Reviewed, UniProtKB/Swiss-Prot P57156 (ARGC_BUCAI)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	BU048

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (Acyrthosiphon pisum symbiotic bacterium) [Complete proteome] [HAMAP]

Taxonomic identifier

118099 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112391
Sites
	Active site	154	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P57156-1 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 1032E60048AFA90A	FASTA	334	37,815
	10 20 30 40 50 60 MLNVVIVGAS GYAGAELVNY MHRHRFANIK KIFVSKNSLN IDKLFSDVHQ QFKNIVDLRF 70 80 90 100 110 120 DTIRNCTLIK KNIDAVFLAT DHRVSHSLVP FFLSSNCIVF DLSASYRMNN KKVYLDYYGF 130 140 150 160 170 180 VHEYEELLKN SVYGLAEWEQ EKIKKANLIA LPGCYATCIQ LALKPLIKEN VLCDKNIPII 190 200 210 220 230 240 NAISGVSGAG RKASLNNSFC EVSLQPYNIF THRHTPEIIE KLGVPVIFIP HLGPFSRGII 250 260 270 280 290 300 ATITCKLKPN VKSIDIHNIF NKFYKNKPLI RIYKKYLPSI KSVEKQPFCD IGFVIKDDYI 310 320 330 VIVAAEDNLL KGAAAQAVQC FNVRFGFSET ESII

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tokyo 1998.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000003 Genomic DNA. Translation: BAB12771.1.
RefSeq	NP_239885.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1109455.
GenomeReviews	Gene locus BU048 in contig BA000003_GR.
KEGG	buc:BU048.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P57156.
OMA	VCRIAVH.
Enzyme and pathway databases
BioCyc	BSP107806:BU048-MON.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BUCAI

Accession

Primary (citable) accession number: P57156

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)