Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Synaptojanin-2-binding protein

Gene

SYNJ2BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. intracellular distribution of mitochondria Source: Ensembl
  2. negative regulation of activin receptor signaling pathway Source: Ensembl
  3. positive regulation of activin receptor signaling pathway Source: Ensembl
  4. positive regulation of protein localization to cell surface Source: Ensembl
  5. positive regulation of receptor internalization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptojanin-2-binding protein
Alternative name(s):
Mitochondrial outer membrane protein 25
Gene namesi
Name:SYNJ2BP
Synonyms:OMP25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:18955. SYNJ2BP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 117117CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Topological domaini139 – 1457Mitochondrial intermembraneSequence Analysis

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of mitochondrial outer membrane Source: Ensembl
  3. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38768.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Synaptojanin-2-binding proteinPRO_0000072383Add
BLAST

Proteomic databases

MaxQBiP57105.
PaxDbiP57105.
PRIDEiP57105.

PTM databases

PhosphoSiteiP57105.

Expressioni

Gene expression databases

BgeeiP57105.
CleanExiHS_SYNJ2BP.
ExpressionAtlasiP57105. baseline and differential.
GenevestigatoriP57105.

Organism-specific databases

HPAiHPA000866.

Interactioni

Subunit structurei

Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus). Interacts with MAPK12.By similarity

Protein-protein interaction databases

BioGridi120614. 22 interactions.
IntActiP57105. 1 interaction.
STRINGi9606.ENSP00000256366.

Structurei

Secondary structure

1
145
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 83Combined sources
Beta strandi9 – 179Combined sources
Beta strandi20 – 223Combined sources
Beta strandi25 – 295Combined sources
Turni31 – 333Combined sources
Beta strandi35 – 384Combined sources
Beta strandi42 – 476Combined sources
Beta strandi49 – 513Combined sources
Helixi52 – 565Combined sources
Beta strandi64 – 685Combined sources
Helixi78 – 869Combined sources
Beta strandi90 – 10011Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ENONMR-A1-107[»]
2JIKX-ray1.35A/B6-100[»]
2JINX-ray1.50A4-99[»]
SMRiP57105. Positions 4-99.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57105.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 10088PDZPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG241504.
GeneTreeiENSGT00780000121922.
HOGENOMiHOG000146436.
HOVERGENiHBG061461.
InParanoidiP57105.
OMAiQNGPVGH.
OrthoDBiEOG7JQBQV.
PhylomeDBiP57105.
TreeFamiTF318964.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIYVSRIKEN
60 70 80 90 100
GAAALDGRLQ EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL
110 120 130 140
QVQNGPIGHR GEGDPSGIPI FMVLVPVFAL TMVAAWAFMR YRQQL
Length:145
Mass (Da):15,928
Last modified:August 13, 2002 - v2
Checksum:iA62A82AC06A64995
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681V → A in BAA92098 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91V → I.
Corresponds to variant rs4356408 [ dbSNP | Ensembl ].
VAR_051394

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534623 mRNA. Translation: AAT01566.1.
AK002133 mRNA. Translation: BAA92098.1.
CH471061 Genomic DNA. Translation: EAW81032.1.
BC007704 mRNA. Translation: AAH07704.1.
CCDSiCCDS9803.1.
RefSeqiNP_060843.2. NM_018373.2.
UniGeneiHs.443661.
Hs.704691.

Genome annotation databases

EnsembliENST00000256366; ENSP00000256366; ENSG00000213463.
GeneIDi55333.
KEGGihsa:55333.
UCSCiuc001xmc.4. human.

Polymorphism databases

DMDMi22261816.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534623 mRNA. Translation: AAT01566.1.
AK002133 mRNA. Translation: BAA92098.1.
CH471061 Genomic DNA. Translation: EAW81032.1.
BC007704 mRNA. Translation: AAH07704.1.
CCDSiCCDS9803.1.
RefSeqiNP_060843.2. NM_018373.2.
UniGeneiHs.443661.
Hs.704691.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ENONMR-A1-107[»]
2JIKX-ray1.35A/B6-100[»]
2JINX-ray1.50A4-99[»]
SMRiP57105. Positions 4-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120614. 22 interactions.
IntActiP57105. 1 interaction.
STRINGi9606.ENSP00000256366.

PTM databases

PhosphoSiteiP57105.

Polymorphism databases

DMDMi22261816.

Proteomic databases

MaxQBiP57105.
PaxDbiP57105.
PRIDEiP57105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256366; ENSP00000256366; ENSG00000213463.
GeneIDi55333.
KEGGihsa:55333.
UCSCiuc001xmc.4. human.

Organism-specific databases

CTDi55333.
GeneCardsiGC14M070833.
HGNCiHGNC:18955. SYNJ2BP.
HPAiHPA000866.
MIMi609411. gene.
neXtProtiNX_P57105.
PharmGKBiPA38768.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG241504.
GeneTreeiENSGT00780000121922.
HOGENOMiHOG000146436.
HOVERGENiHBG061461.
InParanoidiP57105.
OMAiQNGPVGH.
OrthoDBiEOG7JQBQV.
PhylomeDBiP57105.
TreeFamiTF318964.

Miscellaneous databases

EvolutionaryTraceiP57105.
GeneWikiiSYNJ2BP.
GenomeRNAii55333.
NextBioi59629.
PROiP57105.
SOURCEiSearch...

Gene expression databases

BgeeiP57105.
CleanExiHS_SYNJ2BP.
ExpressionAtlasiP57105. baseline and differential.
GenevestigatoriP57105.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel protein interacting with activin receptor II A."
    Yang Y., Tai G.X., Xu G.Y., Zhang P.Y., Liu Z.H.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  5. "Solution structure of the PDZ domain from human synaptojanin 2 binding protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1-113.
  6. "Crystal structure of PDZ domain of synaptojanin-2 binding protein."
    Tickle J., Phillips C., Pike A.C.W., Cooper C., Salah E., Elkins J., Turnbull A.P., Edwards A., Arrowsmith C.H., Weigelt J., Sundstrom M., Doyle D.
    Submitted (MAY-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 5-101.

Entry informationi

Entry nameiSYJ2B_HUMAN
AccessioniPrimary (citable) accession number: P57105
Secondary accession number(s): Q49SH3, Q96IA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 13, 2002
Last modified: April 1, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.