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P57190

- IPYR_BUCAI

UniProt

P57190 - IPYR_BUCAI

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Protein
Inorganic pyrophosphatase
Gene
ppa, BU088
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi66 – 661Magnesium 1 By similarity
Metal bindingi71 – 711Magnesium 1 By similarity
Metal bindingi71 – 711Magnesium 2 By similarity
Metal bindingi103 – 1031Magnesium 1 By similarity

GO - Molecular functioni

  1. inorganic diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. phosphate-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-88-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:ppa
Ordered Locus Names:BU088
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Inorganic pyrophosphataseUniRule annotation
PRO_0000137484Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP57190.
SMRiP57190. Positions 2-174.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.

Phylogenomic databases

eggNOGiCOG0221.
HOGENOMiHOG000236473.
KOiK01507.
OMAiHETGRVY.
OrthoDBiEOG6NKR4X.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57190-1 [UniParc]FASTAAdd to Basket

« Hide

MNLNKIVAGD DIPNDIYVII EISSNSSPIK YEVDKKSGML FVDRFIPTPM    50
FYPCNYGYIN HTLSLDGDPL DVLVPSHYPI KSSCVIHCKP IGILNMQDES 100
GDDAKIIAVP KSKICQEYKN INDISDISEL LKKQITHFFQ NYKTLEKEKW 150
VEIIGWGNCQ DAKLEINDAY NRAKKNSIFL NK 182
Length:182
Mass (Da):20,763
Last modified:December 1, 2000 - v1
Checksum:i2503EC5605F9C9B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12808.1.
RefSeqiNP_239922.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12808; BAB12808; BAB12808.
GeneIDi1109492.
KEGGibuc:BU088.
PATRICi21243686. VBIBucAph127364_0096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12808.1 .
RefSeqi NP_239922.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57190.
SMRi P57190. Positions 2-174.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB12808 ; BAB12808 ; BAB12808 .
GeneIDi 1109492.
KEGGi buc:BU088.
PATRICi 21243686. VBIBucAph127364_0096.

Phylogenomic databases

eggNOGi COG0221.
HOGENOMi HOG000236473.
KOi K01507.
OMAi HETGRVY.
OrthoDBi EOG6NKR4X.

Enzyme and pathway databases

BioCyci BAPH107806:GBZJ-88-MONOMER.

Family and domain databases

Gene3Di 3.90.80.10. 1 hit.
HAMAPi MF_00209. Inorganic_PPase.
InterProi IPR008162. Pyrophosphatase.
[Graphical view ]
PANTHERi PTHR10286. PTHR10286. 1 hit.
Pfami PF00719. Pyrophosphatase. 1 hit.
[Graphical view ]
SUPFAMi SSF50324. SSF50324. 1 hit.
PROSITEi PS00387. PPASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiIPYR_BUCAI
AccessioniPrimary (citable) accession number: P57190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi