Reviewed,
UniProtKB/Swiss-Prot P57078 (RIPK4_HUMAN)
Last modified
November 25, 2008.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Receptor-interacting serine/threonine-protein kinase 4 EC=2.7.11.1 Alternative name(s): Ankyrin repeat domain-containing protein 3 PKC-delta-interacting protein kinase | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 832 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Plays a role in NF-kappa B activation. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Subunit structure | Interacts with PRKCB By similarity. Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. |
| Subcellular location | Cytoplasm. Membrane; Peripheral membrane proteinBy similarity. |
| Post-translational modification | May be phosphorylated by MAP3K2 and MAP3K3 By similarity. Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-388 and Asp-426. |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains 10 ANK repeats. Contains 1 protein kinase domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | ANK repeat Repeat |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Receptor Serine/threonine-protein kinase Transferase |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activityInferred from electronic annotation. Source: InterPro receptor activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: P57078-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: P57078-2) The sequence of this isoform differs from the canonical sequence as follows: 278-325: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 832 | 832 | Receptor-interacting serine/threonine-protein kinase 4 | PRO_0000086613 | |||||
Regions | |||||||||
| Domain | 22 – 286 | 265 | Protein kinase | ||||||
| Repeat | 485 – 514 | 30 | ANK 1 | ||||||
| Repeat | 518 – 547 | 30 | ANK 2 | ||||||
| Repeat | 551 – 580 | 30 | ANK 3 | ||||||
| Repeat | 584 – 613 | 30 | ANK 4 | ||||||
| Repeat | 617 – 647 | 31 | ANK 5 | ||||||
| Repeat | 651 – 680 | 30 | ANK 6 | ||||||
| Repeat | 684 – 713 | 30 | ANK 7 | ||||||
| Repeat | 717 – 746 | 30 | ANK 8 | ||||||
| Repeat | 750 – 780 | 31 | ANK 9 | ||||||
| Repeat | 782 – 811 | 30 | ANK 10 | ||||||
| Nucleotide binding | 28 – 36 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 143 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 51 | 1 | ATP By similarity | ||||||
| Site | 388 – 389 | 2 | Cleavage | ||||||
| Site | 426 – 427 | 2 | Cleavage | ||||||
Natural variations | |||||||||
| Alternative sequence | 278 – 325 | 48 | Missing in isoform 2. | VSP_004862 | |||||
| Natural variant | 12 | 1 | A → G: dbSNP rs6586239. | VAR_030160 | |||||
| Natural variant | 177 | 1 | S → N: dbSNP rs12482626. | VAR_030161 | |||||
| Natural variant | 462 | 1 | I → N | VAR_041050 | |||||
| Natural variant | 463 | 1 | V → M | VAR_041051 | |||||
| Natural variant | 562 | 1 | N → Y | VAR_041052 | |||||
| Natural variant | 669 | 1 | R → H | VAR_041053 | |||||
| Natural variant | 749 | 1 | P → S | VAR_041054 | |||||
Experimental info | |||||||||
| Sequence conflict | 714 | 1 | M → V in BAB56136. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Shimizu N., Kudoh J., Shibuya K. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Fetal kidney and Fetal lung. |
| [2] | "The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. Yaspo M.-L.Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis." Meylan E., Martinon F., Thome M., Gschwendt M., Tschopp J. EMBO Rep. 3:1201-1208(2002) [PubMed: 12446564] [Abstract] Cited for: CLEAVAGE AT ASP-388 AND ASP-426, INTERACTION WITH TRAF1; TRAF2; TRAF3 AND TRAF5, FUNCTION. |
| [4] | "Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R.Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-462; MET-463; TYR-562; HIS-669 AND SER-749. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB047783 mRNA. Translation: BAB56136.1. AP001743 Genomic DNA. Translation: BAA95526.1. | |
| UniGene | Hs.517310 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1OY3 based on UniProtKB Q60778. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P57078. |
Genome annotation databases | |
| Ensembl | ENSG00000183421. Homo sapiens. [Contig view] |
Organism-specific databases | |
| HGNC | HGNC:496. RIPK4. |
| MIM | 605706. gene. |
| PharmGKB | PA24805. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P57078. |
| HOVERGEN | P57078. |
Gene expression databases | |
| ArrayExpress | P57078. |
| CleanEx | HS_RIPK4. |
| GermOnline | ENSG00000183421. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002110. ANK. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view] |
| Pfam | PF00023. Ank. 10 hits. PF00069. Pkinase. 1 hit. [Graphical view] |
| PRINTS | PR01415. ANKYRIN. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00248. ANK. 10 hits. [Graphical view] |
| PROSITE | PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 9 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | RIPK4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P57078 Secondary accession number(s): Q96KH0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 21 Human chromosome 21: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


