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Protein

Synaptojanin-2-binding protein

Gene

SYNJ2BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.By similarity

GO - Biological processi

  • intracellular distribution of mitochondria Source: Ensembl
  • negative regulation of angiogenesis Source: UniProtKB
  • negative regulation of endothelial cell migration Source: UniProtKB
  • negative regulation of endothelial cell proliferation Source: UniProtKB
  • negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • negative regulation of sprouting angiogenesis Source: UniProtKB
  • protein targeting Source: Ensembl
  • regulation of endocytosis Source: Ensembl
  • regulation of Notch signaling pathway Source: UniProtKB
  • Rho protein signal transduction Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31710-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptojanin-2-binding protein
Alternative name(s):
Mitochondrial outer membrane protein 25
Gene namesi
Name:SYNJ2BP
Synonyms:OMP25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:18955. SYNJ2BP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 117CytoplasmicSequence analysisAdd BLAST117
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 145Mitochondrial intermembraneSequence analysis7

GO - Cellular componenti

  • integral component of mitochondrial outer membrane Source: Ensembl
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55333.
OpenTargetsiENSG00000213463.
PharmGKBiPA38768.

Polymorphism and mutation databases

BioMutaiSYNJ2BP.
DMDMi22261816.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000723831 – 145Synaptojanin-2-binding proteinAdd BLAST145

Proteomic databases

EPDiP57105.
MaxQBiP57105.
PaxDbiP57105.
PeptideAtlasiP57105.
PRIDEiP57105.
TopDownProteomicsiP57105.

PTM databases

iPTMnetiP57105.
PhosphoSitePlusiP57105.

Expressioni

Gene expression databases

BgeeiENSG00000213463.
CleanExiHS_SYNJ2BP.
ExpressionAtlasiP57105. baseline and differential.
GenevisibleiP57105. HS.

Organism-specific databases

HPAiHPA000866.

Interactioni

Subunit structurei

Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus) (By similarity). Interacts (via C-terminus) with RALBP1. Interacts (via PDZ domain) with ACVR2A (via C-terminus) and ACVR2B (via C-terminus). Forms a ternary complex with ACVR2A and RALBP1 (By similarity). Interacts with MAPK12 (By similarity). Interacts with DLL1; enhances DLL1 protein stability, and promotes notch signaling in endothelial cells (PubMed:24025447).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
USHBP1Q8N6Y05EBI-1049004,EBI-739895

Protein-protein interaction databases

BioGridi120614. 23 interactors.
IntActiP57105. 2 interactors.
STRINGi9606.ENSP00000256366.

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Beta strandi9 – 17Combined sources9
Beta strandi20 – 22Combined sources3
Beta strandi25 – 29Combined sources5
Turni31 – 33Combined sources3
Beta strandi35 – 38Combined sources4
Beta strandi42 – 47Combined sources6
Beta strandi49 – 51Combined sources3
Helixi52 – 56Combined sources5
Beta strandi64 – 68Combined sources5
Helixi78 – 86Combined sources9
Beta strandi90 – 100Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ENONMR-A1-107[»]
2JIKX-ray1.35A/B6-100[»]
2JINX-ray1.50A4-99[»]
ProteinModelPortaliP57105.
SMRiP57105.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57105.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 100PDZPROSITE-ProRule annotationAdd BLAST88

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITA3. Eukaryota.
ENOG4111VAQ. LUCA.
GeneTreeiENSGT00830000128402.
HOGENOMiHOG000146436.
HOVERGENiHBG061461.
InParanoidiP57105.
KOiK20057.
OrthoDBiEOG091G0G6P.
PhylomeDBiP57105.
TreeFamiTF318964.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIYVSRIKEN
60 70 80 90 100
GAAALDGRLQ EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL
110 120 130 140
QVQNGPIGHR GEGDPSGIPI FMVLVPVFAL TMVAAWAFMR YRQQL
Length:145
Mass (Da):15,928
Last modified:August 13, 2002 - v2
Checksum:iA62A82AC06A64995
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68V → A in BAA92098 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0513949V → I.Corresponds to variant rs4356408dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534623 mRNA. Translation: AAT01566.1.
AK002133 mRNA. Translation: BAA92098.1.
CH471061 Genomic DNA. Translation: EAW81032.1.
BC007704 mRNA. Translation: AAH07704.1.
CCDSiCCDS9803.1.
RefSeqiNP_060843.2. NM_018373.2.
UniGeneiHs.443661.
Hs.704691.

Genome annotation databases

EnsembliENST00000256366; ENSP00000256366; ENSG00000213463.
GeneIDi55333.
KEGGihsa:55333.
UCSCiuc001xmc.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534623 mRNA. Translation: AAT01566.1.
AK002133 mRNA. Translation: BAA92098.1.
CH471061 Genomic DNA. Translation: EAW81032.1.
BC007704 mRNA. Translation: AAH07704.1.
CCDSiCCDS9803.1.
RefSeqiNP_060843.2. NM_018373.2.
UniGeneiHs.443661.
Hs.704691.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ENONMR-A1-107[»]
2JIKX-ray1.35A/B6-100[»]
2JINX-ray1.50A4-99[»]
ProteinModelPortaliP57105.
SMRiP57105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120614. 23 interactors.
IntActiP57105. 2 interactors.
STRINGi9606.ENSP00000256366.

PTM databases

iPTMnetiP57105.
PhosphoSitePlusiP57105.

Polymorphism and mutation databases

BioMutaiSYNJ2BP.
DMDMi22261816.

Proteomic databases

EPDiP57105.
MaxQBiP57105.
PaxDbiP57105.
PeptideAtlasiP57105.
PRIDEiP57105.
TopDownProteomicsiP57105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256366; ENSP00000256366; ENSG00000213463.
GeneIDi55333.
KEGGihsa:55333.
UCSCiuc001xmc.5. human.

Organism-specific databases

CTDi55333.
DisGeNETi55333.
GeneCardsiSYNJ2BP.
HGNCiHGNC:18955. SYNJ2BP.
HPAiHPA000866.
MIMi609411. gene.
neXtProtiNX_P57105.
OpenTargetsiENSG00000213463.
PharmGKBiPA38768.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITA3. Eukaryota.
ENOG4111VAQ. LUCA.
GeneTreeiENSGT00830000128402.
HOGENOMiHOG000146436.
HOVERGENiHBG061461.
InParanoidiP57105.
KOiK20057.
OrthoDBiEOG091G0G6P.
PhylomeDBiP57105.
TreeFamiTF318964.

Enzyme and pathway databases

BioCyciZFISH:G66-31710-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP57105.
GeneWikiiSYNJ2BP.
GenomeRNAii55333.
PROiP57105.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213463.
CleanExiHS_SYNJ2BP.
ExpressionAtlasiP57105. baseline and differential.
GenevisibleiP57105. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYJ2B_HUMAN
AccessioniPrimary (citable) accession number: P57105
Secondary accession number(s): Q49SH3, Q96IA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 13, 2002
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.