Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P57105

- SYJ2B_HUMAN

UniProt

P57105 - SYJ2B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Synaptojanin-2-binding protein

Gene

SYNJ2BP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. intracellular distribution of mitochondria Source: Ensembl
  2. negative regulation of activin receptor signaling pathway Source: Ensembl
  3. positive regulation of activin receptor signaling pathway Source: Ensembl
  4. positive regulation of protein localization to cell surface Source: Ensembl
  5. positive regulation of receptor internalization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptojanin-2-binding protein
Alternative name(s):
Mitochondrial outer membrane protein 25
Gene namesi
Name:SYNJ2BP
Synonyms:OMP25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:18955. SYNJ2BP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 117117CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Topological domaini139 – 1457Mitochondrial intermembraneSequence Analysis

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of mitochondrial outer membrane Source: Ensembl
  3. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38768.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Synaptojanin-2-binding proteinPRO_0000072383Add
BLAST

Proteomic databases

MaxQBiP57105.
PaxDbiP57105.
PRIDEiP57105.

PTM databases

PhosphoSiteiP57105.

Expressioni

Gene expression databases

BgeeiP57105.
CleanExiHS_SYNJ2BP.
GenevestigatoriP57105.

Organism-specific databases

HPAiHPA000866.

Interactioni

Subunit structurei

Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus). Interacts with MAPK12.By similarity

Protein-protein interaction databases

BioGridi120614. 21 interactions.
IntActiP57105. 1 interaction.
STRINGi9606.ENSP00000256366.

Structurei

Secondary structure

1
145
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 83Combined sources
Beta strandi9 – 179Combined sources
Beta strandi20 – 223Combined sources
Beta strandi25 – 295Combined sources
Turni31 – 333Combined sources
Beta strandi35 – 384Combined sources
Beta strandi42 – 476Combined sources
Beta strandi49 – 513Combined sources
Helixi52 – 565Combined sources
Beta strandi64 – 685Combined sources
Helixi78 – 869Combined sources
Beta strandi90 – 10011Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ENONMR-A1-107[»]
2JIKX-ray1.35A/B6-100[»]
2JINX-ray1.50A4-99[»]
ProteinModelPortaliP57105.
SMRiP57105. Positions 4-99.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57105.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 10088PDZPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG241504.
GeneTreeiENSGT00770000120649.
HOGENOMiHOG000146436.
HOVERGENiHBG061461.
InParanoidiP57105.
OMAiIFVSRIK.
OrthoDBiEOG7JQBQV.
PhylomeDBiP57105.
TreeFamiTF318964.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57105-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIYVSRIKEN
60 70 80 90 100
GAAALDGRLQ EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL
110 120 130 140
QVQNGPIGHR GEGDPSGIPI FMVLVPVFAL TMVAAWAFMR YRQQL
Length:145
Mass (Da):15,928
Last modified:August 13, 2002 - v2
Checksum:iA62A82AC06A64995
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681V → A in BAA92098. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91V → I.
Corresponds to variant rs4356408 [ dbSNP | Ensembl ].
VAR_051394

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534623 mRNA. Translation: AAT01566.1.
AK002133 mRNA. Translation: BAA92098.1.
CH471061 Genomic DNA. Translation: EAW81032.1.
BC007704 mRNA. Translation: AAH07704.1.
CCDSiCCDS9803.1.
RefSeqiNP_060843.2. NM_018373.2.
UniGeneiHs.443661.
Hs.704691.

Genome annotation databases

EnsembliENST00000256366; ENSP00000256366; ENSG00000213463.
GeneIDi55333.
KEGGihsa:55333.
UCSCiuc001xmc.4. human.

Polymorphism databases

DMDMi22261816.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534623 mRNA. Translation: AAT01566.1 .
AK002133 mRNA. Translation: BAA92098.1 .
CH471061 Genomic DNA. Translation: EAW81032.1 .
BC007704 mRNA. Translation: AAH07704.1 .
CCDSi CCDS9803.1.
RefSeqi NP_060843.2. NM_018373.2.
UniGenei Hs.443661.
Hs.704691.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ENO NMR - A 1-107 [» ]
2JIK X-ray 1.35 A/B 6-100 [» ]
2JIN X-ray 1.50 A 4-99 [» ]
ProteinModelPortali P57105.
SMRi P57105. Positions 4-99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120614. 21 interactions.
IntActi P57105. 1 interaction.
STRINGi 9606.ENSP00000256366.

PTM databases

PhosphoSitei P57105.

Polymorphism databases

DMDMi 22261816.

Proteomic databases

MaxQBi P57105.
PaxDbi P57105.
PRIDEi P57105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256366 ; ENSP00000256366 ; ENSG00000213463 .
GeneIDi 55333.
KEGGi hsa:55333.
UCSCi uc001xmc.4. human.

Organism-specific databases

CTDi 55333.
GeneCardsi GC14M070833.
HGNCi HGNC:18955. SYNJ2BP.
HPAi HPA000866.
MIMi 609411. gene.
neXtProti NX_P57105.
PharmGKBi PA38768.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241504.
GeneTreei ENSGT00770000120649.
HOGENOMi HOG000146436.
HOVERGENi HBG061461.
InParanoidi P57105.
OMAi IFVSRIK.
OrthoDBi EOG7JQBQV.
PhylomeDBi P57105.
TreeFami TF318964.

Miscellaneous databases

EvolutionaryTracei P57105.
GeneWikii SYNJ2BP.
GenomeRNAii 55333.
NextBioi 59629.
PROi P57105.
SOURCEi Search...

Gene expression databases

Bgeei P57105.
CleanExi HS_SYNJ2BP.
Genevestigatori P57105.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR001478. PDZ.
[Graphical view ]
Pfami PF00595. PDZ. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel protein interacting with activin receptor II A."
    Yang Y., Tai G.X., Xu G.Y., Zhang P.Y., Liu Z.H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Solution structure of the PDZ domain from human synaptojanin 2 binding protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (MAR-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1-113.
  7. "Crystal structure of PDZ domain of synaptojanin-2 binding protein."
    Tickle J., Phillips C., Pike A.C.W., Cooper C., Salah E., Elkins J., Turnbull A.P., Edwards A., Arrowsmith C.H., Weigelt J., Sundstrom M., Doyle D.
    Submitted (JUN-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 5-101.

Entry informationi

Entry nameiSYJ2B_HUMAN
AccessioniPrimary (citable) accession number: P57105
Secondary accession number(s): Q49SH3, Q96IA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 13, 2002
Last modified: November 26, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3