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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei604For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:BU026
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353112 – 609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST608

Proteomic databases

PRIDEiP57138.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi107806.BU026.

Structurei

3D structure databases

ProteinModelPortaliP57138.
SMRiP57138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 219Glutamine amidotransferase type-2UniRule annotationAdd BLAST218
Domaini288 – 428SIS 1UniRule annotationAdd BLAST141
Domaini460 – 599SIS 2UniRule annotationAdd BLAST140

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
HOGENOMiHOG000258896.
KOiK00820.
OMAiASEYRYA.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF15. PTHR10937:SF15. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57138-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVAAVTQ RNIANFLIDG IKKLEYRGYD SSGLAVIDNK NNIVRIRCVG
60 70 80 90 100
KVNELIKKTN KKKILGSIGV AHTRWATHGK VSKENTHPHI SSNIIVVHNG
110 120 130 140 150
IIENNSTLRG FLKKQGYIFS SDTDTEVIAH LLHWEQNKKK DSLIKVIQNS
160 170 180 190 200
IKKLDGNYSM VVIDQNNPSK LIAARSGSPL IIGLGTEENF IASDQIALLH
210 220 230 240 250
VTKRFIYLEE GDIAIVARKE INIFNKNNSI IQREEVVSNI EYKSAKKGKY
260 270 280 290 300
RYYMEKEIHE QPKSIRNTLK NRLTNSNKVH FSELGSKENN IFYNTEHIQI
310 320 330 340 350
VACGTSYNAA MVSRYWFEEL ANIPCDVEIA SEFSSRKLVV RKKSLLITLS
360 370 380 390 400
QSGETADTLS ALRYSKKLGY LGNLTICNMK SSSLVRESDF YILTKAGLEI
410 420 430 440 450
GVASTKSFTT QLTVLLLLVA KIINSKKENN NTSKRIVQTL SILPVRIEEI
460 470 480 490 500
LKKKQLIQDM ANTLANKKNM LFLGRGNQYP IAMEGALKLK EISYIHAEAY
510 520 530 540 550
PSGELKHGPL ALIDKNIPVI MIAPENSLLE KNKKNIKEIC SRGGIVYVFS
560 570 580 590 600
NQEFDYEENI NTIKLPYVEE LIAPIFYTIP LQLFAYYVAL KKGRDIDQPR

HLAKSVTVE
Length:609
Mass (Da):68,682
Last modified:January 23, 2007 - v2
Checksum:i5FF11730FEB2D715
GO

Sequence cautioni

The sequence BAB12753 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB12753.1. Different initiation.
RefSeqiNP_239867.2. NC_002528.1.
WP_009873987.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB12753; BAB12753; BAB12753.
GeneIDi1109534.
KEGGibuc:BU026.
PATRICifig|107806.10.peg.38.

Similar proteinsi

Entry informationi

Entry nameiGLMS_BUCAI
AccessioniPrimary (citable) accession number: P57138
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names