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P57060

- RWD2B_HUMAN

UniProt

P57060 - RWD2B_HUMAN

Protein

RWD domain-containing protein 2B

Gene

RWDD2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RWD domain-containing protein 2B
    Gene namesi
    Name:RWDD2B
    Synonyms:C21orf6
    ORF Names:GL011
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:1302. RWDD2B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162402318.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319RWD domain-containing protein 2BPRO_0000079504Add
    BLAST

    Proteomic databases

    MaxQBiP57060.
    PaxDbiP57060.
    PeptideAtlasiP57060.
    PRIDEiP57060.

    PTM databases

    PhosphoSiteiP57060.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    BgeeiP57060.
    CleanExiHS_RWDD2B.
    GenevestigatoriP57060.

    Organism-specific databases

    HPAiHPA018316.

    Interactioni

    Protein-protein interaction databases

    BioGridi115380. 6 interactions.
    IntActiP57060. 5 interactions.
    MINTiMINT-1424212.
    STRINGi9606.ENSP00000418693.

    Structurei

    Secondary structure

    1
    319
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi34 – 4916
    Beta strandi52 – 598
    Helixi61 – 7313
    Beta strandi83 – 9210
    Beta strandi98 – 10710
    Beta strandi119 – 1213
    Helixi127 – 14317
    Helixi152 – 16514

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DAXNMR-A34-172[»]
    ProteinModelPortaliP57060.
    SMRiP57060. Positions 34-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP57060.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 165125RWDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RWD domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG41494.
    HOGENOMiHOG000007195.
    HOVERGENiHBG051223.
    InParanoidiP57060.
    OMAiLGDVCIL.
    OrthoDBiEOG71G9VN.
    PhylomeDBiP57060.
    TreeFamiTF324344.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR010541. DUF1115.
    IPR006575. RWD-domain.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    IPR017359. UCP038021_RWD.
    [Graphical view]
    PANTHERiPTHR15955. PTHR15955. 1 hit.
    PfamiPF06544. DUF1115. 1 hit.
    PF05773. RWD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038021. UCP038021_RWDD2. 1 hit.
    SMARTiSM00591. RWD. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS50908. RWD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57060-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIELSMQPW NPGYSSEGAT AQETYTCPKM IEMEQAEAQL AELDLLASMF    50
    PGENELIVND QLAVAELKDC IEKKTMEGRS SKVYFTINMN LDVSDEKMAM 100
    FSLACILPFK YPAVLPEITV RSVLLSRSQQ TQLNTDLTAF LQKHCHGDVC 150
    ILNATEWVRE HASGYVSRDT SSSPTTGSTV QSVDLIFTRL WIYSHHIYNK 200
    CKRKNILEWA KELSLSGFSM PGKPGVVCVE GPQSACEEFW SRLRKLNWKR 250
    ILIRHREDIP FDGTNDETER QRKFSIFEEK VFSVNGARGN HMDFGQLYQF 300
    LNTKGCGDVF QMFFGVEGQ 319
    Length:319
    Mass (Da):36,332
    Last modified:December 1, 2000 - v1
    Checksum:i1E04418893C889B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y19009 mRNA. Translation: CAB88085.1.
    AF212232 mRNA. Translation: AAK14918.1.
    AK000056 mRNA. Translation: BAA90913.1.
    AL163249 Genomic DNA. Translation: CAB90431.1.
    BC012546 mRNA. Translation: AAH12546.1.
    BC017912 mRNA. Translation: AAH17912.1.
    CCDSiCCDS13582.1.
    RefSeqiNP_058636.1. NM_016940.2.
    UniGeneiHs.713123.

    Genome annotation databases

    EnsembliENST00000493196; ENSP00000418693; ENSG00000156253.
    GeneIDi10069.
    KEGGihsa:10069.
    UCSCiuc002yms.3. human.

    Polymorphism databases

    DMDMi9972769.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y19009 mRNA. Translation: CAB88085.1 .
    AF212232 mRNA. Translation: AAK14918.1 .
    AK000056 mRNA. Translation: BAA90913.1 .
    AL163249 Genomic DNA. Translation: CAB90431.1 .
    BC012546 mRNA. Translation: AAH12546.1 .
    BC017912 mRNA. Translation: AAH17912.1 .
    CCDSi CCDS13582.1.
    RefSeqi NP_058636.1. NM_016940.2.
    UniGenei Hs.713123.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DAX NMR - A 34-172 [» ]
    ProteinModelPortali P57060.
    SMRi P57060. Positions 34-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115380. 6 interactions.
    IntActi P57060. 5 interactions.
    MINTi MINT-1424212.
    STRINGi 9606.ENSP00000418693.

    PTM databases

    PhosphoSitei P57060.

    Polymorphism databases

    DMDMi 9972769.

    Proteomic databases

    MaxQBi P57060.
    PaxDbi P57060.
    PeptideAtlasi P57060.
    PRIDEi P57060.

    Protocols and materials databases

    DNASUi 10069.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000493196 ; ENSP00000418693 ; ENSG00000156253 .
    GeneIDi 10069.
    KEGGi hsa:10069.
    UCSCi uc002yms.3. human.

    Organism-specific databases

    CTDi 10069.
    GeneCardsi GC21M030376.
    H-InvDB HIX0016046.
    HGNCi HGNC:1302. RWDD2B.
    HPAi HPA018316.
    neXtProti NX_P57060.
    PharmGKBi PA162402318.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41494.
    HOGENOMi HOG000007195.
    HOVERGENi HBG051223.
    InParanoidi P57060.
    OMAi LGDVCIL.
    OrthoDBi EOG71G9VN.
    PhylomeDBi P57060.
    TreeFami TF324344.

    Miscellaneous databases

    EvolutionaryTracei P57060.
    GeneWikii RWDD2B.
    GenomeRNAii 10069.
    NextBioi 38059.
    PROi P57060.

    Gene expression databases

    Bgeei P57060.
    CleanExi HS_RWDD2B.
    Genevestigatori P57060.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR010541. DUF1115.
    IPR006575. RWD-domain.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    IPR017359. UCP038021_RWD.
    [Graphical view ]
    PANTHERi PTHR15955. PTHR15955. 1 hit.
    Pfami PF06544. DUF1115. 1 hit.
    PF05773. RWD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038021. UCP038021_RWDD2. 1 hit.
    SMARTi SM00591. RWD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS50908. RWD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and of its murine ortholog, orf5."
      Orti R., Rachidi M., Vialard F., Toyama K., Lopes C., Taudien S., Rosenthal A., Yaspo M.-L., Sinet P.-M., Delabar J.-M.
      Genomics 64:203-210(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A novel gene expressed in human liver non-tumor tissues."
      Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    4. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Solution structure of the RWD domain of human protein C21orf6."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 34-173.

    Entry informationi

    Entry nameiRWD2B_HUMAN
    AccessioniPrimary (citable) accession number: P57060
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3