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Protein

Transmembrane protein 33

Gene

TMEM33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696).2 Publications

GO - Molecular functioni

GO - Biological processi

  • cellular protein localization Source: GO_Central
  • nuclear pore complex assembly Source: GO_Central
  • positive regulation of IRE1-mediated unfolded protein response Source: UniProtKB
  • positive regulation of PERK-mediated unfolded protein response Source: UniProtKB
  • regulation of endoplasmic reticulum tubular network organization Source: UniProtKB
  • response to endoplasmic reticulum stress Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 33
Alternative name(s):
Protein DB83
SHINC-31 Publication
Gene namesi
Name:TMEM33
Synonyms:DB83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25541. TMEM33.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3130Lumenal1 PublicationAdd
BLAST
Transmembranei32 – 5221HelicalSequence analysisAdd
BLAST
Topological domaini53 – 10048Cytoplasmic1 PublicationAdd
BLAST
Transmembranei101 – 12121HelicalSequence analysisAdd
BLAST
Topological domaini122 – 15534Lumenal1 PublicationAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Topological domaini177 – 24771Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: AgBase
  • endoplasmic reticulum membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of endoplasmic reticulum membrane Source: UniProtKB
  • melanosome Source: UniProtKB
  • nuclear envelope Source: AgBase
  • nuclear pore Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134963055.

Polymorphism and mutation databases

BioMutaiTMEM33.
DMDMi23503056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 247246Transmembrane protein 33PRO_0000220899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP57088.
MaxQBiP57088.
PaxDbiP57088.
PeptideAtlasiP57088.
PRIDEiP57088.
TopDownProteomicsiP57088.

PTM databases

iPTMnetiP57088.
PhosphoSiteiP57088.
SwissPalmiP57088.

Expressioni

Tissue specificityi

Prostate cancer and several cancer cell lines (at protein level). Widely expressed. Expressed at higher levels in endocrine-resistant breast cancer cells as compared to endocrine-sensitive breast cancer cells. Expressed at higher levels in early recurrence breast cancer tissues as compared to non-recurrent breast tumors.1 Publication

Inductioni

By endoplasmic reticulum (ER) stress.1 Publication

Gene expression databases

BgeeiENSG00000109133.
CleanExiHS_TMEM33.
ExpressionAtlasiP57088. baseline and differential.
GenevisibleiP57088. HS.

Interactioni

Subunit structurei

Interacts with EIF2AK3 (PubMed:26268696). Interacts with ARL6IP1, isoform RTN1-A of RTN1, isoform RTN2-B of RTN2, isoform 3 of RTN3 and isoform 3 of RTN4 (PubMed:25612671).2 Publications

Protein-protein interaction databases

BioGridi120462. 21 interactions.
IntActiP57088. 21 interactions.
MINTiMINT-3021719.
STRINGi9606.ENSP00000422473.

Structurei

3D structure databases

ProteinModelPortaliP57088.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PER33/POM33 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4002. Eukaryota.
ENOG4111BM3. LUCA.
GeneTreeiENSGT00390000011368.
HOVERGENiHBG054225.
InParanoidiP57088.
OMAiIMKPSCP.
OrthoDBiEOG091G0IX8.
PhylomeDBiP57088.
TreeFamiTF314068.

Family and domain databases

InterProiIPR005344. Per33/Pom33.
[Graphical view]
PfamiPF03661. UPF0121. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTTPNGPQ GAGAVQFMMT NKLDTAMWLS RLFTVYCSAL FVLPLLGLHE
60 70 80 90 100
AASFYQRALL ANALTSALRL HQRLPHFQLS RAFLAQALLE DSCHYLLYSL
110 120 130 140 150
IFVNSYPVTM SIFPVLLFSL LHAATYTKKV LDARGSNSLP LLRSVLDKLS
160 170 180 190 200
ANQQNILKFI ACNEIFLMPA TVFMLFSGQG SLLQPFIYYR FLTLRYSSRR
210 220 230 240
NPYCRTLFNE LRIVVEHIIM KPACPLFVRR LCLQSIAFIS RLAPTVP
Length:247
Mass (Da):27,978
Last modified:September 19, 2002 - v2
Checksum:i392A53377511A6A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71N → S in BAA91665 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001387 mRNA. Translation: BAA91665.1.
AK023062 mRNA. Translation: BAB14384.1.
AK094190 mRNA. Translation: BAG52840.1.
CR457260 mRNA. Translation: CAG33541.1.
CH471069 Genomic DNA. Translation: EAW92991.1.
BC000948 mRNA. Translation: AAH00948.2.
CCDSiCCDS3464.1.
RefSeqiNP_060596.2. NM_018126.2.
XP_005248173.1. XM_005248116.3.
XP_005248174.1. XM_005248117.2.
UniGeneiHs.31082.

Genome annotation databases

EnsembliENST00000325094; ENSP00000441455; ENSG00000109133.
ENST00000504986; ENSP00000422473; ENSG00000109133.
ENST00000513702; ENSP00000427006; ENSG00000109133.
GeneIDi55161.
KEGGihsa:55161.
UCSCiuc003gwi.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001387 mRNA. Translation: BAA91665.1.
AK023062 mRNA. Translation: BAB14384.1.
AK094190 mRNA. Translation: BAG52840.1.
CR457260 mRNA. Translation: CAG33541.1.
CH471069 Genomic DNA. Translation: EAW92991.1.
BC000948 mRNA. Translation: AAH00948.2.
CCDSiCCDS3464.1.
RefSeqiNP_060596.2. NM_018126.2.
XP_005248173.1. XM_005248116.3.
XP_005248174.1. XM_005248117.2.
UniGeneiHs.31082.

3D structure databases

ProteinModelPortaliP57088.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120462. 21 interactions.
IntActiP57088. 21 interactions.
MINTiMINT-3021719.
STRINGi9606.ENSP00000422473.

PTM databases

iPTMnetiP57088.
PhosphoSiteiP57088.
SwissPalmiP57088.

Polymorphism and mutation databases

BioMutaiTMEM33.
DMDMi23503056.

Proteomic databases

EPDiP57088.
MaxQBiP57088.
PaxDbiP57088.
PeptideAtlasiP57088.
PRIDEiP57088.
TopDownProteomicsiP57088.

Protocols and materials databases

DNASUi55161.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325094; ENSP00000441455; ENSG00000109133.
ENST00000504986; ENSP00000422473; ENSG00000109133.
ENST00000513702; ENSP00000427006; ENSG00000109133.
GeneIDi55161.
KEGGihsa:55161.
UCSCiuc003gwi.3. human.

Organism-specific databases

CTDi55161.
GeneCardsiTMEM33.
HGNCiHGNC:25541. TMEM33.
neXtProtiNX_P57088.
PharmGKBiPA134963055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4002. Eukaryota.
ENOG4111BM3. LUCA.
GeneTreeiENSGT00390000011368.
HOVERGENiHBG054225.
InParanoidiP57088.
OMAiIMKPSCP.
OrthoDBiEOG091G0IX8.
PhylomeDBiP57088.
TreeFamiTF314068.

Miscellaneous databases

ChiTaRSiTMEM33. human.
GenomeRNAii55161.
PROiP57088.

Gene expression databases

BgeeiENSG00000109133.
CleanExiHS_TMEM33.
ExpressionAtlasiP57088. baseline and differential.
GenevisibleiP57088. HS.

Family and domain databases

InterProiIPR005344. Per33/Pom33.
[Graphical view]
PfamiPF03661. UPF0121. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM33_HUMAN
AccessioniPrimary (citable) accession number: P57088
Secondary accession number(s): B3KSS8, Q9H953
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 19, 2002
Last modified: September 7, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.