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P57153 (MURB_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase

EC=1.3.1.98
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene names
Name:murB
Ordered Locus Names:BU045
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00037

Catalytic activity

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH. HAMAP-Rule MF_00037

Cofactor

FAD By similarity. HAMAP-Rule MF_00037

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00037

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00037.

Sequence similarities

Belongs to the MurB family.

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP-Rule MF_00037
PRO_0000179187

Regions

Domain20 – 190171FAD-binding PCMH-type

Sites

Active site1661 By similarity
Active site2361Proton donor By similarity
Active site3311 By similarity

Sequences

Sequence LengthMass (Da)Tools
P57153 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 103486BF1DE25EA7

FASTA35640,593
        10         20         30         40         50         60 
MHKKKYFSSQ SLKDLNTFAI DVTAKKIIFV KTIQSLIDIS KICQLSNIPY IILGEGSNVL 

        70         80         90        100        110        120 
FLENYVGVVI INRIKGIKIV EKKNFWLLHV FSGEKWHNLV KLTLNLGILG LENLALIPGC 

       130        140        150        160        170        180 
IGSAAIQNIG AYGLEFKDVC QYVDILSLKD NTIKRIYKNS CKFSYRNSIF KDQYKNEHAV 

       190        200        210        220        230        240 
IRVGIKLSKK WRPILFSSLE NYITPINITA YKIFNIICKI RKKKLPDPKK IGNAGSFFKN 

       250        260        270        280        290        300 
PLIKKKKAQK LINLYKVPNY PQKNGLVKIS AAWLIENYKF KHLQIGDAAI HKKQKLILIN 

       310        320        330        340        350 
KKNATAQEII KLAKIIHKCI LKKFNILLEP EVDLIGASGK IKASKIFKLN SKLKVI 

« Hide

References

[1]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000003 Genomic DNA. Translation: BAB12768.1.
RefSeqNP_239882.1. NC_002528.1.

3D structure databases

ProteinModelPortalP57153.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB12768; BAB12768; BAB12768.
GeneID1109549.
KEGGbuc:BU045.
PATRIC21243596. VBIBucAph127364_0054.

Phylogenomic databases

eggNOGCOG0812.
HOGENOMHOG000284356.
KOK00075.
OMARDSVFKH.
OrthoDBEOG60CWQ3.
ProtClustDBPRK00046.

Enzyme and pathway databases

BioCycBAPH107806:GBZJ-45-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPMF_00037. MurB.
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERPTHR21071. PTHR21071. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsTIGR00179. murB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMURB_BUCAI
AccessionPrimary (citable) accession number: P57153
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: February 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names