Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Major outer membrane protein P.IA

Gene

porA

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Serves as a slightly cation selective porin. Major antigen on the gonococcal cell surface and it may have pathogenic properties in addition to its porin activity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Major outer membrane protein P.IA
Short name:
PIA
Short name:
Protein IA
Alternative name(s):
Class 1 protein
Gene namesi
Name:porA
Ordered Locus Names:NMA1642
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000626 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000002527320 – 395Major outer membrane protein P.IAAdd BLAST376

Interactioni

Subunit structurei

Homotrimer.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QKZX-ray1.95P46-55[»]
ProteinModelPortaliP57041.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57041.

Family & Domainsi

Sequence similaritiesi

Belongs to the Gram-negative porin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

HOGENOMiHOG000114654.
KOiK18132.
OMAiAHGFDFI.

Family and domain databases

CDDicd00342. gram_neg_porins. 1 hit.
Gene3Di2.40.160.10. 1 hit.
InterProiIPR033900. Gram_neg_porin_domain.
IPR023614. Porin_dom.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
IPR002299. Porin_Neis.
[Graphical view]
PfamiPF00267. Porin_1. 1 hit.
[Graphical view]
PRINTSiPR00182. ECOLNEIPORIN.
PR00184. NEISSPPORIN.
PROSITEiPS00576. GRAM_NEG_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKKLTALVL SALPLAAVAD VSLYGEIKAG VEGRNYQLQL TEAQAANGGA
60 70 80 90 100
SGQVKVTKVT KAKSRIRTKI SDFGSFIGFK GSEDLGEGLK AVWQLEQDVS
110 120 130 140 150
VAGGGATQWG NRESFIGLAG EFGTLRAGRV ANQFDDASQA IDPWDSNNDV
160 170 180 190 200
ASQLGIFKRH DDMPVSVRYD SPEFSGFSGS VQFVPAQNSK SAYKPAYWTT
210 220 230 240 250
VNTGSATTTT FVPAVVGKPG SDVYYAGLNY KNGGFAGNYA FKYARHANVG
260 270 280 290 300
RDAFELFLLG SGSDQAKGTD PLKNHQVHRL TGGYEEGGLN LALAAQLDLS
310 320 330 340 350
ENGDKTKNST TEIAATASYR FGNAVPRISY AHGFDFIERG KKGENTSYDQ
360 370 380 390
IIAGVDYDFS KRTSAIVSGA WLKRNTGIGN YTQINAASVG LRHKF
Length:395
Mass (Da):42,270
Last modified:December 1, 2000 - v1
Checksum:iF7D9CE6480586577
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM08777.1.
PIRiF81858.
RefSeqiWP_002247001.1. NC_003116.1.

Genome annotation databases

EnsemblBacteriaiCAM08777; CAM08777; NMA1642.
KEGGinma:NMA1642.
PATRICi20364411. VBINeiMen132687_1909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM08777.1.
PIRiF81858.
RefSeqiWP_002247001.1. NC_003116.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QKZX-ray1.95P46-55[»]
ProteinModelPortaliP57041.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM08777; CAM08777; NMA1642.
KEGGinma:NMA1642.
PATRICi20364411. VBINeiMen132687_1909.

Phylogenomic databases

HOGENOMiHOG000114654.
KOiK18132.
OMAiAHGFDFI.

Miscellaneous databases

EvolutionaryTraceiP57041.

Family and domain databases

CDDicd00342. gram_neg_porins. 1 hit.
Gene3Di2.40.160.10. 1 hit.
InterProiIPR033900. Gram_neg_porin_domain.
IPR023614. Porin_dom.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
IPR002299. Porin_Neis.
[Graphical view]
PfamiPF00267. Porin_1. 1 hit.
[Graphical view]
PRINTSiPR00182. ECOLNEIPORIN.
PR00184. NEISSPPORIN.
PROSITEiPS00576. GRAM_NEG_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOMPA_NEIMA
AccessioniPrimary (citable) accession number: P57041
Secondary accession number(s): A1ISL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.