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P57016

- LAD1_MOUSE

UniProt

P57016 - LAD1_MOUSE

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Protein
Ladinin-1
Gene
Lad1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Anchoring filament protein which is a component of the basement membrane zone.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Ladinin-1
Short name:
Lad-1
Alternative name(s):
Linear IgA disease antigen homolog
Short name:
LADA
Gene namesi
Name:Lad1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:109343. Lad1.

Subcellular locationi

Secretedextracellular spaceextracellular matrixbasement membrane 1 Publication

GO - Cellular componenti

  1. actin cytoskeleton Source: Ensembl
  2. basement membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Ladinin-1
PRO_0000084350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Phosphothreonine By similarity
Modified residuei38 – 381Phosphoserine By similarity
Modified residuei62 – 621Phosphoserine By similarity
Modified residuei119 – 1191Phosphoserine By similarity
Modified residuei405 – 4051Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP57016.
PaxDbiP57016.
PRIDEiP57016.

PTM databases

PhosphoSiteiP57016.

Expressioni

Tissue specificityi

Expressed in kidney, lung and keratinocytes followed by liver, spleen and brain. Not expressed in testis, skeletal and heart muscle and in fibroblasts.1 Publication

Gene expression databases

BgeeiP57016.
CleanExiMM_LAD1.
GenevestigatoriP57016.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044630.

Structurei

3D structure databases

ProteinModelPortaliP57016.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati184 – 1863SEK 1
Repeati190 – 1923SEK 2
Repeati202 – 2043SEK 3
Repeati208 – 2103SEK 4
Repeati269 – 2713SEK 5
Repeati279 – 2813SEK 6

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni184 – 281986 X SEK repeats
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 358Poly-Arg

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG84480.
GeneTreeiENSGT00390000005256.
HOGENOMiHOG000113274.
HOVERGENiHBG006240.
InParanoidiP57016.
OMAiHTAIQRS.
OrthoDBiEOG77WWD6.
PhylomeDBiP57016.
TreeFamiTF335896.

Family and domain databases

InterProiIPR017404. Ladinin_1.
[Graphical view]
PIRSFiPIRSF038144. Ladinin_1. 1 hit.

Sequencei

Sequence statusi: Complete.

P57016-1 [UniParc]FASTAAdd to Basket

« Hide

MSVSRKDWSA LSSLARQRTL EDEEEQERER RRRHRNLSST TDDESPKLTQ    50
NGAQRSVERL PSVEEAEVSK PSPPASKDED EDFQAILRTR KERRQRRQVV 100
EAVQAPVQER PEAEEERDSL GPEQTSSQPL VPKKKVEALP RRRLSREQRG 150
PWAQDEERLK NRELAEGEKR LPEETVAQQK TLVSEKTPVS EKTPVPAKRL 200
VSEKACPSEK GTATEKASLT EKRHSPEKLV PEKTSVTEKS PVPEKTLVSL 250
KTAAPERRSP PVLEKAIVSE KMQERKLVSE KASIFEKSLV SEAKLTPKKA 300
AVSEQPQTTG GSQATTREPR GRALPDKSPP SSAEQSTPAP PTKASRFPPI 350
TLQVKIPSKD EDADTPSPTL LTYSSSLKRS SPRTISFRMS PRKDNSETPL 400
TRSASVRLPA STVKLGEKLE RYHTAIQRSE SVRSPGSSRT EVLVTPAGVA 450
SKRHLFEKEL SGQNRTEPTS IRKENLRLSG VVTSRLNLWI SKTQDSGDHG 500
SQEVRKEASV TKRAQWGSKP STSLDAEV 528
Length:528
Mass (Da):58,864
Last modified:December 1, 2000 - v1
Checksum:i3893C72B0C92609C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58011 mRNA. Translation: AAC53044.1.
AK083526 mRNA. Translation: BAC38941.1.
BC016257 mRNA. Translation: AAH16257.1.
BC031131 mRNA. Translation: AAH31131.1.
CCDSiCCDS35723.1.
RefSeqiNP_598425.2. NM_133664.3.
UniGeneiMm.36726.

Genome annotation databases

EnsembliENSMUST00000038760; ENSMUSP00000044630; ENSMUSG00000041782.
GeneIDi16763.
KEGGimmu:16763.
UCSCiuc007ctt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58011 mRNA. Translation: AAC53044.1 .
AK083526 mRNA. Translation: BAC38941.1 .
BC016257 mRNA. Translation: AAH16257.1 .
BC031131 mRNA. Translation: AAH31131.1 .
CCDSi CCDS35723.1.
RefSeqi NP_598425.2. NM_133664.3.
UniGenei Mm.36726.

3D structure databases

ProteinModelPortali P57016.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000044630.

PTM databases

PhosphoSitei P57016.

Proteomic databases

MaxQBi P57016.
PaxDbi P57016.
PRIDEi P57016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038760 ; ENSMUSP00000044630 ; ENSMUSG00000041782 .
GeneIDi 16763.
KEGGi mmu:16763.
UCSCi uc007ctt.1. mouse.

Organism-specific databases

CTDi 3898.
MGIi MGI:109343. Lad1.

Phylogenomic databases

eggNOGi NOG84480.
GeneTreei ENSGT00390000005256.
HOGENOMi HOG000113274.
HOVERGENi HBG006240.
InParanoidi P57016.
OMAi HTAIQRS.
OrthoDBi EOG77WWD6.
PhylomeDBi P57016.
TreeFami TF335896.

Miscellaneous databases

NextBioi 290576.
PROi P57016.
SOURCEi Search...

Gene expression databases

Bgeei P57016.
CleanExi MM_LAD1.
Genevestigatori P57016.

Family and domain databases

InterProi IPR017404. Ladinin_1.
[Graphical view ]
PIRSFi PIRSF038144. Ladinin_1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal mapping of mouse ladinin, a novel basement membrane zone component."
    Motoki K., Megahed M., LaForgia S., Uitto J.
    Genomics 39:323-330(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Skin.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland and Salivary gland.

Entry informationi

Entry nameiLAD1_MOUSE
AccessioniPrimary (citable) accession number: P57016
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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