P57103 (NAC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/calcium exchanger 3

Alternative name(s):
Na(+)/Ca(2+)-exchange protein 3
Solute carrier family 8 member 3

Gene names

Name:	SLC8A3
Synonyms:	NCX3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	927 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Rapidly transports Ca2+ during excitation-contraction coupling. Ca2+ is extruded from the cell during relaxation so as to prevent overloading of intracellular stores By similarity.
Enzyme regulation	By intracellular calcium ions By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle. Ref.3
Sequence similarities	Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. Contains 2 Calx-beta domains.

Ontologies

Keywords
Biological process	Antiport Calcium transport Ion transport Sodium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Calmodulin-binding Sodium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Traceable author statement. Source: Reactome calcium ion export from cell Inferred from electronic annotation. Source: Ensembl calcium ion import into cell Inferred from electronic annotation. Source: Ensembl calcium ion transport into cytosol Inferred from electronic annotation. Source: Ensembl cell communication Inferred from electronic annotation. Source: InterPro cellular response to cAMP Inferred from electronic annotation. Source: Ensembl ion transport Traceable author statement. Source: Reactome telencephalon development Inferred from electronic annotation. Source: Ensembl transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	dendritic spine Inferred from electronic annotation. Source: Ensembl integral component of membrane Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: Ensembl mitochondrion Inferred from electronic annotation. Source: Ensembl neuronal cell body Inferred from electronic annotation. Source: Ensembl plasma membrane Traceable author statement. Source: Reactome sarcolemma Inferred from electronic annotation. Source: Ensembl
Molecular_function	calcium:sodium antiporter activity Inferred from electronic annotation. Source: Ensembl
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: P57103-1)

Also known as: NCX3.3;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P57103-2)

Also known as: NCX3.2;

The sequence of this isoform differs from the canonical sequence as follows:
     630-635: Missing.

Isoform 4 (identifier: P57103-3)

Also known as: NCX3.4;

The sequence of this isoform differs from the canonical sequence as follows:
     596-620: KTIRVKIVDEEEYERQENFFIALGE → CDRQEADYGRRGGQEDSRDGKASIG
     621-927: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Isoform 5 (identifier: P57103-4)

Also known as: NCX3-tN.1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-643: Missing.

Note: Expressed in fetal brain.

Isoform 6 (identifier: P57103-5)

Also known as: NCX3-tN.2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-623: Missing.
     630-635: Missing.

Note: Expressed in fetal brain.

Isoform 7 (identifier: P57103-6)

The sequence of this isoform differs from the canonical sequence as follows:
     636-638: Missing.

Isoform 8 (identifier: P57103-7)

The sequence of this isoform differs from the canonical sequence as follows:
     599-638: RVKIVDEEEY...SALLLSPDVT → HIKVIDDEAY...SFQKALLLSP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 927	897	Sodium/calcium exchanger 3		PRO_0000019384
Regions
	Topological domain	31 – 73	43	Extracellular Potential
	Transmembrane	74 – 94	21	Helical; Potential
	Topological domain	95 – 147	53	Cytoplasmic Potential
	Transmembrane	148 – 168	21	Helical; Potential
	Topological domain	169	1	Extracellular Potential
	Transmembrane	170 – 190	21	Helical; Potential
	Topological domain	191 – 202	12	Cytoplasmic Potential
	Transmembrane	203 – 223	21	Helical; Potential
	Topological domain	224 – 230	7	Extracellular Potential
	Transmembrane	231 – 251	21	Helical; Potential
	Topological domain	252 – 726	475	Cytoplasmic Potential
	Transmembrane	727 – 747	21	Helical; Potential
	Topological domain	748 – 754	7	Extracellular Potential
	Transmembrane	755 – 775	21	Helical; Potential
	Topological domain	776 – 778	3	Cytoplasmic Potential
	Transmembrane	779 – 799	21	Helical; Potential
	Topological domain	800 – 828	29	Extracellular Potential
	Transmembrane	829 – 849	21	Helical; Potential
	Topological domain	850 – 860	11	Cytoplasmic Potential
	Transmembrane	861 – 881	21	Helical; Potential
	Topological domain	882 – 903	22	Extracellular Potential
	Transmembrane	904 – 924	21	Helical; Potential
	Topological domain	925 – 927	3	Cytoplasmic Potential
	Repeat	140 – 180	41	Alpha-1
	Domain	386 – 485	100	Calx-beta 1
	Domain	519 – 619	101	Calx-beta 2
	Repeat	796 – 832	37	Alpha-2
	Region	253 – 272	20	Calmodulin-binding By similarity
Amino acid modifications
	Glycosylation	45	1	N-linked (GlcNAc...) Potential
	Glycosylation	823	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 643	643	Missing in isoform 5.		VSP_043125
	Alternative sequence	1 – 623	623	Missing in isoform 6.		VSP_043126
	Alternative sequence	596 – 620	25	KTIRV…IALGE → CDRQEADYGRRGGQEDSRDG KASIG in isoform 4.		VSP_008117
	Alternative sequence	599 – 638	40	RVKIV…SPDVT → HIKVIDDEAYEKNKNYFIEM MGPRMVDMSFQKALLLSP in isoform 8.		VSP_044502
	Alternative sequence	621 – 927	307	Missing in isoform 4.		VSP_008118
	Alternative sequence	630 – 635	6	Missing in isoform 2 and isoform 6.		VSP_008116
	Alternative sequence	636 – 638	3	Missing in isoform 7.		VSP_043850
	Natural variant	612	1	E → Q in a breast cancer sample; somatic mutation. Ref.8		VAR_036463

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 (NCX3.3) [UniParc]. Last modified August 29, 2003. Version 2. Checksum: 7B43CB6A9D77615E	FASTA	927	103,010
	10 20 30 40 50 60 MAWLRLQPLT SAFLHFGLVT FVLFLNGLRA EAGGSGDVPS TGQNNESCSG SSDCKEGVIL 70 80 90 100 110 120 PIWYPENPSL GDKIARVIVY FVALIYMFLG VSIIADRFMA SIEVITSQER EVTIKKPNGE 130 140 150 160 170 180 TSTTTIRVWN ETVSNLTLMA LGSSAPEILL SLIEVCGHGF IAGDLGPSTI VGSAAFNMFI 190 200 210 220 230 240 IIGICVYVIP DGETRKIKHL RVFFITAAWS IFAYIWLYMI LAVFSPGVVQ VWEGLLTLFF 250 260 270 280 290 300 FPVCVLLAWV ADKRLLFYKY MHKKYRTDKH RGIIIETEGD HPKGIEMDGK MMNSHFLDGN 310 320 330 340 350 360 LVPLEGKEVD ESRREMIRIL KDLKQKHPEK DLDQLVEMAN YYALSHQQKS RAFYRIQATR 370 380 390 400 410 420 MMTGAGNILK KHAAEQAKKA SSMSEVHTDE PEDFISKVFF DPCSYQCLEN CGAVLLTVVR 430 440 450 460 470 480 KGGDMSKTMY VDYKTEDGSA NAGADYEFTE GTVVLKPGET QKEFSVGIID DDIFEEDEHF 490 500 510 520 530 540 FVRLSNVRIE EEQPEEGMPP AIFNSLPLPR AVLASPCVAT VTILDDDHAG IFTFECDTIH 550 560 570 580 590 600 VSESIGVMEV KVLRTSGARG TVIVPFRTVE GTAKGGGEDF EDTYGELEFK NDETVKTIRV 610 620 630 640 650 660 KIVDEEEYER QENFFIALGE PKWMERGISA LLLSPDVTDR KLTMEEEEAK RIAEMGKPVL 670 680 690 700 710 720 GEHPKLEVII EESYEFKTTV DKLIKKTNLA LVVGTHSWRD QFMEAITVSA AGDEDEDESG 730 740 750 760 770 780 EERLPSCFDY VMHFLTVFWK VLFACVPPTE YCHGWACFAV SILIIGMLTA IIGDLASHFG 790 800 810 820 830 840 CTIGLKDSVT AVVFVAFGTS VPDTFASKAA ALQDVYADAS IGNVTGSNAV NVFLGIGLAW 850 860 870 880 890 900 SVAAIYWALQ GQEFHVSAGT LAFSVTLFTI FAFVCISVLL YRRRPHLGGE LGGPRGCKLA 910 920 TTWLFVSLWL LYILFATLEA YCYIKGF
	Isoform 2 (NCX3.2) [UniParc]. Checksum: 9E7E932E8EAE13F7	FASTA	921	102,415
	10 20 30 40 50 60 MAWLRLQPLT SAFLHFGLVT FVLFLNGLRA EAGGSGDVPS TGQNNESCSG SSDCKEGVIL 70 80 90 100 110 120 PIWYPENPSL GDKIARVIVY FVALIYMFLG VSIIADRFMA SIEVITSQER EVTIKKPNGE 130 140 150 160 170 180 TSTTTIRVWN ETVSNLTLMA LGSSAPEILL SLIEVCGHGF IAGDLGPSTI VGSAAFNMFI 190 200 210 220 230 240 IIGICVYVIP DGETRKIKHL RVFFITAAWS IFAYIWLYMI LAVFSPGVVQ VWEGLLTLFF 250 260 270 280 290 300 FPVCVLLAWV ADKRLLFYKY MHKKYRTDKH RGIIIETEGD HPKGIEMDGK MMNSHFLDGN 310 320 330 340 350 360 LVPLEGKEVD ESRREMIRIL KDLKQKHPEK DLDQLVEMAN YYALSHQQKS RAFYRIQATR 370 380 390 400 410 420 MMTGAGNILK KHAAEQAKKA SSMSEVHTDE PEDFISKVFF DPCSYQCLEN CGAVLLTVVR 430 440 450 460 470 480 KGGDMSKTMY VDYKTEDGSA NAGADYEFTE GTVVLKPGET QKEFSVGIID DDIFEEDEHF 490 500 510 520 530 540 FVRLSNVRIE EEQPEEGMPP AIFNSLPLPR AVLASPCVAT VTILDDDHAG IFTFECDTIH 550 560 570 580 590 600 VSESIGVMEV KVLRTSGARG TVIVPFRTVE GTAKGGGEDF EDTYGELEFK NDETVKTIRV 610 620 630 640 650 660 KIVDEEEYER QENFFIALGE PKWMERGISD VTDRKLTMEE EEAKRIAEMG KPVLGEHPKL 670 680 690 700 710 720 EVIIEESYEF KTTVDKLIKK TNLALVVGTH SWRDQFMEAI TVSAAGDEDE DESGEERLPS 730 740 750 760 770 780 CFDYVMHFLT VFWKVLFACV PPTEYCHGWA CFAVSILIIG MLTAIIGDLA SHFGCTIGLK 790 800 810 820 830 840 DSVTAVVFVA FGTSVPDTFA SKAAALQDVY ADASIGNVTG SNAVNVFLGI GLAWSVAAIY 850 860 870 880 890 900 WALQGQEFHV SAGTLAFSVT LFTIFAFVCI SVLLYRRRPH LGGELGGPRG CKLATTWLFV 910 920 SLWLLYILFA TLEAYCYIKG F
	Isoform 4 (NCX3.4) [UniParc]. Checksum: 0FBEC381D196FD7C	FASTA	620	68,947
	10 20 30 40 50 60 MAWLRLQPLT SAFLHFGLVT FVLFLNGLRA EAGGSGDVPS TGQNNESCSG SSDCKEGVIL 70 80 90 100 110 120 PIWYPENPSL GDKIARVIVY FVALIYMFLG VSIIADRFMA SIEVITSQER EVTIKKPNGE 130 140 150 160 170 180 TSTTTIRVWN ETVSNLTLMA LGSSAPEILL SLIEVCGHGF IAGDLGPSTI VGSAAFNMFI 190 200 210 220 230 240 IIGICVYVIP DGETRKIKHL RVFFITAAWS IFAYIWLYMI LAVFSPGVVQ VWEGLLTLFF 250 260 270 280 290 300 FPVCVLLAWV ADKRLLFYKY MHKKYRTDKH RGIIIETEGD HPKGIEMDGK MMNSHFLDGN 310 320 330 340 350 360 LVPLEGKEVD ESRREMIRIL KDLKQKHPEK DLDQLVEMAN YYALSHQQKS RAFYRIQATR 370 380 390 400 410 420 MMTGAGNILK KHAAEQAKKA SSMSEVHTDE PEDFISKVFF DPCSYQCLEN CGAVLLTVVR 430 440 450 460 470 480 KGGDMSKTMY VDYKTEDGSA NAGADYEFTE GTVVLKPGET QKEFSVGIID DDIFEEDEHF 490 500 510 520 530 540 FVRLSNVRIE EEQPEEGMPP AIFNSLPLPR AVLASPCVAT VTILDDDHAG IFTFECDTIH 550 560 570 580 590 600 VSESIGVMEV KVLRTSGARG TVIVPFRTVE GTAKGGGEDF EDTYGELEFK NDETVCDRQE 610 620 ADYGRRGGQE DSRDGKASIG
	Isoform 5 (NCX3-tN.1) [UniParc]. Checksum: 14B4A98B3DE17144	FASTA	284	31,142
	10 20 30 40 50 60 MEEEEAKRIA EMGKPVLGEH PKLEVIIEES YEFKTTVDKL IKKTNLALVV GTHSWRDQFM 70 80 90 100 110 120 EAITVSAAGD EDEDESGEER LPSCFDYVMH FLTVFWKVLF ACVPPTEYCH GWACFAVSIL 130 140 150 160 170 180 IIGMLTAIIG DLASHFGCTI GLKDSVTAVV FVAFGTSVPD TFASKAAALQ DVYADASIGN 190 200 210 220 230 240 VTGSNAVNVF LGIGLAWSVA AIYWALQGQE FHVSAGTLAF SVTLFTIFAF VCISVLLYRR 250 260 270 280 RPHLGGELGG PRGCKLATTW LFVSLWLLYI LFATLEAYCY IKGF
	Isoform 6 (NCX3-tN.2) [UniParc]. Checksum: 6B91455189B786D7	FASTA	298	32,745
	10 20 30 40 50 60 MERGISDVTD RKLTMEEEEA KRIAEMGKPV LGEHPKLEVI IEESYEFKTT VDKLIKKTNL 70 80 90 100 110 120 ALVVGTHSWR DQFMEAITVS AAGDEDEDES GEERLPSCFD YVMHFLTVFW KVLFACVPPT 130 140 150 160 170 180 EYCHGWACFA VSILIIGMLT AIIGDLASHF GCTIGLKDSV TAVVFVAFGT SVPDTFASKA 190 200 210 220 230 240 AALQDVYADA SIGNVTGSNA VNVFLGIGLA WSVAAIYWAL QGQEFHVSAG TLAFSVTLFT 250 260 270 280 290 IFAFVCISVL LYRRRPHLGG ELGGPRGCKL ATTWLFVSLW LLYILFATLE AYCYIKGF
	Isoform 7 [UniParc]. Checksum: A0A556B753998A07	FASTA	924	102,694
	10 20 30 40 50 60 MAWLRLQPLT SAFLHFGLVT FVLFLNGLRA EAGGSGDVPS TGQNNESCSG SSDCKEGVIL 70 80 90 100 110 120 PIWYPENPSL GDKIARVIVY FVALIYMFLG VSIIADRFMA SIEVITSQER EVTIKKPNGE 130 140 150 160 170 180 TSTTTIRVWN ETVSNLTLMA LGSSAPEILL SLIEVCGHGF IAGDLGPSTI VGSAAFNMFI 190 200 210 220 230 240 IIGICVYVIP DGETRKIKHL RVFFITAAWS IFAYIWLYMI LAVFSPGVVQ VWEGLLTLFF 250 260 270 280 290 300 FPVCVLLAWV ADKRLLFYKY MHKKYRTDKH RGIIIETEGD HPKGIEMDGK MMNSHFLDGN 310 320 330 340 350 360 LVPLEGKEVD ESRREMIRIL KDLKQKHPEK DLDQLVEMAN YYALSHQQKS RAFYRIQATR 370 380 390 400 410 420 MMTGAGNILK KHAAEQAKKA SSMSEVHTDE PEDFISKVFF DPCSYQCLEN CGAVLLTVVR 430 440 450 460 470 480 KGGDMSKTMY VDYKTEDGSA NAGADYEFTE GTVVLKPGET QKEFSVGIID DDIFEEDEHF 490 500 510 520 530 540 FVRLSNVRIE EEQPEEGMPP AIFNSLPLPR AVLASPCVAT VTILDDDHAG IFTFECDTIH 550 560 570 580 590 600 VSESIGVMEV KVLRTSGARG TVIVPFRTVE GTAKGGGEDF EDTYGELEFK NDETVKTIRV 610 620 630 640 650 660 KIVDEEEYER QENFFIALGE PKWMERGISA LLLSPDRKLT MEEEEAKRIA EMGKPVLGEH 670 680 690 700 710 720 PKLEVIIEES YEFKTTVDKL IKKTNLALVV GTHSWRDQFM EAITVSAAGD EDEDESGEER 730 740 750 760 770 780 LPSCFDYVMH FLTVFWKVLF ACVPPTEYCH GWACFAVSIL IIGMLTAIIG DLASHFGCTI 790 800 810 820 830 840 GLKDSVTAVV FVAFGTSVPD TFASKAAALQ DVYADASIGN VTGSNAVNVF LGIGLAWSVA 850 860 870 880 890 900 AIYWALQGQE FHVSAGTLAF SVTLFTIFAF VCISVLLYRR RPHLGGELGG PRGCKLATTW 910 920 LFVSLWLLYI LFATLEAYCY IKGF
	Isoform 8 [UniParc]. Checksum: 0CCF8DA0881C4FDA	FASTA	925	102,804
	10 20 30 40 50 60 MAWLRLQPLT SAFLHFGLVT FVLFLNGLRA EAGGSGDVPS TGQNNESCSG SSDCKEGVIL 70 80 90 100 110 120 PIWYPENPSL GDKIARVIVY FVALIYMFLG VSIIADRFMA SIEVITSQER EVTIKKPNGE 130 140 150 160 170 180 TSTTTIRVWN ETVSNLTLMA LGSSAPEILL SLIEVCGHGF IAGDLGPSTI VGSAAFNMFI 190 200 210 220 230 240 IIGICVYVIP DGETRKIKHL RVFFITAAWS IFAYIWLYMI LAVFSPGVVQ VWEGLLTLFF 250 260 270 280 290 300 FPVCVLLAWV ADKRLLFYKY MHKKYRTDKH RGIIIETEGD HPKGIEMDGK MMNSHFLDGN 310 320 330 340 350 360 LVPLEGKEVD ESRREMIRIL KDLKQKHPEK DLDQLVEMAN YYALSHQQKS RAFYRIQATR 370 380 390 400 410 420 MMTGAGNILK KHAAEQAKKA SSMSEVHTDE PEDFISKVFF DPCSYQCLEN CGAVLLTVVR 430 440 450 460 470 480 KGGDMSKTMY VDYKTEDGSA NAGADYEFTE GTVVLKPGET QKEFSVGIID DDIFEEDEHF 490 500 510 520 530 540 FVRLSNVRIE EEQPEEGMPP AIFNSLPLPR AVLASPCVAT VTILDDDHAG IFTFECDTIH 550 560 570 580 590 600 VSESIGVMEV KVLRTSGARG TVIVPFRTVE GTAKGGGEDF EDTYGELEFK NDETVKTIHI 610 620 630 640 650 660 KVIDDEAYEK NKNYFIEMMG PRMVDMSFQK ALLLSPDRKL TMEEEEAKRI AEMGKPVLGE 670 680 690 700 710 720 HPKLEVIIEE SYEFKTTVDK LIKKTNLALV VGTHSWRDQF MEAITVSAAG DEDEDESGEE 730 740 750 760 770 780 RLPSCFDYVM HFLTVFWKVL FACVPPTEYC HGWACFAVSI LIIGMLTAII GDLASHFGCT 790 800 810 820 830 840 IGLKDSVTAV VFVAFGTSVP DTFASKAAAL QDVYADASIG NVTGSNAVNV FLGIGLAWSV 850 860 870 880 890 900 AAIYWALQGQ EFHVSAGTLA FSVTLFTIFA FVCISVLLYR RRPHLGGELG GPRGCKLATT 910 920 WLFVSLWLLY ILFATLEAYC YIKGF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human SLC8A3 gene and the tissue-specific Na+/Ca2+ exchanger 3 isoforms." Gabellini N., Bortoluzzi S., Danieli G.A., Carafoli E. Gene 298:1-7(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2; 3; 4; 7 AND 8).
[2]	"Control of the Na+/Ca2+ exchanger 3 promoter by cyclic adenosine monophosphate and Ca2+ in differentiating neurons." Gabellini N., Bortoluzzi S., Danieli G.A., Carafoli E. J. Neurochem. 84:282-293(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3).
[3]	"Molecular cloning and characterization of two novel truncated isoforms of human Na+/Ca2+ exchanger 3, expressed in fetal brain." Lindgren R.M., Zhao J., Heller S., Berglind H., Nister M. Gene 348:143-155(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6), TISSUE SPECIFICITY. Tissue: Brain.
[4]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
[7]	"The organization of the human gene of the sodium-calcium exchanger." Kraev A.S., Chumakov I.M., Carafoli E. Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-595.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-612.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF510501 mRNA. Translation: AAN60790.1. AF510502 mRNA. Translation: AAN60791.1. AF510503 mRNA. Translation: AAN60792.1. AF508982 Genomic DNA. Translation: AAM90955.1. AJ304852 mRNA. Translation: CAC40984.1. AJ304853 mRNA. Translation: CAC40985.1. AJ745101 mRNA. Translation: CAG33739.1. AJ745102 mRNA. Translation: CAG33740.1. AL135747 Genomic DNA. No translation available. AL160191 Genomic DNA. No translation available. CH471061 Genomic DNA. Translation: EAW81019.1. CH471061 Genomic DNA. Translation: EAW81021.1. CH471061 Genomic DNA. Translation: EAW81026.1. BC142969 mRNA. Translation: AAI42970.1. X93017 Genomic DNA. No translation available.
CCDS	CCDS35498.1. [P57103-1] CCDS41967.1. [P57103-4] CCDS45131.1. [P57103-5] CCDS53904.1. [P57103-6] CCDS9799.1. [P57103-7] CCDS9800.1. [P57103-2]
RefSeq	NP_001123889.1. NM_001130417.2. [P57103-5] NP_150287.1. NM_033262.4. [P57103-7] NP_489479.1. NM_058240.3. [P57103-6] NP_891977.1. NM_182932.2. [P57103-2] NP_891981.1. NM_182936.2. [P57103-4] NP_892114.1. NM_183002.2. [P57103-1]
UniGene	Hs.337696.
3D structure databases
ProteinModelPortal	P57103.
SMR	P57103. Positions 395-681, 758-872.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000370669.
Protein family/group databases
TCDB	2.A.19.3.3. the ca(2+):cation antiporter (caca) family.
PTM databases
PhosphoSite	P57103.
Polymorphism databases
DMDM	34395973.
Proteomic databases
PaxDb	P57103.
PRIDE	P57103.
Protocols and materials databases
DNASU	6547.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000216568; ENSP00000216568; ENSG00000100678. [P57103-5] ENST00000356921; ENSP00000349392; ENSG00000100678. [P57103-2] ENST00000357887; ENSP00000350560; ENSG00000100678. [P57103-7] ENST00000381269; ENSP00000370669; ENSG00000100678. [P57103-1] ENST00000394330; ENSP00000377863; ENSG00000100678. [P57103-4] ENST00000494208; ENSP00000436332; ENSG00000100678. [P57103-3] ENST00000528359; ENSP00000433531; ENSG00000100678. [P57103-7] ENST00000534137; ENSP00000436688; ENSG00000100678. [P57103-6]
GeneID	6547.
KEGG	hsa:6547.
UCSC	uc001xlu.3. human. [P57103-4] uc001xlv.3. human. [P57103-5] uc001xlw.3. human. [P57103-6] uc001xlx.3. human. [P57103-7] uc001xly.3. human. [P57103-1] uc001xlz.3. human. [P57103-2]
Organism-specific databases
CTD	6547.
GeneCards	GC14M070510.
HGNC	HGNC:11070. SLC8A3.
HPA	HPA001669.
MIM	607991. gene.
neXtProt	NX_P57103.
PharmGKB	PA315.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG241889.
HOGENOM	HOG000266971.
HOVERGEN	HBG006441.
InParanoid	P57103.
KO	K05849.
OMA	CGHGFIA.
OrthoDB	EOG7S4X56.
PhylomeDB	P57103.
TreeFam	TF314308.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	P57103.
Bgee	P57103.
CleanEx	HS_SLC8A3.
Genevestigator	P57103.
Family and domain databases
InterPro	IPR003644. Calx_beta. IPR004836. Na_Ca_Ex. IPR004837. NaCa_Exmemb. [Graphical view]
Pfam	PF03160. Calx-beta. 2 hits. PF01699. Na_Ca_ex. 2 hits. [Graphical view]
PRINTS	PR01259. NACAEXCHNGR.
SMART	SM00237. Calx_beta. 2 hits. [Graphical view]
TIGRFAMs	TIGR00845. caca. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	SLC8A3. human.
GenomeRNAi	6547.
NextBio	25473.
PRO	P57103.
SOURCE	Search...

Entry information

Entry name

NAC3_HUMAN

Accession

Primary (citable) accession number: P57103
Secondary accession number(s): Q5K3P6 , Q5K3P7, Q8IUE9, Q8IUF0, Q8NFI7, Q96QG1, Q96QG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	August 29, 2003
Last modified:	July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.