Reviewed, UniProtKB/Swiss-Prot P57118 (ATP6_BUCAI)

Names and origin

Protein names

Recommended name:
    ATP synthase subunit a
Alternative name(s):
    F-ATPase subunit 6
    ATP synthase F0 sector subunit a

Gene names

Name:	atpB
Ordered Locus Names:	BU002

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (Acyrthosiphon pisum symbiotic bacterium) [Complete proteome] [HAMAP]

Taxonomic identifier

118099 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane By similarity.
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ATPase A chain family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	plasma membrane ATP synthesis coupled proton transport Inferred from electronic annotation. Source: HAMAP
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	ATP synthase subunit a HAMAP MF_01393		PRO_0000082049
Regions
	Transmembrane	44 – 64	21	Potential
	Transmembrane	110 – 130	21	Potential
	Transmembrane	142 – 164	23	Potential
	Transmembrane	212 – 232	21	Potential
	Transmembrane	243 – 263	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P57118-1 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 4B2321336EFE78A4	FASTA	274	31,364
	10 20 30 40 50 60 MILEKISDPQ KYISHHLSHL QIDLRSFKII QPGALSSDYW TVNVDSMFFS LVLGSFFLSI 70 80 90 100 110 120 FYMVGKKITQ GIPGKLQTAI ELIFEFVNLN VKSMYQGKNA LIAPLSLTVF IWVFLMNLMD 130 140 150 160 170 180 LVPIDFFPFI SEKVFELPAM RIVPSADINI TLSMSLGVFF LILFYTVKIK GYVGFLKELI 190 200 210 220 230 240 LQPFNHPVFS IFNFILEFVS LVSKPISLGL RLFGNMYAGE MIFILIAGLL PWWTQCFLNV 250 260 270 PWAIFHILII SLQAFIFMVL TIVYLSMASQ SHKD

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tokyo 1998.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000003 Genomic DNA. Translation: BAB12730.1.
RefSeq	NP_239844.1.
3D structure databases
SMR	P57118. Positions 96-266.
ModBase	Search...
Genome annotation databases
GeneID	1109511.
GenomeReviews	Gene locus BU002 in contig BA000003_GR.
KEGG	buc:BU002.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P57118.
OMA	FMLIALM
Enzyme and pathway databases
BioCyc	BSP107806:BU002-MON.
Family and domain databases
HAMAP	MF_01393. [Tree]
InterPro	IPR000568. ATPase_F0-cplx_asu. [Graphical view]
Gene3D	G3DSA:1.20.120.220. ATPase_F0_A. 1 hit.
PANTHER	PTHR11410. ATPase_F0_A. 1 hit.
Pfam	PF00119. ATP-synt_A. 1 hit. [Graphical view]
PRINTS	PR00123. ATPASEA.
TIGRFAMs	TIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITE	PS00449. ATPASE_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATP6_BUCAI

Accession

Primary (citable) accession number: P57118

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	November 24, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)