ID   SCND1_HUMAN             Reviewed;         179 AA.
AC   P57086; Q6IAG7;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   27-MAR-2024, entry version 178.
DE   RecName: Full=SCAN domain-containing protein 1;
GN   Name=SCAND1; Synonyms=SDP1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10747874; DOI=10.1074/jbc.m000119200;
RA   Schumacher C., Wang H., Honer C., Ding W., Koehn J., Lawrence Q.,
RA   Coulis C.M., Wang L.L., Ballinger D., Bowen B.R., Wagner S.;
RT   "The SCAN domain mediates selective oligomerization.";
RL   J. Biol. Chem. 275:17173-17179(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May regulate transcriptional activity.
CC   -!- SUBUNIT: Interacts with ZNF202.
CC   -!- INTERACTION:
CC       P57086; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-745846, EBI-11522760;
CC       P57086; Q96BI3: APH1A; NbExp=3; IntAct=EBI-745846, EBI-2606935;
CC       P57086; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-745846, EBI-739580;
CC       P57086; Q96ER9: CCDC51; NbExp=3; IntAct=EBI-745846, EBI-11926384;
CC       P57086; Q6ZPD8: DGAT2L6; NbExp=3; IntAct=EBI-745846, EBI-12831978;
CC       P57086; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-745846, EBI-5916454;
CC       P57086; Q9H8Y8: GORASP2; NbExp=6; IntAct=EBI-745846, EBI-739467;
CC       P57086; Q6A162: KRT40; NbExp=3; IntAct=EBI-745846, EBI-10171697;
CC       P57086; Q969G2: LHX4; NbExp=3; IntAct=EBI-745846, EBI-2865388;
CC       P57086; O43674: NDUFB5; NbExp=3; IntAct=EBI-745846, EBI-1246293;
CC       P57086; Q96JS3: PGBD1; NbExp=11; IntAct=EBI-745846, EBI-10290053;
CC       P57086; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-745846, EBI-79165;
CC       P57086; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-745846, EBI-302345;
CC       P57086; Q16633: POU2AF1; NbExp=3; IntAct=EBI-745846, EBI-943588;
CC       P57086; O15258: RER1; NbExp=3; IntAct=EBI-745846, EBI-716910;
CC       P57086; Q9NXI6: RNF186; NbExp=3; IntAct=EBI-745846, EBI-2129361;
CC       P57086; Q9NS64: RPRM; NbExp=3; IntAct=EBI-745846, EBI-1052363;
CC       P57086; Q8WV19: SFT2D1; NbExp=3; IntAct=EBI-745846, EBI-2854842;
CC       P57086; Q8N114-3: SHISA5; NbExp=3; IntAct=EBI-745846, EBI-13369834;
CC       P57086; Q9BYT1: SLC17A9; NbExp=3; IntAct=EBI-745846, EBI-3940816;
CC       P57086; Q6UWW9: TMEM207; NbExp=3; IntAct=EBI-745846, EBI-13301303;
CC       P57086; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-745846, EBI-11528917;
CC       P57086; Q3KNT9: TMEM95; NbExp=3; IntAct=EBI-745846, EBI-12892569;
CC       P57086; Q15654: TRIP6; NbExp=3; IntAct=EBI-745846, EBI-742327;
CC       P57086; A6NH52: TVP23A; NbExp=3; IntAct=EBI-745846, EBI-13296313;
CC       P57086; Q9BRR0: ZKSCAN3; NbExp=3; IntAct=EBI-745846, EBI-1965777;
CC       P57086; Q969J2: ZKSCAN4; NbExp=7; IntAct=EBI-745846, EBI-2818641;
CC       P57086; Q9P0L1: ZKSCAN7; NbExp=4; IntAct=EBI-745846, EBI-743851;
CC       P57086; Q9P0L1-2: ZKSCAN7; NbExp=6; IntAct=EBI-745846, EBI-10698225;
CC       P57086; P49910: ZNF165; NbExp=11; IntAct=EBI-745846, EBI-741694;
CC       P57086; Q15697-2: ZNF174; NbExp=3; IntAct=EBI-745846, EBI-11158827;
CC       P57086; O14771: ZNF213; NbExp=3; IntAct=EBI-745846, EBI-12838388;
CC       P57086; P17028: ZNF24; NbExp=7; IntAct=EBI-745846, EBI-707773;
CC       P57086; O14978: ZNF263; NbExp=5; IntAct=EBI-745846, EBI-744493;
CC       P57086; Q53GI3: ZNF394; NbExp=11; IntAct=EBI-745846, EBI-10211248;
CC       P57086; Q96N95-3: ZNF396; NbExp=6; IntAct=EBI-745846, EBI-12328453;
CC       P57086; Q8NF99-2: ZNF397; NbExp=4; IntAct=EBI-745846, EBI-11524467;
CC       P57086; Q9NWS9-2: ZNF446; NbExp=5; IntAct=EBI-745846, EBI-740232;
CC       P57086; Q6P9G9: ZNF449; NbExp=8; IntAct=EBI-745846, EBI-10215956;
CC       P57086; Q6P088: ZNF483; NbExp=3; IntAct=EBI-745846, EBI-10196963;
CC       P57086; Q96IT1: ZNF496; NbExp=3; IntAct=EBI-745846, EBI-743906;
CC       P57086; O43309: ZSCAN12; NbExp=5; IntAct=EBI-745846, EBI-1210440;
CC       P57086; Q9H4T2: ZSCAN16; NbExp=3; IntAct=EBI-745846, EBI-723596;
CC       P57086; Q8TBC5: ZSCAN18; NbExp=3; IntAct=EBI-745846, EBI-3919096;
CC       P57086; P10073: ZSCAN22; NbExp=6; IntAct=EBI-745846, EBI-10178224;
CC       P57086; Q3MJ62: ZSCAN23; NbExp=8; IntAct=EBI-745846, EBI-5667532;
CC       P57086; Q6NSZ9-2: ZSCAN25; NbExp=3; IntAct=EBI-745846, EBI-14650477;
CC       P57086; Q9NX65: ZSCAN32; NbExp=3; IntAct=EBI-745846, EBI-739949;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
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DR   EMBL; AF204271; AAF59839.1; -; mRNA.
DR   EMBL; CR457188; CAG33469.1; -; mRNA.
DR   EMBL; AL109965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471077; EAW76150.1; -; Genomic_DNA.
DR   EMBL; BC000785; AAH00785.1; -; mRNA.
DR   EMBL; BC036709; AAH36709.1; -; mRNA.
DR   EMBL; BC041022; AAH41022.1; -; mRNA.
DR   CCDS; CCDS13269.1; -.
DR   RefSeq; NP_057642.1; NM_016558.3.
DR   RefSeq; NP_361012.2; NM_033630.2.
DR   AlphaFoldDB; P57086; -.
DR   SMR; P57086; -.
DR   BioGRID; 119434; 115.
DR   IntAct; P57086; 57.
DR   MINT; P57086; -.
DR   STRING; 9606.ENSP00000363103; -.
DR   MoonDB; P57086; Predicted.
DR   iPTMnet; P57086; -.
DR   PhosphoSitePlus; P57086; -.
DR   BioMuta; SCAND1; -.
DR   DMDM; 10720272; -.
DR   EPD; P57086; -.
DR   jPOST; P57086; -.
DR   MassIVE; P57086; -.
DR   MaxQB; P57086; -.
DR   PaxDb; 9606-ENSP00000363103; -.
DR   PeptideAtlas; P57086; -.
DR   ProteomicsDB; 56995; -.
DR   Pumba; P57086; -.
DR   Antibodypedia; 11616; 262 antibodies from 28 providers.
DR   DNASU; 51282; -.
DR   Ensembl; ENST00000305978.7; ENSP00000301995.2; ENSG00000171222.11.
DR   Ensembl; ENST00000373991.3; ENSP00000363103.3; ENSG00000171222.11.
DR   Ensembl; ENST00000615116.1; ENSP00000481289.1; ENSG00000171222.11.
DR   GeneID; 51282; -.
DR   KEGG; hsa:51282; -.
DR   MANE-Select; ENST00000305978.7; ENSP00000301995.2; NM_033630.3; NP_361012.3.
DR   UCSC; uc002xen.3; human.
DR   AGR; HGNC:10566; -.
DR   CTD; 51282; -.
DR   DisGeNET; 51282; -.
DR   GeneCards; SCAND1; -.
DR   HGNC; HGNC:10566; SCAND1.
DR   HPA; ENSG00000171222; Low tissue specificity.
DR   MIM; 610416; gene.
DR   neXtProt; NX_P57086; -.
DR   OpenTargets; ENSG00000171222; -.
DR   PharmGKB; PA34979; -.
DR   VEuPathDB; HostDB:ENSG00000171222; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000163024; -.
DR   HOGENOM; CLU_107409_0_0_1; -.
DR   InParanoid; P57086; -.
DR   OMA; EKSEGAC; -.
DR   OrthoDB; 4298141at2759; -.
DR   PhylomeDB; P57086; -.
DR   PathwayCommons; P57086; -.
DR   SignaLink; P57086; -.
DR   SIGNOR; P57086; -.
DR   BioGRID-ORCS; 51282; 35 hits in 1156 CRISPR screens.
DR   ChiTaRS; SCAND1; human.
DR   GeneWiki; SCAND1; -.
DR   GenomeRNAi; 51282; -.
DR   Pharos; P57086; Tbio.
DR   PRO; PR:P57086; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; P57086; Protein.
DR   Bgee; ENSG00000171222; Expressed in mucosa of transverse colon and 191 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IDA:LIFEdb.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR   CDD; cd07936; SCAN; 1.
DR   Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR   InterPro; IPR003309; SCAN_dom.
DR   InterPro; IPR038269; SCAN_sf.
DR   PANTHER; PTHR45935; PROTEIN ZBED8-RELATED; 1.
DR   PANTHER; PTHR45935:SF10; SCAN DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF02023; SCAN; 1.
DR   SMART; SM00431; SCAN; 1.
DR   SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   Genevisible; P57086; HS.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..179
FT                   /note="SCAN domain-containing protein 1"
FT                   /id="PRO_0000097632"
FT   DOMAIN          108..166
FT                   /note="SCAN box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT   REGION          1..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..57
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   179 AA;  19082 MW;  88AFEFC8E4DC9796 CRC64;
     MAATEPILAA TGSPAAVPPE KLEGAGSSSA PERNCVGSSL PEASPPAPEP SSPNAAVPEA
     IPTPRAAASA ALELPLGPAP VSVAPQAEAE ARSTPGPAGS RLGPETFRQR FRQFRYQDAA
     GPREAFRQLR ELSRQWLRPD IRTKEQIVEM LVQEQLLAIL PEAARARRIR RRTDVRITG
//