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P57016

- LAD1_MOUSE

UniProt

P57016 - LAD1_MOUSE

Protein

Ladinin-1

Gene

Lad1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Anchoring filament protein which is a component of the basement membrane zone.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ladinin-1
    Short name:
    Lad-1
    Alternative name(s):
    Linear IgA disease antigen homolog
    Short name:
    LADA
    Gene namesi
    Name:Lad1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:109343. Lad1.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrixbasement membrane 1 Publication

    GO - Cellular componenti

    1. actin cytoskeleton Source: Ensembl
    2. basement membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Basement membrane, Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 528528Ladinin-1PRO_0000084350Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei19 – 191PhosphothreonineBy similarity
    Modified residuei38 – 381PhosphoserineBy similarity
    Modified residuei62 – 621PhosphoserineBy similarity
    Modified residuei119 – 1191PhosphoserineBy similarity
    Modified residuei405 – 4051PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP57016.
    PaxDbiP57016.
    PRIDEiP57016.

    PTM databases

    PhosphoSiteiP57016.

    Expressioni

    Tissue specificityi

    Expressed in kidney, lung and keratinocytes followed by liver, spleen and brain. Not expressed in testis, skeletal and heart muscle and in fibroblasts.1 Publication

    Gene expression databases

    BgeeiP57016.
    CleanExiMM_LAD1.
    GenevestigatoriP57016.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000044630.

    Structurei

    3D structure databases

    ProteinModelPortaliP57016.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati184 – 1863SEK 1
    Repeati190 – 1923SEK 2
    Repeati202 – 2043SEK 3
    Repeati208 – 2103SEK 4
    Repeati269 – 2713SEK 5
    Repeati279 – 2813SEK 6

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni184 – 281986 X SEK repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi28 – 358Poly-Arg

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG84480.
    GeneTreeiENSGT00390000005256.
    HOGENOMiHOG000113274.
    HOVERGENiHBG006240.
    InParanoidiP57016.
    OMAiHTAIQRS.
    OrthoDBiEOG77WWD6.
    PhylomeDBiP57016.
    TreeFamiTF335896.

    Family and domain databases

    InterProiIPR017404. Ladinin_1.
    [Graphical view]
    PIRSFiPIRSF038144. Ladinin_1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P57016-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVSRKDWSA LSSLARQRTL EDEEEQERER RRRHRNLSST TDDESPKLTQ    50
    NGAQRSVERL PSVEEAEVSK PSPPASKDED EDFQAILRTR KERRQRRQVV 100
    EAVQAPVQER PEAEEERDSL GPEQTSSQPL VPKKKVEALP RRRLSREQRG 150
    PWAQDEERLK NRELAEGEKR LPEETVAQQK TLVSEKTPVS EKTPVPAKRL 200
    VSEKACPSEK GTATEKASLT EKRHSPEKLV PEKTSVTEKS PVPEKTLVSL 250
    KTAAPERRSP PVLEKAIVSE KMQERKLVSE KASIFEKSLV SEAKLTPKKA 300
    AVSEQPQTTG GSQATTREPR GRALPDKSPP SSAEQSTPAP PTKASRFPPI 350
    TLQVKIPSKD EDADTPSPTL LTYSSSLKRS SPRTISFRMS PRKDNSETPL 400
    TRSASVRLPA STVKLGEKLE RYHTAIQRSE SVRSPGSSRT EVLVTPAGVA 450
    SKRHLFEKEL SGQNRTEPTS IRKENLRLSG VVTSRLNLWI SKTQDSGDHG 500
    SQEVRKEASV TKRAQWGSKP STSLDAEV 528
    Length:528
    Mass (Da):58,864
    Last modified:December 1, 2000 - v1
    Checksum:i3893C72B0C92609C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58011 mRNA. Translation: AAC53044.1.
    AK083526 mRNA. Translation: BAC38941.1.
    BC016257 mRNA. Translation: AAH16257.1.
    BC031131 mRNA. Translation: AAH31131.1.
    CCDSiCCDS35723.1.
    RefSeqiNP_598425.2. NM_133664.3.
    UniGeneiMm.36726.

    Genome annotation databases

    EnsembliENSMUST00000038760; ENSMUSP00000044630; ENSMUSG00000041782.
    GeneIDi16763.
    KEGGimmu:16763.
    UCSCiuc007ctt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58011 mRNA. Translation: AAC53044.1 .
    AK083526 mRNA. Translation: BAC38941.1 .
    BC016257 mRNA. Translation: AAH16257.1 .
    BC031131 mRNA. Translation: AAH31131.1 .
    CCDSi CCDS35723.1.
    RefSeqi NP_598425.2. NM_133664.3.
    UniGenei Mm.36726.

    3D structure databases

    ProteinModelPortali P57016.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000044630.

    PTM databases

    PhosphoSitei P57016.

    Proteomic databases

    MaxQBi P57016.
    PaxDbi P57016.
    PRIDEi P57016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038760 ; ENSMUSP00000044630 ; ENSMUSG00000041782 .
    GeneIDi 16763.
    KEGGi mmu:16763.
    UCSCi uc007ctt.1. mouse.

    Organism-specific databases

    CTDi 3898.
    MGIi MGI:109343. Lad1.

    Phylogenomic databases

    eggNOGi NOG84480.
    GeneTreei ENSGT00390000005256.
    HOGENOMi HOG000113274.
    HOVERGENi HBG006240.
    InParanoidi P57016.
    OMAi HTAIQRS.
    OrthoDBi EOG77WWD6.
    PhylomeDBi P57016.
    TreeFami TF335896.

    Miscellaneous databases

    NextBioi 290576.
    PROi P57016.
    SOURCEi Search...

    Gene expression databases

    Bgeei P57016.
    CleanExi MM_LAD1.
    Genevestigatori P57016.

    Family and domain databases

    InterProi IPR017404. Ladinin_1.
    [Graphical view ]
    PIRSFi PIRSF038144. Ladinin_1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and chromosomal mapping of mouse ladinin, a novel basement membrane zone component."
      Motoki K., Megahed M., LaForgia S., Uitto J.
      Genomics 39:323-330(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: Skin.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland and Salivary gland.

    Entry informationi

    Entry nameiLAD1_MOUSE
    AccessioniPrimary (citable) accession number: P57016
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3