P57118 (ATP6_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP synthase subunit a

Alternative name(s):
ATP synthase F0 sector subunit a
F-ATPase subunit 6

Gene names

Name:	atpB
Ordered Locus Names:	BU002

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)

Taxonomic identifier

107806 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane By similarity. HAMAP MF_01393
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01393.
Sequence similarities	Belongs to the ATPase A chain family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrogen ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	ATP synthase subunit a HAMAP MF_01393		PRO_0000082049
Regions
	Transmembrane	44 – 64	21	Helical; Potential
	Transmembrane	110 – 130	21	Helical; Potential
	Transmembrane	142 – 164	23	Helical; Potential
	Transmembrane	212 – 232	21	Helical; Potential
	Transmembrane	243 – 263	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P57118 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 4B2321336EFE78A4	FASTA	274	31,364
	10 20 30 40 50 60 MILEKISDPQ KYISHHLSHL QIDLRSFKII QPGALSSDYW TVNVDSMFFS LVLGSFFLSI 70 80 90 100 110 120 FYMVGKKITQ GIPGKLQTAI ELIFEFVNLN VKSMYQGKNA LIAPLSLTVF IWVFLMNLMD 130 140 150 160 170 180 LVPIDFFPFI SEKVFELPAM RIVPSADINI TLSMSLGVFF LILFYTVKIK GYVGFLKELI 190 200 210 220 230 240 LQPFNHPVFS IFNFILEFVS LVSKPISLGL RLFGNMYAGE MIFILIAGLL PWWTQCFLNV 250 260 270 PWAIFHILII SLQAFIFMVL TIVYLSMASQ SHKD

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: APS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000003 Genomic DNA. Translation: BAB12730.1.
RefSeq	NP_239844.1. NC_002528.1.
3D structure databases
ProteinModelPortal	P57118.
SMR	P57118. Positions 96-266.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000003033; EBBUCP00000002809; EBBUCG00000003033.
GeneID	1109511.
GenomeReviews	Gene locus BU002 in contig BA000003_GR.
KEGG	buc:BU002.
PATRIC	21243508. VBIBucAph127364_0015.
Phylogenomic databases
GeneTree	EBGT00050000007817.
HOGENOM	HBG734175.
OMA	AFYNRKL.
PhylomeDB	P57118.
ProtClustDB	PRK05815.
Enzyme and pathway databases
BioCyc	BSP107806:BU002-MONOMER.
Family and domain databases
HAMAP	MF_01393. ATP_synth_a_bact. [Tree]
InterPro	IPR000568. ATPase_F0-cplx_asu. IPR023011. ATPase_F0-cplx_asu_AS. [Graphical view]
Gene3D	G3DSA:1.20.120.220. ATPase_F0_A. 1 hit.
KO	K02108.
PANTHER	PTHR11410. ATPase_F0_A. 1 hit.
Pfam	PF00119. ATP-synt_A. 1 hit. [Graphical view]
PRINTS	PR00123. ATPASEA.
SUPFAM	SSF81336. ATPase_F0_A. 1 hit.
TIGRFAMs	TIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITE	PS00449. ATPASE_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATP6_BUCAI

Accession

Primary (citable) accession number: P57118

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program