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Protein

Hormonally up-regulated neu tumor-associated kinase

Gene

HUNK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91ATPPROSITE-ProRule annotation1
Active sitei186Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 76ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • multicellular organism development Source: ProtInc
  • protein phosphorylation Source: GO_Central
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP57058.

Names & Taxonomyi

Protein namesi
Recommended name:
Hormonally up-regulated neu tumor-associated kinase (EC:2.7.11.1)
Alternative name(s):
B19
Serine/threonine-protein kinase MAK-V
Gene namesi
Name:HUNK
Synonyms:MAKV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000142149.8.
HGNCiHGNC:13326. HUNK.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi30811.
OpenTargetsiENSG00000142149.
PharmGKBiPA29563.

Chemistry databases

ChEMBLiCHEMBL1795165.
GuidetoPHARMACOLOGYi2037.

Polymorphism and mutation databases

BioMutaiHUNK.
DMDMi9973393.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000860041 – 714Hormonally up-regulated neu tumor-associated kinaseAdd BLAST714

Proteomic databases

EPDiP57058.
PaxDbiP57058.
PeptideAtlasiP57058.
PRIDEiP57058.
TopDownProteomicsiP57058.

PTM databases

iPTMnetiP57058.
PhosphoSitePlusiP57058.

Expressioni

Gene expression databases

BgeeiENSG00000142149.
CleanExiHS_HUNK.
ExpressionAtlasiP57058. baseline and differential.
GenevisibleiP57058. HS.

Organism-specific databases

HPAiHPA027295.
HPA027372.

Interactioni

Protein-protein interaction databases

BioGridi119035. 4 interactors.
DIPiDIP-58064N.
IntActiP57058. 2 interactors.
MINTiMINT-7969531.
STRINGi9606.ENSP00000270112.

Chemistry databases

BindingDBiP57058.

Structurei

3D structure databases

ProteinModelPortaliP57058.
SMRiP57058.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 320Protein kinasePROSITE-ProRule annotationAdd BLAST259

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00880000137920.
HOGENOMiHOG000112978.
HOVERGENiHBG006086.
InParanoidiP57058.
KOiK08797.
OMAiEFHAVQD.
OrthoDBiEOG091G0I19.
PhylomeDBiP57058.
TreeFamiTF352373.

Family and domain databases

CDDicd14070. STKc_HUNK. 1 hit.
InterProiView protein in InterPro
IPR034671. Hunk.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

P57058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAAAGDGLL GEPAAPGGGG GAEDAARPAA ACEGSFLPAW VSGVPRERLR
60 70 80 90 100
DFQHHKRVGN YLIGSRKLGE GSFAKVREGL HVLTGEKVAI KVIDKKRAKK
110 120 130 140 150
DTYVTKNLRR EGQIQQMIRH PNITQLLDIL ETENSYYLVM ELCPGGNLMH
160 170 180 190 200
KIYEKKRLEE SEARRYIRQL ISAVEHLHRA GVVHRDLKIE NLLLDEDNNI
210 220 230 240 250
KLIDFGLSNC AGILGYSDPF STQCGSPAYA APELLARKKY GPKIDVWSIG
260 270 280 290 300
VNMYAMLTGT LPFTVEPFSL RALYQKMVDK EMNPLPTQLS TGAISFLRSL
310 320 330 340 350
LEPDPVKRPN IQQALANRWL NENYTGKVPC NVTYPNRISL EDLSPSVVLH
360 370 380 390 400
MTEKLGYKNS DVINTVLSNR ACHILAIYFL LNKKLERYLS GKSDIQDSLC
410 420 430 440 450
YKTRLYQIEK YRAPKESYEA SLDTWTRDLE FHAVQDKKPK EQEKRGDFLH
460 470 480 490 500
RPFSKKLDKN LPSHKQPSGS LMTQIQNTKA LLKDRKASKS SFPDKDSFGC
510 520 530 540 550
RNIFRKTSDS NCVASSSMEF IPVPPPRTPR IVKKPEPHQP GPGSTGIPHK
560 570 580 590 600
EDPLMLDMVR SFESVDRDDH VEVLSPSHHY RILNSPVSLA RRNSSERTLS
610 620 630 640 650
PGLPSGSMSP LHTPLHPTLV SFAHEDKNSP PKEEGLCCPP PVPSNGPMQP
660 670 680 690 700
LGSPNCVKSR GRFPMMGIGQ MLRKRHQSLQ PSADRPLEAS LPPLQPLAPV
710
NLAFDMADGV KTQC
Length:714
Mass (Da):79,686
Last modified:December 1, 2000 - v1
Checksum:i87FC85C67D838AA7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040561157R → W1 PublicationCorresponds to variant dbSNP:rs35133981Ensembl.1
Natural variantiVAR_040562591R → C1 PublicationCorresponds to variant dbSNP:rs10775648Ensembl.1
Natural variantiVAR_040563625E → K1 PublicationCorresponds to variant dbSNP:rs56021554Ensembl.1
Natural variantiVAR_040564648M → T1 PublicationCorresponds to variant dbSNP:rs56240027Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271722 mRNA. Translation: CAB71146.1.
CCDSiCCDS13610.1.
RefSeqiNP_055401.1. NM_014586.1.
UniGeneiHs.109437.

Genome annotation databases

EnsembliENST00000270112; ENSP00000270112; ENSG00000142149.
GeneIDi30811.
KEGGihsa:30811.
UCSCiuc002yph.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHUNK_HUMAN
AccessioniPrimary (citable) accession number: P57058
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 27, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families