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P57058

- HUNK_HUMAN

UniProt

P57058 - HUNK_HUMAN

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Protein

Hormonally up-regulated neu tumor-associated kinase

Gene

HUNK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911ATPPROSITE-ProRule annotation
Active sitei186 – 1861Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 769ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: ProtInc

GO - Biological processi

  1. multicellular organismal development Source: ProtInc
  2. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP57058.

Names & Taxonomyi

Protein namesi
Recommended name:
Hormonally up-regulated neu tumor-associated kinase (EC:2.7.11.1)
Alternative name(s):
B19
Serine/threonine-protein kinase MAK-V
Gene namesi
Name:HUNK
Synonyms:MAKV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:13326. HUNK.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29563.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 714714Hormonally up-regulated neu tumor-associated kinasePRO_0000086004Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki483 – 483Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP57058.
PRIDEiP57058.

PTM databases

PhosphoSiteiP57058.

Expressioni

Gene expression databases

BgeeiP57058.
CleanExiHS_HUNK.
ExpressionAtlasiP57058. baseline and differential.
GenevestigatoriP57058.

Organism-specific databases

HPAiHPA027295.
HPA027372.

Interactioni

Protein-protein interaction databases

BioGridi119035. 6 interactions.
DIPiDIP-58064N.
IntActiP57058. 2 interactions.
MINTiMINT-7969531.
STRINGi9606.ENSP00000270112.

Structurei

3D structure databases

ProteinModelPortaliP57058.
SMRiP57058. Positions 30-384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 320259Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119244.
HOGENOMiHOG000112978.
HOVERGENiHBG006086.
InParanoidiP57058.
KOiK08797.
OMAiFLPAWVS.
OrthoDBiEOG7CNZGM.
PhylomeDBiP57058.
TreeFamiTF352373.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57058-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAAAGDGLL GEPAAPGGGG GAEDAARPAA ACEGSFLPAW VSGVPRERLR
60 70 80 90 100
DFQHHKRVGN YLIGSRKLGE GSFAKVREGL HVLTGEKVAI KVIDKKRAKK
110 120 130 140 150
DTYVTKNLRR EGQIQQMIRH PNITQLLDIL ETENSYYLVM ELCPGGNLMH
160 170 180 190 200
KIYEKKRLEE SEARRYIRQL ISAVEHLHRA GVVHRDLKIE NLLLDEDNNI
210 220 230 240 250
KLIDFGLSNC AGILGYSDPF STQCGSPAYA APELLARKKY GPKIDVWSIG
260 270 280 290 300
VNMYAMLTGT LPFTVEPFSL RALYQKMVDK EMNPLPTQLS TGAISFLRSL
310 320 330 340 350
LEPDPVKRPN IQQALANRWL NENYTGKVPC NVTYPNRISL EDLSPSVVLH
360 370 380 390 400
MTEKLGYKNS DVINTVLSNR ACHILAIYFL LNKKLERYLS GKSDIQDSLC
410 420 430 440 450
YKTRLYQIEK YRAPKESYEA SLDTWTRDLE FHAVQDKKPK EQEKRGDFLH
460 470 480 490 500
RPFSKKLDKN LPSHKQPSGS LMTQIQNTKA LLKDRKASKS SFPDKDSFGC
510 520 530 540 550
RNIFRKTSDS NCVASSSMEF IPVPPPRTPR IVKKPEPHQP GPGSTGIPHK
560 570 580 590 600
EDPLMLDMVR SFESVDRDDH VEVLSPSHHY RILNSPVSLA RRNSSERTLS
610 620 630 640 650
PGLPSGSMSP LHTPLHPTLV SFAHEDKNSP PKEEGLCCPP PVPSNGPMQP
660 670 680 690 700
LGSPNCVKSR GRFPMMGIGQ MLRKRHQSLQ PSADRPLEAS LPPLQPLAPV
710
NLAFDMADGV KTQC
Length:714
Mass (Da):79,686
Last modified:December 1, 2000 - v1
Checksum:i87FC85C67D838AA7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti157 – 1571R → W.1 Publication
Corresponds to variant rs35133981 [ dbSNP | Ensembl ].
VAR_040561
Natural varianti591 – 5911R → C.1 Publication
Corresponds to variant rs10775648 [ dbSNP | Ensembl ].
VAR_040562
Natural varianti625 – 6251E → K.1 Publication
Corresponds to variant rs56021554 [ dbSNP | Ensembl ].
VAR_040563
Natural varianti648 – 6481M → T.1 Publication
Corresponds to variant rs56240027 [ dbSNP | Ensembl ].
VAR_040564

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271722 mRNA. Translation: CAB71146.1.
CCDSiCCDS13610.1.
RefSeqiNP_055401.1. NM_014586.1.
UniGeneiHs.109437.

Genome annotation databases

EnsembliENST00000270112; ENSP00000270112; ENSG00000142149.
GeneIDi30811.
KEGGihsa:30811.
UCSCiuc002yph.3. human.

Polymorphism databases

DMDMi9973393.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271722 mRNA. Translation: CAB71146.1 .
CCDSi CCDS13610.1.
RefSeqi NP_055401.1. NM_014586.1.
UniGenei Hs.109437.

3D structure databases

ProteinModelPortali P57058.
SMRi P57058. Positions 30-384.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119035. 6 interactions.
DIPi DIP-58064N.
IntActi P57058. 2 interactions.
MINTi MINT-7969531.
STRINGi 9606.ENSP00000270112.

Chemistry

BindingDBi P57058.
ChEMBLi CHEMBL1795165.
GuidetoPHARMACOLOGYi 2037.

PTM databases

PhosphoSitei P57058.

Polymorphism databases

DMDMi 9973393.

Proteomic databases

PaxDbi P57058.
PRIDEi P57058.

Protocols and materials databases

DNASUi 30811.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000270112 ; ENSP00000270112 ; ENSG00000142149 .
GeneIDi 30811.
KEGGi hsa:30811.
UCSCi uc002yph.3. human.

Organism-specific databases

CTDi 30811.
GeneCardsi GC21P033245.
HGNCi HGNC:13326. HUNK.
HPAi HPA027295.
HPA027372.
MIMi 606532. gene.
neXtProti NX_P57058.
PharmGKBi PA29563.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119244.
HOGENOMi HOG000112978.
HOVERGENi HBG006086.
InParanoidi P57058.
KOi K08797.
OMAi FLPAWVS.
OrthoDBi EOG7CNZGM.
PhylomeDBi P57058.
TreeFami TF352373.

Enzyme and pathway databases

SignaLinki P57058.

Miscellaneous databases

ChiTaRSi HUNK. human.
GenomeRNAii 30811.
NextBioi 52856.
PROi P57058.
SOURCEi Search...

Gene expression databases

Bgeei P57058.
CleanExi HS_HUNK.
ExpressionAtlasi P57058. baseline and differential.
Genevestigatori P57058.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A putative serine/threonine protein kinase MAK-V on human chromosome 21q22.1."
    Scott H.S., Antonarakis S.E., Papasavvas M.P., Michaud J.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
    Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
    J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-483.
    Tissue: Lung adenocarcinoma.
  3. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-157; CYS-591; LYS-625 AND THR-648.

Entry informationi

Entry nameiHUNK_HUMAN
AccessioniPrimary (citable) accession number: P57058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 26, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3