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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.

Cofactori

FADBy similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei166By similarity1
Active sitei236Proton donorBy similarity1
Active sitei331By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase (EC:1.3.1.98)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene namesi
Name:murB
Ordered Locus Names:BU045
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791871 – 356UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST356

Interactioni

Protein-protein interaction databases

STRINGi107806.BU045

Structurei

3D structure databases

ProteinModelPortaliP57153
SMRiP57153
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 190FAD-binding PCMH-typeAdd BLAST171

Sequence similaritiesi

Belongs to the MurB family.Curated

Phylogenomic databases

eggNOGiENOG4105D4A Bacteria
COG0812 LUCA
HOGENOMiHOG000284356
KOiK00075
OMAiIGNAGSF

Family and domain databases

Gene3Di3.30.43.10, 1 hit
3.90.78.10, 1 hit
HAMAPiMF_00037 MurB, 1 hit
InterProiView protein in InterPro
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR003170 MurB
IPR011601 MurB_C
IPR036635 MurB_C_sf
IPR006094 Oxid_FAD_bind_N
PANTHERiPTHR21071 PTHR21071, 1 hit
PfamiView protein in Pfam
PF01565 FAD_binding_4, 1 hit
PF02873 MurB_C, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
SSF56194 SSF56194, 1 hit
TIGRFAMsiTIGR00179 murB, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

P57153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKKKYFSSQ SLKDLNTFAI DVTAKKIIFV KTIQSLIDIS KICQLSNIPY
60 70 80 90 100
IILGEGSNVL FLENYVGVVI INRIKGIKIV EKKNFWLLHV FSGEKWHNLV
110 120 130 140 150
KLTLNLGILG LENLALIPGC IGSAAIQNIG AYGLEFKDVC QYVDILSLKD
160 170 180 190 200
NTIKRIYKNS CKFSYRNSIF KDQYKNEHAV IRVGIKLSKK WRPILFSSLE
210 220 230 240 250
NYITPINITA YKIFNIICKI RKKKLPDPKK IGNAGSFFKN PLIKKKKAQK
260 270 280 290 300
LINLYKVPNY PQKNGLVKIS AAWLIENYKF KHLQIGDAAI HKKQKLILIN
310 320 330 340 350
KKNATAQEII KLAKIIHKCI LKKFNILLEP EVDLIGASGK IKASKIFKLN

SKLKVI
Length:356
Mass (Da):40,593
Last modified:December 1, 2000 - v1
Checksum:i103486BF1DE25EA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA Translation: BAB12768.1
RefSeqiNP_239882.1, NC_002528.1
WP_010895915.1, NC_002528.1

Genome annotation databases

EnsemblBacteriaiBAB12768; BAB12768; BAB12768
GeneIDi1109549
KEGGibuc:BU045
PATRICifig|107806.10.peg.54

Similar proteinsi

Entry informationi

Entry nameiMURB_BUCAI
AccessioniPrimary (citable) accession number: P57153
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health