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Protein

PR domain zinc finger protein 15

Gene

PRDM15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri563 – 58523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri738 – 76023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri765 – 78824C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri826 – 84823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri853 – 87523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri902 – 92423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri929 – 95123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri992 – 101524C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1020 – 104223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1056 – 107823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1084 – 110623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1112 – 113423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1140 – 116223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1168 – 119023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1196 – 121924C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1225 – 124824C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PR domain zinc finger protein 15 (EC:2.1.1.-)
Alternative name(s):
PR domain-containing protein 15
Zinc finger protein 298
Gene namesi
Name:PRDM15
Synonyms:C21orf83, ZNF298
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:13999. PRDM15.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33713.

Polymorphism and mutation databases

BioMutaiPRDM15.
DMDMi118572696.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15071507PR domain zinc finger protein 15PRO_0000047772Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki883 – 883Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP57071.
MaxQBiP57071.
PaxDbiP57071.
PRIDEiP57071.

PTM databases

iPTMnetiP57071.
PhosphoSiteiP57071.

Expressioni

Tissue specificityi

Detected in all tissues examined.1 Publication

Developmental stagei

Expressed in fetal tissues.1 Publication

Gene expression databases

BgeeiP57071.
CleanExiHS_PRDM15.
ExpressionAtlasiP57071. baseline and differential.
GenevisibleiP57071. HS.

Organism-specific databases

HPAiHPA024268.

Interactioni

Protein-protein interaction databases

BioGridi122024. 8 interactions.
IntActiP57071. 1 interaction.
STRINGi9606.ENSP00000269844.

Structurei

3D structure databases

ProteinModelPortaliP57071.
SMRiP57071. Positions 311-532, 735-1245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini415 – 525111SETPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi92 – 976Poly-Pro
Compositional biasi690 – 6956Poly-Thr
Compositional biasi1499 – 15035Poly-Gln

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri563 – 58523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri738 – 76023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri765 – 78824C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri826 – 84823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri853 – 87523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri902 – 92423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri929 – 95123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri992 – 101524C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1020 – 104223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1056 – 107823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1084 – 110623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1112 – 113423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1140 – 116223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1168 – 119023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1196 – 121924C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1225 – 124824C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129941.
HOGENOMiHOG000115685.
HOVERGENiHBG053669.
InParanoidiP57071.
OMAiATEYEHQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP57071.
TreeFamiTF331419.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 17 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P57071-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRRRPPASG AAQFPERIAT RSPDPIPLCT FQRQPRAAPV QPPCRLFFVT
60 70 80 90 100
FAGCGHRWRS ESKPGWISRS RSGIALRAAR PPGSSPPRPA APRPPPPGGV
110 120 130 140 150
VAEAPGDVVI PRPRVQPMRV ARGGPWTPNP AFREAESWSQ IGNQRVSEQL
160 170 180 190 200
LETSLGNEVS DTEPLSPASA GLRRNPALPP GPFAQNFSWG NQENLPPALG
210 220 230 240 250
KIANGGGTGA GKAECGYETE SHLLEPHEIP LNVNTHKFSD CEFPYEFCTV
260 270 280 290 300
CFSPFKLLGM SGVEGVWNQH SRSASMHTFL NHSATGIREA GCRKDMPVSE
310 320 330 340 350
MAEDGSEEIM FIWCEDCSQY HDSECPELGP VVMVKDSFVL SRARSWPASG
360 370 380 390 400
HVHTQAGQGM RGYEDRDRAD PQQLPEAVPA GLVRRLSGQQ LPCRSTLTWG
410 420 430 440 450
RLCHLVAQGR SSLPPNLEIR RLEDGAEGVF AITQLVKRTQ FGPFESRRVA
460 470 480 490 500
KWEKESAFPL KVFQKDGHPV CFDTSNEDDC NWMMLVRPAA EAEHQNLTAY
510 520 530 540 550
QHGSDVYFTT SRDIPPGTEL RVWYAAFYAK KMDKPMLKQA GSGVHAAGTP
560 570 580 590 600
ENSAPVESEP SQWACKVCSA TFLELQLLNE HLLGHLEQAK SLPPGSQSEA
610 620 630 640 650
AAPEKEQDTP RGEPPAVPES ENVATKEQKK KPRRGRKPKV SKAEQPLVIV
660 670 680 690 700
EDKEPTEQVA EIITEVPPDE PVSATPDERI MELVLGKLAT TTTDTSSVPK
710 720 730 740 750
FTHHQNNTIT LKRSLILSSR HGIRRKLIKQ LGEHKRVYQC NICSKIFQNS
760 770 780 790 800
SNLSRHVRSH GDKLFKCEEC AKLFSRKESL KQHVSYKHSR NEVDGEYRYR
810 820 830 840 850
CGTCEKTFRI ESALEFHNCR TDDKTFQCEM CFRFFSTNSN LSKHKKKHGD
860 870 880 890 900
KKFACEVCSK MFYRKDVMLD HQRRHLEGVR RVKREDLEAG GENLVRYKKE
910 920 930 940 950
PSGCPVCGKV FSCRSNMNKH LLTHGDKKYT CEICGRKFFR VDVLRDHIHV
960 970 980 990 1000
HFKDIALMDD HQREEFIGKI GISSEENDDN SDESADSEPH KYSCKRCQLT
1010 1020 1030 1040 1050
FGRGKEYLKH IMEVHKEKGY GCSICNRRFA LKATYHAHMV IHRENLPDPN
1060 1070 1080 1090 1100
VQKYIHPCEI CGRIFNSIGN LERHKLIHTG VKSHACEQCG KSFARKDMLK
1110 1120 1130 1140 1150
EHMRVHDNVR EYLCAECGKG MKTKHALRHH MKLHKGIKEY ECKECHRRFA
1160 1170 1180 1190 1200
QKVNMLKHCK RHTGIKDFMC ELCGKTFSER NTMETHKLIH TVGKQWTCSV
1210 1220 1230 1240 1250
CDKKYVTEYM LQKHVQLTHD KVEAQSCQLC GTKVSTRASM SRHMRRKHPE
1260 1270 1280 1290 1300
VLAVRIDDLD HLPETTTIDA SSIGIVQPEL TLEQEDLAEG KHGKAAKRSH
1310 1320 1330 1340 1350
KRKQKPEEEA GAPVPEDATF SEYSEKETEF TGSVGDETNS AVQSIQQVVV
1360 1370 1380 1390 1400
TLGDPNVTTP SSSVGLTNIT VTPITTAAAT QFTNLQPVAV GHLTTPERQL
1410 1420 1430 1440 1450
QLDNSILTVT FDTVSGSAML HNRQNDVQIH PQPEASNPQS VAHFINLTTL
1460 1470 1480 1490 1500
VNSITPLGSQ LSDQHPLTWR AVPQTDVLPP SQPQAPPQQA AQPQVQAEQQ

QQQMYSY
Length:1,507
Mass (Da):169,269
Last modified:November 28, 2006 - v4
Checksum:iE980A7EDB97239D0
GO
Isoform 2 (identifier: P57071-2) [UniParc]FASTAAdd to basket

Also known as: ZNF298b

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.
     821-821: T → TGLIAHPGEGGPGGSRLRDLP

Show »
Length:1,198
Mass (Da):135,670
Checksum:i6EEA445CDDCA07A7
GO
Isoform 3 (identifier: P57071-3) [UniParc]FASTAAdd to basket

Also known as: ZNF298a

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.

Show »
Length:1,178
Mass (Da):133,732
Checksum:i6F51396D6B31F50B
GO
Isoform 4 (identifier: P57071-5) [UniParc]FASTAAdd to basket

Also known as: ZNF298c

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.
     822-884: DDKTFQCEMC...HLEGVRRVKR → GLIAHPGEGG...SAGTWKECGE
     885-1507: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:555
Mass (Da):62,097
Checksum:i7676D13685BAC4C8
GO
Isoform 5 (identifier: P57071-6) [UniParc]FASTAAdd to basket

Also known as: ZNF298d

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.
     701-720: Missing.
     822-864: DDKTFQCEMC...CEVCSKMFYR → ATSPSTRRST...SAGTWKECGE
     865-1507: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:515
Mass (Da):57,810
Checksum:i44CC7B8E12AE587A
GO

Sequence cautioni

The sequence AAL60596.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAM53515.1 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated
The sequence AAM53516.1 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated
The sequence BAA95527.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAD99015.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD99016.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD99017.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD99018.1 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated
The sequence BAD99020.1 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1147 – 11471R → G in AAL60596 (PubMed:12036297).Curated
Sequence conflicti1167 – 11671D → I in AAL60596 (PubMed:12036297).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1342 – 13421V → I.
Corresponds to variant rs3819158 [ dbSNP | Ensembl ].
VAR_014992
Natural varianti1376 – 13761T → S.
Corresponds to variant rs2236695 [ dbSNP | Ensembl ].
VAR_014993
Natural varianti1481 – 14811S → P.3 Publications
Corresponds to variant rs3850706 [ dbSNP | Ensembl ].
VAR_014994

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei35 – 297263Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 1 PublicationVSP_055110Add
BLAST
Alternative sequencei344 – 40966Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 1 PublicationVSP_055111Add
BLAST
Alternative sequencei701 – 72020Missing in isoform 5. 1 PublicationVSP_055112Add
BLAST
Alternative sequencei821 – 8211T → TGLIAHPGEGGPGGSRLRDL P in isoform 2. 1 PublicationVSP_055113
Alternative sequencei822 – 88463DDKTF…RRVKR → GLIAHPGEGGPGGSRLRDLP ATSPSTRRSTATRSLPVRSA ARCSTARTSCWTTSAGTWKE CGE in isoform 4. 1 PublicationVSP_055114Add
BLAST
Alternative sequencei822 – 86443DDKTF…KMFYR → ATSPSTRRSTATRSLPVRSA ARCSTARTSCWTTSAGTWKE CGE in isoform 5. 1 PublicationVSP_055115Add
BLAST
Alternative sequencei865 – 1507643Missing in isoform 5. 1 PublicationVSP_055116Add
BLAST
Alternative sequencei885 – 1507623Missing in isoform 4. 1 PublicationVSP_055117Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078498 mRNA. Translation: AAL85487.2.
AB051812 mRNA. Translation: BAD99015.1. Different initiation.
AB051813 mRNA. Translation: BAD99016.1. Different initiation.
AB051814 mRNA. Translation: BAD99017.1. Different initiation.
AB051814 mRNA. Translation: BAD99018.1. Sequence problems.
AB051815 mRNA. Translation: BAD99020.1. Sequence problems.
AB126081 Genomic DNA. No translation available.
AP001580 Genomic DNA. No translation available.
AP001618 Genomic DNA. No translation available.
AP001619 Genomic DNA. No translation available.
AP001745 Genomic DNA. Translation: BAA95527.1. Sequence problems.
AP002955 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09585.1.
AF276513 mRNA. Translation: AAF78093.1.
AY063456 mRNA. Translation: AAL60596.1. Different initiation.
AF426259 mRNA. Translation: AAM53515.1. Sequence problems.
AF426260 mRNA. Translation: AAM53516.1. Sequence problems.
CCDSiCCDS13676.1. [P57071-1]
CCDS42932.1. [P57071-3]
CCDS63370.1. [P57071-2]
RefSeqiNP_001035514.1. NM_001040424.2. [P57071-3]
NP_001269863.1. NM_001282934.1. [P57071-2]
NP_071398.3. NM_022115.4. [P57071-1]
UniGeneiHs.473893.
Hs.726680.

Genome annotation databases

EnsembliENST00000269844; ENSP00000269844; ENSG00000141956. [P57071-1]
ENST00000398548; ENSP00000381556; ENSG00000141956. [P57071-3]
ENST00000422911; ENSP00000408592; ENSG00000141956. [P57071-2]
ENST00000433067; ENSP00000415471; ENSG00000141956. [P57071-1]
ENST00000449395; ENSP00000396943; ENSG00000141956. [P57071-5]
GeneIDi63977.
KEGGihsa:63977.
UCSCiuc002yzo.4. human. [P57071-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078498 mRNA. Translation: AAL85487.2.
AB051812 mRNA. Translation: BAD99015.1. Different initiation.
AB051813 mRNA. Translation: BAD99016.1. Different initiation.
AB051814 mRNA. Translation: BAD99017.1. Different initiation.
AB051814 mRNA. Translation: BAD99018.1. Sequence problems.
AB051815 mRNA. Translation: BAD99020.1. Sequence problems.
AB126081 Genomic DNA. No translation available.
AP001580 Genomic DNA. No translation available.
AP001618 Genomic DNA. No translation available.
AP001619 Genomic DNA. No translation available.
AP001745 Genomic DNA. Translation: BAA95527.1. Sequence problems.
AP002955 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09585.1.
AF276513 mRNA. Translation: AAF78093.1.
AY063456 mRNA. Translation: AAL60596.1. Different initiation.
AF426259 mRNA. Translation: AAM53515.1. Sequence problems.
AF426260 mRNA. Translation: AAM53516.1. Sequence problems.
CCDSiCCDS13676.1. [P57071-1]
CCDS42932.1. [P57071-3]
CCDS63370.1. [P57071-2]
RefSeqiNP_001035514.1. NM_001040424.2. [P57071-3]
NP_001269863.1. NM_001282934.1. [P57071-2]
NP_071398.3. NM_022115.4. [P57071-1]
UniGeneiHs.473893.
Hs.726680.

3D structure databases

ProteinModelPortaliP57071.
SMRiP57071. Positions 311-532, 735-1245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122024. 8 interactions.
IntActiP57071. 1 interaction.
STRINGi9606.ENSP00000269844.

PTM databases

iPTMnetiP57071.
PhosphoSiteiP57071.

Polymorphism and mutation databases

BioMutaiPRDM15.
DMDMi118572696.

Proteomic databases

EPDiP57071.
MaxQBiP57071.
PaxDbiP57071.
PRIDEiP57071.

Protocols and materials databases

DNASUi63977.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269844; ENSP00000269844; ENSG00000141956. [P57071-1]
ENST00000398548; ENSP00000381556; ENSG00000141956. [P57071-3]
ENST00000422911; ENSP00000408592; ENSG00000141956. [P57071-2]
ENST00000433067; ENSP00000415471; ENSG00000141956. [P57071-1]
ENST00000449395; ENSP00000396943; ENSG00000141956. [P57071-5]
GeneIDi63977.
KEGGihsa:63977.
UCSCiuc002yzo.4. human. [P57071-1]

Organism-specific databases

CTDi63977.
GeneCardsiPRDM15.
HGNCiHGNC:13999. PRDM15.
HPAiHPA024268.
neXtProtiNX_P57071.
PharmGKBiPA33713.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129941.
HOGENOMiHOG000115685.
HOVERGENiHBG053669.
InParanoidiP57071.
OMAiATEYEHQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP57071.
TreeFamiTF331419.

Miscellaneous databases

GenomeRNAii63977.
NextBioi35501649.
PROiP57071.

Gene expression databases

BgeeiP57071.
CleanExiHS_PRDM15.
ExpressionAtlasiP57071. baseline and differential.
GenevisibleiP57071. HS.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 17 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis."
    Gardiner K., Slavov D., Bechtel L., Davisson M.
    Genomics 79:833-843(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Identification of a novel zinc finger protein gene (ZNF298) in the GAP2 of human chromosome 21q."
    Shibuya K., Kudoh J., Okui M., Shimizu N.
    Biochem. Biophys. Res. Commun. 332:557-568(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), VARIANT PRO-1481, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Thymus.
  3. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-1481.
  5. "A family of novel PR-domain (PRDM) genes as candidate tumor suppressors."
    Yang X.-H., Huang S.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-951 (ISOFORM 1).
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1136-1507 (ISOFORMS 1/2), VARIANT PRO-1481.
  7. "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability."
    Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., Vertegaal A.C.
    Mol. Cell. Proteomics 14:1419-1434(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-883, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPRD15_HUMAN
AccessioniPrimary (citable) accession number: P57071
Secondary accession number(s): E9PDJ6
, E9PF37, E9PGL3, Q4W8S0, Q4W8S3, Q4W8S4, Q4W8S5, Q8N0X3, Q8NEX0, Q9NQV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 28, 2006
Last modified: May 11, 2016
This is version 153 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.