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Protein

MAP3K7 C-terminal-like protein

Gene

MAP3K7CL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MAP3K7 C-terminal-like protein
Alternative name(s):
TAK1-like protein
Gene namesi
Name:MAP3K7CL
Synonyms:C21orf7, TAK1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:16457. MAP3K7CL.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25864.

Polymorphism and mutation databases

DMDMi10719918.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242MAP3K7 C-terminal-like proteinPRO_0000072423Add
BLAST

Proteomic databases

MaxQBiP57077.
PaxDbiP57077.
PeptideAtlasiP57077.
PRIDEiP57077.

Expressioni

Tissue specificityi

Detected in lung and peripheral blood leukocytes. Expressed predominantly in peripheral blood leukocytes and ubiquitously in adult and fetal tissues. Also expressed strongly in breast carcinoma GI-101, colon adenocarcinoma GI-112, and prostatic adenocarcinoma PC3.1 Publication

Gene expression databases

BgeeiP57077.
CleanExiHS_C21orf7.
ExpressionAtlasiP57077. baseline and differential.
GenevisibleiP57077. HS.

Organism-specific databases

HPAiHPA042439.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AK8Q96MA63EBI-10215880,EBI-8466265
GPS2Q132272EBI-748831,EBI-713355
KRT31Q153233EBI-10215880,EBI-948001
RELQ048643EBI-10215880,EBI-307352
TAB3Q8N5C83EBI-10215880,EBI-359964

Protein-protein interaction databases

BioGridi121239. 6 interactions.
IntActiP57077. 6 interactions.
MINTiMINT-1440684.
STRINGi9606.ENSP00000343212.

Structurei

3D structure databases

ProteinModelPortaliP57077.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Contains a C-terminal domain similar to that of the C-terminal section of MAP3K7.

Phylogenomic databases

eggNOGiENOG410IVJJ. Eukaryota.
ENOG410YMMN. LUCA.
GeneTreeiENSGT00770000120675.
HOGENOMiHOG000036056.
HOVERGENiHBG054220.
InParanoidiP57077.
OMAiSGAHMIS.
PhylomeDBiP57077.
TreeFamiTF335499.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.

Isoform A (identifier: P57077-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQLIAPLEV MWNEAADLKP LALSRRLECS GGIMAHYSPD LLGPEMESRY
60 70 80 90 100
FAQVGLEHLA SSSPPAFGFL KCLDYSISVL CSATSLAMLE DNPKVSKLAT
110 120 130 140 150
GDWMLTLKPK SITVPVEIPS SPLDDTPPED SIPLVFPELD QQLQPLPPCH
160 170 180 190 200
DSEESMEVFK QHCQIAEEYH EVKKEITLLE QRKKELIAKL DQAEKEKVDA
210 220 230 240
AELVREFEAL TEENRTLRLA QSQCVEQLEK LRIQYQKRQG SS
Length:242
Mass (Da):27,248
Last modified:December 1, 2000 - v1
Checksum:iFFED148FE9AB838C
GO
Isoform B (identifier: P57077-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-138: DTPPEDSIPLVFPE → CQWLLCSRCSLVSH
     139-242: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:138
Mass (Da):15,068
Checksum:iB66D4F14EC8981FD
GO
Isoform C (identifier: P57077-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-145: DDTPPEDSIPLVFPELDQQLQP → AGRPRRRRRLRCPHDQHSQGTC
     146-242: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:145
Mass (Da):15,962
Checksum:i4454A57F2250A21D
GO
Isoform D (identifier: P57077-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.
     101-123: GDWMLTLKPKSITVPVEIPSSPL → MISTARVPADKPVRIAFSLNDAS

Show »
Length:142
Mass (Da):16,372
Checksum:i7F9BCBAF69F25444
GO

Sequence cautioni

The sequence CAB90434.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601K → R in CAD28500 (PubMed:17974005).Curated
Sequence conflicti170 – 1701H → L in CAD28500 (PubMed:17974005).Curated
Sequence conflicti195 – 1951K → E in CAD28500 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121I → V.
Corresponds to variant rs3746843 [ dbSNP | Ensembl ].
VAR_051408

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 100100Missing in isoform D. 2 PublicationsVSP_004140Add
BLAST
Alternative sequencei101 – 12323GDWML…PSSPL → MISTARVPADKPVRIAFSLN DAS in isoform D. 2 PublicationsVSP_004141Add
BLAST
Alternative sequencei124 – 14522DDTPP…QQLQP → AGRPRRRRRLRCPHDQHSQG TC in isoform C. CuratedVSP_004144Add
BLAST
Alternative sequencei125 – 13814DTPPE…LVFPE → CQWLLCSRCSLVSH in isoform B. CuratedVSP_004142Add
BLAST
Alternative sequencei139 – 242104Missing in isoform B. CuratedVSP_004143Add
BLAST
Alternative sequencei146 – 24297Missing in isoform C. CuratedVSP_004145Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269161 mRNA. Translation: AAF81751.1.
AF269162 mRNA. Translation: AAF81752.1.
AF269163 mRNA. Translation: AAF81753.1.
AF269164 mRNA. Translation: AAF81754.1.
AY033900 mRNA. Translation: AAK68718.1.
AY171599 mRNA. Translation: AAO16519.1.
AL713701 mRNA. Translation: CAD28500.1.
AL163249 Genomic DNA. Translation: CAB90434.1. Sequence problems.
CH471079 Genomic DNA. Translation: EAX09921.1.
CH471079 Genomic DNA. Translation: EAX09923.1.
BC008567 mRNA. Translation: AAH08567.1.
CCDSiCCDS13584.1. [P57077-1]
CCDS68182.1. [P57077-4]
RefSeqiNP_001273546.1. NM_001286617.1. [P57077-4]
NP_001273547.1. NM_001286618.1. [P57077-4]
NP_001273548.1. NM_001286619.1. [P57077-4]
NP_001273549.1. NM_001286620.1. [P57077-4]
NP_001273551.1. NM_001286622.1.
NP_001273553.1. NM_001286624.1.
NP_001273563.1. NM_001286634.1. [P57077-1]
NP_064537.1. NM_020152.3. [P57077-1]
UniGeneiHs.222802.

Genome annotation databases

EnsembliENST00000286791; ENSP00000286791; ENSG00000156265. [P57077-1]
ENST00000339024; ENSP00000345777; ENSG00000156265. [P57077-4]
ENST00000341618; ENSP00000343212; ENSG00000156265. [P57077-1]
ENST00000399925; ENSP00000382809; ENSG00000156265. [P57077-4]
ENST00000399926; ENSP00000382810; ENSG00000156265. [P57077-4]
ENST00000399928; ENSP00000382812; ENSG00000156265. [P57077-4]
ENST00000399934; ENSP00000382816; ENSG00000156265. [P57077-4]
ENST00000399935; ENSP00000382817; ENSG00000156265. [P57077-4]
ENST00000399947; ENSP00000382828; ENSG00000156265. [P57077-1]
GeneIDi56911.
KEGGihsa:56911.
UCSCiuc002ynd.5. human. [P57077-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269161 mRNA. Translation: AAF81751.1.
AF269162 mRNA. Translation: AAF81752.1.
AF269163 mRNA. Translation: AAF81753.1.
AF269164 mRNA. Translation: AAF81754.1.
AY033900 mRNA. Translation: AAK68718.1.
AY171599 mRNA. Translation: AAO16519.1.
AL713701 mRNA. Translation: CAD28500.1.
AL163249 Genomic DNA. Translation: CAB90434.1. Sequence problems.
CH471079 Genomic DNA. Translation: EAX09921.1.
CH471079 Genomic DNA. Translation: EAX09923.1.
BC008567 mRNA. Translation: AAH08567.1.
CCDSiCCDS13584.1. [P57077-1]
CCDS68182.1. [P57077-4]
RefSeqiNP_001273546.1. NM_001286617.1. [P57077-4]
NP_001273547.1. NM_001286618.1. [P57077-4]
NP_001273548.1. NM_001286619.1. [P57077-4]
NP_001273549.1. NM_001286620.1. [P57077-4]
NP_001273551.1. NM_001286622.1.
NP_001273553.1. NM_001286624.1.
NP_001273563.1. NM_001286634.1. [P57077-1]
NP_064537.1. NM_020152.3. [P57077-1]
UniGeneiHs.222802.

3D structure databases

ProteinModelPortaliP57077.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121239. 6 interactions.
IntActiP57077. 6 interactions.
MINTiMINT-1440684.
STRINGi9606.ENSP00000343212.

Polymorphism and mutation databases

DMDMi10719918.

Proteomic databases

MaxQBiP57077.
PaxDbiP57077.
PeptideAtlasiP57077.
PRIDEiP57077.

Protocols and materials databases

DNASUi56911.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286791; ENSP00000286791; ENSG00000156265. [P57077-1]
ENST00000339024; ENSP00000345777; ENSG00000156265. [P57077-4]
ENST00000341618; ENSP00000343212; ENSG00000156265. [P57077-1]
ENST00000399925; ENSP00000382809; ENSG00000156265. [P57077-4]
ENST00000399926; ENSP00000382810; ENSG00000156265. [P57077-4]
ENST00000399928; ENSP00000382812; ENSG00000156265. [P57077-4]
ENST00000399934; ENSP00000382816; ENSG00000156265. [P57077-4]
ENST00000399935; ENSP00000382817; ENSG00000156265. [P57077-4]
ENST00000399947; ENSP00000382828; ENSG00000156265. [P57077-1]
GeneIDi56911.
KEGGihsa:56911.
UCSCiuc002ynd.5. human. [P57077-1]

Organism-specific databases

CTDi56911.
GeneCardsiMAP3K7CL.
H-InvDBHIX0016050.
HGNCiHGNC:16457. MAP3K7CL.
HPAiHPA042439.
MIMi611110. gene.
neXtProtiNX_P57077.
PharmGKBiPA25864.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJJ. Eukaryota.
ENOG410YMMN. LUCA.
GeneTreeiENSGT00770000120675.
HOGENOMiHOG000036056.
HOVERGENiHBG054220.
InParanoidiP57077.
OMAiSGAHMIS.
PhylomeDBiP57077.
TreeFamiTF335499.

Miscellaneous databases

GeneWikiiC21orf7.
GenomeRNAii56911.
PROiP57077.
SOURCEiSearch...

Gene expression databases

BgeeiP57077.
CleanExiHS_C21orf7.
ExpressionAtlasiP57077. baseline and differential.
GenevisibleiP57077. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a new gene, C21orf7, similar to the TAB2-binding region of TAK1."
    Solans A., Domenech A., Estivill X., de la Luna S.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS A; B; C AND D).
  2. "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
    Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.
    Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM D).
  3. "Cloning and characterization of a novel human TGF-beta activated kinase-like gene."
    Li J., Ji C., Yang Q., Chen J., Gu S., Ying K., Xie Y., Mao Y.
    Biochem. Genet. 42:129-137(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D).
    Tissue: Brain.
  5. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D).
    Tissue: Brain.
  8. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).

Entry informationi

Entry nameiM3KCL_HUMAN
AccessioniPrimary (citable) accession number: P57077
Secondary accession number(s): D3DSE0, Q8TCL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 6, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.