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Protein

Ladinin-1

Gene

Lad1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Anchoring filament protein which is a component of the basement membrane zone.1 Publication

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ladinin-1
Short name:
Lad-1
Alternative name(s):
Linear IgA disease antigen homolog
Short name:
LADA
Gene namesi
Name:Lad1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:109343. Lad1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843501 – 528Ladinin-1Add BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei62PhosphoserineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei119PhosphoserineBy similarity1
Modified residuei328PhosphoserineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1
Modified residuei405PhosphoserineBy similarity1
Modified residuei496PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP57016.
PaxDbiP57016.
PeptideAtlasiP57016.
PRIDEiP57016.

PTM databases

iPTMnetiP57016.
PhosphoSitePlusiP57016.

Expressioni

Tissue specificityi

Expressed in kidney, lung and keratinocytes followed by liver, spleen and brain. Not expressed in testis, skeletal and heart muscle and in fibroblasts.1 Publication

Gene expression databases

BgeeiENSMUSG00000041782.
CleanExiMM_LAD1.
GenevisibleiP57016. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044630.

Structurei

3D structure databases

ProteinModelPortaliP57016.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati184 – 186SEK 13
Repeati190 – 192SEK 23
Repeati202 – 204SEK 33
Repeati208 – 210SEK 43
Repeati269 – 271SEK 53
Repeati279 – 281SEK 63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni184 – 2816 X SEK repeatsAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 35Poly-Arg8

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIRJ. Eukaryota.
ENOG410YZPA. LUCA.
GeneTreeiENSGT00390000005256.
HOGENOMiHOG000113274.
HOVERGENiHBG006240.
InParanoidiP57016.
OMAiHTAIQRS.
OrthoDBiEOG091G0AOB.
PhylomeDBiP57016.
TreeFamiTF335896.

Family and domain databases

InterProiIPR017404. Ladinin_1.
[Graphical view]
PIRSFiPIRSF038144. Ladinin_1. 1 hit.

Sequencei

Sequence statusi: Complete.

P57016-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSRKDWSA LSSLARQRTL EDEEEQERER RRRHRNLSST TDDESPKLTQ
60 70 80 90 100
NGAQRSVERL PSVEEAEVSK PSPPASKDED EDFQAILRTR KERRQRRQVV
110 120 130 140 150
EAVQAPVQER PEAEEERDSL GPEQTSSQPL VPKKKVEALP RRRLSREQRG
160 170 180 190 200
PWAQDEERLK NRELAEGEKR LPEETVAQQK TLVSEKTPVS EKTPVPAKRL
210 220 230 240 250
VSEKACPSEK GTATEKASLT EKRHSPEKLV PEKTSVTEKS PVPEKTLVSL
260 270 280 290 300
KTAAPERRSP PVLEKAIVSE KMQERKLVSE KASIFEKSLV SEAKLTPKKA
310 320 330 340 350
AVSEQPQTTG GSQATTREPR GRALPDKSPP SSAEQSTPAP PTKASRFPPI
360 370 380 390 400
TLQVKIPSKD EDADTPSPTL LTYSSSLKRS SPRTISFRMS PRKDNSETPL
410 420 430 440 450
TRSASVRLPA STVKLGEKLE RYHTAIQRSE SVRSPGSSRT EVLVTPAGVA
460 470 480 490 500
SKRHLFEKEL SGQNRTEPTS IRKENLRLSG VVTSRLNLWI SKTQDSGDHG
510 520
SQEVRKEASV TKRAQWGSKP STSLDAEV
Length:528
Mass (Da):58,864
Last modified:December 1, 2000 - v1
Checksum:i3893C72B0C92609C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58011 mRNA. Translation: AAC53044.1.
AK083526 mRNA. Translation: BAC38941.1.
BC016257 mRNA. Translation: AAH16257.1.
BC031131 mRNA. Translation: AAH31131.1.
CCDSiCCDS35723.1.
RefSeqiNP_598425.2. NM_133664.3.
UniGeneiMm.36726.

Genome annotation databases

EnsembliENSMUST00000038760; ENSMUSP00000044630; ENSMUSG00000041782.
GeneIDi16763.
KEGGimmu:16763.
UCSCiuc007ctt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58011 mRNA. Translation: AAC53044.1.
AK083526 mRNA. Translation: BAC38941.1.
BC016257 mRNA. Translation: AAH16257.1.
BC031131 mRNA. Translation: AAH31131.1.
CCDSiCCDS35723.1.
RefSeqiNP_598425.2. NM_133664.3.
UniGeneiMm.36726.

3D structure databases

ProteinModelPortaliP57016.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044630.

PTM databases

iPTMnetiP57016.
PhosphoSitePlusiP57016.

Proteomic databases

MaxQBiP57016.
PaxDbiP57016.
PeptideAtlasiP57016.
PRIDEiP57016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038760; ENSMUSP00000044630; ENSMUSG00000041782.
GeneIDi16763.
KEGGimmu:16763.
UCSCiuc007ctt.1. mouse.

Organism-specific databases

CTDi3898.
MGIiMGI:109343. Lad1.

Phylogenomic databases

eggNOGiENOG410IIRJ. Eukaryota.
ENOG410YZPA. LUCA.
GeneTreeiENSGT00390000005256.
HOGENOMiHOG000113274.
HOVERGENiHBG006240.
InParanoidiP57016.
OMAiHTAIQRS.
OrthoDBiEOG091G0AOB.
PhylomeDBiP57016.
TreeFamiTF335896.

Miscellaneous databases

PROiP57016.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041782.
CleanExiMM_LAD1.
GenevisibleiP57016. MM.

Family and domain databases

InterProiIPR017404. Ladinin_1.
[Graphical view]
PIRSFiPIRSF038144. Ladinin_1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLAD1_MOUSE
AccessioniPrimary (citable) accession number: P57016
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.