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P57153

- MURB_BUCAI

UniProt

P57153 - MURB_BUCAI

Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Cell wall formation.By similarity

    Catalytic activityi

    UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei166 – 1661By similarity
    Active sitei236 – 2361Proton donorBy similarity
    Active sitei331 – 3311By similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. UDP-N-acetylmuramate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    BioCyciBAPH107806:GBZJ-45-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylenolpyruvoylglucosamine reductase (EC:1.3.1.98)
    Alternative name(s):
    UDP-N-acetylmuramate dehydrogenase
    Gene namesi
    Name:murB
    Ordered Locus Names:BU045
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
    Taxonomic identifieri107806 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000001806: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356UDP-N-acetylenolpyruvoylglucosamine reductasePRO_0000179187Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP57153.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 190171FAD-binding PCMH-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MurB family.Curated
    Contains 1 FAD-binding PCMH-type domain.Curated

    Phylogenomic databases

    eggNOGiCOG0812.
    HOGENOMiHOG000284356.
    KOiK00075.
    OMAiHVNGGEN.
    OrthoDBiEOG60CWQ3.

    Family and domain databases

    Gene3Di3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    3.90.78.10. 1 hit.
    HAMAPiMF_00037. MurB.
    InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR003170. MurB.
    IPR011601. MurB_C.
    IPR006094. Oxid_FAD_bind_N.
    [Graphical view]
    PANTHERiPTHR21071. PTHR21071. 1 hit.
    PfamiPF01565. FAD_binding_4. 1 hit.
    PF02873. MurB_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF56176. SSF56176. 1 hit.
    SSF56194. SSF56194. 1 hit.
    TIGRFAMsiTIGR00179. murB. 1 hit.
    PROSITEiPS51387. FAD_PCMH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57153-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHKKKYFSSQ SLKDLNTFAI DVTAKKIIFV KTIQSLIDIS KICQLSNIPY    50
    IILGEGSNVL FLENYVGVVI INRIKGIKIV EKKNFWLLHV FSGEKWHNLV 100
    KLTLNLGILG LENLALIPGC IGSAAIQNIG AYGLEFKDVC QYVDILSLKD 150
    NTIKRIYKNS CKFSYRNSIF KDQYKNEHAV IRVGIKLSKK WRPILFSSLE 200
    NYITPINITA YKIFNIICKI RKKKLPDPKK IGNAGSFFKN PLIKKKKAQK 250
    LINLYKVPNY PQKNGLVKIS AAWLIENYKF KHLQIGDAAI HKKQKLILIN 300
    KKNATAQEII KLAKIIHKCI LKKFNILLEP EVDLIGASGK IKASKIFKLN 350
    SKLKVI 356
    Length:356
    Mass (Da):40,593
    Last modified:December 1, 2000 - v1
    Checksum:i103486BF1DE25EA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12768.1.
    RefSeqiNP_239882.1. NC_002528.1.

    Genome annotation databases

    EnsemblBacteriaiBAB12768; BAB12768; BAB12768.
    GeneIDi1109549.
    KEGGibuc:BU045.
    PATRICi21243596. VBIBucAph127364_0054.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000003 Genomic DNA. Translation: BAB12768.1 .
    RefSeqi NP_239882.1. NC_002528.1.

    3D structure databases

    ProteinModelPortali P57153.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB12768 ; BAB12768 ; BAB12768 .
    GeneIDi 1109549.
    KEGGi buc:BU045.
    PATRICi 21243596. VBIBucAph127364_0054.

    Phylogenomic databases

    eggNOGi COG0812.
    HOGENOMi HOG000284356.
    KOi K00075.
    OMAi HVNGGEN.
    OrthoDBi EOG60CWQ3.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci BAPH107806:GBZJ-45-MONOMER.

    Family and domain databases

    Gene3Di 3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    3.90.78.10. 1 hit.
    HAMAPi MF_00037. MurB.
    InterProi IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR003170. MurB.
    IPR011601. MurB_C.
    IPR006094. Oxid_FAD_bind_N.
    [Graphical view ]
    PANTHERi PTHR21071. PTHR21071. 1 hit.
    Pfami PF01565. FAD_binding_4. 1 hit.
    PF02873. MurB_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56176. SSF56176. 1 hit.
    SSF56194. SSF56194. 1 hit.
    TIGRFAMsi TIGR00179. murB. 1 hit.
    PROSITEi PS51387. FAD_PCMH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
      Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
      Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APS.

    Entry informationi

    Entry nameiMURB_BUCAI
    AccessioniPrimary (citable) accession number: P57153
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
      Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3