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Protein

Glucose-6-phosphate exchanger SLC37A1

Gene

SLC37A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.1 Publication

Enzyme regulationi

Inhibited by vanadate but not by chlorogenic acid.1 Publication

GO - Molecular functioni

GO - Biological processi

  • anion transport Source: GO_Central
  • carbohydrate transport Source: UniProtKB-KW
  • glucose-6-phosphate transport Source: UniProtKB
  • phosphate ion transmembrane transport Source: UniProtKB
  • transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Antiport, Sugar transport, Transport

Protein family/group databases

TCDBi2.A.1.4.7. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate exchanger SLC37A11 Publication
Alternative name(s):
Glycerol-3-phosphate permease1 Publication
Short name:
G-3-P permease1 Publication
Solute carrier family 37 member 1Imported
Gene namesi
Name:SLC37A1Imported
Synonyms:G3PP1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:11024. SLC37A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence analysisAdd
BLAST
Transmembranei334 – 35421HelicalSequence analysisAdd
BLAST
Transmembranei366 – 38621HelicalSequence analysisAdd
BLAST
Transmembranei394 – 41421HelicalSequence analysisAdd
BLAST
Transmembranei423 – 44321HelicalSequence analysisAdd
BLAST
Transmembranei466 – 48621HelicalSequence analysisAdd
BLAST
Transmembranei490 – 51021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: GO_Central
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35892.

Polymorphism and mutation databases

BioMutaiSLC37A1.
DMDMi317373359.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Glucose-6-phosphate exchanger SLC37A1PRO_0000199890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence analysis
Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP57057.
PaxDbiP57057.
PRIDEiP57057.

PTM databases

iPTMnetiP57057.

Expressioni

Tissue specificityi

Expressed in numerous tissues, with highest expression in pancreas, kidney, bone marrow, spleen, liver, small intestine, as well as in fetal brain, liver and spleen.2 Publications

Gene expression databases

BgeeiP57057.
CleanExiHS_SLC37A1.
ExpressionAtlasiP57057. baseline and differential.
GenevisibleiP57057. HS.

Organism-specific databases

HPAiCAB034154.
HPA030418.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344648.

Structurei

3D structure databases

ProteinModelPortaliP57057.
SMRiP57057. Positions 179-211, 357-398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP3Z. Eukaryota.
COG2271. LUCA.
GeneTreeiENSGT00530000062949.
HOGENOMiHOG000230522.
HOVERGENiHBG005851.
InParanoidiP57057.
KOiK13783.
OMAiFSAISKM.
PhylomeDBiP57057.
TreeFamiTF314991.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLPAGIRF IISFSRDQWY RAFIFILTFL LYASFHLSRK PISIVKGELH
60 70 80 90 100
KYCTAWDEAD VRFSSQNRKS GSAAPHQLPD NETDCGWAPF DKNNYQQLLG
110 120 130 140 150
ALDYSFLCAY AVGMYLSGII GERLPIRYYL TFGMLASGAF TALFGLGYFY
160 170 180 190 200
NIHSFGFYVV TQVINGLVQT TGWPSVVTCL GNWFGKGRRG LIMGVWNSHT
210 220 230 240 250
SVGNILGSLI AGYWVSTCWG LSFVVPGAIV AAMGIVCFLF LIEHPNDVRC
260 270 280 290 300
SSTLVTHSKG YENGTNRLRL QKQILKSEKN KPLDPEMQCL LLSDGKGSIH
310 320 330 340 350
PNHVVILPGD GGSGTAAISF TGALKIPGVI EFSLCLLFAK LVSYTFLFWL
360 370 380 390 400
PLYITNVDHL DAKKAGELST LFDVGGIFGG ILAGVISDRL EKRASTCGLM
410 420 430 440 450
LLLAAPTLYI FSTVSKMGLE ATIAMLLLSG ALVSGPYTLI TTAVSADLGT
460 470 480 490 500
HKSLKGNAHA LSTVTAIIDG TGSVGAALGP LLAGLLSPSG WSNVFYMLMF
510 520 530
ADACALLFLI RLIHKELSCP GSATGDQVPF KEQ
Length:533
Mass (Da):57,648
Last modified:January 11, 2011 - v2
Checksum:iFA978FE2943C80AA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231F → L in AAG29853 (Ref. 2) Curated
Sequence conflicti303 – 3031H → Q in AAG29853 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti247 – 2471D → N.1 Publication
VAR_017110
Natural varianti414 – 4141V → I.1 Publication
Corresponds to variant rs228104 [ dbSNP | Ensembl ].
VAR_017111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ269529 mRNA. Translation: CAB87248.1.
AJ277912 mRNA. Translation: CAB91985.1.
AJ277913 mRNA. Translation: CAB91986.1.
AF311320 mRNA. Translation: AAG29853.1.
AP001625 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09552.1.
CH471079 Genomic DNA. Translation: EAX09553.1.
CCDSiCCDS13689.1.
RefSeqiNP_001307466.1. NM_001320537.1.
NP_061837.3. NM_018964.3.
UniGeneiHs.547009.

Genome annotation databases

EnsembliENST00000352133; ENSP00000344648; ENSG00000160190.
ENST00000398341; ENSP00000381383; ENSG00000160190.
GeneIDi54020.
KEGGihsa:54020.
UCSCiuc002zbi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ269529 mRNA. Translation: CAB87248.1.
AJ277912 mRNA. Translation: CAB91985.1.
AJ277913 mRNA. Translation: CAB91986.1.
AF311320 mRNA. Translation: AAG29853.1.
AP001625 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09552.1.
CH471079 Genomic DNA. Translation: EAX09553.1.
CCDSiCCDS13689.1.
RefSeqiNP_001307466.1. NM_001320537.1.
NP_061837.3. NM_018964.3.
UniGeneiHs.547009.

3D structure databases

ProteinModelPortaliP57057.
SMRiP57057. Positions 179-211, 357-398.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000344648.

Protein family/group databases

TCDBi2.A.1.4.7. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP57057.

Polymorphism and mutation databases

BioMutaiSLC37A1.
DMDMi317373359.

Proteomic databases

MaxQBiP57057.
PaxDbiP57057.
PRIDEiP57057.

Protocols and materials databases

DNASUi54020.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352133; ENSP00000344648; ENSG00000160190.
ENST00000398341; ENSP00000381383; ENSG00000160190.
GeneIDi54020.
KEGGihsa:54020.
UCSCiuc002zbi.3. human.

Organism-specific databases

CTDi54020.
GeneCardsiSLC37A1.
H-InvDBHIX0027807.
HGNCiHGNC:11024. SLC37A1.
HPAiCAB034154.
HPA030418.
MIMi608094. gene.
neXtProtiNX_P57057.
PharmGKBiPA35892.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IP3Z. Eukaryota.
COG2271. LUCA.
GeneTreeiENSGT00530000062949.
HOGENOMiHOG000230522.
HOVERGENiHBG005851.
InParanoidiP57057.
KOiK13783.
OMAiFSAISKM.
PhylomeDBiP57057.
TreeFamiTF314991.

Miscellaneous databases

ChiTaRSiSLC37A1. human.
GenomeRNAii54020.
PROiP57057.
SOURCEiSearch...

Gene expression databases

BgeeiP57057.
CleanExiHS_SLC37A1.
ExpressionAtlasiP57057. baseline and differential.
GenevisibleiP57057. HS.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency."
    Bartoloni L., Wattenhofer M., Kudoh J., Berry A., Shibuya K., Kawasaki K., Wang J., Asakawa S., Talior I., Bonne-Tamir B., Rossier C., Michaud J., McCabe E.R.B., Minoshima S., Shimizu N., Scott H.S., Antonarakis S.E.
    Genomics 70:190-200(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-247, TISSUE SPECIFICITY.
  2. "Cloning and characterization of human glycerol 3-phosphate permease gene (SLC37A1)."
    Solans A., Estivill X., de la Luna S.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-414.
  3. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters."
    Pan C.J., Chen S.Y., Jun H.S., Lin S.R., Mansfield B.C., Chou J.Y.
    PLoS ONE 6:E23157-E23157(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, ENZYME REGULATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiG6PT2_HUMAN
AccessioniPrimary (citable) accession number: P57057
Secondary accession number(s): D3DSJ7, Q9HAQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 11, 2011
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.