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P57088

- TMM33_HUMAN

UniProt

P57088 - TMM33_HUMAN

Protein

Transmembrane protein 33

Gene

TMEM33

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (19 Sep 2002)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 33
    Alternative name(s):
    Protein DB83
    Gene namesi
    Name:TMEM33
    Synonyms:DB83
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:25541. TMEM33.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Melanosome 1 Publication
    Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. melanosome Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134963055.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 247246Transmembrane protein 33PRO_0000220899Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP57088.
    PaxDbiP57088.
    PeptideAtlasiP57088.
    PRIDEiP57088.

    PTM databases

    PhosphoSiteiP57088.

    Expressioni

    Gene expression databases

    ArrayExpressiP57088.
    BgeeiP57088.
    CleanExiHS_TMEM33.
    GenevestigatoriP57088.

    Interactioni

    Protein-protein interaction databases

    BioGridi120462. 14 interactions.
    IntActiP57088. 11 interactions.
    MINTiMINT-3021719.
    STRINGi9606.ENSP00000264452.

    Structurei

    3D structure databases

    ProteinModelPortaliP57088.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PER33/POM33 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG236583.
    HOVERGENiHBG054225.
    InParanoidiP57088.
    OMAiIMKPSCP.
    OrthoDBiEOG78SQJW.
    PhylomeDBiP57088.
    TreeFamiTF314068.

    Family and domain databases

    InterProiIPR005344. UPF0121.
    [Graphical view]
    PfamiPF03661. UPF0121. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P57088-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADTTPNGPQ GAGAVQFMMT NKLDTAMWLS RLFTVYCSAL FVLPLLGLHE    50
    AASFYQRALL ANALTSALRL HQRLPHFQLS RAFLAQALLE DSCHYLLYSL 100
    IFVNSYPVTM SIFPVLLFSL LHAATYTKKV LDARGSNSLP LLRSVLDKLS 150
    ANQQNILKFI ACNEIFLMPA TVFMLFSGQG SLLQPFIYYR FLTLRYSSRR 200
    NPYCRTLFNE LRIVVEHIIM KPACPLFVRR LCLQSIAFIS RLAPTVP 247
    Length:247
    Mass (Da):27,978
    Last modified:September 19, 2002 - v2
    Checksum:i392A53377511A6A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71N → S in BAA91665. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001387 mRNA. Translation: BAA91665.1.
    AK023062 mRNA. Translation: BAB14384.1.
    AK094190 mRNA. Translation: BAG52840.1.
    CR457260 mRNA. Translation: CAG33541.1.
    CH471069 Genomic DNA. Translation: EAW92991.1.
    BC000948 mRNA. Translation: AAH00948.2.
    CCDSiCCDS3464.1.
    RefSeqiNP_060596.2. NM_018126.2.
    XP_005248173.1. XM_005248116.1.
    XP_005248174.1. XM_005248117.1.
    UniGeneiHs.31082.

    Genome annotation databases

    EnsembliENST00000325094; ENSP00000441455; ENSG00000109133.
    ENST00000504986; ENSP00000422473; ENSG00000109133.
    ENST00000513702; ENSP00000427006; ENSG00000109133.
    GeneIDi55161.
    KEGGihsa:55161.
    UCSCiuc003gwi.2. human.

    Polymorphism databases

    DMDMi23503056.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001387 mRNA. Translation: BAA91665.1 .
    AK023062 mRNA. Translation: BAB14384.1 .
    AK094190 mRNA. Translation: BAG52840.1 .
    CR457260 mRNA. Translation: CAG33541.1 .
    CH471069 Genomic DNA. Translation: EAW92991.1 .
    BC000948 mRNA. Translation: AAH00948.2 .
    CCDSi CCDS3464.1.
    RefSeqi NP_060596.2. NM_018126.2.
    XP_005248173.1. XM_005248116.1.
    XP_005248174.1. XM_005248117.1.
    UniGenei Hs.31082.

    3D structure databases

    ProteinModelPortali P57088.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120462. 14 interactions.
    IntActi P57088. 11 interactions.
    MINTi MINT-3021719.
    STRINGi 9606.ENSP00000264452.

    PTM databases

    PhosphoSitei P57088.

    Polymorphism databases

    DMDMi 23503056.

    Proteomic databases

    MaxQBi P57088.
    PaxDbi P57088.
    PeptideAtlasi P57088.
    PRIDEi P57088.

    Protocols and materials databases

    DNASUi 55161.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325094 ; ENSP00000441455 ; ENSG00000109133 .
    ENST00000504986 ; ENSP00000422473 ; ENSG00000109133 .
    ENST00000513702 ; ENSP00000427006 ; ENSG00000109133 .
    GeneIDi 55161.
    KEGGi hsa:55161.
    UCSCi uc003gwi.2. human.

    Organism-specific databases

    CTDi 55161.
    GeneCardsi GC04P041937.
    HGNCi HGNC:25541. TMEM33.
    neXtProti NX_P57088.
    PharmGKBi PA134963055.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG236583.
    HOVERGENi HBG054225.
    InParanoidi P57088.
    OMAi IMKPSCP.
    OrthoDBi EOG78SQJW.
    PhylomeDBi P57088.
    TreeFami TF314068.

    Miscellaneous databases

    ChiTaRSi TMEM33. human.
    GenomeRNAii 55161.
    NextBioi 58921.
    PROi P57088.

    Gene expression databases

    ArrayExpressi P57088.
    Bgeei P57088.
    CleanExi HS_TMEM33.
    Genevestigatori P57088.

    Family and domain databases

    InterProi IPR005344. UPF0121.
    [Graphical view ]
    Pfami PF03661. UPF0121. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Melanoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTMM33_HUMAN
    AccessioniPrimary (citable) accession number: P57088
    Secondary accession number(s): B3KSS8, Q9H953
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3