Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P57095 (AXIN2_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Axin-2
Alternative name(s):
Axis inhibition protein 2
Gene names
Name:axin2
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length812 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B By similarity.

Subcellular location

Cytoplasm By similarity.

Post-translational modification

Probably phosphorylated by GSK3B and dephosphorylated by PP2A By similarity.

Sequence similarities

Contains 1 DIX domain.

Contains 1 RGS domain.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentCytoplasm
   Molecular functionDevelopmental protein
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway involved in somitogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell death

Inferred from Biological aspect of Ancestor. Source: RefGenome

cellular response to organic cyclic compound

Inferred from Biological aspect of Ancestor. Source: RefGenome

dorsal/ventral axis specification

Inferred from Biological aspect of Ancestor. Source: RefGenome

dorsal/ventral pattern formation

Inferred from direct assay Ref.1. Source: ZFIN

intramembranous ossification

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of canonical Wnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of osteoblast differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of GTPase activity

Inferred from Biological aspect of Ancestor. Source: GOC

regulation of catenin import into nucleus

Inferred from Biological aspect of Ancestor. Source: RefGenome

termination of G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcell cortex

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasmic membrane-bounded vesicle

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasmic microtubule

Inferred from Biological aspect of Ancestor. Source: RefGenome

plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

postsynaptic density

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionGTPase activator activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

armadillo repeat domain binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

beta-catenin binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein kinase binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

signal transducer activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 812812Axin-2
PRO_0000220898

Regions

Domain84 – 203120RGS
Domain730 – 81283DIX
Region329 – 41587Interaction with GSK3B By similarity
Region415 – 46753Interaction with beta-catenin By similarity
Compositional bias412 – 4198Poly-Ser

Sequences

Sequence LengthMass (Da)Tools
P57095 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 46E5ADA6DE2240CC

FASTA81291,497
        10         20         30         40         50         60 
MNRTLTDPMV SSFREDDPRP PVPGEEGETT CHHPSKLAMM RPKDPVKTIM ADLRCSTARR 

        70         80         90        100        110        120 
DEDGLGEPEG SASPDSPLAR WTKSLHFLLG DQDGAQLFRA YLEREKCVDT LDFWFACNGF 

       130        140        150        160        170        180 
RQMDLKDTKT HRVAKAIYKR YIENNSIVAK QLKPATKTFI RDNIKRQQID SAMFDQAQME 

       190        200        210        220        230        240 
IQTAMEENAY QMFLTSDIYL EYVRTGCENP SHVNPNGLGG LKLVCGYLPT LNEEEEWSCN 

       250        260        270        280        290        300 
DFKAKALATV VGLSAKTLRS PPLRAVEALE KGYRSYRRSD PGNPNRFTSG YSFAPATSAN 

       310        320        330        340        350        360 
DSEVSSDALT DDSMSMTDSS VDAIPPYKLG SKKQLQREMQ RNMRMNGQVS LPPFPRTRRP 

       370        380        390        400        410        420 
PKEMTPVEPA AFAAQLIARL ERLKREQETM SSLEERLQQI QEEEERDESE MSSSSASHSL 

       430        440        450        460        470        480 
PLLPPGTCEE DPQAILDEHL SRVLKTPGCQ SPGLLRHSPR SRSPEQRPLP RGGLSTRSQS 

       490        500        510        520        530        540 
SSMNGYVPAK TFISRQSTKH IHHHYIHHHA GPKSKEQIEV EATQRVQCLC HGTSECCTAP 

       550        560        570        580        590        600 
YIRSRSLGRD QCASPAEVAL GHSSTLSKRL CKSGEEVNME GLENSLLQLP ADSTDRSQNV 

       610        620        630        640        650        660 
WQWILESDRQ TKHKPHSTQN VKKSHSLEPT RTHTWGGGGS SGHLRAHQPA HPFVQDPAMP 

       670        680        690        700        710        720 
PLPPPNTLAQ LEEARRRLEE VSKPSKQRHS TSSLQRDKSH PVPVQNGSSA FPMDERKDPK 

       730        740        750        760        770        780 
KMSGCHSSLG SETVVTYFFC GEEIPYRRMM KTHSLTLGHF KEQLRKKGNY RYFFKRASDE 

       790        800        810 
FECGAVFEEV WDDCTVLPMY EGKILGKVDR MD 

« Hide

References

[1]"Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish."
Shimizu T., Yamanaka Y., Ryu S.-L., Hashimoto H., Yabe T., Hirata T., Bae Y.-K., Hibi M., Hirano T.
Mech. Dev. 91:293-303(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of zebrafish axin2."
Pogoda H.-M., Meyer D.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Functional Analysis of Zebrafish axin2 during embryogenesis."
Tsai J.N., Chang W.C.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB032263 mRNA. Translation: BAA92440.1.
AF387812 mRNA. Translation: AAK70877.1.
AJ854187 mRNA. Translation: CAH69531.1.
RefSeqNP_571636.1. NM_131561.1.
UniGeneDr.3727.

3D structure databases

ProteinModelPortalP57095.
SMRP57095. Positions 731-812.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000020575; ENSDARP00000003845; ENSDARG00000014147.
GeneID58080.
KEGGdre:58080.

Organism-specific databases

CTD8313.
ZFINZDB-GENE-000403-2. axin2.

Phylogenomic databases

eggNOGNOG238205.
GeneTreeENSGT00390000010011.
HOVERGENHBG004324.
InParanoidP57095.
KOK04385.
OMAERDESEM.
OrthoDBEOG79PJQ0.
PhylomeDBP57095.
TreeFamTF315454.

Gene expression databases

BgeeP57095.

Family and domain databases

Gene3D1.10.196.10. 2 hits.
InterProIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20892339.
PROP57095.

Entry information

Entry nameAXIN2_DANRE
AccessionPrimary (citable) accession number: P57095
Secondary accession number(s): Q335M5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: June 11, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families