P57109 (MAAI_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Maleylacetoacetate isomerase
Short name=MAAI
EC=5.2.1.2

Gene names

Name:	maiA
Ordered Locus Names:	PA2007

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]

Taxonomic identifier

208964 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa group › Pseudomonas aeruginosa

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4-maleylacetoacetate = 4-fumarylacetoacetate.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6.
Sequence similarities	Belongs to the GST superfamily. Zeta family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	maleylacetoacetate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Maleylacetoacetate isomerase		PRO_0000186035
Regions
	Domain	1 – 83	83	GST N-terminal
	Domain	88 – 211	124	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	P57109 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 534F21D1680C7F4A	FASTA	212	23,685
	10 20 30 40 50 60 MKLYTYYRST SSYRVRIALA LKGLDYQSLP VNLIRDGGEH RQPAYLALNP QGRVPALQVD 70 80 90 100 110 120 EGELLIQSPA IIEYLEERYP QPALLSSDPL RRARERGVAA LVGCDIHPLH NASVLNLLRQ 130 140 150 160 170 180 WGHDEEQVRQ WIGHWVGQGL AAVEQLIGDQ GWCFGDRPGL ADVYLVPQLY AAERFGVALD 190 200 210 AWPRIRRVAD LAAAHPAFRQ AHPANQPDTP AA

References

[1]

"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004091 Genomic DNA. Translation: AAG05395.1.
PIR	D83394.
RefSeq	NP_250697.1. NC_002516.2.
3D structure databases
ProteinModelPortal	P57109.
SMR	P57109. Positions 1-209.
ModBase	Search...
Protein-protein interaction databases
STRING	208964.PA2007.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	879853.
KEGG	pae:PA2007.
PATRIC	19838421. VBIPseAer58763_2091.
Organism-specific databases
PseudoCAP	PA2007.
Phylogenomic databases
eggNOG	COG0625.
HOGENOM	HOG000125758.
KO	K01800.
OMA	EYRAVTR.
ProtClustDB	CLSK866950.
Enzyme and pathway databases
UniPathway	UPA00139; UER00340.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR005955. Mal_ac_isom. IPR012336. Thioredoxin-like_fold. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR01262. maiA. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MAAI_PSEAE

Accession

Primary (citable) accession number: P57109

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program