BUCAI
    AccessioniPrimary (citable) accession number: P57190
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3