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P57105

- SYJ2B_HUMAN

UniProt

P57105 - SYJ2B_HUMAN

Protein

Synaptojanin-2-binding protein

Gene

SYNJ2BP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Biological processi

    1. intracellular distribution of mitochondria Source: Ensembl
    2. negative regulation of activin receptor signaling pathway Source: Ensembl
    3. positive regulation of activin receptor signaling pathway Source: Ensembl
    4. positive regulation of protein localization to cell surface Source: Ensembl
    5. positive regulation of receptor internalization Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptojanin-2-binding protein
    Alternative name(s):
    Mitochondrial outer membrane protein 25
    Gene namesi
    Name:SYNJ2BP
    Synonyms:OMP25
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:18955. SYNJ2BP.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of mitochondrial outer membrane Source: Ensembl
    3. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38768.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 145145Synaptojanin-2-binding proteinPRO_0000072383Add
    BLAST

    Proteomic databases

    MaxQBiP57105.
    PaxDbiP57105.
    PRIDEiP57105.

    PTM databases

    PhosphoSiteiP57105.

    Expressioni

    Gene expression databases

    BgeeiP57105.
    CleanExiHS_SYNJ2BP.
    GenevestigatoriP57105.

    Organism-specific databases

    HPAiHPA000866.

    Interactioni

    Subunit structurei

    Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus). Interacts with MAPK12.By similarity

    Protein-protein interaction databases

    BioGridi120614. 20 interactions.
    IntActiP57105. 1 interaction.
    STRINGi9606.ENSP00000256366.

    Structurei

    Secondary structure

    1
    145
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 83
    Beta strandi9 – 179
    Beta strandi20 – 223
    Beta strandi25 – 295
    Turni31 – 333
    Beta strandi35 – 384
    Beta strandi42 – 476
    Beta strandi49 – 513
    Helixi52 – 565
    Beta strandi64 – 685
    Helixi78 – 869
    Beta strandi90 – 10011

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ENONMR-A1-107[»]
    2JIKX-ray1.35A/B6-100[»]
    2JINX-ray1.50A4-99[»]
    ProteinModelPortaliP57105.
    SMRiP57105. Positions 4-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP57105.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 117117CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini139 – 1457Mitochondrial intermembraneSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 10088PDZPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG241504.
    HOGENOMiHOG000146436.
    HOVERGENiHBG061461.
    InParanoidiP57105.
    OMAiIFVSRIK.
    OrthoDBiEOG7JQBQV.
    PhylomeDBiP57105.
    TreeFamiTF318964.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    [Graphical view]
    PfamiPF00595. PDZ. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57105-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIYVSRIKEN    50
    GAAALDGRLQ EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL 100
    QVQNGPIGHR GEGDPSGIPI FMVLVPVFAL TMVAAWAFMR YRQQL 145
    Length:145
    Mass (Da):15,928
    Last modified:August 13, 2002 - v2
    Checksum:iA62A82AC06A64995
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 681V → A in BAA92098. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91V → I.
    Corresponds to variant rs4356408 [ dbSNP | Ensembl ].
    VAR_051394

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY534623 mRNA. Translation: AAT01566.1.
    AK002133 mRNA. Translation: BAA92098.1.
    CH471061 Genomic DNA. Translation: EAW81032.1.
    BC007704 mRNA. Translation: AAH07704.1.
    CCDSiCCDS9803.1.
    RefSeqiNP_060843.2. NM_018373.2.
    UniGeneiHs.443661.
    Hs.704691.

    Genome annotation databases

    EnsembliENST00000256366; ENSP00000256366; ENSG00000213463.
    GeneIDi55333.
    KEGGihsa:55333.
    UCSCiuc001xmc.4. human.

    Polymorphism databases

    DMDMi22261816.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY534623 mRNA. Translation: AAT01566.1 .
    AK002133 mRNA. Translation: BAA92098.1 .
    CH471061 Genomic DNA. Translation: EAW81032.1 .
    BC007704 mRNA. Translation: AAH07704.1 .
    CCDSi CCDS9803.1.
    RefSeqi NP_060843.2. NM_018373.2.
    UniGenei Hs.443661.
    Hs.704691.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ENO NMR - A 1-107 [» ]
    2JIK X-ray 1.35 A/B 6-100 [» ]
    2JIN X-ray 1.50 A 4-99 [» ]
    ProteinModelPortali P57105.
    SMRi P57105. Positions 4-99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120614. 20 interactions.
    IntActi P57105. 1 interaction.
    STRINGi 9606.ENSP00000256366.

    PTM databases

    PhosphoSitei P57105.

    Polymorphism databases

    DMDMi 22261816.

    Proteomic databases

    MaxQBi P57105.
    PaxDbi P57105.
    PRIDEi P57105.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256366 ; ENSP00000256366 ; ENSG00000213463 .
    GeneIDi 55333.
    KEGGi hsa:55333.
    UCSCi uc001xmc.4. human.

    Organism-specific databases

    CTDi 55333.
    GeneCardsi GC14M070833.
    HGNCi HGNC:18955. SYNJ2BP.
    HPAi HPA000866.
    MIMi 609411. gene.
    neXtProti NX_P57105.
    PharmGKBi PA38768.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241504.
    HOGENOMi HOG000146436.
    HOVERGENi HBG061461.
    InParanoidi P57105.
    OMAi IFVSRIK.
    OrthoDBi EOG7JQBQV.
    PhylomeDBi P57105.
    TreeFami TF318964.

    Miscellaneous databases

    EvolutionaryTracei P57105.
    GeneWikii SYNJ2BP.
    GenomeRNAii 55333.
    NextBioi 59629.
    PROi P57105.
    SOURCEi Search...

    Gene expression databases

    Bgeei P57105.
    CleanExi HS_SYNJ2BP.
    Genevestigatori P57105.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    [Graphical view ]
    Pfami PF00595. PDZ. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel protein interacting with activin receptor II A."
      Yang Y., Tai G.X., Xu G.Y., Zhang P.Y., Liu Z.H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Solution structure of the PDZ domain from human synaptojanin 2 binding protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (MAR-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1-113.
    7. "Crystal structure of PDZ domain of synaptojanin-2 binding protein."
      Tickle J., Phillips C., Pike A.C.W., Cooper C., Salah E., Elkins J., Turnbull A.P., Edwards A., Arrowsmith C.H., Weigelt J., Sundstrom M., Doyle D.
      Submitted (JUN-2007) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 5-101.

    Entry informationi

    Entry nameiSYJ2B_HUMAN
    AccessioniPrimary (citable) accession number: P57105
    Secondary accession number(s): Q49SH3, Q96IA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: August 13, 2002
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3