Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Junctional adhesion molecule B

Gene

JAM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the processes of lymphocyte homing to secondary lymphoid organs.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Junctional adhesion molecule B
Short name:
JAM-B
Alternative name(s):
Junctional adhesion molecule 2
Short name:
JAM-2
Vascular endothelial junction-associated molecule
Short name:
VE-JAM
CD_antigen: CD322
Gene namesi
Name:JAM2
Synonyms:C21orf43, VEJAM
ORF Names:UNQ219/PRO245
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000154721.14
HGNCiHGNC:14686 JAM2
MIMi606870 gene
neXtProtiNX_P57087

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 238ExtracellularSequence analysisAdd BLAST210
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 298CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi58494
OpenTargetsiENSG00000154721
PharmGKBiPA29992

Polymorphism and mutation databases

BioMutaiJAM2
DMDMi10720348

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 282 PublicationsAdd BLAST28
ChainiPRO_000001506929 – 298Junctional adhesion molecule BAdd BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 109PROSITE-ProRule annotation
Glycosylationi98N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi155 ↔ 214PROSITE-ProRule annotation
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP57087
MaxQBiP57087
PaxDbiP57087
PeptideAtlasiP57087
PRIDEiP57087

PTM databases

iPTMnetiP57087
PhosphoSitePlusiP57087
SwissPalmiP57087

Expressioni

Tissue specificityi

Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells.1 Publication

Gene expression databases

BgeeiENSG00000154721
CleanExiHS_JAM2
ExpressionAtlasiP57087 baseline and differential
GenevisibleiP57087 HS

Organism-specific databases

HPAiHPA046547

Interactioni

Subunit structurei

Interacts with JAM3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
JAM3Q9BX672EBI-3918416,EBI-4314733

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121824, 10 interactors
CORUMiP57087
IntActiP57087, 8 interactors
MINTiP57087
STRINGi9606.ENSP00000420419

Structurei

3D structure databases

ProteinModelPortaliP57087
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 127Ig-like V-typeAdd BLAST96
Domaini134 – 238Ig-like C2-typeAdd BLAST105

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDXS Eukaryota
ENOG41100KX LUCA
GeneTreeiENSGT00730000110678
HOGENOMiHOG000247041
HOVERGENiHBG000518
InParanoidiP57087
KOiK06735
OrthoDBiEOG091G05PI
PhylomeDBiP57087
TreeFamiTF331459

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P57087-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARRSRHRLL LLLLRYLVVA LGYHKAYGFS APKDQQVVTA VEYQEAILAC
60 70 80 90 100
KTPKKTVSSR LEWKKLGRSV SFVYYQQTLQ GDFKNRAEMI DFNIRIKNVT
110 120 130 140 150
RSDAGKYRCE VSAPSEQGQN LEEDTVTLEV LVAPAVPSCE VPSSALSGTV
160 170 180 190 200
VELRCQDKEG NPAPEYTWFK DGIRLLENPR LGSQSTNSSY TMNTKTGTLQ
210 220 230 240 250
FNTVSKLDTG EYSCEARNSV GYRRCPGKRM QVDDLNISGI IAAVVVVALV
260 270 280 290
ISVCGLGVCY AQRKGYFSKE TSFQKSNSSS KATTMSENDF KHTKSFII
Length:298
Mass (Da):33,207
Last modified:December 1, 2000 - v1
Checksum:iCA78E518E22DCAEE
GO
Isoform 2 (identifier: P57087-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-79: Missing.

Show »
Length:262
Mass (Da):29,037
Checksum:i9892E90CBCB97C74
GO
Isoform 3 (identifier: P57087-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-298: DFKHTKSFII → VQWLTPVIPALWKAAAGGSRGQEF

Note: No experimental confirmation available.
Show »
Length:312
Mass (Da):34,554
Checksum:i7FAE85F8B54D7B0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270E → G in AAL82538 (PubMed:12036298).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049973286S → R. Corresponds to variant dbSNP:rs9976382Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04515344 – 79Missing in isoform 2. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_047352289 – 298DFKHTKSFII → VQWLTPVIPALWKAAAGGSR GQEF in isoform 3. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255910 mRNA Translation: AAF81223.1
AY016009 mRNA Translation: AAG49022.1
AY077698 mRNA Translation: AAL82538.1
AY358361 mRNA Translation: AAQ88727.1
AK294769 mRNA Translation: BAG57900.1
AK312708 mRNA Translation: BAG35586.1
AP000223 Genomic DNA No translation available.
AP000224 Genomic DNA No translation available.
AP000225 Genomic DNA No translation available.
AP000226 Genomic DNA No translation available.
BC017779 mRNA Translation: AAH17779.1
CCDSiCCDS42911.1 [P57087-1]
CCDS58787.1 [P57087-3]
CCDS58788.1 [P57087-2]
RefSeqiNP_001257336.1, NM_001270407.1 [P57087-2]
NP_001257337.1, NM_001270408.1 [P57087-3]
NP_067042.1, NM_021219.3 [P57087-1]
UniGeneiHs.517227

Genome annotation databases

EnsembliENST00000312957; ENSP00000318416; ENSG00000154721 [P57087-2]
ENST00000400532; ENSP00000383376; ENSG00000154721 [P57087-3]
ENST00000480456; ENSP00000420419; ENSG00000154721 [P57087-1]
GeneIDi58494
KEGGihsa:58494
UCSCiuc002ylp.3 human [P57087-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiJAM2_HUMAN
AccessioniPrimary (citable) accession number: P57087
Secondary accession number(s): B2R6T9
, B4DGT9, Q6UXG6, Q6YNC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health