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Protein

Transmembrane protein 33

Gene

TMEM33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696).2 Publications

GO - Molecular functioni

GO - Biological processi

  • cellular protein localization Source: GO_Central
  • nuclear pore complex assembly Source: GO_Central
  • positive regulation of IRE1-mediated unfolded protein response Source: UniProtKB
  • positive regulation of PERK-mediated unfolded protein response Source: UniProtKB
  • regulation of endoplasmic reticulum tubular network organization Source: UniProtKB
  • response to endoplasmic reticulum stress Source: UniProtKB

Protein family/group databases

TCDBi9.B.180.1.3 the tetra spanning protein 1 (tts1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 33
Alternative name(s):
Protein DB83
SHINC-31 Publication
Gene namesi
Name:TMEM33
Synonyms:DB83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109133.12
HGNCiHGNC:25541 TMEM33
neXtProtiNX_P57088

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 31Lumenal1 PublicationAdd BLAST30
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 100Cytoplasmic1 PublicationAdd BLAST48
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 155Lumenal1 PublicationAdd BLAST34
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 247Cytoplasmic1 PublicationAdd BLAST71

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55161
OpenTargetsiENSG00000109133
PharmGKBiPA134963055

Polymorphism and mutation databases

BioMutaiTMEM33
DMDMi23503056

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002208992 – 247Transmembrane protein 33Add BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP57088
MaxQBiP57088
PaxDbiP57088
PeptideAtlasiP57088
PRIDEiP57088
TopDownProteomicsiP57088

PTM databases

iPTMnetiP57088
PhosphoSitePlusiP57088
SwissPalmiP57088

Expressioni

Tissue specificityi

Prostate cancer and several cancer cell lines (at protein level). Widely expressed. Expressed at higher levels in endocrine-resistant breast cancer cells as compared to endocrine-sensitive breast cancer cells. Expressed at higher levels in early recurrence breast cancer tissues as compared to non-recurrent breast tumors.1 Publication

Inductioni

By endoplasmic reticulum (ER) stress.1 Publication

Gene expression databases

BgeeiENSG00000109133
CleanExiHS_TMEM33
ExpressionAtlasiP57088 baseline and differential
GenevisibleiP57088 HS

Interactioni

Subunit structurei

Interacts with EIF2AK3 (PubMed:26268696). Interacts with ARL6IP1, isoform RTN1-A of RTN1, isoform RTN2-B of RTN2, isoform 3 of RTN3 and isoform 3 of RTN4 (PubMed:25612671).2 Publications

Protein-protein interaction databases

BioGridi120462, 23 interactors
IntActiP57088, 25 interactors
MINTiP57088
STRINGi9606.ENSP00000422473

Structurei

3D structure databases

SMRiP57088
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PER33/POM33 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4002 Eukaryota
ENOG4111BM3 LUCA
GeneTreeiENSGT00390000011368
HOVERGENiHBG054225
InParanoidiP57088
KOiK20724
OMAiIMKPSCP
OrthoDBiEOG091G0IX8
PhylomeDBiP57088
TreeFamiTF314068

Family and domain databases

InterProiView protein in InterPro
IPR005344 TMEM33/Pom33
PfamiView protein in Pfam
PF03661 UPF0121, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTTPNGPQ GAGAVQFMMT NKLDTAMWLS RLFTVYCSAL FVLPLLGLHE
60 70 80 90 100
AASFYQRALL ANALTSALRL HQRLPHFQLS RAFLAQALLE DSCHYLLYSL
110 120 130 140 150
IFVNSYPVTM SIFPVLLFSL LHAATYTKKV LDARGSNSLP LLRSVLDKLS
160 170 180 190 200
ANQQNILKFI ACNEIFLMPA TVFMLFSGQG SLLQPFIYYR FLTLRYSSRR
210 220 230 240
NPYCRTLFNE LRIVVEHIIM KPACPLFVRR LCLQSIAFIS RLAPTVP
Length:247
Mass (Da):27,978
Last modified:September 19, 2002 - v2
Checksum:i392A53377511A6A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7N → S in BAA91665 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001387 mRNA Translation: BAA91665.1
AK023062 mRNA Translation: BAB14384.1
AK094190 mRNA Translation: BAG52840.1
CR457260 mRNA Translation: CAG33541.1
CH471069 Genomic DNA Translation: EAW92991.1
BC000948 mRNA Translation: AAH00948.2
CCDSiCCDS3464.1
RefSeqiNP_060596.2, NM_018126.2
XP_005248173.1, XM_005248116.3
XP_005248174.1, XM_005248117.2
UniGeneiHs.31082

Genome annotation databases

EnsembliENST00000325094; ENSP00000441455; ENSG00000109133
ENST00000504986; ENSP00000422473; ENSG00000109133
ENST00000513702; ENSP00000427006; ENSG00000109133
GeneIDi55161
KEGGihsa:55161
UCSCiuc003gwi.3 human

Similar proteinsi

Entry informationi

Entry nameiTMM33_HUMAN
AccessioniPrimary (citable) accession number: P57088
Secondary accession number(s): B3KSS8, Q9H953
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 19, 2002
Last modified: May 23, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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