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P57105 (SYJ2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptojanin-2-binding protein
Alternative name(s):
Mitochondrial outer membrane protein 25
Gene names
Name:SYNJ2BP
Synonyms:OMP25
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length145 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Binds (via the PDZ domain) to isoform 2Aof SYNJ2 (via the unique motif in the C-terminus) By similarity. Interacts with MAPK12 By similarity.

Subcellular location

Mitochondrion outer membrane By similarity.

Sequence similarities

Contains 1 PDZ (DHR) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 145145Synaptojanin-2-binding protein
PRO_0000072383

Regions

Topological domain1 – 117117Cytoplasmic Potential
Transmembrane118 – 13821Helical; Potential
Topological domain139 – 1457Mitochondrial intermembrane Potential
Domain13 – 10088PDZ

Natural variations

Natural variant91V → I.
Corresponds to variant rs4356408 [ dbSNP | Ensembl ].
VAR_051394

Experimental info

Sequence conflict681V → A in BAA92098. Ref.2

Secondary structure

....................... 145
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P57105 [UniParc].

Last modified August 13, 2002. Version 2.
Checksum: A62A82AC06A64995

FASTA14515,928
        10         20         30         40         50         60 
MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIYVSRIKEN GAAALDGRLQ 

        70         80         90        100        110        120 
EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL QVQNGPIGHR GEGDPSGIPI 

       130        140 
FMVLVPVFAL TMVAAWAFMR YRQQL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a novel protein interacting with activin receptor II A."
Yang Y., Tai G.X., Xu G.Y., Zhang P.Y., Liu Z.H.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Solution structure of the PDZ domain from human synaptojanin 2 binding protein."
RIKEN structural genomics initiative (RSGI)
Submitted (MAR-2007) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 1-113.
[7]"Crystal structure of PDZ domain of synaptojanin-2 binding protein."
Tickle J., Phillips C., Pike A.C.W., Cooper C., Salah E., Elkins J., Turnbull A.P., Edwards A., Arrowsmith C.H., Weigelt J., Sundstrom M., Doyle D.
Submitted (JUN-2007) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 5-101.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY534623 mRNA. Translation: AAT01566.1.
AK002133 mRNA. Translation: BAA92098.1.
CH471061 Genomic DNA. Translation: EAW81032.1.
BC007704 mRNA. Translation: AAH07704.1.
RefSeqNP_060843.2. NM_018373.2.
UniGeneHs.443661.
Hs.704691.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2ENONMR-A1-107[»]
2JIKX-ray1.35A/B6-100[»]
2JINX-ray1.50A4-99[»]
ProteinModelPortalP57105.
SMRP57105. Positions 4-99.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120614. 20 interactions.
IntActP57105. 1 interaction.
STRING9606.ENSP00000256366.

PTM databases

PhosphoSiteP57105.

Polymorphism databases

DMDM22261816.

Proteomic databases

PaxDbP57105.
PRIDEP57105.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256366; ENSP00000256366; ENSG00000213463.
GeneID55333.
KEGGhsa:55333.
UCSCuc001xmc.4. human.

Organism-specific databases

CTD55333.
GeneCardsGC14M070833.
HGNCHGNC:18955. SYNJ2BP.
HPAHPA000866.
MIM609411. gene.
neXtProtNX_P57105.
PharmGKBPA38768.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG241504.
HOGENOMHOG000146436.
HOVERGENHBG061461.
InParanoidP57105.
OMAQNGPLGH.
OrthoDBEOG7JQBQV.
PhylomeDBP57105.
TreeFamTF318964.

Gene expression databases

BgeeP57105.
CleanExHS_SYNJ2BP.
GenevestigatorP57105.

Family and domain databases

Gene3D2.30.42.10. 1 hit.
InterProIPR001478. PDZ.
[Graphical view]
PfamPF00595. PDZ. 1 hit.
[Graphical view]
SMARTSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
PROSITEPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP57105.
GeneWikiSYNJ2BP.
GenomeRNAi55333.
NextBio59629.
PROP57105.
SOURCESearch...

Entry information

Entry nameSYJ2B_HUMAN
AccessionPrimary (citable) accession number: P57105
Secondary accession number(s): Q49SH3, Q96IA4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 13, 2002
Last modified: April 16, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM