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P57097

- MERTK_RAT

UniProt

P57097 - MERTK_RAT

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Protein

Tyrosine-protein kinase Mer

Gene

Mertk

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei610 – 6101ATPPROSITE-ProRule annotation
Active sitei718 – 7181Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi588 – 5969ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. transmembrane receptor protein tyrosine kinase activity Source: RGD

GO - Biological processi

  1. apoptotic cell clearance Source: Ensembl
  2. natural killer cell differentiation Source: Ensembl
  3. negative regulation of lymphocyte activation Source: Ensembl
  4. peptidyl-tyrosine phosphorylation Source: GOC
  5. phagocytosis Source: RGD
  6. platelet activation Source: Ensembl
  7. positive regulation of phagocytosis Source: Ensembl
  8. protein kinase B signaling Source: Ensembl
  9. protein phosphorylation Source: RGD
  10. retina development in camera-type eye Source: Ensembl
  11. secretion by cell Source: Ensembl
  12. spermatogenesis Source: Ensembl
  13. substrate adhesion-dependent cell spreading Source: Ensembl
  14. vagina development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Mer (EC:2.7.10.1)
Alternative name(s):
Proto-oncogene c-Mer
Receptor tyrosine kinase MerTK
Gene namesi
Name:Mertk
Synonyms:Mer
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi69283. Mertk.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. photoreceptor outer segment Source: RGD
  5. rhabdomere Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Mertk are the cause of retinal dystrophy (rdy) in the royal college of surgeons (RCS) rats.

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 994976Tyrosine-protein kinase MerPRO_0000024445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi109 ↔ 170PROSITE-ProRule annotation
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi213 ↔ 257PROSITE-ProRule annotation
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi384 – 3841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
Modified residuei538 – 5381PhosphoserineBy similarity
Modified residuei744 – 7441Phosphotyrosine; by autocatalysisBy similarity
Modified residuei748 – 7481Phosphotyrosine; by autocatalysisBy similarity
Modified residuei749 – 7491Phosphotyrosine; by autocatalysisBy similarity
Modified residuei867 – 8671Phosphotyrosine; by autocatalysisBy similarity

Post-translational modificationi

Autophosphorylated on Tyr-744, Tyr-748 and Tyr-749 in the activation loop allowing full activity. Autophosphorylated on Tyr-867 leading to recruitment of downstream partners of the signaling cascade such as PLCG2 (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP57097.
PRIDEiP57097.

PTM databases

PhosphoSiteiP57097.

Expressioni

Gene expression databases

ExpressionAtlasiP57097. baseline.
GenevestigatoriP57097.

Interactioni

Subunit structurei

Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6. Interacts with VAV1 in a phosphotyrosine-independent manner (By similarity).By similarity

Protein-protein interaction databases

BioGridi249230. 1 interaction.
STRINGi10116.ENSRNOP00000023419.

Structurei

3D structure databases

ProteinModelPortaliP57097.
SMRiP57097. Positions 361-487, 570-858.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 497479ExtracellularSequence AnalysisAdd
BLAST
Topological domaini519 – 994476CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei498 – 51821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 18196Ig-like C2-type 1Add
BLAST
Domaini192 – 26877Ig-like C2-type 2Add
BLAST
Domaini281 – 37696Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini381 – 47898Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini582 – 852271Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.PROSITE-ProRule annotation
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119065.
HOGENOMiHOG000231685.
HOVERGENiHBG006346.
InParanoidiP57097.
KOiK05117.
OMAiNEIGWSA.
OrthoDBiEOG77DJ5C.
PhylomeDBiP57097.
TreeFamiTF317402.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57097-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MVLAPLLLGL LLLSALWNGG TAEKEEEIKP DQPFSGPLPG SLPADHRPFF
60 70 80 90 100
APHSSGDQLS PSQTGRSHPA HTATPQMTSA ASNLLPPVAF KNTIGRIVLS
110 120 130 140 150
EHKSVKFNCS INIPNVYQET AGISWWKDGK ELLGAHHSIT QFYPDEEGVS
160 170 180 190 200
IIALFSITSV QRSDNGSYIC KMKVNDREVV SDPIYVEVQG LPYFTKQPES
210 220 230 240 250
VNVTRNTAFN LTCQAVGPPE PVNIFWVQNS SRVNENPERS PSVLTVAGLT
260 270 280 290 300
ETAVFSCEAH NDKGLTVSKG VQINIKVIPS PPTEVHILNS TAHSILVSWV
310 320 330 340 350
PGFDGYSPLQ NCSIQVKEAD QLSNGSVMVF NTSASPHLYE VQQLQALANY
360 370 380 390 400
SVTVSCRNEI GWSAVSPWIL ASTTEGAPAV APLNITVFLN ESSNNLEIRW
410 420 430 440 450
TKPPIKRQDG ELVGYRISHV WESAGTSKEL SEEVSQNGSW AQVPVQMHNA
460 470 480 490 500
TCTVRIAVIT KGGIGPFSEP VDVAIPEHSR VDYAPSSTPA PGNTESMLII
510 520 530 540 550
LGCFCGFVLM GLILYLSLAI KRRVQETKFG GAFSEEDSQL VVNYRAKKSF
560 570 580 590 600
CRRAIELTLQ SLGVSEELQN KLEDVVVDRN LLILGKVLGE GEFGSVMEGN
610 620 630 640 650
LKQEDGTSQK VAVKTMKLDN FSLREIEEFL SEAACMKDFN HPNVIRLLGV
660 670 680 690 700
CIELSSQGIP KPMVILPFMK YGDLHTFLLY SRIESVPKSI PLQTLLKFMV
710 720 730 740 750
DIAQGMEYLS SRNFLHRDLA ARNCMLRDDM TVCVADFGLS KKIYSGDYYR
760 770 780 790 800
QGRIAKMPVK WIAIESLADR VYTSKSDVWA FGVTMWEIAT RGMTPYPGVQ
810 820 830 840 850
NHEMYDYLLH GHRLKQPEDC LDDLYEIMYS CWSADPLDRP TFSVLRLQLE
860 870 880 890 900
KLSESLPDAQ DKESIIYINT QLLESCEGLA NRSSLAGLDM NIDPDSIIAS
910 920 930 940 950
CTAGAAVSVV MAEVHENNLH EERYILNGGN EEWEDVASTP FATVTAGKDG
960 970 980 990
VLPEDRLTKN GISWSHHSTL PLGSPSPDEL LFADDSSGDS EVLM
Length:994
Mass (Da):109,423
Last modified:December 1, 2000 - v1
Checksum:i339717117FB4242B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF208235 mRNA. Translation: AAF44060.1.
PIRiPT0194.
RefSeqiNP_075232.1. NM_022943.1.
UniGeneiRn.48789.

Genome annotation databases

EnsembliENSRNOT00000023419; ENSRNOP00000023419; ENSRNOG00000017319.
GeneIDi65037.
KEGGirno:65037.
UCSCiRGD:69283. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF208235 mRNA. Translation: AAF44060.1 .
PIRi PT0194.
RefSeqi NP_075232.1. NM_022943.1.
UniGenei Rn.48789.

3D structure databases

ProteinModelPortali P57097.
SMRi P57097. Positions 361-487, 570-858.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249230. 1 interaction.
STRINGi 10116.ENSRNOP00000023419.

PTM databases

PhosphoSitei P57097.

Proteomic databases

PaxDbi P57097.
PRIDEi P57097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000023419 ; ENSRNOP00000023419 ; ENSRNOG00000017319 .
GeneIDi 65037.
KEGGi rno:65037.
UCSCi RGD:69283. rat.

Organism-specific databases

CTDi 10461.
RGDi 69283. Mertk.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119065.
HOGENOMi HOG000231685.
HOVERGENi HBG006346.
InParanoidi P57097.
KOi K05117.
OMAi NEIGWSA.
OrthoDBi EOG77DJ5C.
PhylomeDBi P57097.
TreeFami TF317402.

Enzyme and pathway databases

BRENDAi 2.7.10.1. 5301.

Miscellaneous databases

NextBioi 613844.
PROi P57097.

Gene expression databases

ExpressionAtlasi P57097. baseline.
Genevestigatori P57097.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SMARTi SM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat."
    D'Cruz P.M., Yasumura D., Weir J., Matthes M.T., Abderrahim H., LaVail M.M., Vollrath D.
    Hum. Mol. Genet. 9:645-651(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: RCS.

Entry informationi

Entry nameiMERTK_RAT
AccessioniPrimary (citable) accession number: P57097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3