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P57081

- WDR4_HUMAN

UniProt

P57081 - WDR4_HUMAN

Protein

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Gene

WDR4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (11 Feb 2002)
      Previous versions | rss
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    Functioni

    Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.1 PublicationUniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. RNA (guanine-N7)-methylation Source: InterPro
    2. tRNA methylation Source: UniProtKB-HAMAP
    3. tRNA modification Source: UniProtKB

    Keywords - Biological processi

    tRNA processing

    Enzyme and pathway databases

    SignaLinkiP57081.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4UniRule annotation
    Alternative name(s):
    WD repeat-containing protein 4UniRule annotation
    Gene namesi
    Name:WDR4UniRule annotation
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:12756. WDR4.

    Subcellular locationi

    Nucleus 1 PublicationUniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleoplasm Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37360.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 412411tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4PRO_0000051348Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei391 – 3911Phosphoserine1 Publication
    Modified residuei411 – 4111Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP57081.
    PaxDbiP57081.
    PeptideAtlasiP57081.
    PRIDEiP57081.

    PTM databases

    PhosphoSiteiP57081.

    Expressioni

    Gene expression databases

    BgeeiP57081.
    CleanExiHS_WDR4.
    GenevestigatoriP57081.

    Organism-specific databases

    HPAiHPA017381.

    Interactioni

    Subunit structurei

    Forms a heterodimer with the catalytic subunit METTL1.

    Protein-protein interaction databases

    BioGridi116001. 37 interactions.
    IntActiP57081. 1 interaction.
    MINTiMINT-1440842.
    STRINGi9606.ENSP00000328671.

    Structurei

    3D structure databases

    ProteinModelPortaliP57081.
    SMRiP57081. Positions 70-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati59 – 9840WD 1Add
    BLAST
    Repeati100 – 13940WD 2Add
    BLAST
    Repeati143 – 18341WD 3Add
    BLAST
    Repeati186 – 22641WD 4Add
    BLAST
    Repeati287 – 32741WD 5Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat TRM82 family.UniRule annotation
    Contains 5 WD repeats.UniRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG253533.
    HOVERGENiHBG022880.
    InParanoidiP57081.
    KOiK15443.
    OMAiTIANSND.
    OrthoDBiEOG7GXPCK.
    PhylomeDBiP57081.
    TreeFamiTF105877.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    HAMAPiMF_03056. TRM82.
    InterProiIPR028884. Trm82.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 2 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 4 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P57081-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGSVGLALC GQTLVVRGGS RFLATSIASS DDDSLFIYDC SAAEKKSQEN    50
    KGEDAPLDQG SGAILASTFS KSGSYFALTD DSKRLILFRT KPWQCLSVRT 100
    VARRCTALTF IASEEKVLVA DKSGDVYSFS VLEPHGCGRL ELGHLSMLLD 150
    VAVSPDDRFI LTADRDEKIR VSWAAAPHSI ESFCLGHTEF VSRISVVPTQ 200
    PGLLLSSSGD GTLRLWEYRS GRQLHCCHLA SLQELVDPQA PQKFAASRIA 250
    FWCQENCVAL LCDGTPVVYI FQLDARRQQL VYRQQLAFQH QVWDVAFEET 300
    QGLWVLQDCQ EAPLVLYRPV GDQWQSVPES TVLKKVSGVL RGNWAMLEGS 350
    AGADASFSSL YKATFDNVTS YLKKKEERLQ QQLEKKQRRR SPPPGPDGHA 400
    KKMRPGEATL SC 412
    Length:412
    Mass (Da):45,490
    Last modified:February 11, 2002 - v2
    Checksum:i394B11A2AFB1CADB
    GO
    Isoform 2 (identifier: P57081-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         243-243: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:411
    Mass (Da):45,362
    Checksum:iA32E06F66CE6574F
    GO
    Isoform 3 (identifier: P57081-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-146: Missing.

    Show »
    Length:266
    Mass (Da):29,946
    Checksum:i121DF7AE95363BD0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti141 – 1411E → K in CAB93144. (PubMed:10950928)Curated
    Sequence conflicti141 – 1411E → K in CAB93145. (PubMed:10950928)Curated
    Sequence conflicti149 – 1491L → V in CAB93144. (PubMed:10950928)Curated
    Sequence conflicti149 – 1491L → V in CAB93145. (PubMed:10950928)Curated
    Sequence conflicti236 – 2361V → A in BAG37500. (PubMed:14702039)Curated
    Sequence conflicti318 – 3181R → K in BAG60319. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti71 – 711K → N.2 Publications
    Corresponds to variant rs2248490 [ dbSNP | Ensembl ].
    VAR_020120
    Natural varianti266 – 2661P → S.2 Publications
    Corresponds to variant rs15736 [ dbSNP | Ensembl ].
    VAR_033121
    Natural varianti390 – 3901R → Q.
    Corresponds to variant rs6586250 [ dbSNP | Ensembl ].
    VAR_033122

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 146146Missing in isoform 3. 2 PublicationsVSP_036935Add
    BLAST
    Alternative sequencei243 – 2431Missing in isoform 2. 1 PublicationVSP_036936

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243912 mRNA. Translation: CAB93144.1.
    AJ243913 mRNA. Translation: CAB93145.1.
    AK056343 mRNA. Translation: BAG51684.1.
    AK292923 mRNA. Translation: BAF85612.1.
    AK298015 mRNA. Translation: BAG60319.1.
    AK315008 mRNA. Translation: BAG37500.1.
    AB039887 Genomic DNA. Translation: BAB13726.1.
    AP001629 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09528.1.
    CH471079 Genomic DNA. Translation: EAX09529.1.
    BC001074 mRNA. Translation: AAH01074.1.
    BC006341 mRNA. Translation: AAH06341.1.
    CCDSiCCDS13691.1. [P57081-1]
    RefSeqiNP_001247403.1. NM_001260474.1. [P57081-2]
    NP_001247404.1. NM_001260475.1. [P57081-3]
    NP_001247405.1. NM_001260476.1. [P57081-3]
    NP_001247406.1. NM_001260477.1. [P57081-3]
    NP_061139.2. NM_018669.5. [P57081-1]
    NP_387510.1. NM_033661.4. [P57081-1]
    XP_006724022.1. XM_006723959.1. [P57081-1]
    UniGeneiHs.248815.
    Hs.711744.

    Genome annotation databases

    EnsembliENST00000330317; ENSP00000328671; ENSG00000160193. [P57081-1]
    ENST00000398208; ENSP00000381266; ENSG00000160193. [P57081-1]
    GeneIDi10785.
    KEGGihsa:10785.
    UCSCiuc002zci.4. human. [P57081-1]
    uc010gpg.2. human. [P57081-2]

    Polymorphism databases

    DMDMi20141943.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243912 mRNA. Translation: CAB93144.1 .
    AJ243913 mRNA. Translation: CAB93145.1 .
    AK056343 mRNA. Translation: BAG51684.1 .
    AK292923 mRNA. Translation: BAF85612.1 .
    AK298015 mRNA. Translation: BAG60319.1 .
    AK315008 mRNA. Translation: BAG37500.1 .
    AB039887 Genomic DNA. Translation: BAB13726.1 .
    AP001629 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09528.1 .
    CH471079 Genomic DNA. Translation: EAX09529.1 .
    BC001074 mRNA. Translation: AAH01074.1 .
    BC006341 mRNA. Translation: AAH06341.1 .
    CCDSi CCDS13691.1. [P57081-1 ]
    RefSeqi NP_001247403.1. NM_001260474.1. [P57081-2 ]
    NP_001247404.1. NM_001260475.1. [P57081-3 ]
    NP_001247405.1. NM_001260476.1. [P57081-3 ]
    NP_001247406.1. NM_001260477.1. [P57081-3 ]
    NP_061139.2. NM_018669.5. [P57081-1 ]
    NP_387510.1. NM_033661.4. [P57081-1 ]
    XP_006724022.1. XM_006723959.1. [P57081-1 ]
    UniGenei Hs.248815.
    Hs.711744.

    3D structure databases

    ProteinModelPortali P57081.
    SMRi P57081. Positions 70-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116001. 37 interactions.
    IntActi P57081. 1 interaction.
    MINTi MINT-1440842.
    STRINGi 9606.ENSP00000328671.

    PTM databases

    PhosphoSitei P57081.

    Polymorphism databases

    DMDMi 20141943.

    Proteomic databases

    MaxQBi P57081.
    PaxDbi P57081.
    PeptideAtlasi P57081.
    PRIDEi P57081.

    Protocols and materials databases

    DNASUi 10785.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330317 ; ENSP00000328671 ; ENSG00000160193 . [P57081-1 ]
    ENST00000398208 ; ENSP00000381266 ; ENSG00000160193 . [P57081-1 ]
    GeneIDi 10785.
    KEGGi hsa:10785.
    UCSCi uc002zci.4. human. [P57081-1 ]
    uc010gpg.2. human. [P57081-2 ]

    Organism-specific databases

    CTDi 10785.
    GeneCardsi GC21M044263.
    HGNCi HGNC:12756. WDR4.
    HPAi HPA017381.
    MIMi 605924. gene.
    neXtProti NX_P57081.
    PharmGKBi PA37360.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253533.
    HOVERGENi HBG022880.
    InParanoidi P57081.
    KOi K15443.
    OMAi TIANSND.
    OrthoDBi EOG7GXPCK.
    PhylomeDBi P57081.
    TreeFami TF105877.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    SignaLinki P57081.

    Miscellaneous databases

    ChiTaRSi WDR4. human.
    GeneWikii WDR4.
    GenomeRNAii 10785.
    NextBioi 40960.
    PROi P57081.
    SOURCEi Search...

    Gene expression databases

    Bgeei P57081.
    CleanExi HS_WDR4.
    Genevestigatori P57081.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    HAMAPi MF_03056. TRM82.
    InterProi IPR028884. Trm82.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 2 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 4 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein."
      Michaud J., Kudoh J., Berry A., Bonne-Tamir B., Lalioti M.D., Rossier C., Shibuya K., Kawasaki K., Asakawa S., Minoshima S., Shimizu N., Antonarakis S.E., Scott H.S.
      Genomics 68:71-79(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANTS ASN-71 AND SER-266.
      Tissue: Lung and Trachea.
    3. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-71.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT SER-266.
      Tissue: Lung and Uterus.
    6. Bienvenut W.V.
      Submitted (JAN-2010) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-17 AND 105-116, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Ovarian carcinoma.
    7. "Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA."
      Alexandrov A., Martzen M.R., Phizicky E.M.
      RNA 8:1253-1266(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH METTL1.
    8. "The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells."
      Cartlidge R.A., Knebel A., Peggie M., Alexandrov A., Phizicky E.M., Cohen P.
      EMBO J. 24:1696-1705(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH METTL1.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiWDR4_HUMAN
    AccessioniPrimary (citable) accession number: P57081
    Secondary accession number(s): A8KA58
    , B2RCA3, B4DNQ7, D3DSK3, Q9BVM5, Q9HCR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: February 11, 2002
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3