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Protein

Synaptojanin-2-binding protein

Gene

SYNJ2BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.By similarity

GO - Biological processi

  • intracellular distribution of mitochondria Source: Ensembl
  • negative regulation of angiogenesis Source: UniProtKB
  • negative regulation of endothelial cell migration Source: UniProtKB
  • negative regulation of endothelial cell proliferation Source: UniProtKB
  • negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • negative regulation of sprouting angiogenesis Source: UniProtKB
  • protein targeting Source: Ensembl
  • regulation of endocytosis Source: Ensembl
  • regulation of Notch signaling pathway Source: UniProtKB
  • Rho protein signal transduction Source: Ensembl

Protein family/group databases

TCDBi8.A.24.1.5 the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptojanin-2-binding protein
Alternative name(s):
Mitochondrial outer membrane protein 25
Gene namesi
Name:SYNJ2BP
Synonyms:OMP25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000213463.4
HGNCiHGNC:18955 SYNJ2BP
MIMi609411 gene
neXtProtiNX_P57105

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 117CytoplasmicSequence analysisAdd BLAST117
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 145Mitochondrial intermembraneSequence analysis7

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55333
OpenTargetsiENSG00000213463
PharmGKBiPA38768

Polymorphism and mutation databases

BioMutaiSYNJ2BP
DMDMi22261816

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000723831 – 145Synaptojanin-2-binding proteinAdd BLAST145

Proteomic databases

EPDiP57105
MaxQBiP57105
PaxDbiP57105
PeptideAtlasiP57105
PRIDEiP57105
TopDownProteomicsiP57105

PTM databases

iPTMnetiP57105
PhosphoSitePlusiP57105

Expressioni

Gene expression databases

BgeeiENSG00000213463
CleanExiHS_SYNJ2BP
ExpressionAtlasiP57105 baseline and differential
GenevisibleiP57105 HS

Organism-specific databases

HPAiHPA000866

Interactioni

Subunit structurei

Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus) (By similarity). Interacts (via C-terminus) with RALBP1. Interacts (via PDZ domain) with ACVR2A (via C-terminus) and ACVR2B (via C-terminus). Forms a ternary complex with ACVR2A and RALBP1 (By similarity). Interacts with MAPK12 (By similarity). Interacts with DLL1; enhances DLL1 protein stability, and promotes notch signaling in endothelial cells (PubMed:24025447).By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120614, 37 interactors
IntActiP57105, 5 interactors
STRINGi9606.ENSP00000256366

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Beta strandi9 – 17Combined sources9
Beta strandi20 – 22Combined sources3
Beta strandi25 – 29Combined sources5
Turni31 – 33Combined sources3
Beta strandi35 – 38Combined sources4
Beta strandi42 – 47Combined sources6
Beta strandi49 – 51Combined sources3
Helixi52 – 56Combined sources5
Beta strandi64 – 68Combined sources5
Helixi78 – 86Combined sources9
Beta strandi90 – 100Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ENONMR-A1-107[»]
2JIKX-ray1.35A/B6-100[»]
2JINX-ray1.50A4-99[»]
ProteinModelPortaliP57105
SMRiP57105
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57105

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 100PDZPROSITE-ProRule annotationAdd BLAST88

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITA3 Eukaryota
ENOG4111VAQ LUCA
GeneTreeiENSGT00830000128402
HOGENOMiHOG000146436
HOVERGENiHBG061461
InParanoidiP57105
KOiK20057
OrthoDBiEOG091G0G6P
PhylomeDBiP57105
TreeFamiTF318964

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

P57105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIYVSRIKEN
60 70 80 90 100
GAAALDGRLQ EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL
110 120 130 140
QVQNGPIGHR GEGDPSGIPI FMVLVPVFAL TMVAAWAFMR YRQQL
Length:145
Mass (Da):15,928
Last modified:August 13, 2002 - v2
Checksum:iA62A82AC06A64995
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68V → A in BAA92098 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0513949V → I. Corresponds to variant dbSNP:rs4356408Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534623 mRNA Translation: AAT01566.1
AK002133 mRNA Translation: BAA92098.1
CH471061 Genomic DNA Translation: EAW81032.1
BC007704 mRNA Translation: AAH07704.1
CCDSiCCDS9803.1
RefSeqiNP_060843.2, NM_018373.2
UniGeneiHs.443661
Hs.704691

Genome annotation databases

EnsembliENST00000256366; ENSP00000256366; ENSG00000213463
GeneIDi55333
KEGGihsa:55333
UCSCiuc001xmc.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSYJ2B_HUMAN
AccessioniPrimary (citable) accession number: P57105
Secondary accession number(s): Q49SH3, Q96IA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 13, 2002
Last modified: May 23, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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