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Protein

Splicing regulator RBM11

Gene

RBM11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.1 Publication

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(U) RNA binding Source: MGI
  • protein homodimerization activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33032-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing regulator RBM11
Alternative name(s):
RNA-binding motif protein 11
Gene namesi
Name:RBM11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:9897. RBM11.

Subcellular locationi

GO - Cellular componenti

  • nuclear speck Source: MGI
  • nucleoplasm Source: HPA
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185272.
PharmGKBiPA34260.

Polymorphism and mutation databases

BioMutaiRBM11.
DMDMi9978670.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817691 – 281Splicing regulator RBM11Add BLAST281

Proteomic databases

PaxDbiP57052.
PeptideAtlasiP57052.
PRIDEiP57052.

PTM databases

iPTMnetiP57052.
PhosphoSitePlusiP57052.

Expressioni

Tissue specificityi

Expressed in brain, hippocampus, prefrontal cortex, cerebellum, spinal cord, testis, mammary gland, spleen and kidney. Also expressed in fetal brain.3 Publications

Gene expression databases

BgeeiENSG00000185272.
CleanExiHS_RBM11.
GenevisibleiP57052. HS.

Organism-specific databases

HPAiHPA045885.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GABPB1Q065473EBI-741332,EBI-618165
QKIQ96PU83EBI-741332,EBI-945792
SNRPCQ5TAL43EBI-741332,EBI-10246938
ZNF774Q6NX453EBI-741332,EBI-10251462

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi119845. 16 interactors.
IntActiP57052. 7 interactors.
MINTiMINT-1452231.
STRINGi9606.ENSP00000383421.

Structurei

Secondary structure

1281
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 10Combined sources3
Beta strandi11 – 15Combined sources5
Helixi23 – 30Combined sources8
Helixi31 – 33Combined sources3
Beta strandi36 – 43Combined sources8
Beta strandi49 – 59Combined sources11
Helixi61 – 70Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YWKX-ray1.54A1-82[»]
ProteinModelPortaliP57052.
SMRiP57052.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57052.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 87RRMPROSITE-ProRule annotationAdd BLAST78

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi245 – 280Bipartite nuclear localization signalCuratedAdd BLAST36

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IY0E. Eukaryota.
ENOG4111UDH. LUCA.
GeneTreeiENSGT00860000133762.
HOGENOMiHOG000146448.
HOVERGENiHBG061506.
InParanoidiP57052.
OMAiYRFGSSR.
OrthoDBiEOG091G15TA.
PhylomeDBiP57052.
TreeFamiTF323596.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P57052-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPAQEEADR TVFVGNLEAR VREEILYELF LQAGPLTKVT ICKDREGKPK
60 70 80 90 100
SFGFVCFKHP ESVSYAIALL NGIRLYGRPI NVQYRFGSSR SSEPANQSFE
110 120 130 140 150
SCVKINSHNY RNEEMLVGRS SFPMQYFPIN NTSLPQEYFL FQKMQWHVYN
160 170 180 190 200
PVLQLPYYEM TAPLPNSASV SSSLNHVPDL EAGPSSYKWT HQQPSDSDLY
210 220 230 240 250
QMTAPLPNSA SVSSSLNHVP DLEAGPSSYK WTHQQPSDSD LYQMNKRKRQ
260 270 280
KQTSDSDSST DNNRGNECSQ KFRKSKKKKR Y
Length:281
Mass (Da):32,179
Last modified:December 1, 2000 - v1
Checksum:i0F9478888F6F1D98
GO
Isoform 2 (identifier: P57052-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: MFPAQEEADR...GRPINVQYRF → LRPRPEDVPC...GRDSVRAVPS

Note: Incomplete sequence.
Show »
Length:233
Mass (Da):26,465
Checksum:i891A5E9130B95FEC
GO

Sequence cautioni

The sequence AAH30196 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL82535 differs from that shown. Reason: Frameshift at position 33.Curated
The sequence BAC03638 differs from that shown. Reason: Frameshift at position 33.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32Q → QFLIG in BAC03638 (PubMed:14702039).Curated1
Sequence conflicti32Q → QFLIG in AAL82535 (PubMed:12036298).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024621116L → V.2 PublicationsCorresponds to variant rs409782dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0273711 – 86MFPAQ…VQYRF → LRPRPEDVPCSGGGRQDRVC WEFRGPSSGRDSVRAVPS in isoform 2. 1 PublicationAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001660 Genomic DNA. Translation: BAA95545.1.
AK091331 mRNA. Translation: BAC03638.1. Frameshift.
BC030196 mRNA. Translation: AAH30196.2. Different initiation.
AY077695 mRNA. Translation: AAL82535.1. Frameshift.
AF519623 mRNA. Translation: AAM75350.1.
CCDSiCCDS46635.1. [P57052-1]
RefSeqiNP_001307531.1. NM_001320602.1.
NP_658983.3. NM_144770.4. [P57052-1]
XP_016883874.1. XM_017028385.1.
XP_016883875.1. XM_017028386.1.
XP_016883876.1. XM_017028387.1.
UniGeneiHs.283828.

Genome annotation databases

EnsembliENST00000400577; ENSP00000383421; ENSG00000185272. [P57052-1]
GeneIDi54033.
KEGGihsa:54033.
UCSCiuc002yjo.5. human. [P57052-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001660 Genomic DNA. Translation: BAA95545.1.
AK091331 mRNA. Translation: BAC03638.1. Frameshift.
BC030196 mRNA. Translation: AAH30196.2. Different initiation.
AY077695 mRNA. Translation: AAL82535.1. Frameshift.
AF519623 mRNA. Translation: AAM75350.1.
CCDSiCCDS46635.1. [P57052-1]
RefSeqiNP_001307531.1. NM_001320602.1.
NP_658983.3. NM_144770.4. [P57052-1]
XP_016883874.1. XM_017028385.1.
XP_016883875.1. XM_017028386.1.
XP_016883876.1. XM_017028387.1.
UniGeneiHs.283828.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YWKX-ray1.54A1-82[»]
ProteinModelPortaliP57052.
SMRiP57052.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119845. 16 interactors.
IntActiP57052. 7 interactors.
MINTiMINT-1452231.
STRINGi9606.ENSP00000383421.

PTM databases

iPTMnetiP57052.
PhosphoSitePlusiP57052.

Polymorphism and mutation databases

BioMutaiRBM11.
DMDMi9978670.

Proteomic databases

PaxDbiP57052.
PeptideAtlasiP57052.
PRIDEiP57052.

Protocols and materials databases

DNASUi54033.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400577; ENSP00000383421; ENSG00000185272. [P57052-1]
GeneIDi54033.
KEGGihsa:54033.
UCSCiuc002yjo.5. human. [P57052-1]

Organism-specific databases

CTDi54033.
GeneCardsiRBM11.
HGNCiHGNC:9897. RBM11.
HPAiHPA045885.
neXtProtiNX_P57052.
OpenTargetsiENSG00000185272.
PharmGKBiPA34260.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY0E. Eukaryota.
ENOG4111UDH. LUCA.
GeneTreeiENSGT00860000133762.
HOGENOMiHOG000146448.
HOVERGENiHBG061506.
InParanoidiP57052.
OMAiYRFGSSR.
OrthoDBiEOG091G15TA.
PhylomeDBiP57052.
TreeFamiTF323596.

Enzyme and pathway databases

BioCyciZFISH:G66-33032-MONOMER.

Miscellaneous databases

ChiTaRSiRBM11. human.
EvolutionaryTraceiP57052.
GeneWikiiRBM11.
GenomeRNAii54033.
PROiP57052.

Gene expression databases

BgeeiENSG00000185272.
CleanExiHS_RBM11.
GenevisibleiP57052. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM11_HUMAN
AccessioniPrimary (citable) accession number: P57052
Secondary accession number(s): Q6YNC2, Q8NBA1, Q8NFF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.