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Protein

RWD domain-containing protein 2B

Gene

RWDD2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RWD domain-containing protein 2B
Gene namesi
Name:RWDD2B
Synonyms:C21orf6
ORF Names:GL011
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:1302. RWDD2B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402318.

Polymorphism and mutation databases

BioMutaiRWDD2B.
DMDMi9972769.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319RWD domain-containing protein 2BPRO_0000079504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP57060.
PaxDbiP57060.
PeptideAtlasiP57060.
PRIDEiP57060.

PTM databases

PhosphoSiteiP57060.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiP57060.
CleanExiHS_RWDD2B.
GenevestigatoriP57060.

Organism-specific databases

HPAiHPA018316.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DVL3Q929973EBI-724442,EBI-739789
EPB41P11171-23EBI-724442,EBI-10197451
GADD45GO952576EBI-724442,EBI-448202
IKZF1Q134224EBI-724442,EBI-745305
KIAA1958Q8N8K93EBI-724442,EBI-10181113
KRT40Q6A1623EBI-724442,EBI-10171697
KRTAP10-7P604093EBI-724442,EBI-10172290
PHC2Q8IXK03EBI-724442,EBI-713786

Protein-protein interaction databases

BioGridi115380. 23 interactions.
IntActiP57060. 11 interactions.
MINTiMINT-1424212.
STRINGi9606.ENSP00000418693.

Structurei

Secondary structure

1
319
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi34 – 4916Combined sources
Beta strandi52 – 598Combined sources
Helixi61 – 7313Combined sources
Beta strandi83 – 9210Combined sources
Beta strandi98 – 10710Combined sources
Beta strandi119 – 1213Combined sources
Helixi127 – 14317Combined sources
Helixi152 – 16514Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DAXNMR-A34-172[»]
ProteinModelPortaliP57060.
SMRiP57060. Positions 34-177.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57060.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 165125RWDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RWD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG41494.
GeneTreeiENSGT00390000007224.
HOGENOMiHOG000007195.
HOVERGENiHBG051223.
InParanoidiP57060.
OMAiLGDVCIL.
OrthoDBiEOG71G9VN.
PhylomeDBiP57060.
TreeFamiTF324344.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR010541. DUF1115.
IPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR017359. UCP038021_RWD.
[Graphical view]
PANTHERiPTHR15955. PTHR15955. 1 hit.
PfamiPF06544. DUF1115. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
PIRSFiPIRSF038021. UCP038021_RWDD2. 1 hit.
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIELSMQPW NPGYSSEGAT AQETYTCPKM IEMEQAEAQL AELDLLASMF
60 70 80 90 100
PGENELIVND QLAVAELKDC IEKKTMEGRS SKVYFTINMN LDVSDEKMAM
110 120 130 140 150
FSLACILPFK YPAVLPEITV RSVLLSRSQQ TQLNTDLTAF LQKHCHGDVC
160 170 180 190 200
ILNATEWVRE HASGYVSRDT SSSPTTGSTV QSVDLIFTRL WIYSHHIYNK
210 220 230 240 250
CKRKNILEWA KELSLSGFSM PGKPGVVCVE GPQSACEEFW SRLRKLNWKR
260 270 280 290 300
ILIRHREDIP FDGTNDETER QRKFSIFEEK VFSVNGARGN HMDFGQLYQF
310
LNTKGCGDVF QMFFGVEGQ
Length:319
Mass (Da):36,332
Last modified:December 1, 2000 - v1
Checksum:i1E04418893C889B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19009 mRNA. Translation: CAB88085.1.
AF212232 mRNA. Translation: AAK14918.1.
AK000056 mRNA. Translation: BAA90913.1.
AL163249 Genomic DNA. Translation: CAB90431.1.
BC012546 mRNA. Translation: AAH12546.1.
BC017912 mRNA. Translation: AAH17912.1.
CCDSiCCDS13582.1.
RefSeqiNP_058636.1. NM_016940.2.
UniGeneiHs.713123.

Genome annotation databases

EnsembliENST00000493196; ENSP00000418693; ENSG00000156253.
GeneIDi10069.
KEGGihsa:10069.
UCSCiuc002yms.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19009 mRNA. Translation: CAB88085.1.
AF212232 mRNA. Translation: AAK14918.1.
AK000056 mRNA. Translation: BAA90913.1.
AL163249 Genomic DNA. Translation: CAB90431.1.
BC012546 mRNA. Translation: AAH12546.1.
BC017912 mRNA. Translation: AAH17912.1.
CCDSiCCDS13582.1.
RefSeqiNP_058636.1. NM_016940.2.
UniGeneiHs.713123.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DAXNMR-A34-172[»]
ProteinModelPortaliP57060.
SMRiP57060. Positions 34-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115380. 23 interactions.
IntActiP57060. 11 interactions.
MINTiMINT-1424212.
STRINGi9606.ENSP00000418693.

PTM databases

PhosphoSiteiP57060.

Polymorphism and mutation databases

BioMutaiRWDD2B.
DMDMi9972769.

Proteomic databases

MaxQBiP57060.
PaxDbiP57060.
PeptideAtlasiP57060.
PRIDEiP57060.

Protocols and materials databases

DNASUi10069.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000493196; ENSP00000418693; ENSG00000156253.
GeneIDi10069.
KEGGihsa:10069.
UCSCiuc002yms.3. human.

Organism-specific databases

CTDi10069.
GeneCardsiGC21M030376.
H-InvDBHIX0016046.
HGNCiHGNC:1302. RWDD2B.
HPAiHPA018316.
neXtProtiNX_P57060.
PharmGKBiPA162402318.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41494.
GeneTreeiENSGT00390000007224.
HOGENOMiHOG000007195.
HOVERGENiHBG051223.
InParanoidiP57060.
OMAiLGDVCIL.
OrthoDBiEOG71G9VN.
PhylomeDBiP57060.
TreeFamiTF324344.

Miscellaneous databases

EvolutionaryTraceiP57060.
GeneWikiiRWDD2B.
GenomeRNAii10069.
NextBioi38059.
PROiP57060.

Gene expression databases

BgeeiP57060.
CleanExiHS_RWDD2B.
GenevestigatoriP57060.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR010541. DUF1115.
IPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR017359. UCP038021_RWD.
[Graphical view]
PANTHERiPTHR15955. PTHR15955. 1 hit.
PfamiPF06544. DUF1115. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
PIRSFiPIRSF038021. UCP038021_RWDD2. 1 hit.
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and of its murine ortholog, orf5."
    Orti R., Rachidi M., Vialard F., Toyama K., Lopes C., Taudien S., Rosenthal A., Yaspo M.-L., Sinet P.-M., Delabar J.-M.
    Genomics 64:203-210(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel gene expressed in human liver non-tumor tissues."
    Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-275, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. "Solution structure of the RWD domain of human protein C21orf6."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 34-173.

Entry informationi

Entry nameiRWD2B_HUMAN
AccessioniPrimary (citable) accession number: P57060
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: April 29, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.