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P57095

- AXIN2_DANRE

UniProt

P57095 - AXIN2_DANRE

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Protein

Axin-2

Gene

axin2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).By similarity

GO - Molecular functioni

  1. armadillo repeat domain binding Source: RefGenome
  2. beta-catenin binding Source: RefGenome
  3. GTPase activator activity Source: RefGenome
  4. protein kinase binding Source: RefGenome

GO - Biological processi

  1. cell death Source: RefGenome
  2. cellular response to organic cyclic compound Source: RefGenome
  3. dorsal/ventral axis specification Source: RefGenome
  4. dorsal/ventral pattern formation Source: ZFIN
  5. intramembranous ossification Source: RefGenome
  6. negative regulation of canonical Wnt signaling pathway Source: RefGenome
  7. negative regulation of osteoblast differentiation Source: RefGenome
  8. positive regulation of GTPase activity Source: GOC
  9. regulation of catenin import into nucleus Source: RefGenome
  10. termination of G-protein coupled receptor signaling pathway Source: InterPro
  11. Wnt signaling pathway involved in somitogenesis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_206533. degradation of AXIN.

Names & Taxonomyi

Protein namesi
Recommended name:
Axin-2
Alternative name(s):
Axis inhibition protein 2
Gene namesi
Name:axin2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-000403-2. axin2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cell cortex Source: RefGenome
  2. cytoplasmic membrane-bounded vesicle Source: RefGenome
  3. cytoplasmic microtubule Source: RefGenome
  4. plasma membrane Source: RefGenome
  5. postsynaptic density Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 812812Axin-2PRO_0000220898Add
BLAST

Post-translational modificationi

Probably phosphorylated by GSK3B and dephosphorylated by PP2A.By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

BgeeiP57095.

Structurei

3D structure databases

ProteinModelPortaliP57095.
SMRiP57095. Positions 731-812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 203120RGSPROSITE-ProRule annotationAdd
BLAST
Domaini730 – 81283DIXPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni329 – 41587Interaction with GSK3BBy similarityAdd
BLAST
Regioni415 – 46753Interaction with beta-cateninBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi412 – 4198Poly-Ser

Sequence similaritiesi

Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG238205.
GeneTreeiENSGT00390000010011.
HOVERGENiHBG004324.
InParanoidiP57095.
KOiK04385.
OMAiERDESEM.
OrthoDBiEOG79PJQ0.
PhylomeDBiP57095.
TreeFamiTF315454.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57095-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRTLTDPMV SSFREDDPRP PVPGEEGETT CHHPSKLAMM RPKDPVKTIM
60 70 80 90 100
ADLRCSTARR DEDGLGEPEG SASPDSPLAR WTKSLHFLLG DQDGAQLFRA
110 120 130 140 150
YLEREKCVDT LDFWFACNGF RQMDLKDTKT HRVAKAIYKR YIENNSIVAK
160 170 180 190 200
QLKPATKTFI RDNIKRQQID SAMFDQAQME IQTAMEENAY QMFLTSDIYL
210 220 230 240 250
EYVRTGCENP SHVNPNGLGG LKLVCGYLPT LNEEEEWSCN DFKAKALATV
260 270 280 290 300
VGLSAKTLRS PPLRAVEALE KGYRSYRRSD PGNPNRFTSG YSFAPATSAN
310 320 330 340 350
DSEVSSDALT DDSMSMTDSS VDAIPPYKLG SKKQLQREMQ RNMRMNGQVS
360 370 380 390 400
LPPFPRTRRP PKEMTPVEPA AFAAQLIARL ERLKREQETM SSLEERLQQI
410 420 430 440 450
QEEEERDESE MSSSSASHSL PLLPPGTCEE DPQAILDEHL SRVLKTPGCQ
460 470 480 490 500
SPGLLRHSPR SRSPEQRPLP RGGLSTRSQS SSMNGYVPAK TFISRQSTKH
510 520 530 540 550
IHHHYIHHHA GPKSKEQIEV EATQRVQCLC HGTSECCTAP YIRSRSLGRD
560 570 580 590 600
QCASPAEVAL GHSSTLSKRL CKSGEEVNME GLENSLLQLP ADSTDRSQNV
610 620 630 640 650
WQWILESDRQ TKHKPHSTQN VKKSHSLEPT RTHTWGGGGS SGHLRAHQPA
660 670 680 690 700
HPFVQDPAMP PLPPPNTLAQ LEEARRRLEE VSKPSKQRHS TSSLQRDKSH
710 720 730 740 750
PVPVQNGSSA FPMDERKDPK KMSGCHSSLG SETVVTYFFC GEEIPYRRMM
760 770 780 790 800
KTHSLTLGHF KEQLRKKGNY RYFFKRASDE FECGAVFEEV WDDCTVLPMY
810
EGKILGKVDR MD
Length:812
Mass (Da):91,497
Last modified:December 1, 2000 - v1
Checksum:i46E5ADA6DE2240CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032263 mRNA. Translation: BAA92440.1.
AF387812 mRNA. Translation: AAK70877.1.
AJ854187 mRNA. Translation: CAH69531.1.
RefSeqiNP_571636.1. NM_131561.1.
UniGeneiDr.3727.

Genome annotation databases

EnsembliENSDART00000020575; ENSDARP00000003845; ENSDARG00000014147.
GeneIDi58080.
KEGGidre:58080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032263 mRNA. Translation: BAA92440.1 .
AF387812 mRNA. Translation: AAK70877.1 .
AJ854187 mRNA. Translation: CAH69531.1 .
RefSeqi NP_571636.1. NM_131561.1.
UniGenei Dr.3727.

3D structure databases

ProteinModelPortali P57095.
SMRi P57095. Positions 731-812.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000020575 ; ENSDARP00000003845 ; ENSDARG00000014147 .
GeneIDi 58080.
KEGGi dre:58080.

Organism-specific databases

CTDi 8313.
ZFINi ZDB-GENE-000403-2. axin2.

Phylogenomic databases

eggNOGi NOG238205.
GeneTreei ENSGT00390000010011.
HOVERGENi HBG004324.
InParanoidi P57095.
KOi K04385.
OMAi ERDESEM.
OrthoDBi EOG79PJQ0.
PhylomeDBi P57095.
TreeFami TF315454.

Enzyme and pathway databases

Reactomei REACT_206533. degradation of AXIN.

Miscellaneous databases

NextBioi 20892339.
PROi P57095.

Gene expression databases

Bgeei P57095.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish."
    Shimizu T., Yamanaka Y., Ryu S.-L., Hashimoto H., Yabe T., Hirata T., Bae Y.-K., Hibi M., Hirano T.
    Mech. Dev. 91:293-303(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of zebrafish axin2."
    Pogoda H.-M., Meyer D.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Functional Analysis of Zebrafish axin2 during embryogenesis."
    Tsai J.N., Chang W.C.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAXIN2_DANRE
AccessioniPrimary (citable) accession number: P57095
Secondary accession number(s): Q335M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3