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P57153

- MURB_BUCAI

UniProt

P57153 - MURB_BUCAI

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Protein
UDP-N-acetylenolpyruvoylglucosamine reductase
Gene
murB, BU045
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei166 – 1661 By similarity
Active sitei236 – 2361Proton donor By similarity
Active sitei331 – 3311 By similarity

GO - Molecular functioni

  1. UDP-N-acetylmuramate dehydrogenase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciBAPH107806:GBZJ-45-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase (EC:1.3.1.98)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene namesi
Name:murB
Ordered Locus Names:BU045
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000001806: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation
PRO_0000179187Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP57153.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 190171FAD-binding PCMH-type
Add
BLAST

Sequence similaritiesi

Belongs to the MurB family.

Phylogenomic databases

eggNOGiCOG0812.
HOGENOMiHOG000284356.
KOiK00075.
OMAiHVNGGEN.
OrthoDBiEOG60CWQ3.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPiMF_00037. MurB.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR21071. PTHR21071. 1 hit.
PfamiPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsiTIGR00179. murB. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57153-1 [UniParc]FASTAAdd to Basket

« Hide

MHKKKYFSSQ SLKDLNTFAI DVTAKKIIFV KTIQSLIDIS KICQLSNIPY    50
IILGEGSNVL FLENYVGVVI INRIKGIKIV EKKNFWLLHV FSGEKWHNLV 100
KLTLNLGILG LENLALIPGC IGSAAIQNIG AYGLEFKDVC QYVDILSLKD 150
NTIKRIYKNS CKFSYRNSIF KDQYKNEHAV IRVGIKLSKK WRPILFSSLE 200
NYITPINITA YKIFNIICKI RKKKLPDPKK IGNAGSFFKN PLIKKKKAQK 250
LINLYKVPNY PQKNGLVKIS AAWLIENYKF KHLQIGDAAI HKKQKLILIN 300
KKNATAQEII KLAKIIHKCI LKKFNILLEP EVDLIGASGK IKASKIFKLN 350
SKLKVI 356
Length:356
Mass (Da):40,593
Last modified:December 1, 2000 - v1
Checksum:i103486BF1DE25EA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12768.1.
RefSeqiNP_239882.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12768; BAB12768; BAB12768.
GeneIDi1109549.
KEGGibuc:BU045.
PATRICi21243596. VBIBucAph127364_0054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000003 Genomic DNA. Translation: BAB12768.1 .
RefSeqi NP_239882.1. NC_002528.1.

3D structure databases

ProteinModelPortali P57153.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB12768 ; BAB12768 ; BAB12768 .
GeneIDi 1109549.
KEGGi buc:BU045.
PATRICi 21243596. VBIBucAph127364_0054.

Phylogenomic databases

eggNOGi COG0812.
HOGENOMi HOG000284356.
KOi K00075.
OMAi HVNGGEN.
OrthoDBi EOG60CWQ3.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci BAPH107806:GBZJ-45-MONOMER.

Family and domain databases

Gene3Di 3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPi MF_00037. MurB.
InterProi IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view ]
PANTHERi PTHR21071. PTHR21071. 1 hit.
Pfami PF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view ]
SUPFAMi SSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsi TIGR00179. murB. 1 hit.
PROSITEi PS51387. FAD_PCMH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
    Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
    Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APS.

Entry informationi

Entry nameiMURB_BUCAI
AccessioniPrimary (citable) accession number: P57153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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