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P57086

- SCND1_HUMAN

UniProt

P57086 - SCND1_HUMAN

Protein

SCAN domain-containing protein 1

Gene

SCAND1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    May regulate transcriptional activity.

    GO - Molecular functioni

    1. identical protein binding Source: UniProtKB
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    4. transcription coactivator activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription from RNA polymerase II promoter Source: GOC
    2. transcription from RNA polymerase II promoter Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SCAN domain-containing protein 1
    Gene namesi
    Name:SCAND1
    Synonyms:SDP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:10566. SCAND1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: LIFEdb

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34979.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179SCAN domain-containing protein 1PRO_0000097632Add
    BLAST

    Proteomic databases

    MaxQBiP57086.
    PaxDbiP57086.
    PRIDEiP57086.

    PTM databases

    PhosphoSiteiP57086.

    Expressioni

    Gene expression databases

    ArrayExpressiP57086.
    BgeeiP57086.
    CleanExiHS_SCAND1.
    GenevestigatoriP57086.

    Organism-specific databases

    HPAiCAB034284.

    Interactioni

    Subunit structurei

    Interacts with ZNF202.

    Protein-protein interaction databases

    BioGridi119434. 13 interactions.
    IntActiP57086. 8 interactions.
    MINTiMINT-1435996.
    STRINGi9606.ENSP00000301995.

    Structurei

    3D structure databases

    ProteinModelPortaliP57086.
    SMRiP57086. Positions 104-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini108 – 16659SCAN boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG291024.
    HOVERGENiHBG079091.
    InParanoidiP57086.
    OMAiPERNSAG.
    OrthoDBiEOG7PS1JD.
    PhylomeDBiP57086.

    Family and domain databases

    InterProiIPR027775. C2H2_Znf_fam.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    [Graphical view]
    PANTHERiPTHR10032. PTHR10032. 1 hit.
    PfamiPF02023. SCAN. 1 hit.
    [Graphical view]
    SMARTiSM00431. SCAN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    PROSITEiPS50804. SCAN_BOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57086-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATEPILAA TGSPAAVPPE KLEGAGSSSA PERNCVGSSL PEASPPAPEP    50
    SSPNAAVPEA IPTPRAAASA ALELPLGPAP VSVAPQAEAE ARSTPGPAGS 100
    RLGPETFRQR FRQFRYQDAA GPREAFRQLR ELSRQWLRPD IRTKEQIVEM 150
    LVQEQLLAIL PEAARARRIR RRTDVRITG 179
    Length:179
    Mass (Da):19,082
    Last modified:December 1, 2000 - v1
    Checksum:i88AFEFC8E4DC9796
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF204271 mRNA. Translation: AAF59839.1.
    CR457188 mRNA. Translation: CAG33469.1.
    AL109965 Genomic DNA. Translation: CAC09390.1.
    CH471077 Genomic DNA. Translation: EAW76150.1.
    BC000785 mRNA. Translation: AAH00785.1.
    BC036709 mRNA. Translation: AAH36709.1.
    BC041022 mRNA. Translation: AAH41022.1.
    CCDSiCCDS13269.1.
    RefSeqiNP_057642.1. NM_016558.3.
    UniGeneiHs.584909.

    Genome annotation databases

    EnsembliENST00000305978; ENSP00000301995; ENSG00000171222.
    ENST00000373991; ENSP00000363103; ENSG00000171222.
    GeneIDi51282.
    KEGGihsa:51282.
    UCSCiuc002xeo.3. human.

    Polymorphism databases

    DMDMi10720272.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF204271 mRNA. Translation: AAF59839.1 .
    CR457188 mRNA. Translation: CAG33469.1 .
    AL109965 Genomic DNA. Translation: CAC09390.1 .
    CH471077 Genomic DNA. Translation: EAW76150.1 .
    BC000785 mRNA. Translation: AAH00785.1 .
    BC036709 mRNA. Translation: AAH36709.1 .
    BC041022 mRNA. Translation: AAH41022.1 .
    CCDSi CCDS13269.1.
    RefSeqi NP_057642.1. NM_016558.3.
    UniGenei Hs.584909.

    3D structure databases

    ProteinModelPortali P57086.
    SMRi P57086. Positions 104-162.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119434. 13 interactions.
    IntActi P57086. 8 interactions.
    MINTi MINT-1435996.
    STRINGi 9606.ENSP00000301995.

    PTM databases

    PhosphoSitei P57086.

    Polymorphism databases

    DMDMi 10720272.

    Proteomic databases

    MaxQBi P57086.
    PaxDbi P57086.
    PRIDEi P57086.

    Protocols and materials databases

    DNASUi 51282.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305978 ; ENSP00000301995 ; ENSG00000171222 .
    ENST00000373991 ; ENSP00000363103 ; ENSG00000171222 .
    GeneIDi 51282.
    KEGGi hsa:51282.
    UCSCi uc002xeo.3. human.

    Organism-specific databases

    CTDi 51282.
    GeneCardsi GC20M034542.
    HGNCi HGNC:10566. SCAND1.
    HPAi CAB034284.
    MIMi 610416. gene.
    neXtProti NX_P57086.
    PharmGKBi PA34979.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291024.
    HOVERGENi HBG079091.
    InParanoidi P57086.
    OMAi PERNSAG.
    OrthoDBi EOG7PS1JD.
    PhylomeDBi P57086.

    Miscellaneous databases

    ChiTaRSi SCAND1. human.
    GeneWikii SCAND1.
    GenomeRNAii 51282.
    NextBioi 54517.
    PROi P57086.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P57086.
    Bgeei P57086.
    CleanExi HS_SCAND1.
    Genevestigatori P57086.

    Family and domain databases

    InterProi IPR027775. C2H2_Znf_fam.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    [Graphical view ]
    PANTHERi PTHR10032. PTHR10032. 1 hit.
    Pfami PF02023. SCAN. 1 hit.
    [Graphical view ]
    SMARTi SM00431. SCAN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    PROSITEi PS50804. SCAN_BOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Skin.

    Entry informationi

    Entry nameiSCND1_HUMAN
    AccessioniPrimary (citable) accession number: P57086
    Secondary accession number(s): Q6IAG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3