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P57060

- RWD2B_HUMAN

UniProt

P57060 - RWD2B_HUMAN

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Protein

RWD domain-containing protein 2B

Gene
RWDD2B, C21orf6, GL011
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RWD domain-containing protein 2B
Gene namesi
Name:RWDD2B
Synonyms:C21orf6
ORF Names:GL011
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:1302. RWDD2B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402318.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319RWD domain-containing protein 2BPRO_0000079504Add
BLAST

Proteomic databases

MaxQBiP57060.
PaxDbiP57060.
PeptideAtlasiP57060.
PRIDEiP57060.

PTM databases

PhosphoSiteiP57060.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiP57060.
CleanExiHS_RWDD2B.
GenevestigatoriP57060.

Organism-specific databases

HPAiHPA018316.

Interactioni

Protein-protein interaction databases

BioGridi115380. 6 interactions.
IntActiP57060. 5 interactions.
MINTiMINT-1424212.
STRINGi9606.ENSP00000418693.

Structurei

Secondary structure

1
319
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi34 – 4916
Beta strandi52 – 598
Helixi61 – 7313
Beta strandi83 – 9210
Beta strandi98 – 10710
Beta strandi119 – 1213
Helixi127 – 14317
Helixi152 – 16514

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DAXNMR-A34-172[»]
ProteinModelPortaliP57060.
SMRiP57060. Positions 34-177.

Miscellaneous databases

EvolutionaryTraceiP57060.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 165125RWDAdd
BLAST

Sequence similaritiesi

Contains 1 RWD domain.

Phylogenomic databases

eggNOGiNOG41494.
HOGENOMiHOG000007195.
HOVERGENiHBG051223.
InParanoidiP57060.
OMAiLGDVCIL.
OrthoDBiEOG71G9VN.
PhylomeDBiP57060.
TreeFamiTF324344.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR010541. DUF1115.
IPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR017359. UCP038021_RWD.
[Graphical view]
PANTHERiPTHR15955. PTHR15955. 1 hit.
PfamiPF06544. DUF1115. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
PIRSFiPIRSF038021. UCP038021_RWDD2. 1 hit.
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57060-1 [UniParc]FASTAAdd to Basket

« Hide

MKIELSMQPW NPGYSSEGAT AQETYTCPKM IEMEQAEAQL AELDLLASMF    50
PGENELIVND QLAVAELKDC IEKKTMEGRS SKVYFTINMN LDVSDEKMAM 100
FSLACILPFK YPAVLPEITV RSVLLSRSQQ TQLNTDLTAF LQKHCHGDVC 150
ILNATEWVRE HASGYVSRDT SSSPTTGSTV QSVDLIFTRL WIYSHHIYNK 200
CKRKNILEWA KELSLSGFSM PGKPGVVCVE GPQSACEEFW SRLRKLNWKR 250
ILIRHREDIP FDGTNDETER QRKFSIFEEK VFSVNGARGN HMDFGQLYQF 300
LNTKGCGDVF QMFFGVEGQ 319
Length:319
Mass (Da):36,332
Last modified:December 1, 2000 - v1
Checksum:i1E04418893C889B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y19009 mRNA. Translation: CAB88085.1.
AF212232 mRNA. Translation: AAK14918.1.
AK000056 mRNA. Translation: BAA90913.1.
AL163249 Genomic DNA. Translation: CAB90431.1.
BC012546 mRNA. Translation: AAH12546.1.
BC017912 mRNA. Translation: AAH17912.1.
CCDSiCCDS13582.1.
RefSeqiNP_058636.1. NM_016940.2.
UniGeneiHs.713123.

Genome annotation databases

EnsembliENST00000493196; ENSP00000418693; ENSG00000156253.
GeneIDi10069.
KEGGihsa:10069.
UCSCiuc002yms.3. human.

Polymorphism databases

DMDMi9972769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y19009 mRNA. Translation: CAB88085.1 .
AF212232 mRNA. Translation: AAK14918.1 .
AK000056 mRNA. Translation: BAA90913.1 .
AL163249 Genomic DNA. Translation: CAB90431.1 .
BC012546 mRNA. Translation: AAH12546.1 .
BC017912 mRNA. Translation: AAH17912.1 .
CCDSi CCDS13582.1.
RefSeqi NP_058636.1. NM_016940.2.
UniGenei Hs.713123.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DAX NMR - A 34-172 [» ]
ProteinModelPortali P57060.
SMRi P57060. Positions 34-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115380. 6 interactions.
IntActi P57060. 5 interactions.
MINTi MINT-1424212.
STRINGi 9606.ENSP00000418693.

PTM databases

PhosphoSitei P57060.

Polymorphism databases

DMDMi 9972769.

Proteomic databases

MaxQBi P57060.
PaxDbi P57060.
PeptideAtlasi P57060.
PRIDEi P57060.

Protocols and materials databases

DNASUi 10069.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000493196 ; ENSP00000418693 ; ENSG00000156253 .
GeneIDi 10069.
KEGGi hsa:10069.
UCSCi uc002yms.3. human.

Organism-specific databases

CTDi 10069.
GeneCardsi GC21M030376.
H-InvDB HIX0016046.
HGNCi HGNC:1302. RWDD2B.
HPAi HPA018316.
neXtProti NX_P57060.
PharmGKBi PA162402318.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41494.
HOGENOMi HOG000007195.
HOVERGENi HBG051223.
InParanoidi P57060.
OMAi LGDVCIL.
OrthoDBi EOG71G9VN.
PhylomeDBi P57060.
TreeFami TF324344.

Miscellaneous databases

EvolutionaryTracei P57060.
GeneWikii RWDD2B.
GenomeRNAii 10069.
NextBioi 38059.
PROi P57060.

Gene expression databases

Bgeei P57060.
CleanExi HS_RWDD2B.
Genevestigatori P57060.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR010541. DUF1115.
IPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR017359. UCP038021_RWD.
[Graphical view ]
PANTHERi PTHR15955. PTHR15955. 1 hit.
Pfami PF06544. DUF1115. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view ]
PIRSFi PIRSF038021. UCP038021_RWDD2. 1 hit.
SMARTi SM00591. RWD. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS50908. RWD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and of its murine ortholog, orf5."
    Orti R., Rachidi M., Vialard F., Toyama K., Lopes C., Taudien S., Rosenthal A., Yaspo M.-L., Sinet P.-M., Delabar J.-M.
    Genomics 64:203-210(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel gene expressed in human liver non-tumor tissues."
    Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Solution structure of the RWD domain of human protein C21orf6."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 34-173.

Entry informationi

Entry nameiRWD2B_HUMAN
AccessioniPrimary (citable) accession number: P57060
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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