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P57094

- AXIN1_DANRE

UniProt

P57094 - AXIN1_DANRE

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Protein

Axin-1

Gene

axin1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.1 Publication

GO - Molecular functioni

  1. armadillo repeat domain binding Source: RefGenome
  2. beta-catenin binding Source: RefGenome
  3. GTPase activator activity Source: RefGenome
  4. protein homodimerization activity Source: UniProtKB
  5. protein kinase binding Source: RefGenome

GO - Biological processi

  1. activation of JUN kinase activity Source: ZFIN
  2. axial mesoderm formation Source: RefGenome
  3. canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation Source: ZFIN
  4. cell death Source: RefGenome
  5. cellular response to organic cyclic compound Source: RefGenome
  6. cytoplasmic microtubule organization Source: RefGenome
  7. determination of left/right symmetry Source: ZFIN
  8. dorsal/ventral axis specification Source: MGI
  9. dorsal/ventral pattern formation Source: MGI
  10. embryonic eye morphogenesis Source: ZFIN
  11. embryonic skeletal joint morphogenesis Source: RefGenome
  12. eye development Source: ZFIN
  13. fin regeneration Source: ZFIN
  14. forebrain anterior/posterior pattern specification Source: ZFIN
  15. forebrain development Source: ZFIN
  16. muscle cell development Source: ZFIN
  17. negative regulation of canonical Wnt signaling pathway Source: ZFIN
  18. negative regulation of fat cell differentiation Source: RefGenome
  19. negative regulation of Wnt signaling pathway Source: ZFIN
  20. neural plate anterior/posterior regionalization Source: ZFIN
  21. olfactory placode formation Source: ZFIN
  22. optic placode formation Source: ZFIN
  23. positive regulation of GTPase activity Source: GOC
  24. positive regulation of JNK cascade Source: UniProtKB
  25. positive regulation of JUN kinase activity Source: MGI
  26. regulation of catenin import into nucleus Source: RefGenome
  27. termination of G-protein coupled receptor signaling pathway Source: InterPro
  28. Wnt-activated signaling pathway involved in forebrain neuron fate commitment Source: ZFIN
  29. Wnt signaling pathway involved in somitogenesis Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Axin-1
Alternative name(s):
Axis inhibition protein 1
Gene namesi
Name:axin1
Synonyms:axin
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-000403-1. axin1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. beta-catenin destruction complex Source: ZFIN
  2. cell cortex Source: RefGenome
  3. cytoplasmic membrane-bounded vesicle Source: RefGenome
  4. cytoplasmic microtubule Source: RefGenome
  5. plasma membrane Source: RefGenome
  6. postsynaptic density Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 835835Axin-1PRO_0000220893Add
BLAST

Post-translational modificationi

Probably phosphorylated by GSK3B and dephosphorylated by PP2A.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with dixdc1.By similarity1 Publication

Protein-protein interaction databases

BioGridi78941. 3 interactions.
STRINGi7955.ENSDARP00000036978.

Structurei

3D structure databases

ProteinModelPortaliP57094.
SMRiP57094. Positions 78-223, 752-835.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini92 – 214123RGSPROSITE-ProRule annotationAdd
BLAST
Domaini753 – 83583DIXPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni351 – 43686Interaction with GSK3BBy similarityAdd
BLAST
Regioni437 – 51276Interaction with beta-cateninBy similarityAdd
BLAST

Domaini

The DIX domain mediates interaction with dixdc1.

Sequence similaritiesi

Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG238205.
HOVERGENiHBG004324.
InParanoidiP57094.
KOiK02157.
PhylomeDBiP57094.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57094-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSMSVNEKGI CYLPDLGSSF TEDAPRPPVP GEEGDLVSSD GRQYNHSFYS
60 70 80 90 100
SKSDSLKNEA SIATPRRPDL DLGYEPEGSA SPTPPYLKWA ESLHSLLDDQ
110 120 130 140 150
DGIHLFRTFL KQEECADMLD FWFACSGFRK QEANDGNEKM LKLAKAIYKK
160 170 180 190 200
YILDNNGIVS RQIKPATKSF IKDCVTKLHI DPAMFDQAQT EIQTMMEENT
210 220 230 240 250
YPLFLKSDIY LEYTRTGGES PKLFSDQSSV SGNGKVLPGY LPTVIEDVEW
260 270 280 290 300
RCDQEEEQIA ESDPTPSNRL TQKLPLETVP QRVANSKRYQ DNREYRHASW
310 320 330 340 350
REPVNPYYVN SGYALAPATS ANDSEQQSMS SDADTLSLTD SSVDGVPPYR
360 370 380 390 400
YRKPHRREIH ESAKVNGRVP LPHIPRTNRI PKDIHVEPEK FAAELISRLE
410 420 430 440 450
GVLREREAQE KLEERLKRVR LEEEGDDADI STGPSLANHR VPPAVHVQHY
460 470 480 490 500
GGRYSEMSYN GLQLRDAHEE NPESILDEHV QRVMKTPGCQ SPGTGRHSPK
510 520 530 540 550
SRSPDGLPAG KIPGLMMPLS GGQGKHQARQ GPKGEAAHLH HHKHIHHTHY
560 570 580 590 600
AAAGKPKEQA EAEAARMHGG FAWNTEQHHY GPKSRNYADG MSVGPNTMDP
610 620 630 640 650
MGYSSKGSTL SKRPVRKGED GRNFEMREPL PADDMERNQK ILQWMMEGEK
660 670 680 690 700
EAGRYKRGPY GSISGPKKAQ GHEPARPSSV ERLGAVHPWV TAQLRNNVQP
710 720 730 740 750
SHPFIQDPTM PPNPAPNPLT QLEEARRRLE EERRKSGTLQ AKQRHKNMKK
760 770 780 790 800
QPCENITVAY YFRGEPIPYR TSVKGRIVTL GQFKELLTKK GSYKYYFKKV
810 820 830
SYEFDCGVVF EEVREDDAIL PIFEEKIIGK VEKVD
Length:835
Mass (Da):94,329
Last modified:July 22, 2008 - v2
Checksum:i7ABEE52E1DE2FAB6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti176 – 1761T → M in BAA92439. (PubMed:10704853)Curated
Sequence conflicti275 – 2751P → L in BAA92439. (PubMed:10704853)Curated
Sequence conflicti658 – 6581G → S in BAA92439. (PubMed:10704853)Curated
Sequence conflicti763 – 7631R → C in BAA92439. (PubMed:10704853)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032262 mRNA. Translation: BAA92439.1.
BC099991 mRNA. Translation: AAH99991.1.
RefSeqiNP_571578.2. NM_131503.2.
UniGeneiDr.80549.

Genome annotation databases

GeneIDi57931.
KEGGidre:57931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032262 mRNA. Translation: BAA92439.1 .
BC099991 mRNA. Translation: AAH99991.1 .
RefSeqi NP_571578.2. NM_131503.2.
UniGenei Dr.80549.

3D structure databases

ProteinModelPortali P57094.
SMRi P57094. Positions 78-223, 752-835.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 78941. 3 interactions.
STRINGi 7955.ENSDARP00000036978.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 57931.
KEGGi dre:57931.

Organism-specific databases

CTDi 8312.
ZFINi ZDB-GENE-000403-1. axin1.

Phylogenomic databases

eggNOGi NOG238205.
HOVERGENi HBG004324.
InParanoidi P57094.
KOi K02157.
PhylomeDBi P57094.

Miscellaneous databases

NextBioi 20891945.
PROi P57094.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish."
    Shimizu T., Yamanaka Y., Ryu S.-L., Hashimoto H., Yabe T., Hirata T., Bae Y.-K., Hibi M., Hirano T.
    Mech. Dev. 91:293-303(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.
  3. "Ccd1, a novel protein with a DIX domain, is a positive regulator in the Wnt signaling during zebrafish neural patterning."
    Shiomi K., Uchida H., Keino-Masu K., Masu M.
    Curr. Biol. 13:73-77(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DIXDC1.
  4. "A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida."
    Rui Y., Xu Z., Xiong B., Cao Y., Lin S., Zhang M., Chan S.-C., Luo W., Han Y., Lu Z., Ye Z., Zhou H.-M., Han J., Meng A., Lin S.-C.
    Dev. Cell 13:268-282(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiAXIN1_DANRE
AccessioniPrimary (citable) accession number: P57094
Secondary accession number(s): Q499B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 22, 2008
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3