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P57103

- NAC3_HUMAN

UniProt

P57103 - NAC3_HUMAN

Protein

Sodium/calcium exchanger 3

Gene

SLC8A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (29 Aug 2003)
      Previous versions | rss
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    Functioni

    Rapidly transports Ca2+ during excitation-contraction coupling. Ca2+ is extruded from the cell during relaxation so as to prevent overloading of intracellular stores By similarity.By similarity

    Enzyme regulationi

    By intracellular calcium ions.By similarity

    GO - Molecular functioni

    1. calcium:sodium antiporter activity Source: Ensembl

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. calcium ion export from cell Source: Ensembl
    3. calcium ion import into cell Source: Ensembl
    4. calcium ion transport into cytosol Source: Ensembl
    5. cell communication Source: InterPro
    6. cellular response to cAMP Source: Ensembl
    7. ion transport Source: Reactome
    8. telencephalon development Source: Ensembl
    9. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Antiport, Calcium transport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Calcium, Calmodulin-binding, Sodium

    Enzyme and pathway databases

    ReactomeiREACT_19320. Sodium/Calcium exchangers.
    REACT_23765. Reduction of cytosolic Ca++ levels.

    Protein family/group databases

    TCDBi2.A.19.3.3. the ca(2+):cation antiporter (caca) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/calcium exchanger 3
    Alternative name(s):
    Na(+)/Ca(2+)-exchange protein 3
    Solute carrier family 8 member 3
    Gene namesi
    Name:SLC8A3
    Synonyms:NCX3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:11070. SLC8A3.

    Subcellular locationi

    GO - Cellular componenti

    1. dendritic spine Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. microtubule Source: Ensembl
    4. mitochondrion Source: Ensembl
    5. neuronal cell body Source: Ensembl
    6. plasma membrane Source: Reactome
    7. sarcolemma Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA315.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 927897Sodium/calcium exchanger 3PRO_0000019384Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi823 – 8231N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP57103.
    PRIDEiP57103.

    PTM databases

    PhosphoSiteiP57103.

    Expressioni

    Tissue specificityi

    Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiP57103.
    BgeeiP57103.
    CleanExiHS_SLC8A3.
    GenevestigatoriP57103.

    Organism-specific databases

    HPAiHPA001669.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000370669.

    Structurei

    3D structure databases

    ProteinModelPortaliP57103.
    SMRiP57103. Positions 395-681, 758-872.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 7343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini95 – 14753CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini169 – 1691ExtracellularSequence Analysis
    Topological domaini191 – 20212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini224 – 2307ExtracellularSequence Analysis
    Topological domaini252 – 726475CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini748 – 7547ExtracellularSequence Analysis
    Topological domaini776 – 7783CytoplasmicSequence Analysis
    Topological domaini800 – 82829ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini850 – 86011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini882 – 90322ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini925 – 9273CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei74 – 9421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei727 – 74721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei755 – 77521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei779 – 79921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei829 – 84921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei861 – 88121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei904 – 92421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati140 – 18041Alpha-1Add
    BLAST
    Domaini386 – 485100Calx-beta 1Add
    BLAST
    Domaini519 – 619101Calx-beta 2Add
    BLAST
    Repeati796 – 83237Alpha-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni253 – 27220Calmodulin-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 2 Calx-beta domains.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG241889.
    HOGENOMiHOG000266971.
    HOVERGENiHBG006441.
    InParanoidiP57103.
    KOiK05849.
    OMAiCGHGFIA.
    OrthoDBiEOG7S4X56.
    PhylomeDBiP57103.
    TreeFamiTF314308.

    Family and domain databases

    InterProiIPR003644. Calx_beta.
    IPR004836. Na_Ca_Ex.
    IPR004837. NaCa_Exmemb.
    [Graphical view]
    PfamiPF03160. Calx-beta. 2 hits.
    PF01699. Na_Ca_ex. 2 hits.
    [Graphical view]
    PRINTSiPR01259. NACAEXCHNGR.
    SMARTiSM00237. Calx_beta. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00845. caca. 1 hit.

    Sequences (7)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 3 (identifier: P57103-1) [UniParc]FASTAAdd to Basket

    Also known as: NCX3.3

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAWLRLQPLT SAFLHFGLVT FVLFLNGLRA EAGGSGDVPS TGQNNESCSG    50
    SSDCKEGVIL PIWYPENPSL GDKIARVIVY FVALIYMFLG VSIIADRFMA 100
    SIEVITSQER EVTIKKPNGE TSTTTIRVWN ETVSNLTLMA LGSSAPEILL 150
    SLIEVCGHGF IAGDLGPSTI VGSAAFNMFI IIGICVYVIP DGETRKIKHL 200
    RVFFITAAWS IFAYIWLYMI LAVFSPGVVQ VWEGLLTLFF FPVCVLLAWV 250
    ADKRLLFYKY MHKKYRTDKH RGIIIETEGD HPKGIEMDGK MMNSHFLDGN 300
    LVPLEGKEVD ESRREMIRIL KDLKQKHPEK DLDQLVEMAN YYALSHQQKS 350
    RAFYRIQATR MMTGAGNILK KHAAEQAKKA SSMSEVHTDE PEDFISKVFF 400
    DPCSYQCLEN CGAVLLTVVR KGGDMSKTMY VDYKTEDGSA NAGADYEFTE 450
    GTVVLKPGET QKEFSVGIID DDIFEEDEHF FVRLSNVRIE EEQPEEGMPP 500
    AIFNSLPLPR AVLASPCVAT VTILDDDHAG IFTFECDTIH VSESIGVMEV 550
    KVLRTSGARG TVIVPFRTVE GTAKGGGEDF EDTYGELEFK NDETVKTIRV 600
    KIVDEEEYER QENFFIALGE PKWMERGISA LLLSPDVTDR KLTMEEEEAK 650
    RIAEMGKPVL GEHPKLEVII EESYEFKTTV DKLIKKTNLA LVVGTHSWRD 700
    QFMEAITVSA AGDEDEDESG EERLPSCFDY VMHFLTVFWK VLFACVPPTE 750
    YCHGWACFAV SILIIGMLTA IIGDLASHFG CTIGLKDSVT AVVFVAFGTS 800
    VPDTFASKAA ALQDVYADAS IGNVTGSNAV NVFLGIGLAW SVAAIYWALQ 850
    GQEFHVSAGT LAFSVTLFTI FAFVCISVLL YRRRPHLGGE LGGPRGCKLA 900
    TTWLFVSLWL LYILFATLEA YCYIKGF 927
    Length:927
    Mass (Da):103,010
    Last modified:August 29, 2003 - v2
    Checksum:i7B43CB6A9D77615E
    GO
    Isoform 2 (identifier: P57103-2) [UniParc]FASTAAdd to Basket

    Also known as: NCX3.2

    The sequence of this isoform differs from the canonical sequence as follows:
         630-635: Missing.

    Show »
    Length:921
    Mass (Da):102,415
    Checksum:i9E7E932E8EAE13F7
    GO
    Isoform 4 (identifier: P57103-3) [UniParc]FASTAAdd to Basket

    Also known as: NCX3.4

    The sequence of this isoform differs from the canonical sequence as follows:
         596-620: KTIRVKIVDEEEYERQENFFIALGE → CDRQEADYGRRGGQEDSRDGKASIG
         621-927: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

    Show »
    Length:620
    Mass (Da):68,947
    Checksum:i0FBEC381D196FD7C
    GO
    Isoform 5 (identifier: P57103-4) [UniParc]FASTAAdd to Basket

    Also known as: NCX3-tN.1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-643: Missing.

    Note: Expressed in fetal brain.

    Show »
    Length:284
    Mass (Da):31,142
    Checksum:i14B4A98B3DE17144
    GO
    Isoform 6 (identifier: P57103-5) [UniParc]FASTAAdd to Basket

    Also known as: NCX3-tN.2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-623: Missing.
         630-635: Missing.

    Note: Expressed in fetal brain.

    Show »
    Length:298
    Mass (Da):32,745
    Checksum:i6B91455189B786D7
    GO
    Isoform 7 (identifier: P57103-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         636-638: Missing.

    Show »
    Length:924
    Mass (Da):102,694
    Checksum:iA0A556B753998A07
    GO
    Isoform 8 (identifier: P57103-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         599-638: RVKIVDEEEY...SALLLSPDVT → HIKVIDDEAY...SFQKALLLSP

    Show »
    Length:925
    Mass (Da):102,804
    Checksum:i0CCF8DA0881C4FDA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti612 – 6121E → Q in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036463

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 643643Missing in isoform 5. 1 PublicationVSP_043125Add
    BLAST
    Alternative sequencei1 – 623623Missing in isoform 6. 2 PublicationsVSP_043126Add
    BLAST
    Alternative sequencei596 – 62025KTIRV…IALGE → CDRQEADYGRRGGQEDSRDG KASIG in isoform 4. 1 PublicationVSP_008117Add
    BLAST
    Alternative sequencei599 – 63840RVKIV…SPDVT → HIKVIDDEAYEKNKNYFIEM MGPRMVDMSFQKALLLSP in isoform 8. 1 PublicationVSP_044502Add
    BLAST
    Alternative sequencei621 – 927307Missing in isoform 4. 1 PublicationVSP_008118Add
    BLAST
    Alternative sequencei630 – 6356Missing in isoform 2 and isoform 6. 3 PublicationsVSP_008116
    Alternative sequencei636 – 6383Missing in isoform 7. 1 PublicationVSP_043850

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF510501 mRNA. Translation: AAN60790.1.
    AF510502 mRNA. Translation: AAN60791.1.
    AF510503 mRNA. Translation: AAN60792.1.
    AF508982 Genomic DNA. Translation: AAM90955.1.
    AJ304852 mRNA. Translation: CAC40984.1.
    AJ304853 mRNA. Translation: CAC40985.1.
    AJ745101 mRNA. Translation: CAG33739.1.
    AJ745102 mRNA. Translation: CAG33740.1.
    AL135747 Genomic DNA. No translation available.
    AL160191 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81019.1.
    CH471061 Genomic DNA. Translation: EAW81021.1.
    CH471061 Genomic DNA. Translation: EAW81026.1.
    BC142969 mRNA. Translation: AAI42970.1.
    X93017 Genomic DNA. No translation available.
    CCDSiCCDS35498.1. [P57103-1]
    CCDS41967.1. [P57103-4]
    CCDS45131.1. [P57103-5]
    CCDS53904.1. [P57103-6]
    CCDS9799.1. [P57103-7]
    CCDS9800.1. [P57103-2]
    RefSeqiNP_001123889.1. NM_001130417.2. [P57103-5]
    NP_150287.1. NM_033262.4. [P57103-7]
    NP_489479.1. NM_058240.3. [P57103-6]
    NP_891977.1. NM_182932.2. [P57103-2]
    NP_891981.1. NM_182936.2. [P57103-4]
    NP_892114.1. NM_183002.2. [P57103-1]
    UniGeneiHs.337696.

    Genome annotation databases

    EnsembliENST00000216568; ENSP00000216568; ENSG00000100678. [P57103-5]
    ENST00000356921; ENSP00000349392; ENSG00000100678. [P57103-2]
    ENST00000357887; ENSP00000350560; ENSG00000100678. [P57103-7]
    ENST00000381269; ENSP00000370669; ENSG00000100678. [P57103-1]
    ENST00000394330; ENSP00000377863; ENSG00000100678. [P57103-4]
    ENST00000494208; ENSP00000436332; ENSG00000100678. [P57103-3]
    ENST00000528359; ENSP00000433531; ENSG00000100678. [P57103-7]
    ENST00000534137; ENSP00000436688; ENSG00000100678. [P57103-6]
    GeneIDi6547.
    KEGGihsa:6547.
    UCSCiuc001xlu.3. human. [P57103-4]
    uc001xlv.3. human. [P57103-5]
    uc001xlw.3. human. [P57103-6]
    uc001xlx.3. human. [P57103-7]
    uc001xly.3. human. [P57103-1]
    uc001xlz.3. human. [P57103-2]

    Polymorphism databases

    DMDMi34395973.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF510501 mRNA. Translation: AAN60790.1 .
    AF510502 mRNA. Translation: AAN60791.1 .
    AF510503 mRNA. Translation: AAN60792.1 .
    AF508982 Genomic DNA. Translation: AAM90955.1 .
    AJ304852 mRNA. Translation: CAC40984.1 .
    AJ304853 mRNA. Translation: CAC40985.1 .
    AJ745101 mRNA. Translation: CAG33739.1 .
    AJ745102 mRNA. Translation: CAG33740.1 .
    AL135747 Genomic DNA. No translation available.
    AL160191 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81019.1 .
    CH471061 Genomic DNA. Translation: EAW81021.1 .
    CH471061 Genomic DNA. Translation: EAW81026.1 .
    BC142969 mRNA. Translation: AAI42970.1 .
    X93017 Genomic DNA. No translation available.
    CCDSi CCDS35498.1. [P57103-1 ]
    CCDS41967.1. [P57103-4 ]
    CCDS45131.1. [P57103-5 ]
    CCDS53904.1. [P57103-6 ]
    CCDS9799.1. [P57103-7 ]
    CCDS9800.1. [P57103-2 ]
    RefSeqi NP_001123889.1. NM_001130417.2. [P57103-5 ]
    NP_150287.1. NM_033262.4. [P57103-7 ]
    NP_489479.1. NM_058240.3. [P57103-6 ]
    NP_891977.1. NM_182932.2. [P57103-2 ]
    NP_891981.1. NM_182936.2. [P57103-4 ]
    NP_892114.1. NM_183002.2. [P57103-1 ]
    UniGenei Hs.337696.

    3D structure databases

    ProteinModelPortali P57103.
    SMRi P57103. Positions 395-681, 758-872.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000370669.

    Protein family/group databases

    TCDBi 2.A.19.3.3. the ca(2+):cation antiporter (caca) family.

    PTM databases

    PhosphoSitei P57103.

    Polymorphism databases

    DMDMi 34395973.

    Proteomic databases

    PaxDbi P57103.
    PRIDEi P57103.

    Protocols and materials databases

    DNASUi 6547.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216568 ; ENSP00000216568 ; ENSG00000100678 . [P57103-5 ]
    ENST00000356921 ; ENSP00000349392 ; ENSG00000100678 . [P57103-2 ]
    ENST00000357887 ; ENSP00000350560 ; ENSG00000100678 . [P57103-7 ]
    ENST00000381269 ; ENSP00000370669 ; ENSG00000100678 . [P57103-1 ]
    ENST00000394330 ; ENSP00000377863 ; ENSG00000100678 . [P57103-4 ]
    ENST00000494208 ; ENSP00000436332 ; ENSG00000100678 . [P57103-3 ]
    ENST00000528359 ; ENSP00000433531 ; ENSG00000100678 . [P57103-7 ]
    ENST00000534137 ; ENSP00000436688 ; ENSG00000100678 . [P57103-6 ]
    GeneIDi 6547.
    KEGGi hsa:6547.
    UCSCi uc001xlu.3. human. [P57103-4 ]
    uc001xlv.3. human. [P57103-5 ]
    uc001xlw.3. human. [P57103-6 ]
    uc001xlx.3. human. [P57103-7 ]
    uc001xly.3. human. [P57103-1 ]
    uc001xlz.3. human. [P57103-2 ]

    Organism-specific databases

    CTDi 6547.
    GeneCardsi GC14M070510.
    HGNCi HGNC:11070. SLC8A3.
    HPAi HPA001669.
    MIMi 607991. gene.
    neXtProti NX_P57103.
    PharmGKBi PA315.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241889.
    HOGENOMi HOG000266971.
    HOVERGENi HBG006441.
    InParanoidi P57103.
    KOi K05849.
    OMAi CGHGFIA.
    OrthoDBi EOG7S4X56.
    PhylomeDBi P57103.
    TreeFami TF314308.

    Enzyme and pathway databases

    Reactomei REACT_19320. Sodium/Calcium exchangers.
    REACT_23765. Reduction of cytosolic Ca++ levels.

    Miscellaneous databases

    ChiTaRSi SLC8A3. human.
    GenomeRNAii 6547.
    NextBioi 25473.
    PROi P57103.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P57103.
    Bgeei P57103.
    CleanExi HS_SLC8A3.
    Genevestigatori P57103.

    Family and domain databases

    InterProi IPR003644. Calx_beta.
    IPR004836. Na_Ca_Ex.
    IPR004837. NaCa_Exmemb.
    [Graphical view ]
    Pfami PF03160. Calx-beta. 2 hits.
    PF01699. Na_Ca_ex. 2 hits.
    [Graphical view ]
    PRINTSi PR01259. NACAEXCHNGR.
    SMARTi SM00237. Calx_beta. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00845. caca. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The human SLC8A3 gene and the tissue-specific Na+/Ca2+ exchanger 3 isoforms."
      Gabellini N., Bortoluzzi S., Danieli G.A., Carafoli E.
      Gene 298:1-7(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2; 3; 4; 7 AND 8).
    2. "Control of the Na+/Ca2+ exchanger 3 promoter by cyclic adenosine monophosphate and Ca2+ in differentiating neurons."
      Gabellini N., Bortoluzzi S., Danieli G.A., Carafoli E.
      J. Neurochem. 84:282-293(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3).
    3. "Molecular cloning and characterization of two novel truncated isoforms of human Na+/Ca2+ exchanger 3, expressed in fetal brain."
      Lindgren R.M., Zhao J., Heller S., Berglind H., Nister M.
      Gene 348:143-155(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6), TISSUE SPECIFICITY.
      Tissue: Brain.
    4. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    7. "The organization of the human gene of the sodium-calcium exchanger."
      Kraev A.S., Chumakov I.M., Carafoli E.
      Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-595.
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-612.

    Entry informationi

    Entry nameiNAC3_HUMAN
    AccessioniPrimary (citable) accession number: P57103
    Secondary accession number(s): Q5K3P6
    , Q5K3P7, Q8IUE9, Q8IUF0, Q8NFI7, Q96QG1, Q96QG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: August 29, 2003
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3