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P57088

- TMM33_HUMAN

UniProt

P57088 - TMM33_HUMAN

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Protein

Transmembrane protein 33

Gene

TMEM33

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 33
Alternative name(s):
Protein DB83
Gene namesi
Name:TMEM33
Synonyms:DB83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:25541. TMEM33.

Subcellular locationi

Membrane Curated; Multi-pass membrane protein Curated. Melanosome 1 Publication
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence AnalysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. melanosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134963055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 247246Transmembrane protein 33PRO_0000220899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP57088.
PaxDbiP57088.
PeptideAtlasiP57088.
PRIDEiP57088.

PTM databases

PhosphoSiteiP57088.

Expressioni

Gene expression databases

BgeeiP57088.
CleanExiHS_TMEM33.
ExpressionAtlasiP57088. baseline and differential.
GenevestigatoriP57088.

Interactioni

Protein-protein interaction databases

BioGridi120462. 14 interactions.
IntActiP57088. 11 interactions.
MINTiMINT-3021719.
STRINGi9606.ENSP00000264452.

Structurei

3D structure databases

ProteinModelPortaliP57088.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PER33/POM33 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG236583.
GeneTreeiENSGT00390000011368.
HOVERGENiHBG054225.
InParanoidiP57088.
OMAiIMKPSCP.
OrthoDBiEOG78SQJW.
PhylomeDBiP57088.
TreeFamiTF314068.

Family and domain databases

InterProiIPR005344. UPF0121.
[Graphical view]
PfamiPF03661. UPF0121. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57088-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADTTPNGPQ GAGAVQFMMT NKLDTAMWLS RLFTVYCSAL FVLPLLGLHE
60 70 80 90 100
AASFYQRALL ANALTSALRL HQRLPHFQLS RAFLAQALLE DSCHYLLYSL
110 120 130 140 150
IFVNSYPVTM SIFPVLLFSL LHAATYTKKV LDARGSNSLP LLRSVLDKLS
160 170 180 190 200
ANQQNILKFI ACNEIFLMPA TVFMLFSGQG SLLQPFIYYR FLTLRYSSRR
210 220 230 240
NPYCRTLFNE LRIVVEHIIM KPACPLFVRR LCLQSIAFIS RLAPTVP
Length:247
Mass (Da):27,978
Last modified:September 19, 2002 - v2
Checksum:i392A53377511A6A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71N → S in BAA91665. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001387 mRNA. Translation: BAA91665.1.
AK023062 mRNA. Translation: BAB14384.1.
AK094190 mRNA. Translation: BAG52840.1.
CR457260 mRNA. Translation: CAG33541.1.
CH471069 Genomic DNA. Translation: EAW92991.1.
BC000948 mRNA. Translation: AAH00948.2.
CCDSiCCDS3464.1.
RefSeqiNP_060596.2. NM_018126.2.
XP_005248173.1. XM_005248116.1.
XP_005248174.1. XM_005248117.1.
UniGeneiHs.31082.

Genome annotation databases

EnsembliENST00000325094; ENSP00000441455; ENSG00000109133.
ENST00000504986; ENSP00000422473; ENSG00000109133.
ENST00000513702; ENSP00000427006; ENSG00000109133.
GeneIDi55161.
KEGGihsa:55161.
UCSCiuc003gwi.2. human.

Polymorphism databases

DMDMi23503056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001387 mRNA. Translation: BAA91665.1 .
AK023062 mRNA. Translation: BAB14384.1 .
AK094190 mRNA. Translation: BAG52840.1 .
CR457260 mRNA. Translation: CAG33541.1 .
CH471069 Genomic DNA. Translation: EAW92991.1 .
BC000948 mRNA. Translation: AAH00948.2 .
CCDSi CCDS3464.1.
RefSeqi NP_060596.2. NM_018126.2.
XP_005248173.1. XM_005248116.1.
XP_005248174.1. XM_005248117.1.
UniGenei Hs.31082.

3D structure databases

ProteinModelPortali P57088.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120462. 14 interactions.
IntActi P57088. 11 interactions.
MINTi MINT-3021719.
STRINGi 9606.ENSP00000264452.

PTM databases

PhosphoSitei P57088.

Polymorphism databases

DMDMi 23503056.

Proteomic databases

MaxQBi P57088.
PaxDbi P57088.
PeptideAtlasi P57088.
PRIDEi P57088.

Protocols and materials databases

DNASUi 55161.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000325094 ; ENSP00000441455 ; ENSG00000109133 .
ENST00000504986 ; ENSP00000422473 ; ENSG00000109133 .
ENST00000513702 ; ENSP00000427006 ; ENSG00000109133 .
GeneIDi 55161.
KEGGi hsa:55161.
UCSCi uc003gwi.2. human.

Organism-specific databases

CTDi 55161.
GeneCardsi GC04P041937.
HGNCi HGNC:25541. TMEM33.
neXtProti NX_P57088.
PharmGKBi PA134963055.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG236583.
GeneTreei ENSGT00390000011368.
HOVERGENi HBG054225.
InParanoidi P57088.
OMAi IMKPSCP.
OrthoDBi EOG78SQJW.
PhylomeDBi P57088.
TreeFami TF314068.

Miscellaneous databases

ChiTaRSi TMEM33. human.
GenomeRNAii 55161.
NextBioi 58921.
PROi P57088.

Gene expression databases

Bgeei P57088.
CleanExi HS_TMEM33.
ExpressionAtlasi P57088. baseline and differential.
Genevestigatori P57088.

Family and domain databases

InterProi IPR005344. UPF0121.
[Graphical view ]
Pfami PF03661. UPF0121. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTMM33_HUMAN
AccessioniPrimary (citable) accession number: P57088
Secondary accession number(s): B3KSS8, Q9H953
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 19, 2002
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3