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P57159 (ARLY_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:BU051
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459Argininosuccinate lyase HAMAP MF_00006
PRO_0000137748

Sequences

Sequence LengthMass (Da)Tools
P57159 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 0CF0A882CC6EDA8A

FASTA45952,378
        10         20         30         40         50         60 
MGLWGGRFIN ESNKLFKEFN RSLSFDYILA EEDVISSVAW SKILMKSKII TEKEQITIES 

        70         80         90        100        110        120 
ALFELLKEIK ENNQKILKSK CEDIHSWIEE KLIQKIGILG KKLHTGRSRN DQITTDLKLW 

       130        140        150        160        170        180 
CRKKIHLLLE NIIELQKTFI LSAESNHNII MPGYTHLQRA QPITFSYWCL AYVEMFRRDF 

       190        200        210        220        230        240 
SRLKDVLKRL NVSPLGSAAL SGTAWKINRE ELALSMGFDS ATNNALDTVS DRDYVVELLS 

       250        260        270        280        290        300 
SASISMMHLS RFSEDIIFFN SGEADFIELS DTITSGSSLM PQKKNPDALE LIRAKCGRVH 

       310        320        330        340        350        360 
GSLISILVIL KSLPLSYNKD MQEDKEGLFD SIKTWNDCLC MAILVLKNMQ IKNESCRKAA 

       370        380        390        400        410        420 
EEGYSNATEI ADYLVKKGIA FREAHNISGQ LVLRAISEKK SLNELKLSVF QMYSNLIKND 

       430        440        450 
IYKNITLESC LEKRMSKGGV APSQVYEEII KAKKRLNIF

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed: 10993077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000003 Genomic DNA. Translation: BAB12774.1.
RefSeqNP_239888.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57159.
SMRP57159. Positions 3-456.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000003272; EBBUCP00000003048; EBBUCG00000003272.
GeneID1109458.
GenomeReviewsGene locus BU051 in contig BA000003_GR.
KEGGbuc:BU051.
PATRIC21243608. VBIBucAph127364_0060.

Phylogenomic databases

GeneTreeEBGT00050000007810.
HOGENOMHBG539632.
OMAMAEDLIF.
PhylomeDBP57159.
ProtClustDBPRK04833.

Enzyme and pathway databases

BioCycBSP107806:BU051-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_BUCAI
AccessionPrimary (citable) accession number: P57159
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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