P57108 (GSTZ_EUPES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Glutathione S-transferase zeta class EC=2.5.1.18
Organism	Euphorbia esula (Leafy spurge)
Taxonomic identifier	3993 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Malpighiales › Euphorbiaceae › Euphorbioideae › Euphorbieae › Euphorbia

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GST superfamily. Zeta family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological_process	aromatic amino acid family metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Glutathione S-transferase zeta class		PRO_0000186033
Regions
	Domain	10 – 91	82	GST N-terminal
	Domain	96 – 221	126	GST C-terminal
	Region	20 – 25	6	Glutathione binding By similarity
	Region	75 – 76	2	Glutathione binding By similarity
	Region	119 – 121	3	Glutathione binding By similarity
Sites
	Binding site	49	1	Glutathione By similarity
	Binding site	63	1	Glutathione; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	115	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	P57108 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 50D171F9FF346F32	FASTA	225	25,348
	10 20 30 40 50 60 MASVEQPNKP KLKLYSYFRS SCSFRVRIAL NLKGLDYEYV PVNLLKGEQF TPEFLKINPI 70 80 90 100 110 120 GYVPALVDGE DVISDSFAIL MYLEEKYPEH PILPADIHKK AINYQAANIV SSSIQPLQNL 130 140 150 160 170 180 AVLNFIGEKV SPDEKVPWVQ RHISKGFAAL EKLLQGHAGR FATGDEVYLA DLFLEPQIHA 190 200 210 220 AITRFNVDMT QFPLLLRLHE AYSQLPEFQN AMPDKQPDST SPTAS

References

[1]	"Identification of mRNAs expressed in underground adventitious buds of Euphorbia esula (leafy spurge)." Anderson J.V., Horvath D.P. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Underground adventitious buds.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF263737 mRNA. Translation: AAF72197.1.
3D structure databases
ProteinModelPortal	P57108.
SMR	P57108. Positions 11-223.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR005955. Mal_ac_isom. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR01262. maiA. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTZ_EUPES

Accession

Primary (citable) accession number: P57108
Secondary accession number(s): Q9M4Q6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	March 6, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program