P57076 (CU059_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C21orf59

Gene names

Name:	C21orf59
Synonyms:	C21orf48

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

To D.melanogaster CG18675.

Ontologies

Keywords
PTM	Acetylation Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytosol Inferred from direct assay. Source: UniProtKB nucleus Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Uncharacterized protein C21orf59		PRO_0000079523
Amino acid modifications
	Modified residue	264	1	Phosphotyrosine Ref.3
	Modified residue	283	1	N6-acetyllysine Ref.5
	Cross-link	210		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P57076 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 4C56A8C989B108DD	FASTA	290	33,224
	10 20 30 40 50 60 MVLLHVKRGD ESQFLLQAPG STELEELTVQ VARVYNGRLK VQRLCSEMEE LAEHGIFLPP 70 80 90 100 110 120 NMQGLTDDQI EELKLKDEWG EKCVPSGGAV FKKDDIGRRN GQAPNEKMKQ VLKKTIEEAK 130 140 150 160 170 180 AIISKKQVEA GVCVTMEMVK DALDQLRGAV MIVYPMGLPP YDPIRMEFEN KEDLSGTQAG 190 200 210 220 230 240 LNVIKEAEAQ LWWAAKELRR TKKLSDYVGK NEKTKIIAKI QQRGQGAPAR EPIISSEEQK 250 260 270 280 290 QLMLYYHRRQ EELKRLEEND DDAYLNSPWA DNTALKRHFH GVKDIKWRPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Lutfalla G. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-264, MASS SPECTROMETRY.
[4]	"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry." Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D. Proteomics 7:868-874(2007) [PubMed: 17370265] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-210, MASS SPECTROMETRY. Tissue: Mammary cancer.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-283, MASS SPECTROMETRY.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF282851 mRNA. Translation: AAG00496.1. BC000709 mRNA. Translation: AAH00709.1.
IPI	IPI00025710.
RefSeq	NP_067077.1. NM_021254.2.
UniGene	Hs.5811.
3D structure databases
ProteinModelPortal	P57076.
ModBase	Search...
PTM databases
PhosphoSite	P57076.
Polymorphism databases
DMDM	10719917.
Proteomic databases
PRIDE	P57076.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000290155; ENSP00000290155; ENSG00000159079.
GeneID	56683.
KEGG	hsa:56683.
UCSC	uc002ypy.1. human.
Organism-specific databases
CTD	56683.
GeneCards	GC21M033951.
HGNC	HGNC:1301. C21orf59.
HPA	CAB034170. HPA018453. HPA019055. HPA028849.
neXtProt	NX_P57076.
PharmGKB	PA25854.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06743.
HOVERGEN	HBG051236.
InParanoid	P57076.
OMA	QAPGSTE.
PhylomeDB	P57076.
Gene expression databases
ArrayExpress	P57076.
Bgee	P57076.
CleanEx	HS_C21orf59.
Genevestigator	P57076.
GermOnline	ENSG00000159079. Homo sapiens.
Family and domain databases
InterPro	IPR021298. DUF2870. [Graphical view]
Pfam	PF11069. DUF2870. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	62191.

Entry information

Entry name

CU059_HUMAN

Accession

Primary (citable) accession number: P57076

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.