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Protein

Axin-2

Gene

axin2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).By similarity

GO - Molecular functioni

  1. armadillo repeat domain binding Source: GO_Central
  2. beta-catenin binding Source: GO_Central
  3. GTPase activator activity Source: GO_Central
  4. protein kinase binding Source: GO_Central

GO - Biological processi

  1. cell death Source: GO_Central
  2. cellular response to organic cyclic compound Source: GO_Central
  3. dorsal/ventral axis specification Source: GO_Central
  4. dorsal/ventral pattern formation Source: ZFIN
  5. intramembranous ossification Source: GO_Central
  6. negative regulation of canonical Wnt signaling pathway Source: GO_Central
  7. negative regulation of osteoblast differentiation Source: GO_Central
  8. positive regulation of GTPase activity Source: GOC
  9. regulation of catenin import into nucleus Source: GO_Central
  10. termination of G-protein coupled receptor signaling pathway Source: InterPro
  11. Wnt signaling pathway involved in somitogenesis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_206533. degradation of AXIN.
REACT_221170. TCF dependent signaling in response to WNT.

Names & Taxonomyi

Protein namesi
Recommended name:
Axin-2
Alternative name(s):
Axis inhibition protein 2
Gene namesi
Name:axin2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-000403-2. axin2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cell cortex Source: GO_Central
  2. cytoplasmic membrane-bounded vesicle Source: GO_Central
  3. cytoplasmic microtubule Source: GO_Central
  4. plasma membrane Source: GO_Central
  5. postsynaptic density Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 812812Axin-2PRO_0000220898Add
BLAST

Post-translational modificationi

Probably phosphorylated by GSK3B and dephosphorylated by PP2A.By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

BgeeiP57095.

Structurei

3D structure databases

ProteinModelPortaliP57095.
SMRiP57095. Positions 731-812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 203120RGSPROSITE-ProRule annotationAdd
BLAST
Domaini730 – 81283DIXPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni329 – 41587Interaction with GSK3BBy similarityAdd
BLAST
Regioni415 – 46753Interaction with beta-cateninBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi412 – 4198Poly-Ser

Sequence similaritiesi

Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG238205.
GeneTreeiENSGT00390000010011.
HOVERGENiHBG004324.
InParanoidiP57095.
KOiK04385.
OMAiLEDHKEP.
OrthoDBiEOG79PJQ0.
PhylomeDBiP57095.
TreeFamiTF315454.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRTLTDPMV SSFREDDPRP PVPGEEGETT CHHPSKLAMM RPKDPVKTIM
60 70 80 90 100
ADLRCSTARR DEDGLGEPEG SASPDSPLAR WTKSLHFLLG DQDGAQLFRA
110 120 130 140 150
YLEREKCVDT LDFWFACNGF RQMDLKDTKT HRVAKAIYKR YIENNSIVAK
160 170 180 190 200
QLKPATKTFI RDNIKRQQID SAMFDQAQME IQTAMEENAY QMFLTSDIYL
210 220 230 240 250
EYVRTGCENP SHVNPNGLGG LKLVCGYLPT LNEEEEWSCN DFKAKALATV
260 270 280 290 300
VGLSAKTLRS PPLRAVEALE KGYRSYRRSD PGNPNRFTSG YSFAPATSAN
310 320 330 340 350
DSEVSSDALT DDSMSMTDSS VDAIPPYKLG SKKQLQREMQ RNMRMNGQVS
360 370 380 390 400
LPPFPRTRRP PKEMTPVEPA AFAAQLIARL ERLKREQETM SSLEERLQQI
410 420 430 440 450
QEEEERDESE MSSSSASHSL PLLPPGTCEE DPQAILDEHL SRVLKTPGCQ
460 470 480 490 500
SPGLLRHSPR SRSPEQRPLP RGGLSTRSQS SSMNGYVPAK TFISRQSTKH
510 520 530 540 550
IHHHYIHHHA GPKSKEQIEV EATQRVQCLC HGTSECCTAP YIRSRSLGRD
560 570 580 590 600
QCASPAEVAL GHSSTLSKRL CKSGEEVNME GLENSLLQLP ADSTDRSQNV
610 620 630 640 650
WQWILESDRQ TKHKPHSTQN VKKSHSLEPT RTHTWGGGGS SGHLRAHQPA
660 670 680 690 700
HPFVQDPAMP PLPPPNTLAQ LEEARRRLEE VSKPSKQRHS TSSLQRDKSH
710 720 730 740 750
PVPVQNGSSA FPMDERKDPK KMSGCHSSLG SETVVTYFFC GEEIPYRRMM
760 770 780 790 800
KTHSLTLGHF KEQLRKKGNY RYFFKRASDE FECGAVFEEV WDDCTVLPMY
810
EGKILGKVDR MD
Length:812
Mass (Da):91,497
Last modified:December 1, 2000 - v1
Checksum:i46E5ADA6DE2240CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032263 mRNA. Translation: BAA92440.1.
AF387812 mRNA. Translation: AAK70877.1.
AJ854187 mRNA. Translation: CAH69531.1.
RefSeqiNP_571636.1. NM_131561.1.
UniGeneiDr.3727.

Genome annotation databases

EnsembliENSDART00000020575; ENSDARP00000003845; ENSDARG00000014147.
GeneIDi58080.
KEGGidre:58080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032263 mRNA. Translation: BAA92440.1.
AF387812 mRNA. Translation: AAK70877.1.
AJ854187 mRNA. Translation: CAH69531.1.
RefSeqiNP_571636.1. NM_131561.1.
UniGeneiDr.3727.

3D structure databases

ProteinModelPortaliP57095.
SMRiP57095. Positions 731-812.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000020575; ENSDARP00000003845; ENSDARG00000014147.
GeneIDi58080.
KEGGidre:58080.

Organism-specific databases

CTDi8313.
ZFINiZDB-GENE-000403-2. axin2.

Phylogenomic databases

eggNOGiNOG238205.
GeneTreeiENSGT00390000010011.
HOVERGENiHBG004324.
InParanoidiP57095.
KOiK04385.
OMAiLEDHKEP.
OrthoDBiEOG79PJQ0.
PhylomeDBiP57095.
TreeFamiTF315454.

Enzyme and pathway databases

ReactomeiREACT_206533. degradation of AXIN.
REACT_221170. TCF dependent signaling in response to WNT.

Miscellaneous databases

NextBioi20892339.
PROiP57095.

Gene expression databases

BgeeiP57095.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish."
    Shimizu T., Yamanaka Y., Ryu S.-L., Hashimoto H., Yabe T., Hirata T., Bae Y.-K., Hibi M., Hirano T.
    Mech. Dev. 91:293-303(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of zebrafish axin2."
    Pogoda H.-M., Meyer D.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Functional Analysis of Zebrafish axin2 during embryogenesis."
    Tsai J.N., Chang W.C.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAXIN2_DANRE
AccessioniPrimary (citable) accession number: P57095
Secondary accession number(s): Q335M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: February 4, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.