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P57058 (HUNK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hormonally up-regulated neu tumor-associated kinase

EC=2.7.11.1
Alternative name(s):
B19
Serine/threonine-protein kinase MAK-V
Gene names
Name:HUNK
Synonyms:MAKV
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length714 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 714714Hormonally up-regulated neu tumor-associated kinase
PRO_0000086004

Regions

Domain62 – 320259Protein kinase
Nucleotide binding68 – 769ATP By similarity

Sites

Active site1861Proton acceptor By similarity
Binding site911ATP By similarity

Amino acid modifications

Cross-link483Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.2

Natural variations

Natural variant1571R → W. Ref.3
Corresponds to variant rs35133981 [ dbSNP | Ensembl ].
VAR_040561
Natural variant5911R → C. Ref.3
Corresponds to variant rs10775648 [ dbSNP | Ensembl ].
VAR_040562
Natural variant6251E → K. Ref.3
Corresponds to variant rs56021554 [ dbSNP | Ensembl ].
VAR_040563
Natural variant6481M → T. Ref.3
Corresponds to variant rs56240027 [ dbSNP | Ensembl ].
VAR_040564

Sequences

Sequence LengthMass (Da)Tools
P57058 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 87FC85C67D838AA7

FASTA71479,686
        10         20         30         40         50         60 
MPAAAGDGLL GEPAAPGGGG GAEDAARPAA ACEGSFLPAW VSGVPRERLR DFQHHKRVGN 

        70         80         90        100        110        120 
YLIGSRKLGE GSFAKVREGL HVLTGEKVAI KVIDKKRAKK DTYVTKNLRR EGQIQQMIRH 

       130        140        150        160        170        180 
PNITQLLDIL ETENSYYLVM ELCPGGNLMH KIYEKKRLEE SEARRYIRQL ISAVEHLHRA 

       190        200        210        220        230        240 
GVVHRDLKIE NLLLDEDNNI KLIDFGLSNC AGILGYSDPF STQCGSPAYA APELLARKKY 

       250        260        270        280        290        300 
GPKIDVWSIG VNMYAMLTGT LPFTVEPFSL RALYQKMVDK EMNPLPTQLS TGAISFLRSL 

       310        320        330        340        350        360 
LEPDPVKRPN IQQALANRWL NENYTGKVPC NVTYPNRISL EDLSPSVVLH MTEKLGYKNS 

       370        380        390        400        410        420 
DVINTVLSNR ACHILAIYFL LNKKLERYLS GKSDIQDSLC YKTRLYQIEK YRAPKESYEA 

       430        440        450        460        470        480 
SLDTWTRDLE FHAVQDKKPK EQEKRGDFLH RPFSKKLDKN LPSHKQPSGS LMTQIQNTKA 

       490        500        510        520        530        540 
LLKDRKASKS SFPDKDSFGC RNIFRKTSDS NCVASSSMEF IPVPPPRTPR IVKKPEPHQP 

       550        560        570        580        590        600 
GPGSTGIPHK EDPLMLDMVR SFESVDRDDH VEVLSPSHHY RILNSPVSLA RRNSSERTLS 

       610        620        630        640        650        660 
PGLPSGSMSP LHTPLHPTLV SFAHEDKNSP PKEEGLCCPP PVPSNGPMQP LGSPNCVKSR 

       670        680        690        700        710 
GRFPMMGIGQ MLRKRHQSLQ PSADRPLEAS LPPLQPLAPV NLAFDMADGV KTQC 

« Hide

References

« Hide 'large scale' references
[1]"A putative serine/threonine protein kinase MAK-V on human chromosome 21q22.1."
Scott H.S., Antonarakis S.E., Papasavvas M.P., Michaud J.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-483.
Tissue: Lung adenocarcinoma.
[3]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-157; CYS-591; LYS-625 AND THR-648.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ271722 mRNA. Translation: CAB71146.1.
RefSeqNP_055401.1. NM_014586.1.
UniGeneHs.109437.

3D structure databases

ProteinModelPortalP57058.
SMRP57058. Positions 30-384.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119035. 6 interactions.
DIPDIP-58064N.
IntActP57058. 2 interactions.
MINTMINT-7969531.
STRING9606.ENSP00000270112.

Chemistry

BindingDBP57058.
ChEMBLCHEMBL1795165.
GuidetoPHARMACOLOGY2037.

PTM databases

PhosphoSiteP57058.

Polymorphism databases

DMDM9973393.

Proteomic databases

PaxDbP57058.
PRIDEP57058.

Protocols and materials databases

DNASU30811.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000270112; ENSP00000270112; ENSG00000142149.
GeneID30811.
KEGGhsa:30811.
UCSCuc002yph.3. human.

Organism-specific databases

CTD30811.
GeneCardsGC21P033245.
HGNCHGNC:13326. HUNK.
HPAHPA027295.
HPA027372.
MIM606532. gene.
neXtProtNX_P57058.
PharmGKBPA29563.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000112978.
HOVERGENHBG006086.
InParanoidP57058.
KOK08797.
OMAFLPAWVS.
OrthoDBEOG7CNZGM.
PhylomeDBP57058.
TreeFamTF352373.

Enzyme and pathway databases

SignaLinkP57058.

Gene expression databases

ArrayExpressP57058.
BgeeP57058.
CleanExHS_HUNK.
GenevestigatorP57058.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi30811.
NextBio52856.
PROP57058.
SOURCESearch...

Entry information

Entry nameHUNK_HUMAN
AccessionPrimary (citable) accession number: P57058
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: March 19, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM