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P57060 (RWD2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RWD domain-containing protein 2B
Gene names
Name:RWDD2B
Synonyms:C21orf6
ORF Names:GL011
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Ubiquitous.

Sequence similarities

Contains 1 RWD domain.

Ontologies

Keywords
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319RWD domain-containing protein 2B
PRO_0000079504

Regions

Domain41 – 165125RWD

Secondary structure

................. 319
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P57060 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 1E04418893C889B4

FASTA31936,332
        10         20         30         40         50         60 
MKIELSMQPW NPGYSSEGAT AQETYTCPKM IEMEQAEAQL AELDLLASMF PGENELIVND 

        70         80         90        100        110        120 
QLAVAELKDC IEKKTMEGRS SKVYFTINMN LDVSDEKMAM FSLACILPFK YPAVLPEITV 

       130        140        150        160        170        180 
RSVLLSRSQQ TQLNTDLTAF LQKHCHGDVC ILNATEWVRE HASGYVSRDT SSSPTTGSTV 

       190        200        210        220        230        240 
QSVDLIFTRL WIYSHHIYNK CKRKNILEWA KELSLSGFSM PGKPGVVCVE GPQSACEEFW 

       250        260        270        280        290        300 
SRLRKLNWKR ILIRHREDIP FDGTNDETER QRKFSIFEEK VFSVNGARGN HMDFGQLYQF 

       310 
LNTKGCGDVF QMFFGVEGQ 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and of its murine ortholog, orf5."
Orti R., Rachidi M., Vialard F., Toyama K., Lopes C., Taudien S., Rosenthal A., Yaspo M.-L., Sinet P.-M., Delabar J.-M.
Genomics 64:203-210(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A novel gene expressed in human liver non-tumor tissues."
Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[4]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skeletal muscle.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Solution structure of the RWD domain of human protein C21orf6."
RIKEN structural genomics initiative (RSGI)
Submitted (JUN-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 34-173.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y19009 mRNA. Translation: CAB88085.1.
AF212232 mRNA. Translation: AAK14918.1.
AK000056 mRNA. Translation: BAA90913.1.
AL163249 Genomic DNA. Translation: CAB90431.1.
BC012546 mRNA. Translation: AAH12546.1.
BC017912 mRNA. Translation: AAH17912.1.
CCDSCCDS13582.1.
RefSeqNP_058636.1. NM_016940.2.
UniGeneHs.713123.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DAXNMR-A34-172[»]
ProteinModelPortalP57060.
SMRP57060. Positions 34-177.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115380. 6 interactions.
IntActP57060. 5 interactions.
MINTMINT-1424212.
STRING9606.ENSP00000418693.

PTM databases

PhosphoSiteP57060.

Polymorphism databases

DMDM9972769.

Proteomic databases

MaxQBP57060.
PaxDbP57060.
PeptideAtlasP57060.
PRIDEP57060.

Protocols and materials databases

DNASU10069.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000493196; ENSP00000418693; ENSG00000156253.
GeneID10069.
KEGGhsa:10069.
UCSCuc002yms.3. human.

Organism-specific databases

CTD10069.
GeneCardsGC21M030376.
H-InvDBHIX0016046.
HGNCHGNC:1302. RWDD2B.
HPAHPA018316.
neXtProtNX_P57060.
PharmGKBPA162402318.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41494.
HOGENOMHOG000007195.
HOVERGENHBG051223.
InParanoidP57060.
OMALGDVCIL.
OrthoDBEOG71G9VN.
PhylomeDBP57060.
TreeFamTF324344.

Gene expression databases

BgeeP57060.
CleanExHS_RWDD2B.
GenevestigatorP57060.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR010541. DUF1115.
IPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR017359. UCP038021_RWD.
[Graphical view]
PANTHERPTHR15955. PTHR15955. 1 hit.
PfamPF06544. DUF1115. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
PIRSFPIRSF038021. UCP038021_RWDD2. 1 hit.
SMARTSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS50908. RWD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP57060.
GeneWikiRWDD2B.
GenomeRNAi10069.
NextBio38059.
PROP57060.

Entry information

Entry nameRWD2B_HUMAN
AccessionPrimary (citable) accession number: P57060
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM