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P57016 (LAD1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ladinin-1
Short name=Lad-1
Alternative name(s):
Linear IgA disease antigen homolog
Short name=LADA
Gene names
Name:Lad1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Anchoring filament protein which is a component of the basement membrane zone. Ref.1

Subcellular location

Secreted › extracellular space › extracellular matrix › basement membrane Ref.1.

Tissue specificity

Expressed in kidney, lung and keratinocytes followed by liver, spleen and brain. Not expressed in testis, skeletal and heart muscle and in fibroblasts. Ref.1

Ontologies

Keywords
   Cellular componentBasement membrane
Extracellular matrix
Secreted
   DomainRepeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentactin cytoskeleton

Inferred from electronic annotation. Source: Compara

basement membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 528528Ladinin-1
PRO_0000084350

Regions

Repeat184 – 1863SEK 1
Repeat190 – 1923SEK 2
Repeat202 – 2043SEK 3
Repeat208 – 2103SEK 4
Repeat269 – 2713SEK 5
Repeat279 – 2813SEK 6
Region184 – 281986 X SEK repeats
Compositional bias28 – 358Poly-Arg

Amino acid modifications

Modified residue191Phosphothreonine By similarity
Modified residue381Phosphoserine By similarity
Modified residue561Phosphoserine Ref.5
Modified residue621Phosphoserine Ref.5
Modified residue1191Phosphoserine By similarity
Modified residue4051Phosphoserine By similarity
Modified residue5231Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
P57016 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 3893C72B0C92609C

FASTA52858,864
        10         20         30         40         50         60 
MSVSRKDWSA LSSLARQRTL EDEEEQERER RRRHRNLSST TDDESPKLTQ NGAQRSVERL 

        70         80         90        100        110        120 
PSVEEAEVSK PSPPASKDED EDFQAILRTR KERRQRRQVV EAVQAPVQER PEAEEERDSL 

       130        140        150        160        170        180 
GPEQTSSQPL VPKKKVEALP RRRLSREQRG PWAQDEERLK NRELAEGEKR LPEETVAQQK 

       190        200        210        220        230        240 
TLVSEKTPVS EKTPVPAKRL VSEKACPSEK GTATEKASLT EKRHSPEKLV PEKTSVTEKS 

       250        260        270        280        290        300 
PVPEKTLVSL KTAAPERRSP PVLEKAIVSE KMQERKLVSE KASIFEKSLV SEAKLTPKKA 

       310        320        330        340        350        360 
AVSEQPQTTG GSQATTREPR GRALPDKSPP SSAEQSTPAP PTKASRFPPI TLQVKIPSKD 

       370        380        390        400        410        420 
EDADTPSPTL LTYSSSLKRS SPRTISFRMS PRKDNSETPL TRSASVRLPA STVKLGEKLE 

       430        440        450        460        470        480 
RYHTAIQRSE SVRSPGSSRT EVLVTPAGVA SKRHLFEKEL SGQNRTEPTS IRKENLRLSG 

       490        500        510        520 
VVTSRLNLWI SKTQDSGDHG SQEVRKEASV TKRAQWGSKP STSLDAEV

« Hide

References

« Hide 'large scale' references
[1]"Cloning and chromosomal mapping of mouse ladinin, a novel basement membrane zone component."
Motoki K., Megahed M., LaForgia S., Uitto J.
Genomics 39:323-330(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: C57BL/6.
Tissue: Skin.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland and Salivary gland.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523, MASS SPECTROMETRY.
Tissue: Liver.
[5]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56 AND SER-62, MASS SPECTROMETRY.
Tissue: Melanoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U58011 mRNA. Translation: AAC53044.1.
AK083526 mRNA. Translation: BAC38941.1.
BC016257 mRNA. Translation: AAH16257.1.
BC031131 mRNA. Translation: AAH31131.1.
IPIIPI00319558.
RefSeqNP_598425.2. NM_133664.3.
UniGeneMm.36726.

3D structure databases

ProteinModelPortalP57016.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000044630.

PTM databases

PhosphoSiteP57016.

Proteomic databases

PaxDbP57016.
PRIDEP57016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038760; ENSMUSP00000044630; ENSMUSG00000041782.
GeneID16763.
KEGGmmu:16763.
UCSCuc007ctt.1. mouse.

Organism-specific databases

CTD3898.
MGIMGI:109343. Lad1.

Phylogenomic databases

eggNOGNOG84480.
GeneTreeENSGT00390000005256.
HOGENOMHOG000113274.
HOVERGENHBG006240.
InParanoidP57016.
OMAPPASKDE.
OrthoDBEOG4RBQJH.

Gene expression databases

BgeeP57016.
CleanExMM_LAD1.
GenevestigatorP57016.
GermOnlineENSMUSG00000041782. Mus musculus.

Family and domain databases

InterProIPR017404. Ladinin_1.
[Graphical view]
PIRSFPIRSF038144. Ladinin_1. 1 hit.
ProtoNetSearch...

Other

NextBio290576.
SOURCESearch...

Entry information

Entry nameLAD1_MOUSE
AccessionPrimary (citable) accession number: P57016
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents