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Protein

RWD domain-containing protein 2B

Gene

RWDD2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RWD domain-containing protein 2B
Gene namesi
Name:RWDD2B
Synonyms:C21orf6
ORF Names:GL011
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000156253.6
HGNCiHGNC:1302 RWDD2B
MIMi617843 gene
neXtProtiNX_P57060

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156253
PharmGKBiPA162402318

Polymorphism and mutation databases

BioMutaiRWDD2B
DMDMi9972769

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000795041 – 319RWD domain-containing protein 2BAdd BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei275PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP57060
MaxQBiP57060
PaxDbiP57060
PeptideAtlasiP57060
PRIDEiP57060
ProteomicsDBi56979

PTM databases

iPTMnetiP57060
PhosphoSitePlusiP57060

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000156253
CleanExiHS_RWDD2B
GenevisibleiP57060 HS

Organism-specific databases

HPAiHPA018316

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115380, 24 interactors
IntActiP57060, 13 interactors
MINTiP57060
STRINGi9606.ENSP00000418693

Structurei

Secondary structure

1319
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi34 – 49Combined sources16
Beta strandi52 – 59Combined sources8
Helixi61 – 73Combined sources13
Beta strandi83 – 92Combined sources10
Beta strandi98 – 107Combined sources10
Beta strandi119 – 121Combined sources3
Helixi127 – 143Combined sources17
Helixi152 – 165Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DAXNMR-A34-172[»]
ProteinModelPortaliP57060
SMRiP57060
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57060

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 165RWDPROSITE-ProRule annotationAdd BLAST125

Phylogenomic databases

eggNOGiENOG410IKH2 Eukaryota
ENOG410Y76V LUCA
GeneTreeiENSGT00390000007224
HOGENOMiHOG000007195
HOVERGENiHBG051223
InParanoidiP57060
OMAiCILPFKY
OrthoDBiEOG091G0E9W
PhylomeDBiP57060
TreeFamiTF324344

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR010541 DUF1115
IPR006575 RWD-domain
IPR016135 UBQ-conjugating_enzyme/RWD
IPR017359 UCP038021_RWD
PANTHERiPTHR15955 PTHR15955, 1 hit
PfamiView protein in Pfam
PF06544 DUF1115, 1 hit
PF05773 RWD, 1 hit
PIRSFiPIRSF038021 UCP038021_RWDD2, 1 hit
SMARTiView protein in SMART
SM00591 RWD, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50908 RWD, 1 hit

Sequencei

Sequence statusi: Complete.

P57060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIELSMQPW NPGYSSEGAT AQETYTCPKM IEMEQAEAQL AELDLLASMF
60 70 80 90 100
PGENELIVND QLAVAELKDC IEKKTMEGRS SKVYFTINMN LDVSDEKMAM
110 120 130 140 150
FSLACILPFK YPAVLPEITV RSVLLSRSQQ TQLNTDLTAF LQKHCHGDVC
160 170 180 190 200
ILNATEWVRE HASGYVSRDT SSSPTTGSTV QSVDLIFTRL WIYSHHIYNK
210 220 230 240 250
CKRKNILEWA KELSLSGFSM PGKPGVVCVE GPQSACEEFW SRLRKLNWKR
260 270 280 290 300
ILIRHREDIP FDGTNDETER QRKFSIFEEK VFSVNGARGN HMDFGQLYQF
310
LNTKGCGDVF QMFFGVEGQ
Length:319
Mass (Da):36,332
Last modified:December 1, 2000 - v1
Checksum:i1E04418893C889B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19009 mRNA Translation: CAB88085.1
AF212232 mRNA Translation: AAK14918.1
AK000056 mRNA Translation: BAA90913.1
AL163249 Genomic DNA Translation: CAB90431.1
BC012546 mRNA Translation: AAH12546.1
BC017912 mRNA Translation: AAH17912.1
CCDSiCCDS13582.1
RefSeqiNP_058636.1, NM_016940.2
UniGeneiHs.713123

Genome annotation databases

EnsembliENST00000493196; ENSP00000418693; ENSG00000156253
GeneIDi10069
KEGGihsa:10069
UCSCiuc002yms.4 human

Similar proteinsi

Entry informationi

Entry nameiRWD2B_HUMAN
AccessioniPrimary (citable) accession number: P57060
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: June 20, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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