Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P57097

- MERTK_RAT

UniProt

P57097 - MERTK_RAT

Protein

Tyrosine-protein kinase Mer

Gene

Mertk

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei610 – 6101ATPPROSITE-ProRule annotation
    Active sitei718 – 7181Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi588 – 5969ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. transmembrane receptor protein tyrosine kinase activity Source: RGD

    GO - Biological processi

    1. apoptotic cell clearance Source: Ensembl
    2. natural killer cell differentiation Source: Ensembl
    3. negative regulation of lymphocyte activation Source: Ensembl
    4. peptidyl-tyrosine phosphorylation Source: GOC
    5. phagocytosis Source: RGD
    6. platelet activation Source: Ensembl
    7. positive regulation of phagocytosis Source: Ensembl
    8. protein kinase B signaling Source: Ensembl
    9. protein phosphorylation Source: RGD
    10. retina development in camera-type eye Source: Ensembl
    11. secretion by cell Source: Ensembl
    12. spermatogenesis Source: Ensembl
    13. substrate adhesion-dependent cell spreading Source: Ensembl
    14. vagina development Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.1. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase Mer (EC:2.7.10.1)
    Alternative name(s):
    Proto-oncogene c-Mer
    Receptor tyrosine kinase MerTK
    Gene namesi
    Name:Mertk
    Synonyms:Mer
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi69283. Mertk.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. photoreceptor outer segment Source: RGD
    5. rhabdomere Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Mertk are the cause of retinal dystrophy (rdy) in the royal college of surgeons (RCS) rats.

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 994976Tyrosine-protein kinase MerPRO_0000024445Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi109 ↔ 170PROSITE-ProRule annotation
    Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi213 ↔ 257PROSITE-ProRule annotation
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi384 – 3841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
    Modified residuei538 – 5381PhosphoserineBy similarity
    Modified residuei744 – 7441Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei748 – 7481Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei749 – 7491Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei867 – 8671Phosphotyrosine; by autocatalysisBy similarity

    Post-translational modificationi

    Autophosphorylated on Tyr-744, Tyr-748 and Tyr-749 in the activation loop allowing full activity. Autophosphorylated on Tyr-867 leading to recruitment of downstream partners of the signaling cascade such as PLCG2 By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP57097.
    PRIDEiP57097.

    PTM databases

    PhosphoSiteiP57097.

    Expressioni

    Gene expression databases

    GenevestigatoriP57097.

    Interactioni

    Subunit structurei

    Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6. Interacts with VAV1 in a phosphotyrosine-independent manner By similarity.By similarity

    Protein-protein interaction databases

    BioGridi249230. 1 interaction.
    STRINGi10116.ENSRNOP00000023419.

    Structurei

    3D structure databases

    ProteinModelPortaliP57097.
    SMRiP57097. Positions 361-487, 570-858.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 497479ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini519 – 994476CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei498 – 51821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini86 – 18196Ig-like C2-type 1Add
    BLAST
    Domaini192 – 26877Ig-like C2-type 2Add
    BLAST
    Domaini281 – 37696Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini381 – 47898Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini582 – 852271Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.PROSITE-ProRule annotation
    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00720000108377.
    HOGENOMiHOG000231685.
    HOVERGENiHBG006346.
    InParanoidiP57097.
    KOiK05117.
    OMAiNEIGWSA.
    OrthoDBiEOG77DJ5C.
    PhylomeDBiP57097.
    TreeFamiTF317402.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF00041. fn3. 1 hit.
    PF07679. I-set. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00060. FN3. 2 hits.
    SM00409. IG. 2 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50853. FN3. 2 hits.
    PS50835. IG_LIKE. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P57097-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLAPLLLGL LLLSALWNGG TAEKEEEIKP DQPFSGPLPG SLPADHRPFF    50
    APHSSGDQLS PSQTGRSHPA HTATPQMTSA ASNLLPPVAF KNTIGRIVLS 100
    EHKSVKFNCS INIPNVYQET AGISWWKDGK ELLGAHHSIT QFYPDEEGVS 150
    IIALFSITSV QRSDNGSYIC KMKVNDREVV SDPIYVEVQG LPYFTKQPES 200
    VNVTRNTAFN LTCQAVGPPE PVNIFWVQNS SRVNENPERS PSVLTVAGLT 250
    ETAVFSCEAH NDKGLTVSKG VQINIKVIPS PPTEVHILNS TAHSILVSWV 300
    PGFDGYSPLQ NCSIQVKEAD QLSNGSVMVF NTSASPHLYE VQQLQALANY 350
    SVTVSCRNEI GWSAVSPWIL ASTTEGAPAV APLNITVFLN ESSNNLEIRW 400
    TKPPIKRQDG ELVGYRISHV WESAGTSKEL SEEVSQNGSW AQVPVQMHNA 450
    TCTVRIAVIT KGGIGPFSEP VDVAIPEHSR VDYAPSSTPA PGNTESMLII 500
    LGCFCGFVLM GLILYLSLAI KRRVQETKFG GAFSEEDSQL VVNYRAKKSF 550
    CRRAIELTLQ SLGVSEELQN KLEDVVVDRN LLILGKVLGE GEFGSVMEGN 600
    LKQEDGTSQK VAVKTMKLDN FSLREIEEFL SEAACMKDFN HPNVIRLLGV 650
    CIELSSQGIP KPMVILPFMK YGDLHTFLLY SRIESVPKSI PLQTLLKFMV 700
    DIAQGMEYLS SRNFLHRDLA ARNCMLRDDM TVCVADFGLS KKIYSGDYYR 750
    QGRIAKMPVK WIAIESLADR VYTSKSDVWA FGVTMWEIAT RGMTPYPGVQ 800
    NHEMYDYLLH GHRLKQPEDC LDDLYEIMYS CWSADPLDRP TFSVLRLQLE 850
    KLSESLPDAQ DKESIIYINT QLLESCEGLA NRSSLAGLDM NIDPDSIIAS 900
    CTAGAAVSVV MAEVHENNLH EERYILNGGN EEWEDVASTP FATVTAGKDG 950
    VLPEDRLTKN GISWSHHSTL PLGSPSPDEL LFADDSSGDS EVLM 994
    Length:994
    Mass (Da):109,423
    Last modified:December 1, 2000 - v1
    Checksum:i339717117FB4242B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF208235 mRNA. Translation: AAF44060.1.
    PIRiPT0194.
    RefSeqiNP_075232.1. NM_022943.1.
    UniGeneiRn.48789.

    Genome annotation databases

    EnsembliENSRNOT00000023419; ENSRNOP00000023419; ENSRNOG00000017319.
    GeneIDi65037.
    KEGGirno:65037.
    UCSCiRGD:69283. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF208235 mRNA. Translation: AAF44060.1 .
    PIRi PT0194.
    RefSeqi NP_075232.1. NM_022943.1.
    UniGenei Rn.48789.

    3D structure databases

    ProteinModelPortali P57097.
    SMRi P57097. Positions 361-487, 570-858.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249230. 1 interaction.
    STRINGi 10116.ENSRNOP00000023419.

    PTM databases

    PhosphoSitei P57097.

    Proteomic databases

    PaxDbi P57097.
    PRIDEi P57097.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000023419 ; ENSRNOP00000023419 ; ENSRNOG00000017319 .
    GeneIDi 65037.
    KEGGi rno:65037.
    UCSCi RGD:69283. rat.

    Organism-specific databases

    CTDi 10461.
    RGDi 69283. Mertk.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00720000108377.
    HOGENOMi HOG000231685.
    HOVERGENi HBG006346.
    InParanoidi P57097.
    KOi K05117.
    OMAi NEIGWSA.
    OrthoDBi EOG77DJ5C.
    PhylomeDBi P57097.
    TreeFami TF317402.

    Enzyme and pathway databases

    BRENDAi 2.7.10.1. 5301.

    Miscellaneous databases

    NextBioi 613844.
    PROi P57097.

    Gene expression databases

    Genevestigatori P57097.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00041. fn3. 1 hit.
    PF07679. I-set. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00060. FN3. 2 hits.
    SM00409. IG. 2 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50853. FN3. 2 hits.
    PS50835. IG_LIKE. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat."
      D'Cruz P.M., Yasumura D., Weir J., Matthes M.T., Abderrahim H., LaVail M.M., Vollrath D.
      Hum. Mol. Genet. 9:645-651(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: RCS.

    Entry informationi

    Entry nameiMERTK_RAT
    AccessioniPrimary (citable) accession number: P57097
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3