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Protein

Glucose-6-phosphate exchanger SLC37A1

Gene

SLC37A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.1 Publication

Enzyme regulationi

Inhibited by vanadate but not by chlorogenic acid.1 Publication

GO - Molecular functioni

  • glucose 6-phosphate:inorganic phosphate antiporter activity Source: UniProtKB

GO - Biological processi

  • carbohydrate transport Source: UniProtKB-KW
  • glucose-6-phosphate transport Source: UniProtKB
  • phosphate ion transmembrane transport Source: UniProtKB

Keywordsi

Biological processAntiport, Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-70263 Gluconeogenesis

Protein family/group databases

TCDBi2.A.1.4.7 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate exchanger SLC37A11 Publication
Alternative name(s):
Glycerol-3-phosphate permease1 Publication
Short name:
G-3-P permease1 Publication
Solute carrier family 37 member 1Imported
Gene namesi
Name:SLC37A1Imported
Synonyms:G3PP1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160190.13
HGNCiHGNC:11024 SLC37A1
MIMi608094 gene
neXtProtiNX_P57057

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei394 – 414HelicalSequence analysisAdd BLAST21
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54020
OpenTargetsiENSG00000160190
PharmGKBiPA35892

Polymorphism and mutation databases

BioMutaiSLC37A1
DMDMi317373359

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001998901 – 533Glucose-6-phosphate exchanger SLC37A1Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi263N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP57057
MaxQBiP57057
PaxDbiP57057
PeptideAtlasiP57057
PRIDEiP57057

PTM databases

iPTMnetiP57057
PhosphoSitePlusiP57057

Expressioni

Tissue specificityi

Expressed in numerous tissues, with highest expression in pancreas, kidney, bone marrow, spleen, liver, small intestine, as well as in fetal brain, liver and spleen.2 Publications

Gene expression databases

BgeeiENSG00000160190
CleanExiHS_SLC37A1
ExpressionAtlasiP57057 baseline and differential
GenevisibleiP57057 HS

Organism-specific databases

HPAiCAB034154
HPA030418

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344648

Structurei

3D structure databases

ProteinModelPortaliP57057
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP3Z Eukaryota
COG2271 LUCA
GeneTreeiENSGT00530000062949
HOGENOMiHOG000230522
HOVERGENiHBG005851
InParanoidiP57057
KOiK13783
OMAiVSTCWGL
OrthoDBiEOG091G06AK
PhylomeDBiP57057
TreeFamiTF314991

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR000849 Sugar_P_transporter
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PIRSFiPIRSF002808 Hexose_phosphate_transp, 1 hit
SUPFAMiSSF103473 SSF103473, 3 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P57057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLPAGIRF IISFSRDQWY RAFIFILTFL LYASFHLSRK PISIVKGELH
60 70 80 90 100
KYCTAWDEAD VRFSSQNRKS GSAAPHQLPD NETDCGWAPF DKNNYQQLLG
110 120 130 140 150
ALDYSFLCAY AVGMYLSGII GERLPIRYYL TFGMLASGAF TALFGLGYFY
160 170 180 190 200
NIHSFGFYVV TQVINGLVQT TGWPSVVTCL GNWFGKGRRG LIMGVWNSHT
210 220 230 240 250
SVGNILGSLI AGYWVSTCWG LSFVVPGAIV AAMGIVCFLF LIEHPNDVRC
260 270 280 290 300
SSTLVTHSKG YENGTNRLRL QKQILKSEKN KPLDPEMQCL LLSDGKGSIH
310 320 330 340 350
PNHVVILPGD GGSGTAAISF TGALKIPGVI EFSLCLLFAK LVSYTFLFWL
360 370 380 390 400
PLYITNVDHL DAKKAGELST LFDVGGIFGG ILAGVISDRL EKRASTCGLM
410 420 430 440 450
LLLAAPTLYI FSTVSKMGLE ATIAMLLLSG ALVSGPYTLI TTAVSADLGT
460 470 480 490 500
HKSLKGNAHA LSTVTAIIDG TGSVGAALGP LLAGLLSPSG WSNVFYMLMF
510 520 530
ADACALLFLI RLIHKELSCP GSATGDQVPF KEQ
Length:533
Mass (Da):57,648
Last modified:January 11, 2011 - v2
Checksum:iFA978FE2943C80AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223F → L in AAG29853 (Ref. 2) Curated1
Sequence conflicti303H → Q in AAG29853 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017110247D → N1 PublicationCorresponds to variant dbSNP:rs768541152Ensembl.1
Natural variantiVAR_017111414V → I1 PublicationCorresponds to variant dbSNP:rs228104Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ269529 mRNA Translation: CAB87248.1
AJ277912 mRNA Translation: CAB91985.1
AJ277913 mRNA Translation: CAB91986.1
AF311320 mRNA Translation: AAG29853.1
AP001625 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09552.1
CH471079 Genomic DNA Translation: EAX09553.1
CCDSiCCDS13689.1
RefSeqiNP_001307466.1, NM_001320537.1
NP_061837.3, NM_018964.3
XP_016883866.1, XM_017028377.1
XP_016883867.1, XM_017028378.1
XP_016883868.1, XM_017028379.1
XP_016883869.1, XM_017028380.1
UniGeneiHs.547009

Genome annotation databases

EnsembliENST00000352133; ENSP00000344648; ENSG00000160190
ENST00000398341; ENSP00000381383; ENSG00000160190
GeneIDi54020
KEGGihsa:54020
UCSCiuc002zbi.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiG6PT2_HUMAN
AccessioniPrimary (citable) accession number: P57057
Secondary accession number(s): D3DSJ7, Q9HAQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 11, 2011
Last modified: March 28, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health