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P57156 (ARGC_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase
Gene names
Name:argC
Ordered Locus Names:BU048
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150

Subcellular location

Cytoplasm Probable HAMAP MF_00150.

Sequence similarities

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionN-acetyl-gamma-glutamyl-phosphate reductase activity

Inferred from electronic annotation. Source: EC

NAD binding

Inferred from electronic annotation. Source: InterPro

protein dimerization activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150
PRO_0000112391

Sites

Active site1541 By similarity

Sequences

Sequence LengthMass (Da)Tools
P57156 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 1032E60048AFA90A

FASTA33437,815
        10         20         30         40         50         60 
MLNVVIVGAS GYAGAELVNY MHRHRFANIK KIFVSKNSLN IDKLFSDVHQ QFKNIVDLRF 

        70         80         90        100        110        120 
DTIRNCTLIK KNIDAVFLAT DHRVSHSLVP FFLSSNCIVF DLSASYRMNN KKVYLDYYGF 

       130        140        150        160        170        180 
VHEYEELLKN SVYGLAEWEQ EKIKKANLIA LPGCYATCIQ LALKPLIKEN VLCDKNIPII 

       190        200        210        220        230        240 
NAISGVSGAG RKASLNNSFC EVSLQPYNIF THRHTPEIIE KLGVPVIFIP HLGPFSRGII 

       250        260        270        280        290        300 
ATITCKLKPN VKSIDIHNIF NKFYKNKPLI RIYKKYLPSI KSVEKQPFCD IGFVIKDDYI 

       310        320        330 
VIVAAEDNLL KGAAAQAVQC FNVRFGFSET ESII

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed: 10993077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000003 Genomic DNA. Translation: BAB12771.1.
RefSeqNP_239885.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57156.
SMRP57156. Positions 1-334.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000003246; EBBUCP00000003022; EBBUCG00000003246.
GeneID1109455.
GenomeReviewsGene locus BU048 in contig BA000003_GR.
KEGGbuc:BU048.
PATRIC21243602. VBIBucAph127364_0057.

Phylogenomic databases

GeneTreeEBGT00050000007856.
HOGENOMHBG294213.
OMAVCRIAVH.
PhylomeDBP57156.
ProtClustDBPRK00436.

Enzyme and pathway databases

BioCycBSP107806:BU048-MONOMER.

Family and domain databases

HAMAPMF_00150. ArgC_type1.
[Tree]
InterProIPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00145.
PfamPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01850. ArgC. 1 hit.
PROSITEPS01224. ARGC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGC_BUCAI
AccessionPrimary (citable) accession number: P57156
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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