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Protein

N-acetyl-gamma-glutamyl-phosphate reductase

Gene

argC

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.UniRule annotation

Catalytic activityi

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Amino-acid acetyltransferase (argA)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine/succinyldiaminopimelate aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei154UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00068; UER00108.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductaseUniRule annotation (EC:1.2.1.38UniRule annotation)
Short name:
AGPRUniRule annotation
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenaseUniRule annotation
Short name:
NAGSA dehydrogenaseUniRule annotation
Gene namesi
Name:argCUniRule annotation
Ordered Locus Names:BU048
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001123911 – 334N-acetyl-gamma-glutamyl-phosphate reductaseAdd BLAST334

Interactioni

Protein-protein interaction databases

STRINGi107806.BU048.

Structurei

3D structure databases

ProteinModelPortaliP57156.
SMRiP57156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C0N. Bacteria.
COG0002. LUCA.
HOGENOMiHOG000254902.
KOiK00145.
OMAiTFVPHLT.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00150. ArgC_type1. 1 hit.
InterProiView protein in InterPro
IPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
PfamiView protein in Pfam
PF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
SMARTiView protein in SMART
SM00859. Semialdhyde_dh. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01850. argC. 1 hit.
PROSITEiView protein in PROSITE
PS01224. ARGC. 1 hit.

Sequencei

Sequence statusi: Complete.

P57156-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNVVIVGAS GYAGAELVNY MHRHRFANIK KIFVSKNSLN IDKLFSDVHQ
60 70 80 90 100
QFKNIVDLRF DTIRNCTLIK KNIDAVFLAT DHRVSHSLVP FFLSSNCIVF
110 120 130 140 150
DLSASYRMNN KKVYLDYYGF VHEYEELLKN SVYGLAEWEQ EKIKKANLIA
160 170 180 190 200
LPGCYATCIQ LALKPLIKEN VLCDKNIPII NAISGVSGAG RKASLNNSFC
210 220 230 240 250
EVSLQPYNIF THRHTPEIIE KLGVPVIFIP HLGPFSRGII ATITCKLKPN
260 270 280 290 300
VKSIDIHNIF NKFYKNKPLI RIYKKYLPSI KSVEKQPFCD IGFVIKDDYI
310 320 330
VIVAAEDNLL KGAAAQAVQC FNVRFGFSET ESII
Length:334
Mass (Da):37,815
Last modified:December 1, 2000 - v1
Checksum:i1032E60048AFA90A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12771.1.
RefSeqiNP_239885.1. NC_002528.1.
WP_009874005.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12771; BAB12771; BAB12771.
GeneIDi1109455.
KEGGibuc:BU048.
PATRICi21243602. VBIBucAph127364_0057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12771.1.
RefSeqiNP_239885.1. NC_002528.1.
WP_009874005.1. NC_002528.1.

3D structure databases

ProteinModelPortaliP57156.
SMRiP57156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi107806.BU048.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB12771; BAB12771; BAB12771.
GeneIDi1109455.
KEGGibuc:BU048.
PATRICi21243602. VBIBucAph127364_0057.

Phylogenomic databases

eggNOGiENOG4105C0N. Bacteria.
COG0002. LUCA.
HOGENOMiHOG000254902.
KOiK00145.
OMAiTFVPHLT.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00108.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00150. ArgC_type1. 1 hit.
InterProiView protein in InterPro
IPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
PfamiView protein in Pfam
PF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
SMARTiView protein in SMART
SM00859. Semialdhyde_dh. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01850. argC. 1 hit.
PROSITEiView protein in PROSITE
PS01224. ARGC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARGC_BUCAI
AccessioniPrimary (citable) accession number: P57156
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: February 15, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.