P57105 (SYJ2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptojanin-2-binding protein

Alternative name(s):
Mitochondrial outer membrane protein 25

Gene names

Name:	SYNJ2BP
Synonyms:	OMP25

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus) By similarity. Interacts with MAPK12 By similarity.
Subcellular location	Mitochondrion outer membrane By similarity.
Sequence similarities	Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular distribution of mitochondria Inferred from electronic annotation. Source: Compara
Cellular_component	integral to mitochondrial outer membrane Inferred from electronic annotation. Source: Compara mitochondrion Inferred from direct assay PubMed 18845145. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 145

145

Synaptojanin-2-binding protein

PRO_0000072383

Regions

Topological domain

1 – 117

117

Cytoplasmic Potential

Transmembrane

118 – 138

21

Helical; Potential

Topological domain

139 – 145

7

Mitochondrial intermembrane Potential

Domain

13 – 100

88

PDZ

Natural variations

Natural variant

9

1

V → I.
Corresponds to variant rs4356408 [ dbSNP | Ensembl ].

VAR_051394

Experimental info

Sequence conflict

68

1

V → A in BAA92098. Ref.2

Secondary structure

1

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145

Helix Strand Turn

Details...

Helix

6 – 8

3

Beta strand

9 – 17

9

Beta strand

20 – 22

3

Beta strand

25 – 29

5

Turn

31 – 33

3

Beta strand

35 – 38

4

Beta strand

42 – 47

6

Beta strand

49 – 51

3

Helix

52 – 56

5

Beta strand

64 – 68

5

Helix

78 – 86

9

Beta strand

90 – 100

11

Sequences

	Sequence		Length	Mass (Da)
	P57105 [UniParc]. Last modified August 13, 2002. Version 2. Checksum: A62A82AC06A64995	FASTA	145	15,928
	10 20 30 40 50 60 MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIYVSRIKEN GAAALDGRLQ 70 80 90 100 110 120 EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL QVQNGPIGHR GEGDPSGIPI 130 140 FMVLVPVFAL TMVAAWAFMR YRQQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel protein interacting with activin receptor II A." Yang Y., Tai G.X., Xu G.Y., Zhang P.Y., Liu Z.H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]	"Solution structure of the PDZ domain from human synaptojanin 2 binding protein." RIKEN structural genomics initiative (RSGI) Submitted (MAR-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1-113.
[7]	"Crystal structure of PDZ domain of synaptojanin-2 binding protein." Tickle J., Phillips C., Pike A.C.W., Cooper C., Salah E., Elkins J., Turnbull A.P., Edwards A., Arrowsmith C.H., Weigelt J., Sundstrom M., Doyle D. Submitted (JUN-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 5-101.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY534623 mRNA. Translation: AAT01566.1.
AK002133 mRNA. Translation: BAA92098.1.
CH471061 Genomic DNA. Translation: EAW81032.1.
BC007704 mRNA. Translation: AAH07704.1.

IPI

IPI00299193.

RefSeq

NP_060843.2. NM_018373.2.

UniGene

Hs.443661.
Hs.704691.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2ENO	NMR	-	A	1-107	[»]
2JIK	X-ray	1.35	A/B	6-100	[»]
2JIN	X-ray	1.50	A	4-99	[»]

ProteinModelPortal

P57105.

ModBase

Search...

Protein-protein interaction databases

IntAct

P57105. 1 interaction.

STRING

9606.ENSP00000256366.

PTM databases

PhosphoSite

P57105.

Polymorphism databases

DMDM

22261816.

Proteomic databases

PaxDb

P57105.

PRIDE

P57105.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000256366; ENSP00000256366; ENSG00000213463.

GeneID

55333.

KEGG

hsa:55333.

UCSC

uc001xmc.4. human.

Organism-specific databases

CTD

55333.

GeneCards

GC14M070833.

HGNC

HGNC:18955. SYNJ2BP.

HPA

HPA000866.

MIM

609411. gene.

neXtProt

NX_P57105.

PharmGKB

PA38768.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG241504.

HOGENOM

HOG000146436.

HOVERGEN

HBG061461.

InParanoid

P57105.

OMA

QNGPLGH.

OrthoDB

EOG49CQ99.

PhylomeDB

P57105.

Gene expression databases

Bgee

P57105.

CleanEx

HS_SYNJ2BP.

Genevestigator

P57105.

GermOnline

ENSG00000133983. Homo sapiens.

Family and domain databases

InterPro

IPR001478. PDZ.
[Graphical view]

Pfam

PF00595. PDZ. 1 hit.
[Graphical view]

SMART

SM00228. PDZ. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 1 hit.

PROSITE

PS50106. PDZ. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P57105.

GenomeRNAi

55333.

NextBio

59629.

SOURCE

Search...

Entry information

Entry name

SYJ2B_HUMAN

Accession

Primary (citable) accession number: P57105
Secondary accession number(s): Q49SH3, Q96IA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	August 13, 2002
Last modified:	May 1, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.