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P57094

- AXIN1_DANRE

UniProt

P57094 - AXIN1_DANRE

Protein

Axin-1

Gene

axin1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.1 Publication

    GO - Molecular functioni

    1. armadillo repeat domain binding Source: RefGenome
    2. beta-catenin binding Source: RefGenome
    3. GTPase activator activity Source: RefGenome
    4. protein homodimerization activity Source: UniProtKB
    5. protein kinase binding Source: RefGenome
    6. signal transducer activity Source: InterPro

    GO - Biological processi

    1. activation of JUN kinase activity Source: ZFIN
    2. axial mesoderm formation Source: RefGenome
    3. canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation Source: ZFIN
    4. cell death Source: RefGenome
    5. cellular response to organic cyclic compound Source: RefGenome
    6. cytoplasmic microtubule organization Source: RefGenome
    7. determination of left/right symmetry Source: ZFIN
    8. dorsal/ventral axis specification Source: MGI
    9. dorsal/ventral pattern formation Source: MGI
    10. embryonic eye morphogenesis Source: ZFIN
    11. embryonic skeletal joint morphogenesis Source: RefGenome
    12. eye development Source: ZFIN
    13. fin regeneration Source: ZFIN
    14. forebrain anterior/posterior pattern specification Source: ZFIN
    15. forebrain development Source: ZFIN
    16. muscle cell development Source: ZFIN
    17. negative regulation of canonical Wnt signaling pathway Source: ZFIN
    18. negative regulation of fat cell differentiation Source: RefGenome
    19. negative regulation of Wnt signaling pathway Source: ZFIN
    20. neural plate anterior/posterior regionalization Source: ZFIN
    21. olfactory placode formation Source: ZFIN
    22. optic placode formation Source: ZFIN
    23. positive regulation of GTPase activity Source: GOC
    24. positive regulation of JNK cascade Source: UniProtKB
    25. positive regulation of JUN kinase activity Source: MGI
    26. regulation of catenin import into nucleus Source: RefGenome
    27. termination of G-protein coupled receptor signaling pathway Source: InterPro
    28. Wnt-activated signaling pathway involved in forebrain neuron fate commitment Source: ZFIN
    29. Wnt signaling pathway involved in somitogenesis Source: ZFIN

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Axin-1
    Alternative name(s):
    Axis inhibition protein 1
    Gene namesi
    Name:axin1
    Synonyms:axin
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-000403-1. axin1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. beta-catenin destruction complex Source: ZFIN
    2. cell cortex Source: RefGenome
    3. cytoplasmic membrane-bounded vesicle Source: RefGenome
    4. cytoplasmic microtubule Source: RefGenome
    5. plasma membrane Source: RefGenome
    6. postsynaptic density Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 835835Axin-1PRO_0000220893Add
    BLAST

    Post-translational modificationi

    Probably phosphorylated by GSK3B and dephosphorylated by PP2A.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homodimer By similarity. Interacts with dixdc1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi78941. 3 interactions.
    STRINGi7955.ENSDARP00000036978.

    Structurei

    3D structure databases

    ProteinModelPortaliP57094.
    SMRiP57094. Positions 78-223, 752-835.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini92 – 214123RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini753 – 83583DIXPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni351 – 43686Interaction with GSK3BBy similarityAdd
    BLAST
    Regioni437 – 51276Interaction with beta-cateninBy similarityAdd
    BLAST

    Domaini

    The DIX domain mediates interaction with dixdc1.

    Sequence similaritiesi

    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG238205.
    HOVERGENiHBG004324.
    InParanoidiQ499B7.
    KOiK02157.
    PhylomeDBiP57094.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57094-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMSVNEKGI CYLPDLGSSF TEDAPRPPVP GEEGDLVSSD GRQYNHSFYS    50
    SKSDSLKNEA SIATPRRPDL DLGYEPEGSA SPTPPYLKWA ESLHSLLDDQ 100
    DGIHLFRTFL KQEECADMLD FWFACSGFRK QEANDGNEKM LKLAKAIYKK 150
    YILDNNGIVS RQIKPATKSF IKDCVTKLHI DPAMFDQAQT EIQTMMEENT 200
    YPLFLKSDIY LEYTRTGGES PKLFSDQSSV SGNGKVLPGY LPTVIEDVEW 250
    RCDQEEEQIA ESDPTPSNRL TQKLPLETVP QRVANSKRYQ DNREYRHASW 300
    REPVNPYYVN SGYALAPATS ANDSEQQSMS SDADTLSLTD SSVDGVPPYR 350
    YRKPHRREIH ESAKVNGRVP LPHIPRTNRI PKDIHVEPEK FAAELISRLE 400
    GVLREREAQE KLEERLKRVR LEEEGDDADI STGPSLANHR VPPAVHVQHY 450
    GGRYSEMSYN GLQLRDAHEE NPESILDEHV QRVMKTPGCQ SPGTGRHSPK 500
    SRSPDGLPAG KIPGLMMPLS GGQGKHQARQ GPKGEAAHLH HHKHIHHTHY 550
    AAAGKPKEQA EAEAARMHGG FAWNTEQHHY GPKSRNYADG MSVGPNTMDP 600
    MGYSSKGSTL SKRPVRKGED GRNFEMREPL PADDMERNQK ILQWMMEGEK 650
    EAGRYKRGPY GSISGPKKAQ GHEPARPSSV ERLGAVHPWV TAQLRNNVQP 700
    SHPFIQDPTM PPNPAPNPLT QLEEARRRLE EERRKSGTLQ AKQRHKNMKK 750
    QPCENITVAY YFRGEPIPYR TSVKGRIVTL GQFKELLTKK GSYKYYFKKV 800
    SYEFDCGVVF EEVREDDAIL PIFEEKIIGK VEKVD 835
    Length:835
    Mass (Da):94,329
    Last modified:July 22, 2008 - v2
    Checksum:i7ABEE52E1DE2FAB6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti176 – 1761T → M in BAA92439. (PubMed:10704853)Curated
    Sequence conflicti275 – 2751P → L in BAA92439. (PubMed:10704853)Curated
    Sequence conflicti658 – 6581G → S in BAA92439. (PubMed:10704853)Curated
    Sequence conflicti763 – 7631R → C in BAA92439. (PubMed:10704853)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032262 mRNA. Translation: BAA92439.1.
    BC099991 mRNA. Translation: AAH99991.1.
    RefSeqiNP_571578.2. NM_131503.2.
    UniGeneiDr.80549.

    Genome annotation databases

    GeneIDi57931.
    KEGGidre:57931.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032262 mRNA. Translation: BAA92439.1 .
    BC099991 mRNA. Translation: AAH99991.1 .
    RefSeqi NP_571578.2. NM_131503.2.
    UniGenei Dr.80549.

    3D structure databases

    ProteinModelPortali P57094.
    SMRi P57094. Positions 78-223, 752-835.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 78941. 3 interactions.
    STRINGi 7955.ENSDARP00000036978.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 57931.
    KEGGi dre:57931.

    Organism-specific databases

    CTDi 8312.
    ZFINi ZDB-GENE-000403-1. axin1.

    Phylogenomic databases

    eggNOGi NOG238205.
    HOVERGENi HBG004324.
    InParanoidi Q499B7.
    KOi K02157.
    PhylomeDBi P57094.

    Miscellaneous databases

    NextBioi 20891945.
    PROi P57094.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish."
      Shimizu T., Yamanaka Y., Ryu S.-L., Hashimoto H., Yabe T., Hirata T., Bae Y.-K., Hibi M., Hirano T.
      Mech. Dev. 91:293-303(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: AB.
    3. "Ccd1, a novel protein with a DIX domain, is a positive regulator in the Wnt signaling during zebrafish neural patterning."
      Shiomi K., Uchida H., Keino-Masu K., Masu M.
      Curr. Biol. 13:73-77(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DIXDC1.
    4. "A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida."
      Rui Y., Xu Z., Xiong B., Cao Y., Lin S., Zhang M., Chan S.-C., Luo W., Han Y., Lu Z., Ye Z., Zhou H.-M., Han J., Meng A., Lin S.-C.
      Dev. Cell 13:268-282(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiAXIN1_DANRE
    AccessioniPrimary (citable) accession number: P57094
    Secondary accession number(s): Q499B7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3