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P57058

- HUNK_HUMAN

UniProt

P57058 - HUNK_HUMAN

Protein

Hormonally up-regulated neu tumor-associated kinase

Gene

HUNK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei91 – 911ATPPROSITE-ProRule annotation
    Active sitei186 – 1861Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 769ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: ProtInc

    GO - Biological processi

    1. multicellular organismal development Source: ProtInc
    2. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiP57058.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hormonally up-regulated neu tumor-associated kinase (EC:2.7.11.1)
    Alternative name(s):
    B19
    Serine/threonine-protein kinase MAK-V
    Gene namesi
    Name:HUNK
    Synonyms:MAKV
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:13326. HUNK.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29563.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 714714Hormonally up-regulated neu tumor-associated kinasePRO_0000086004Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki483 – 483Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiP57058.
    PRIDEiP57058.

    PTM databases

    PhosphoSiteiP57058.

    Expressioni

    Gene expression databases

    ArrayExpressiP57058.
    BgeeiP57058.
    CleanExiHS_HUNK.
    GenevestigatoriP57058.

    Organism-specific databases

    HPAiHPA027295.
    HPA027372.

    Interactioni

    Protein-protein interaction databases

    BioGridi119035. 6 interactions.
    DIPiDIP-58064N.
    IntActiP57058. 2 interactions.
    MINTiMINT-7969531.
    STRINGi9606.ENSP00000270112.

    Structurei

    3D structure databases

    ProteinModelPortaliP57058.
    SMRiP57058. Positions 30-384.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 320259Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000112978.
    HOVERGENiHBG006086.
    InParanoidiP57058.
    KOiK08797.
    OMAiFLPAWVS.
    OrthoDBiEOG7CNZGM.
    PhylomeDBiP57058.
    TreeFamiTF352373.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57058-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAAAGDGLL GEPAAPGGGG GAEDAARPAA ACEGSFLPAW VSGVPRERLR    50
    DFQHHKRVGN YLIGSRKLGE GSFAKVREGL HVLTGEKVAI KVIDKKRAKK 100
    DTYVTKNLRR EGQIQQMIRH PNITQLLDIL ETENSYYLVM ELCPGGNLMH 150
    KIYEKKRLEE SEARRYIRQL ISAVEHLHRA GVVHRDLKIE NLLLDEDNNI 200
    KLIDFGLSNC AGILGYSDPF STQCGSPAYA APELLARKKY GPKIDVWSIG 250
    VNMYAMLTGT LPFTVEPFSL RALYQKMVDK EMNPLPTQLS TGAISFLRSL 300
    LEPDPVKRPN IQQALANRWL NENYTGKVPC NVTYPNRISL EDLSPSVVLH 350
    MTEKLGYKNS DVINTVLSNR ACHILAIYFL LNKKLERYLS GKSDIQDSLC 400
    YKTRLYQIEK YRAPKESYEA SLDTWTRDLE FHAVQDKKPK EQEKRGDFLH 450
    RPFSKKLDKN LPSHKQPSGS LMTQIQNTKA LLKDRKASKS SFPDKDSFGC 500
    RNIFRKTSDS NCVASSSMEF IPVPPPRTPR IVKKPEPHQP GPGSTGIPHK 550
    EDPLMLDMVR SFESVDRDDH VEVLSPSHHY RILNSPVSLA RRNSSERTLS 600
    PGLPSGSMSP LHTPLHPTLV SFAHEDKNSP PKEEGLCCPP PVPSNGPMQP 650
    LGSPNCVKSR GRFPMMGIGQ MLRKRHQSLQ PSADRPLEAS LPPLQPLAPV 700
    NLAFDMADGV KTQC 714
    Length:714
    Mass (Da):79,686
    Last modified:December 1, 2000 - v1
    Checksum:i87FC85C67D838AA7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti157 – 1571R → W.1 Publication
    Corresponds to variant rs35133981 [ dbSNP | Ensembl ].
    VAR_040561
    Natural varianti591 – 5911R → C.1 Publication
    Corresponds to variant rs10775648 [ dbSNP | Ensembl ].
    VAR_040562
    Natural varianti625 – 6251E → K.1 Publication
    Corresponds to variant rs56021554 [ dbSNP | Ensembl ].
    VAR_040563
    Natural varianti648 – 6481M → T.1 Publication
    Corresponds to variant rs56240027 [ dbSNP | Ensembl ].
    VAR_040564

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ271722 mRNA. Translation: CAB71146.1.
    CCDSiCCDS13610.1.
    RefSeqiNP_055401.1. NM_014586.1.
    UniGeneiHs.109437.

    Genome annotation databases

    EnsembliENST00000270112; ENSP00000270112; ENSG00000142149.
    GeneIDi30811.
    KEGGihsa:30811.
    UCSCiuc002yph.3. human.

    Polymorphism databases

    DMDMi9973393.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ271722 mRNA. Translation: CAB71146.1 .
    CCDSi CCDS13610.1.
    RefSeqi NP_055401.1. NM_014586.1.
    UniGenei Hs.109437.

    3D structure databases

    ProteinModelPortali P57058.
    SMRi P57058. Positions 30-384.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119035. 6 interactions.
    DIPi DIP-58064N.
    IntActi P57058. 2 interactions.
    MINTi MINT-7969531.
    STRINGi 9606.ENSP00000270112.

    Chemistry

    BindingDBi P57058.
    ChEMBLi CHEMBL1795165.
    GuidetoPHARMACOLOGYi 2037.

    PTM databases

    PhosphoSitei P57058.

    Polymorphism databases

    DMDMi 9973393.

    Proteomic databases

    PaxDbi P57058.
    PRIDEi P57058.

    Protocols and materials databases

    DNASUi 30811.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270112 ; ENSP00000270112 ; ENSG00000142149 .
    GeneIDi 30811.
    KEGGi hsa:30811.
    UCSCi uc002yph.3. human.

    Organism-specific databases

    CTDi 30811.
    GeneCardsi GC21P033245.
    HGNCi HGNC:13326. HUNK.
    HPAi HPA027295.
    HPA027372.
    MIMi 606532. gene.
    neXtProti NX_P57058.
    PharmGKBi PA29563.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000112978.
    HOVERGENi HBG006086.
    InParanoidi P57058.
    KOi K08797.
    OMAi FLPAWVS.
    OrthoDBi EOG7CNZGM.
    PhylomeDBi P57058.
    TreeFami TF352373.

    Enzyme and pathway databases

    SignaLinki P57058.

    Miscellaneous databases

    GenomeRNAii 30811.
    NextBioi 52856.
    PROi P57058.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P57058.
    Bgeei P57058.
    CleanExi HS_HUNK.
    Genevestigatori P57058.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A putative serine/threonine protein kinase MAK-V on human chromosome 21q22.1."
      Scott H.S., Antonarakis S.E., Papasavvas M.P., Michaud J.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
      Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
      J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-483.
      Tissue: Lung adenocarcinoma.
    3. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-157; CYS-591; LYS-625 AND THR-648.

    Entry informationi

    Entry nameiHUNK_HUMAN
    AccessioniPrimary (citable) accession number: P57058
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3