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P57095

- AXIN2_DANRE

UniProt

P57095 - AXIN2_DANRE

Protein

Axin-2

Gene

axin2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B By similarity.By similarity

    GO - Molecular functioni

    1. armadillo repeat domain binding Source: RefGenome
    2. beta-catenin binding Source: RefGenome
    3. GTPase activator activity Source: RefGenome
    4. protein kinase binding Source: RefGenome
    5. signal transducer activity Source: InterPro

    GO - Biological processi

    1. cell death Source: RefGenome
    2. cellular response to organic cyclic compound Source: RefGenome
    3. dorsal/ventral axis specification Source: RefGenome
    4. dorsal/ventral pattern formation Source: ZFIN
    5. intramembranous ossification Source: RefGenome
    6. negative regulation of canonical Wnt signaling pathway Source: RefGenome
    7. negative regulation of osteoblast differentiation Source: RefGenome
    8. positive regulation of GTPase activity Source: GOC
    9. regulation of catenin import into nucleus Source: RefGenome
    10. termination of G-protein coupled receptor signaling pathway Source: InterPro
    11. Wnt signaling pathway involved in somitogenesis Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_206533. degradation of AXIN.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Axin-2
    Alternative name(s):
    Axis inhibition protein 2
    Gene namesi
    Name:axin2
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 3

    Organism-specific databases

    ZFINiZDB-GENE-000403-2. axin2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cell cortex Source: RefGenome
    2. cytoplasmic membrane-bounded vesicle Source: RefGenome
    3. cytoplasmic microtubule Source: RefGenome
    4. plasma membrane Source: RefGenome
    5. postsynaptic density Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 812812Axin-2PRO_0000220898Add
    BLAST

    Post-translational modificationi

    Probably phosphorylated by GSK3B and dephosphorylated by PP2A.By similarity

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Gene expression databases

    BgeeiP57095.

    Structurei

    3D structure databases

    ProteinModelPortaliP57095.
    SMRiP57095. Positions 731-812.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini84 – 203120RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini730 – 81283DIXPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni329 – 41587Interaction with GSK3BBy similarityAdd
    BLAST
    Regioni415 – 46753Interaction with beta-cateninBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi412 – 4198Poly-Ser

    Sequence similaritiesi

    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG238205.
    GeneTreeiENSGT00390000010011.
    HOVERGENiHBG004324.
    InParanoidiP57095.
    KOiK04385.
    OMAiERDESEM.
    OrthoDBiEOG79PJQ0.
    PhylomeDBiP57095.
    TreeFamiTF315454.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57095-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRTLTDPMV SSFREDDPRP PVPGEEGETT CHHPSKLAMM RPKDPVKTIM    50
    ADLRCSTARR DEDGLGEPEG SASPDSPLAR WTKSLHFLLG DQDGAQLFRA 100
    YLEREKCVDT LDFWFACNGF RQMDLKDTKT HRVAKAIYKR YIENNSIVAK 150
    QLKPATKTFI RDNIKRQQID SAMFDQAQME IQTAMEENAY QMFLTSDIYL 200
    EYVRTGCENP SHVNPNGLGG LKLVCGYLPT LNEEEEWSCN DFKAKALATV 250
    VGLSAKTLRS PPLRAVEALE KGYRSYRRSD PGNPNRFTSG YSFAPATSAN 300
    DSEVSSDALT DDSMSMTDSS VDAIPPYKLG SKKQLQREMQ RNMRMNGQVS 350
    LPPFPRTRRP PKEMTPVEPA AFAAQLIARL ERLKREQETM SSLEERLQQI 400
    QEEEERDESE MSSSSASHSL PLLPPGTCEE DPQAILDEHL SRVLKTPGCQ 450
    SPGLLRHSPR SRSPEQRPLP RGGLSTRSQS SSMNGYVPAK TFISRQSTKH 500
    IHHHYIHHHA GPKSKEQIEV EATQRVQCLC HGTSECCTAP YIRSRSLGRD 550
    QCASPAEVAL GHSSTLSKRL CKSGEEVNME GLENSLLQLP ADSTDRSQNV 600
    WQWILESDRQ TKHKPHSTQN VKKSHSLEPT RTHTWGGGGS SGHLRAHQPA 650
    HPFVQDPAMP PLPPPNTLAQ LEEARRRLEE VSKPSKQRHS TSSLQRDKSH 700
    PVPVQNGSSA FPMDERKDPK KMSGCHSSLG SETVVTYFFC GEEIPYRRMM 750
    KTHSLTLGHF KEQLRKKGNY RYFFKRASDE FECGAVFEEV WDDCTVLPMY 800
    EGKILGKVDR MD 812
    Length:812
    Mass (Da):91,497
    Last modified:December 1, 2000 - v1
    Checksum:i46E5ADA6DE2240CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032263 mRNA. Translation: BAA92440.1.
    AF387812 mRNA. Translation: AAK70877.1.
    AJ854187 mRNA. Translation: CAH69531.1.
    RefSeqiNP_571636.1. NM_131561.1.
    UniGeneiDr.3727.

    Genome annotation databases

    EnsembliENSDART00000020575; ENSDARP00000003845; ENSDARG00000014147.
    GeneIDi58080.
    KEGGidre:58080.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032263 mRNA. Translation: BAA92440.1 .
    AF387812 mRNA. Translation: AAK70877.1 .
    AJ854187 mRNA. Translation: CAH69531.1 .
    RefSeqi NP_571636.1. NM_131561.1.
    UniGenei Dr.3727.

    3D structure databases

    ProteinModelPortali P57095.
    SMRi P57095. Positions 731-812.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000020575 ; ENSDARP00000003845 ; ENSDARG00000014147 .
    GeneIDi 58080.
    KEGGi dre:58080.

    Organism-specific databases

    CTDi 8313.
    ZFINi ZDB-GENE-000403-2. axin2.

    Phylogenomic databases

    eggNOGi NOG238205.
    GeneTreei ENSGT00390000010011.
    HOVERGENi HBG004324.
    InParanoidi P57095.
    KOi K04385.
    OMAi ERDESEM.
    OrthoDBi EOG79PJQ0.
    PhylomeDBi P57095.
    TreeFami TF315454.

    Enzyme and pathway databases

    Reactomei REACT_206533. degradation of AXIN.

    Miscellaneous databases

    NextBioi 20892339.
    PROi P57095.

    Gene expression databases

    Bgeei P57095.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish."
      Shimizu T., Yamanaka Y., Ryu S.-L., Hashimoto H., Yabe T., Hirata T., Bae Y.-K., Hibi M., Hirano T.
      Mech. Dev. 91:293-303(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of zebrafish axin2."
      Pogoda H.-M., Meyer D.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Functional Analysis of Zebrafish axin2 during embryogenesis."
      Tsai J.N., Chang W.C.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiAXIN2_DANRE
    AccessioniPrimary (citable) accession number: P57095
    Secondary accession number(s): Q335M5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3