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Protein

Sodium/calcium exchanger 3

Gene

SLC8A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the electrogenic exchange of Ca2+ against Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes. Contributes to cellular Ca2+ homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca2+ levels due to release of Ca2+ stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca2+ from the cell during the next phase, so that cytoplasmic Ca2+ levels rapidly return to baseline. Contributes to Ca2+ transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca2+ levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca2+ efflux from mitochondria and contributes to mitochondrial Ca2+ ion homeostasis (By similarity).By similarity1 Publication

Enzyme regulationi

Calcium transport is down-regulated by Na+ and stimulated by Ca2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi409Calcium 1By similarity1
Metal bindingi409Calcium 2By similarity1
Metal bindingi409Calcium 3By similarity1
Metal bindingi445Calcium 1By similarity1
Metal bindingi445Calcium 4By similarity1
Metal bindingi470Calcium 2By similarity1
Metal bindingi471Calcium 1By similarity1
Metal bindingi471Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi471Calcium 3By similarity1
Metal bindingi471Calcium 4By similarity1
Metal bindingi473Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi475Calcium 1By similarity1
Metal bindingi475Calcium 3By similarity1
Metal bindingi475Calcium 4By similarity1
Metal bindingi478Calcium 4By similarity1
Metal bindingi525Calcium 3By similarity1
Metal bindingi526Calcium 2By similarity1
Metal bindingi527Calcium 2By similarity1
Metal bindingi527Calcium 3By similarity1
Metal bindingi543Calcium 5By similarity1
Metal bindingi579Calcium 6By similarity1
Metal bindingi606Calcium 6By similarity1
Metal bindingi607Calcium 5; via carbonyl oxygenBy similarity1
Metal bindingi607Calcium 6By similarity1
Metal bindingi672Calcium 5By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Calcium, Calmodulin-binding, Metal-binding, Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100678-MONOMER.
ReactomeiR-HSA-418359. Reduction of cytosolic Ca++ levels.
R-HSA-425561. Sodium/Calcium exchangers.
R-HSA-5578775. Ion homeostasis.

Protein family/group databases

TCDBi2.A.19.3.3. the ca(2+):cation antiporter (caca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/calcium exchanger 3
Alternative name(s):
Na(+)/Ca(2+)-exchange protein 3
Solute carrier family 8 member 3
Gene namesi
Name:SLC8A3
Synonyms:NCX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:11070. SLC8A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 73ExtracellularSequence analysisAdd BLAST43
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 147CytoplasmicSequence analysisAdd BLAST53
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169ExtracellularSequence analysis1
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 202CytoplasmicSequence analysisAdd BLAST12
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 230ExtracellularSequence analysis7
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Topological domaini252 – 726CytoplasmicSequence analysisAdd BLAST475
Transmembranei727 – 747HelicalSequence analysisAdd BLAST21
Topological domaini748 – 754ExtracellularSequence analysis7
Transmembranei755 – 775HelicalSequence analysisAdd BLAST21
Topological domaini776 – 778CytoplasmicSequence analysis3
Transmembranei779 – 799HelicalSequence analysisAdd BLAST21
Topological domaini800 – 828ExtracellularSequence analysisAdd BLAST29
Transmembranei829 – 849HelicalSequence analysisAdd BLAST21
Topological domaini850 – 860CytoplasmicSequence analysisAdd BLAST11
Transmembranei861 – 881HelicalSequence analysisAdd BLAST21
Topological domaini882 – 903ExtracellularSequence analysisAdd BLAST22
Transmembranei904 – 924HelicalSequence analysisAdd BLAST21
Topological domaini925 – 927CytoplasmicSequence analysis3

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6547.
OpenTargetsiENSG00000100678.
PharmGKBiPA315.

Polymorphism and mutation databases

DMDMi34395973.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001938431 – 927Sodium/calcium exchanger 3Add BLAST897

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Glycosylationi823N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP57103.
PeptideAtlasiP57103.
PRIDEiP57103.
TopDownProteomicsiP57103-2. [P57103-2]

PTM databases

iPTMnetiP57103.
PhosphoSitePlusiP57103.

Expressioni

Tissue specificityi

Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.1 Publication

Developmental stagei

Up-regulated during in vitro differentiation of oligodendrocytes (at protein level). Up-regulated during in vitro differentiation of oligodendrocytes.1 Publication

Gene expression databases

BgeeiENSG00000100678.
CleanExiHS_SLC8A3.
ExpressionAtlasiP57103. baseline and differential.
GenevisibleiP57103. HS.

Organism-specific databases

HPAiHPA001669.

Interactioni

Subunit structurei

Interacts with AKAP1.By similarity

Protein-protein interaction databases

BioGridi112437. 8 interactors.
STRINGi9606.ENSP00000370669.

Structurei

3D structure databases

ProteinModelPortaliP57103.
SMRiP57103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati140 – 180Alpha-1Add BLAST41
Domaini386 – 485Calx-beta 1Add BLAST100
Domaini519 – 619Calx-beta 2Add BLAST101
Repeati796 – 832Alpha-2Add BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni253 – 272Putative calmodulin-binding regionBy similarityAdd BLAST20

Domaini

The cytoplasmic Calx-beta domains bind the regulatory Ca2+. The first Calx-beta domain can bind up to four Ca2+ ions. The second domain can bind another two Ca2+ ions that are essential for calcium-regulated ion exchange.By similarity

Sequence similaritiesi

Contains 2 Calx-beta domains.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1306. Eukaryota.
ENOG410XPJP. LUCA.
GeneTreeiENSGT00730000110414.
HOGENOMiHOG000266971.
HOVERGENiHBG006441.
InParanoidiP57103.
KOiK05849.
OMAiVHTDEPE.
OrthoDBiEOG091G0EC1.
PhylomeDBiP57103.
TreeFamiTF314308.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR004836. Na_Ca_Ex.
IPR032452. Na_Ca_Ex_C-exten.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
PF16494. Na_Ca_ex_C. 1 hit.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: P57103-1) [UniParc]FASTAAdd to basket
Also known as: NCX3.3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWLRLQPLT SAFLHFGLVT FVLFLNGLRA EAGGSGDVPS TGQNNESCSG
60 70 80 90 100
SSDCKEGVIL PIWYPENPSL GDKIARVIVY FVALIYMFLG VSIIADRFMA
110 120 130 140 150
SIEVITSQER EVTIKKPNGE TSTTTIRVWN ETVSNLTLMA LGSSAPEILL
160 170 180 190 200
SLIEVCGHGF IAGDLGPSTI VGSAAFNMFI IIGICVYVIP DGETRKIKHL
210 220 230 240 250
RVFFITAAWS IFAYIWLYMI LAVFSPGVVQ VWEGLLTLFF FPVCVLLAWV
260 270 280 290 300
ADKRLLFYKY MHKKYRTDKH RGIIIETEGD HPKGIEMDGK MMNSHFLDGN
310 320 330 340 350
LVPLEGKEVD ESRREMIRIL KDLKQKHPEK DLDQLVEMAN YYALSHQQKS
360 370 380 390 400
RAFYRIQATR MMTGAGNILK KHAAEQAKKA SSMSEVHTDE PEDFISKVFF
410 420 430 440 450
DPCSYQCLEN CGAVLLTVVR KGGDMSKTMY VDYKTEDGSA NAGADYEFTE
460 470 480 490 500
GTVVLKPGET QKEFSVGIID DDIFEEDEHF FVRLSNVRIE EEQPEEGMPP
510 520 530 540 550
AIFNSLPLPR AVLASPCVAT VTILDDDHAG IFTFECDTIH VSESIGVMEV
560 570 580 590 600
KVLRTSGARG TVIVPFRTVE GTAKGGGEDF EDTYGELEFK NDETVKTIRV
610 620 630 640 650
KIVDEEEYER QENFFIALGE PKWMERGISA LLLSPDVTDR KLTMEEEEAK
660 670 680 690 700
RIAEMGKPVL GEHPKLEVII EESYEFKTTV DKLIKKTNLA LVVGTHSWRD
710 720 730 740 750
QFMEAITVSA AGDEDEDESG EERLPSCFDY VMHFLTVFWK VLFACVPPTE
760 770 780 790 800
YCHGWACFAV SILIIGMLTA IIGDLASHFG CTIGLKDSVT AVVFVAFGTS
810 820 830 840 850
VPDTFASKAA ALQDVYADAS IGNVTGSNAV NVFLGIGLAW SVAAIYWALQ
860 870 880 890 900
GQEFHVSAGT LAFSVTLFTI FAFVCISVLL YRRRPHLGGE LGGPRGCKLA
910 920
TTWLFVSLWL LYILFATLEA YCYIKGF
Length:927
Mass (Da):103,010
Last modified:August 29, 2003 - v2
Checksum:i7B43CB6A9D77615E
GO
Isoform 2 (identifier: P57103-2) [UniParc]FASTAAdd to basket
Also known as: NCX3.2

The sequence of this isoform differs from the canonical sequence as follows:
     630-635: Missing.

Show »
Length:921
Mass (Da):102,415
Checksum:i9E7E932E8EAE13F7
GO
Isoform 4 (identifier: P57103-3) [UniParc]FASTAAdd to basket
Also known as: NCX3.4

The sequence of this isoform differs from the canonical sequence as follows:
     596-620: KTIRVKIVDEEEYERQENFFIALGE → CDRQEADYGRRGGQEDSRDGKASIG
     621-927: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:620
Mass (Da):68,947
Checksum:i0FBEC381D196FD7C
GO
Isoform 5 (identifier: P57103-4) [UniParc]FASTAAdd to basket
Also known as: NCX3-tN.1

The sequence of this isoform differs from the canonical sequence as follows:
     1-643: Missing.

Note: Expressed in fetal brain.
Show »
Length:284
Mass (Da):31,142
Checksum:i14B4A98B3DE17144
GO
Isoform 6 (identifier: P57103-5) [UniParc]FASTAAdd to basket
Also known as: NCX3-tN.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-623: Missing.
     630-635: Missing.

Note: Expressed in fetal brain.
Show »
Length:298
Mass (Da):32,745
Checksum:i6B91455189B786D7
GO
Isoform 7 (identifier: P57103-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-638: Missing.

Show »
Length:924
Mass (Da):102,694
Checksum:iA0A556B753998A07
GO
Isoform 8 (identifier: P57103-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     599-638: RVKIVDEEEY...SALLLSPDVT → HIKVIDDEAY...SFQKALLLSP

Show »
Length:925
Mass (Da):102,804
Checksum:i0CCF8DA0881C4FDA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036463612E → Q in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0431251 – 643Missing in isoform 5. 1 PublicationAdd BLAST643
Alternative sequenceiVSP_0431261 – 623Missing in isoform 6. 2 PublicationsAdd BLAST623
Alternative sequenceiVSP_008117596 – 620KTIRV…IALGE → CDRQEADYGRRGGQEDSRDG KASIG in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_044502599 – 638RVKIV…SPDVT → HIKVIDDEAYEKNKNYFIEM MGPRMVDMSFQKALLLSP in isoform 8. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_008118621 – 927Missing in isoform 4. 1 PublicationAdd BLAST307
Alternative sequenceiVSP_008116630 – 635Missing in isoform 2 and isoform 6. 3 Publications6
Alternative sequenceiVSP_043850636 – 638Missing in isoform 7. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510501 mRNA. Translation: AAN60790.1.
AF510502 mRNA. Translation: AAN60791.1.
AF510503 mRNA. Translation: AAN60792.1.
AF508982 Genomic DNA. Translation: AAM90955.1.
AJ304852 mRNA. Translation: CAC40984.1.
AJ304853 mRNA. Translation: CAC40985.1.
AJ745101 mRNA. Translation: CAG33739.1.
AJ745102 mRNA. Translation: CAG33740.1.
AL135747 Genomic DNA. No translation available.
AL160191 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81019.1.
CH471061 Genomic DNA. Translation: EAW81021.1.
CH471061 Genomic DNA. Translation: EAW81026.1.
BC142969 mRNA. Translation: AAI42970.1.
X93017 Genomic DNA. No translation available.
CCDSiCCDS35498.1. [P57103-1]
CCDS41967.1. [P57103-4]
CCDS45131.1. [P57103-5]
CCDS53904.1. [P57103-6]
CCDS9799.1. [P57103-7]
CCDS9800.1. [P57103-2]
RefSeqiNP_001123889.1. NM_001130417.2. [P57103-5]
NP_150287.1. NM_033262.4. [P57103-7]
NP_489479.1. NM_058240.3. [P57103-6]
NP_891977.1. NM_182932.2. [P57103-2]
NP_891981.1. NM_182936.2. [P57103-4]
NP_892114.1. NM_183002.2. [P57103-1]
XP_016877095.1. XM_017021606.1. [P57103-1]
XP_016877097.1. XM_017021608.1. [P57103-2]
UniGeneiHs.337696.

Genome annotation databases

EnsembliENST00000216568; ENSP00000216568; ENSG00000100678. [P57103-5]
ENST00000356921; ENSP00000349392; ENSG00000100678. [P57103-2]
ENST00000357887; ENSP00000350560; ENSG00000100678. [P57103-7]
ENST00000381269; ENSP00000370669; ENSG00000100678. [P57103-1]
ENST00000394330; ENSP00000377863; ENSG00000100678. [P57103-4]
ENST00000494208; ENSP00000436332; ENSG00000100678. [P57103-3]
ENST00000528359; ENSP00000433531; ENSG00000100678. [P57103-7]
ENST00000534137; ENSP00000436688; ENSG00000100678. [P57103-6]
GeneIDi6547.
KEGGihsa:6547.
UCSCiuc001xlu.5. human. [P57103-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510501 mRNA. Translation: AAN60790.1.
AF510502 mRNA. Translation: AAN60791.1.
AF510503 mRNA. Translation: AAN60792.1.
AF508982 Genomic DNA. Translation: AAM90955.1.
AJ304852 mRNA. Translation: CAC40984.1.
AJ304853 mRNA. Translation: CAC40985.1.
AJ745101 mRNA. Translation: CAG33739.1.
AJ745102 mRNA. Translation: CAG33740.1.
AL135747 Genomic DNA. No translation available.
AL160191 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81019.1.
CH471061 Genomic DNA. Translation: EAW81021.1.
CH471061 Genomic DNA. Translation: EAW81026.1.
BC142969 mRNA. Translation: AAI42970.1.
X93017 Genomic DNA. No translation available.
CCDSiCCDS35498.1. [P57103-1]
CCDS41967.1. [P57103-4]
CCDS45131.1. [P57103-5]
CCDS53904.1. [P57103-6]
CCDS9799.1. [P57103-7]
CCDS9800.1. [P57103-2]
RefSeqiNP_001123889.1. NM_001130417.2. [P57103-5]
NP_150287.1. NM_033262.4. [P57103-7]
NP_489479.1. NM_058240.3. [P57103-6]
NP_891977.1. NM_182932.2. [P57103-2]
NP_891981.1. NM_182936.2. [P57103-4]
NP_892114.1. NM_183002.2. [P57103-1]
XP_016877095.1. XM_017021606.1. [P57103-1]
XP_016877097.1. XM_017021608.1. [P57103-2]
UniGeneiHs.337696.

3D structure databases

ProteinModelPortaliP57103.
SMRiP57103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112437. 8 interactors.
STRINGi9606.ENSP00000370669.

Protein family/group databases

TCDBi2.A.19.3.3. the ca(2+):cation antiporter (caca) family.

PTM databases

iPTMnetiP57103.
PhosphoSitePlusiP57103.

Polymorphism and mutation databases

DMDMi34395973.

Proteomic databases

PaxDbiP57103.
PeptideAtlasiP57103.
PRIDEiP57103.
TopDownProteomicsiP57103-2. [P57103-2]

Protocols and materials databases

DNASUi6547.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216568; ENSP00000216568; ENSG00000100678. [P57103-5]
ENST00000356921; ENSP00000349392; ENSG00000100678. [P57103-2]
ENST00000357887; ENSP00000350560; ENSG00000100678. [P57103-7]
ENST00000381269; ENSP00000370669; ENSG00000100678. [P57103-1]
ENST00000394330; ENSP00000377863; ENSG00000100678. [P57103-4]
ENST00000494208; ENSP00000436332; ENSG00000100678. [P57103-3]
ENST00000528359; ENSP00000433531; ENSG00000100678. [P57103-7]
ENST00000534137; ENSP00000436688; ENSG00000100678. [P57103-6]
GeneIDi6547.
KEGGihsa:6547.
UCSCiuc001xlu.5. human. [P57103-1]

Organism-specific databases

CTDi6547.
DisGeNETi6547.
GeneCardsiSLC8A3.
HGNCiHGNC:11070. SLC8A3.
HPAiHPA001669.
MIMi607991. gene.
neXtProtiNX_P57103.
OpenTargetsiENSG00000100678.
PharmGKBiPA315.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1306. Eukaryota.
ENOG410XPJP. LUCA.
GeneTreeiENSGT00730000110414.
HOGENOMiHOG000266971.
HOVERGENiHBG006441.
InParanoidiP57103.
KOiK05849.
OMAiVHTDEPE.
OrthoDBiEOG091G0EC1.
PhylomeDBiP57103.
TreeFamiTF314308.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100678-MONOMER.
ReactomeiR-HSA-418359. Reduction of cytosolic Ca++ levels.
R-HSA-425561. Sodium/Calcium exchangers.
R-HSA-5578775. Ion homeostasis.

Miscellaneous databases

ChiTaRSiSLC8A3. human.
GenomeRNAii6547.
PROiP57103.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100678.
CleanExiHS_SLC8A3.
ExpressionAtlasiP57103. baseline and differential.
GenevisibleiP57103. HS.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR004836. Na_Ca_Ex.
IPR032452. Na_Ca_Ex_C-exten.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
PF16494. Na_Ca_ex_C. 1 hit.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNAC3_HUMAN
AccessioniPrimary (citable) accession number: P57103
Secondary accession number(s): Q5K3P6
, Q5K3P7, Q8IUE9, Q8IUF0, Q8NFI7, Q96QG1, Q96QG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 29, 2003
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.