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P57103 - NAC3_HUMAN

UniProt

P57103 - NAC3_HUMAN

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Protein

Sodium/calcium exchanger 3

Gene

SLC8A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Rapidly transports Ca2+ during excitation-contraction coupling. Ca2+ is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity).By similarity

Enzyme regulationi

By intracellular calcium ions.By similarity

GO - Molecular functioni

  1. calcium:sodium antiporter activity Source: InterPro

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. calcium ion export from cell Source: Ensembl
  3. calcium ion import into cell Source: Ensembl
  4. calcium ion transport into cytosol Source: Ensembl
  5. cell communication Source: InterPro
  6. cellular response to cAMP Source: Ensembl
  7. hematopoietic progenitor cell differentiation Source: Ensembl
  8. ion transport Source: Reactome
  9. telencephalon development Source: Ensembl
  10. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Calcium, Calmodulin-binding, Sodium

Enzyme and pathway databases

ReactomeiREACT_19320. Sodium/Calcium exchangers.
REACT_23765. Reduction of cytosolic Ca++ levels.

Protein family/group databases

TCDBi2.A.19.3.3. the ca(2+):cation antiporter (caca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/calcium exchanger 3
Alternative name(s):
Na(+)/Ca(2+)-exchange protein 3
Solute carrier family 8 member 3
Gene namesi
Name:SLC8A3
Synonyms:NCX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:11070. SLC8A3.

Subcellular locationi

Membrane; Multi-pass membrane protein

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 7343ExtracellularSequence AnalysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence AnalysisAdd
BLAST
Topological domaini95 – 14753CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Topological domaini169 – 1691ExtracellularSequence Analysis
Transmembranei170 – 19021HelicalSequence AnalysisAdd
BLAST
Topological domaini191 – 20212CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence AnalysisAdd
BLAST
Topological domaini224 – 2307ExtracellularSequence Analysis
Transmembranei231 – 25121HelicalSequence AnalysisAdd
BLAST
Topological domaini252 – 726475CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei727 – 74721HelicalSequence AnalysisAdd
BLAST
Topological domaini748 – 7547ExtracellularSequence Analysis
Transmembranei755 – 77521HelicalSequence AnalysisAdd
BLAST
Topological domaini776 – 7783CytoplasmicSequence Analysis
Transmembranei779 – 79921HelicalSequence AnalysisAdd
BLAST
Topological domaini800 – 82829ExtracellularSequence AnalysisAdd
BLAST
Transmembranei829 – 84921HelicalSequence AnalysisAdd
BLAST
Topological domaini850 – 86011CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei861 – 88121HelicalSequence AnalysisAdd
BLAST
Topological domaini882 – 90322ExtracellularSequence AnalysisAdd
BLAST
Transmembranei904 – 92421HelicalSequence AnalysisAdd
BLAST
Topological domaini925 – 9273CytoplasmicSequence Analysis

GO - Cellular componenti

  1. dendritic spine Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. microtubule Source: Ensembl
  4. mitochondrion Source: Ensembl
  5. neuronal cell body Source: Ensembl
  6. plasma membrane Source: Reactome
  7. sarcolemma Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 927897Sodium/calcium exchanger 3PRO_0000019384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi823 – 8231N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP57103.
PRIDEiP57103.

PTM databases

PhosphoSiteiP57103.

Expressioni

Tissue specificityi

Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.1 Publication

Gene expression databases

BgeeiP57103.
CleanExiHS_SLC8A3.
ExpressionAtlasiP57103. baseline and differential.
GenevestigatoriP57103.

Organism-specific databases

HPAiHPA001669.

Interactioni

Protein-protein interaction databases

BioGridi112437. 8 interactions.
STRINGi9606.ENSP00000370669.

Structurei

3D structure databases

ProteinModelPortaliP57103.
SMRiP57103. Positions 395-681, 758-872.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati140 – 18041Alpha-1Add
BLAST
Domaini386 – 485100Calx-beta 1Add
BLAST
Domaini519 – 619101Calx-beta 2Add
BLAST
Repeati796 – 83237Alpha-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni253 – 27220Calmodulin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.Curated
Contains 2 Calx-beta domains.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG241889.
GeneTreeiENSGT00730000110414.
HOGENOMiHOG000266971.
HOVERGENiHBG006441.
InParanoidiP57103.
KOiK05849.
OMAiCGHGFIA.
OrthoDBiEOG7S4X56.
PhylomeDBiP57103.
TreeFamiTF314308.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR004836. Na_Ca_Ex.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: P57103-1) [UniParc]FASTAAdd to Basket

Also known as: NCX3.3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWLRLQPLT SAFLHFGLVT FVLFLNGLRA EAGGSGDVPS TGQNNESCSG 
        60         70         80         90        100
SSDCKEGVIL PIWYPENPSL GDKIARVIVY FVALIYMFLG VSIIADRFMA 
       110        120        130        140        150
SIEVITSQER EVTIKKPNGE TSTTTIRVWN ETVSNLTLMA LGSSAPEILL 
       160        170        180        190        200
SLIEVCGHGF IAGDLGPSTI VGSAAFNMFI IIGICVYVIP DGETRKIKHL 
       210        220        230        240        250
RVFFITAAWS IFAYIWLYMI LAVFSPGVVQ VWEGLLTLFF FPVCVLLAWV 
       260        270        280        290        300
ADKRLLFYKY MHKKYRTDKH RGIIIETEGD HPKGIEMDGK MMNSHFLDGN 
       310        320        330        340        350
LVPLEGKEVD ESRREMIRIL KDLKQKHPEK DLDQLVEMAN YYALSHQQKS 
       360        370        380        390        400
RAFYRIQATR MMTGAGNILK KHAAEQAKKA SSMSEVHTDE PEDFISKVFF 
       410        420        430        440        450
DPCSYQCLEN CGAVLLTVVR KGGDMSKTMY VDYKTEDGSA NAGADYEFTE 
       460        470        480        490        500
GTVVLKPGET QKEFSVGIID DDIFEEDEHF FVRLSNVRIE EEQPEEGMPP 
       510        520        530        540        550
AIFNSLPLPR AVLASPCVAT VTILDDDHAG IFTFECDTIH VSESIGVMEV 
       560        570        580        590        600
KVLRTSGARG TVIVPFRTVE GTAKGGGEDF EDTYGELEFK NDETVKTIRV 
       610        620        630        640        650
KIVDEEEYER QENFFIALGE PKWMERGISA LLLSPDVTDR KLTMEEEEAK 
       660        670        680        690        700
RIAEMGKPVL GEHPKLEVII EESYEFKTTV DKLIKKTNLA LVVGTHSWRD 
       710        720        730        740        750
QFMEAITVSA AGDEDEDESG EERLPSCFDY VMHFLTVFWK VLFACVPPTE 
       760        770        780        790        800
YCHGWACFAV SILIIGMLTA IIGDLASHFG CTIGLKDSVT AVVFVAFGTS 
       810        820        830        840        850
VPDTFASKAA ALQDVYADAS IGNVTGSNAV NVFLGIGLAW SVAAIYWALQ 
       860        870        880        890        900
GQEFHVSAGT LAFSVTLFTI FAFVCISVLL YRRRPHLGGE LGGPRGCKLA 
       910        920 
TTWLFVSLWL LYILFATLEA YCYIKGF
Length:927
Mass (Da):103,010
Last modified:August 29, 2003 - v2
Checksum:i7B43CB6A9D77615E
GO
Isoform 2 (identifier: P57103-2) [UniParc]FASTAAdd to Basket

Also known as: NCX3.2

The sequence of this isoform differs from the canonical sequence as follows:
     630-635: Missing.

Show »
Length:921
Mass (Da):102,415
Checksum:i9E7E932E8EAE13F7
GO
Isoform 4 (identifier: P57103-3) [UniParc]FASTAAdd to Basket

Also known as: NCX3.4

The sequence of this isoform differs from the canonical sequence as follows:
     596-620: KTIRVKIVDEEEYERQENFFIALGE → CDRQEADYGRRGGQEDSRDGKASIG
     621-927: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Show »
Length:620
Mass (Da):68,947
Checksum:i0FBEC381D196FD7C
GO
Isoform 5 (identifier: P57103-4) [UniParc]FASTAAdd to Basket

Also known as: NCX3-tN.1

The sequence of this isoform differs from the canonical sequence as follows:
     1-643: Missing.

Note: Expressed in fetal brain.

Show »
Length:284
Mass (Da):31,142
Checksum:i14B4A98B3DE17144
GO
Isoform 6 (identifier: P57103-5) [UniParc]FASTAAdd to Basket

Also known as: NCX3-tN.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-623: Missing.
     630-635: Missing.

Note: Expressed in fetal brain.

Show »
Length:298
Mass (Da):32,745
Checksum:i6B91455189B786D7
GO
Isoform 7 (identifier: P57103-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-638: Missing.

Show »
Length:924
Mass (Da):102,694
Checksum:iA0A556B753998A07
GO
Isoform 8 (identifier: P57103-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     599-638: RVKIVDEEEY...SALLLSPDVT → HIKVIDDEAY...SFQKALLLSP

Show »
Length:925
Mass (Da):102,804
Checksum:i0CCF8DA0881C4FDA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti612 – 6121E → Q in a breast cancer sample; somatic mutation. 1 Publication
VAR_036463

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 643643Missing in isoform 5. 1 PublicationVSP_043125Add
BLAST
Alternative sequencei1 – 623623Missing in isoform 6. 2 PublicationsVSP_043126Add
BLAST
Alternative sequencei596 – 62025KTIRV…IALGE → CDRQEADYGRRGGQEDSRDG KASIG in isoform 4. 1 PublicationVSP_008117Add
BLAST
Alternative sequencei599 – 63840RVKIV…SPDVT → HIKVIDDEAYEKNKNYFIEM MGPRMVDMSFQKALLLSP in isoform 8. 1 PublicationVSP_044502Add
BLAST
Alternative sequencei621 – 927307Missing in isoform 4. 1 PublicationVSP_008118Add
BLAST
Alternative sequencei630 – 6356Missing in isoform 2 and isoform 6. 3 PublicationsVSP_008116
Alternative sequencei636 – 6383Missing in isoform 7. 1 PublicationVSP_043850

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510501 mRNA. Translation: AAN60790.1.
AF510502 mRNA. Translation: AAN60791.1.
AF510503 mRNA. Translation: AAN60792.1.
AF508982 Genomic DNA. Translation: AAM90955.1.
AJ304852 mRNA. Translation: CAC40984.1.
AJ304853 mRNA. Translation: CAC40985.1.
AJ745101 mRNA. Translation: CAG33739.1.
AJ745102 mRNA. Translation: CAG33740.1.
AL135747 Genomic DNA. No translation available.
AL160191 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81019.1.
CH471061 Genomic DNA. Translation: EAW81021.1.
CH471061 Genomic DNA. Translation: EAW81026.1.
BC142969 mRNA. Translation: AAI42970.1.
X93017 Genomic DNA. No translation available.
CCDSiCCDS35498.1. [P57103-1]
CCDS41967.1. [P57103-4]
CCDS45131.1. [P57103-5]
CCDS53904.1. [P57103-6]
CCDS9799.1. [P57103-7]
CCDS9800.1. [P57103-2]
RefSeqiNP_001123889.1. NM_001130417.2. [P57103-5]
NP_150287.1. NM_033262.4. [P57103-7]
NP_489479.1. NM_058240.3. [P57103-6]
NP_891977.1. NM_182932.2. [P57103-2]
NP_891981.1. NM_182936.2. [P57103-4]
NP_892114.1. NM_183002.2. [P57103-1]
UniGeneiHs.337696.

Genome annotation databases

EnsembliENST00000216568; ENSP00000216568; ENSG00000100678. [P57103-5]
ENST00000356921; ENSP00000349392; ENSG00000100678. [P57103-2]
ENST00000357887; ENSP00000350560; ENSG00000100678. [P57103-7]
ENST00000381269; ENSP00000370669; ENSG00000100678. [P57103-1]
ENST00000394330; ENSP00000377863; ENSG00000100678. [P57103-4]
ENST00000494208; ENSP00000436332; ENSG00000100678. [P57103-3]
ENST00000528359; ENSP00000433531; ENSG00000100678. [P57103-7]
ENST00000534137; ENSP00000436688; ENSG00000100678. [P57103-6]
GeneIDi6547.
KEGGihsa:6547.
UCSCiuc001xlu.3. human. [P57103-4]
uc001xlv.3. human. [P57103-5]
uc001xlw.3. human. [P57103-6]
uc001xlx.3. human. [P57103-7]
uc001xly.3. human. [P57103-1]
uc001xlz.3. human. [P57103-2]

Polymorphism databases

DMDMi34395973.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510501 mRNA. Translation: AAN60790.1.
AF510502 mRNA. Translation: AAN60791.1.
AF510503 mRNA. Translation: AAN60792.1.
AF508982 Genomic DNA. Translation: AAM90955.1.
AJ304852 mRNA. Translation: CAC40984.1.
AJ304853 mRNA. Translation: CAC40985.1.
AJ745101 mRNA. Translation: CAG33739.1.
AJ745102 mRNA. Translation: CAG33740.1.
AL135747 Genomic DNA. No translation available.
AL160191 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81019.1.
CH471061 Genomic DNA. Translation: EAW81021.1.
CH471061 Genomic DNA. Translation: EAW81026.1.
BC142969 mRNA. Translation: AAI42970.1.
X93017 Genomic DNA. No translation available.
CCDSiCCDS35498.1. [P57103-1]
CCDS41967.1. [P57103-4]
CCDS45131.1. [P57103-5]
CCDS53904.1. [P57103-6]
CCDS9799.1. [P57103-7]
CCDS9800.1. [P57103-2]
RefSeqiNP_001123889.1. NM_001130417.2. [P57103-5]
NP_150287.1. NM_033262.4. [P57103-7]
NP_489479.1. NM_058240.3. [P57103-6]
NP_891977.1. NM_182932.2. [P57103-2]
NP_891981.1. NM_182936.2. [P57103-4]
NP_892114.1. NM_183002.2. [P57103-1]
UniGeneiHs.337696.

3D structure databases

ProteinModelPortaliP57103.
SMRiP57103. Positions 395-681, 758-872.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112437. 8 interactions.
STRINGi9606.ENSP00000370669.

Protein family/group databases

TCDBi2.A.19.3.3. the ca(2+):cation antiporter (caca) family.

PTM databases

PhosphoSiteiP57103.

Polymorphism databases

DMDMi34395973.

Proteomic databases

PaxDbiP57103.
PRIDEiP57103.

Protocols and materials databases

DNASUi6547.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216568; ENSP00000216568; ENSG00000100678. [P57103-5]
ENST00000356921; ENSP00000349392; ENSG00000100678. [P57103-2]
ENST00000357887; ENSP00000350560; ENSG00000100678. [P57103-7]
ENST00000381269; ENSP00000370669; ENSG00000100678. [P57103-1]
ENST00000394330; ENSP00000377863; ENSG00000100678. [P57103-4]
ENST00000494208; ENSP00000436332; ENSG00000100678. [P57103-3]
ENST00000528359; ENSP00000433531; ENSG00000100678. [P57103-7]
ENST00000534137; ENSP00000436688; ENSG00000100678. [P57103-6]
GeneIDi6547.
KEGGihsa:6547.
UCSCiuc001xlu.3. human. [P57103-4]
uc001xlv.3. human. [P57103-5]
uc001xlw.3. human. [P57103-6]
uc001xlx.3. human. [P57103-7]
uc001xly.3. human. [P57103-1]
uc001xlz.3. human. [P57103-2]

Organism-specific databases

CTDi6547.
GeneCardsiGC14M070510.
HGNCiHGNC:11070. SLC8A3.
HPAiHPA001669.
MIMi607991. gene.
neXtProtiNX_P57103.
PharmGKBiPA315.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG241889.
GeneTreeiENSGT00730000110414.
HOGENOMiHOG000266971.
HOVERGENiHBG006441.
InParanoidiP57103.
KOiK05849.
OMAiCGHGFIA.
OrthoDBiEOG7S4X56.
PhylomeDBiP57103.
TreeFamiTF314308.

Enzyme and pathway databases

ReactomeiREACT_19320. Sodium/Calcium exchangers.
REACT_23765. Reduction of cytosolic Ca++ levels.

Miscellaneous databases

ChiTaRSiSLC8A3. human.
GenomeRNAii6547.
NextBioi25473.
PROiP57103.
SOURCEiSearch...

Gene expression databases

BgeeiP57103.
CleanExiHS_SLC8A3.
ExpressionAtlasiP57103. baseline and differential.
GenevestigatoriP57103.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR004836. Na_Ca_Ex.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human SLC8A3 gene and the tissue-specific Na+/Ca2+ exchanger 3 isoforms."
    Gabellini N., Bortoluzzi S., Danieli G.A., Carafoli E.
    Gene 298:1-7(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2; 3; 4; 7 AND 8).
  2. "Control of the Na+/Ca2+ exchanger 3 promoter by cyclic adenosine monophosphate and Ca2+ in differentiating neurons."
    Gabellini N., Bortoluzzi S., Danieli G.A., Carafoli E.
    J. Neurochem. 84:282-293(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3).
  3. "Molecular cloning and characterization of two novel truncated isoforms of human Na+/Ca2+ exchanger 3, expressed in fetal brain."
    Lindgren R.M., Zhao J., Heller S., Berglind H., Nister M.
    Gene 348:143-155(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6), TISSUE SPECIFICITY.
    Tissue: Brain.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
  7. "The organization of the human gene of the sodium-calcium exchanger."
    Kraev A.S., Chumakov I.M., Carafoli E.
    Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-595.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-612.

Entry informationi

Entry nameiNAC3_HUMAN
AccessioniPrimary (citable) accession number: P57103
Secondary accession number(s): Q5K3P6
, Q5K3P7, Q8IUE9, Q8IUF0, Q8NFI7, Q96QG1, Q96QG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 29, 2003
Last modified: January 7, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.